Cited by 234Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

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Impulsivity predicts individual susceptibility to high levels of alcohol self-administration

Poulos, Constantine X., Le, A. D., Parker, J. L.·1995·Behavioural Pharmacology

DOI 10.1097/00008877-199512000-00006

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Abstract

Clinical studies indicate large individual differences in susceptibility to alcohol abuse. Poor behavioral self -regulation has been proposed to reflect a predisposing factor. Like humans, only some rats regularly consume large and intoxicating amounts of alcohol. We hypothesized that clinical indications of impaired behavioral self-regulation should be reflected in an animal model of impulse control, and in this study we assessed impulsivity with a delay-of-reward paradigm. We found that three groups representing three levels of impulsivity predicted augmenting levels of alcohol self-administration. Also, overall impulsivity scores were found to be significantly correlated with magnitude of alcohol self-administration. The finding that high impulsivity is linked to elevated consumption represents an animal model that may mirror clinical depictions of an alcohol abuse syndrome. This animal model may help elucidate the neurobiological basis of individual susceptibility to alcohol addiction.

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“Separate groups of rats (n=8 each) were trained in the standard (i.e., impulsivity) and modified (i.e., cue salience) versions of the delayed reinforcement task (Thiebot et al. 1985; Poulos et al. 1995 ).”
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“2005, 2008), and greater use of alcohol (Mitchell et al. 2006; Poulos et al. 1995) and nicotine (Diergaarde et al.”
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“…delay is a predictor of drug abuse vulnerability, as measured in several operant and non-operant paradigms (Anker et al., 2009; Diergaarde et al., 2008; Marusich and Bardo, 2009; Perry et al., 2005, 2008a; Poulos et al., 1995; Yates et al., 2012; but see Diergaarde et al., 2012 for an exception).”
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“…humans (cocaine: Moeller et al., 2001; nicotine: Perkins et al., 2000) and increased self-administration in rats (cocaine: Belin et al., 2008; Dalley et al., 2007; Perry et al., 2005, 2008; methylphenidate: Marusich and Bardo, 2009; ethanol: Poulos et al., 1995; nicotine: Diergaarde et al., 2008).”
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“Poulos and colleagues were among the first to assess how preexisting individual differences in impulsive decision-making in drugnaïve rats subsequently predict vulnerability to ethanol drinking (Poulos et al., 1995; Poulos et al., 1998).”
Background
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“In any case, these results are consistent with previous research showing that rats high in impulsive choice consume more ethanol (Poulos et al. 1995) and self-administer more of a low unit dose of MPH compared to rats low in impulsive choice (Marusich and Bardo 2009).”
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“In other studies, discounting was assessed as a predictor of drug self-administration, and steeper discounting was associated with greater self-administration of alcohol, nicotine, and cocaine (Poulos et al., 1995; Perry et al., 2005; Diergaarde et al., 2008; Anker et al., 2009).”
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Background
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“2008 for review) and that baseline sensitivity to delayed reward and behavioural disinhibition in rodents are predictive of later self-administration of cocaine, ethanol and nicotine (e.g. Dalley et al. 2007; Diergaarde et al. 2008; Oberlin and Grahame 2009; Poulos and Parker 1995).”
Background
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“, 1989), impulsive choice (Diergaarde et al., 2008; Poulos et al., 1995), and impulsive action (Economidou et al.”
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Churchwell, J. C., & Yurgelun-Todd, D. A. (2011) · Springer eBooks · doi:10.1007/978-1-4419-1268-8_6 · Cited by 8
Is premature ejaculation an impulse control disorder?
Özdemir, O. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.03.034 · Cited by 6
“This claim is supported by the finding that impulsivity in rats, quantified by a preference for small immediate reward over a delayed larger reward (delay discounting) is associated with higher rates of cocaine [43,44], alcohol [45] and methylphenidate self-administration [46].”
Background
PREFERENCE REVERSAL AND THE ESTIMATION OF INDIFFERENCE POINTS USING A FAST-ADJUSTING-DELAY PROCEDURE WITH RATS
Bennett, S. M. (2002) · Cited by 6
Sensitivity to reinforcer delay predicts ethanol's suppressant effects, but itself is unaffected by ethanol
Moschak, T. M., & Mitchell, S. H. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2013.07.009 · Cited by 5
“In animals, steeper delay discounters subsequently consume more ethanol (Poulos et al., 1995; but see Diergaarde et al., 2012).”
Background
Contribution of Impulsivity and Serotonin Receptor Neuroadaptations to the Development of an MDMA (‘Ecstasy’) Substance Use Disorder
Schenk, S., & Aronsen, D. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_421 · Cited by 4
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Similarities and Differences in Diagnostic Criterion
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Adaptation of the 5-choice serial reaction time task to measure engagement and motivation for alcohol in mice
Starski, P. A., Maulucci, D. P., Mead, H., & Hopf, F. W. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.968359 · Cited by 4
“Thus, it is interesting that, in addition to high trait impulsivity, people at risk for binging have higher alcohol preference (Poulos et al., 1995; Crews and Boettiger, 2009; Schumann et al., 2011), and impulsivity can be linked to preferences in rodents (Oberlin and Grahame, 2009; Dick et al.”
Background
Psychological drug research: current themes and future developments
Negreiros, J. (2006) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 4
Saccharin Preference in Rats: Relation to Impulsivity and Drug Abuse
Carroll, M. E., Holtz, N. A., & Zlebnik, N. E. (2012) · Neuromethods · doi:10.1007/978-1-62703-104-2_13 · Cited by 3
The Relationship Between Goal-Focused Self-Regulation and Impaired Control on Alcohol: Mediation Effects of Emotion Regulation and Impulsivity
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Effects of chronic voluntary alcohol consumption on PDE10A availability: a longitudinal behavioral and [18F]JNJ42259152 PET study in rats
de Laat, B., Kling, Y. E., Schroyen, G., Ooms, M., Hooker, J. M., Bormans, G. M., Laere, K. V., & Ceccarini, J. (2021) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-021-05448-3 · Cited by 3
Impulsivity
Bari, A., Robbins, T. W., & Dalley, J. W. (2010) · Neuromethods · doi:10.1007/978-1-60761-934-5_14 · Cited by 3
Economic Behavior under Alcohol Influence: An Experiment on Time, Risk, and Social PreferencesPreprint
Corazzini, L., Filippin, A., & Vanin, P. (2014) · SSRN Electronic Journal · doi:10.2139/ssrn.2434511 · Cited by 2
“On the one hand, it could be that subjects become abuser because they are impatient, as suggested for instance by Poulos et al. (1995).”
Maternal separation in the rat : long-term effects of early life events on emotionality, drug response and neurobiology
Marmendal, M. (2005) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 3
Impulsivity as a Predisposing Vulnerability Trait for Reward Sensitivity and Volitional Drug Self-administration: A Scoping Review
Cornelissen, F. E. M., Vries, T. J. D., & Pattij, T. (2025) · Current Addiction Reports · doi:10.1007/s40429-025-00682-3 · Cited by 2
“Two records were added through snowball searching [14, 15 ].”
Diversities of behavioral traits and neuropsychological function in different substance addiction
Wang, H., Wang, T., & Chen, Y.-C. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.05.016 · Cited by 2
“It involves selfharm, aggression and violence, pathological gambling, certain compulsive behavior of psychiatric patients and substance addiction (Poulos et al., 1995).”
Preference for Palatable Food, Impulsivity, and Relation to Drug Addiction in Rats
Carroll, M. E., Zlebnik, N. E., & Holtz, N. A. (2020) · Neuromethods · doi:10.1007/978-1-0716-0924-8_12 · Cited by 4
The Interaction of the Serotoninergic and Other Neuroregulatory Systems in Alcohol Dependence
Sellers, E. M., Romach, M. K., & Lê, A. D. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-60921-3_22 · Cited by 2
Self-citation
Estimating Present Bias Using Behavior History
Yamamoto, S., AKAGI, Y., Tominaga, T., & Kurashima, T. (2025) · IEICE Transactions on Information and Systems · doi:10.1587/transinf.2024edp7248 · Cited by 1
Engagement for alcohol escalates in the 5-choice serial reaction time task after intermittent access
Starski, P. A., Siegle, A., & Hopf, F. W. (2024) · Alcohol · doi:10.1016/j.alcohol.2024.01.004 · Cited by 1
Training Schedule Affects Operant Responding Independent of Motivation in the Neuroligin‐3 R451C Mouse Model of Autism
Dingwall, R., May, C., McDonald, J. A., Hill, T., Brown, R. M., Lawrence, A. J., Hannan, A. J., & Burrows, E. L. (2025) · Genes Brain & Behavior · doi:10.1111/gbb.70032
“As impulsivity accounts for a portion of total responses in operant tasks [28, 29], we also explored the interaction between measures of motivation and pharmacological interventions for impulsivity in NL3 mice.”
INDIVIDUAL DIFFERENCES IN DELAY DISCOUNTING AND NICOTINE SELF-ADMINISTRATION IN RATS
Sweitzer, M. M. (2009) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1

Authors: Poulos, C. X., Le, A. D., & Parker, J. L.
Affiliations: University of Toronto (CA)
ORCID: Parker, J. L.
Venue: Behavioural Pharmacology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1995-12
Volume: 6
Issue: 8
Pages: 810???814
ISSN: 0955-8810 (ISSN-L)
DOI: 10.1097/00008877-199512000-00006
OpenAlex: W1974743544
Cited by: 234
References: 0
Citations by year: 2025: 6 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 3 · 2018: 14 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 12 · 2013: 13 · 2012: 15
FWCI: 1.06
Type: journal article
Language: en
Open access: closed
Locations: Behavioural Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: impulsivity, alcohol self-administration, behavioral self-regulation, reward delay, alcoholism, alcohol abuse

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Impulsivity predicts individual susceptibility to high levels of alcohol self-administration

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