The DOI matches its Crossref record.
Impulsivity predicts individual susceptibility to high levels of alcohol self-administration
Abstract
Clinical studies indicate large individual differences in susceptibility to alcohol abuse. Poor behavioral self -regulation has been proposed to reflect a predisposing factor. Like humans, only some rats regularly consume large and intoxicating amounts of alcohol. We hypothesized that clinical indications of impaired behavioral self-regulation should be reflected in an animal model of impulse control, and in this study we assessed impulsivity with a delay-of-reward paradigm. We found that three groups representing three levels of impulsivity predicted augmenting levels of alcohol self-administration. Also, overall impulsivity scores were found to be significantly correlated with magnitude of alcohol self-administration. The finding that high impulsivity is linked to elevated consumption represents an animal model that may mirror clinical depictions of an alcohol abuse syndrome. This animal model may help elucidate the neurobiological basis of individual susceptibility to alcohol addiction.
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In the citing paper
“This finding has been inconsistently replicated, however, with other drugs of abuse”
From Changing Delay Discounting and Impulsive Choice: Implications for Addictions, Prevention, and Human Health (2019) · cites this paper as Poulos et al., 1995
In the citing paper
“In rats, high impulsivity – measured by delay discounting – is a vulnerability factor for both alcohol (Poulos et al., 1995) and cocaine (Perry and Carroll, 2008; Perry et al., 2005) self-administration.”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Poulos et al., 1995
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Impulsivity, compulsivity, and top-down cognitive control
Dalley, J. W., Everitt, B. J., & Robbins, T. W. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.020 · Cited by 1,589
“…was the finding that rats preferentially (75% of trials) choosing small (two food pellets), immediate rewards over large (12 pellets) rewards delivered after a delay of 15 s subsequently consumed significantly more of a 12% alcohol solution than the less impulsive subgroups (Poulos et al., 1995).”
Verdejo‐García, A., Lawrence, A. J., & Clark, L. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.11.003 · Cited by 1,502
“The high impulsive animals also showed more rapid acquisition of drug self-administration and consume more cocaine than rats classified as non-impulsive (Perry et al., 2005; Piazza et al., 1989; Poulos et al., 1995).”
BackgroundPrefrontal executive and cognitive functions in rodents: neural and neurochemical substrates
Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.006 · Cited by 1,329
“It has been considered a normal human characteristic, but impulsive choice contributes to deleterious states such as drug addiction [11,49,65,86,104] and has been suggested to underlie a number of other clinical disorders, including ADHD [116,117].”
BackgroundHigh Impulsivity Predicts the Switch to Compulsive Cocaine-Taking
Belin, D., Mar, A. C., Dalley, J. W., Robbins, T. W., & Everitt, B. J. (2008) · Science · doi:10.1126/science.1158136 · Cited by 989
The role of impulsive behavior in drug abuse
Perry, J. L., & Carroll, M. E. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1173-0 · Cited by 805
“Preclinical models show that impulsive choice predicted elevated alcohol intake (Poulos et al. 1995), faster acquisition of cocaine self-administration (Perry et al.”
BackgroundMethodInfluential
Metadata
- Authors
- Poulos, C. X., Le, A. D., & Parker, J. L.
- Affiliations
- University of Toronto (CA)
- ORCID
- Parker, J. L.
- Venue
- Behavioural Pharmacology
- Published
- 1995-12
- Volume
- 6
- Issue
- 8
- Pages
- 810???814
- ISSN
- 0955-8810 (ISSN-L)
- OpenAlex
- W1974743544
- Cited by
- 234
- References
- 0
- Citations by year
- 2025: 6 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 3 · 2018: 14 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 12 · 2013: 13 · 2012: 15
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- impulsivity, alcohol self-administration, behavioral self-regulation, reward delay, alcoholism, alcohol abuse
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