High Impulsivity Predicts the Switch to Compulsive Cocaine-Taking
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Both impulsivity and novelty-seeking have been suggested to be behavioral markers of the propensity to take addictive drugs. However, their relevance for the vulnerability to compulsively seek and take drugs, which is a hallmark feature of addiction, is unknown. We report here that, whereas high reactivity to novelty predicts the propensity to initiate cocaine self-administration, high impulsivity predicts the development of addiction-like behavior in rats, including persistent or compulsive drug-taking in the face of aversive outcomes. This study shows experimental evidence that a shift from impulsivity to compulsivity occurs during the development of addictive behavior, which provides insights into the genesis and neural mechanisms of drug addiction.
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The observed general shift towards S-R habits could be a consequence of chronic alcohol use by repeated exposure to the harmful effects of drugs of abuse, or a predisposing trait or vulnerability for the development of compulsive and impulse regulation disorders, or both.
“This observed general shift towards S–R habits could be a consequence of chronic alcohol use by repeated exposure to the harmful effects of drugs of abuse31,56,57 or a predisposing trait or vulnerability for the development of compulsive and impulse regulation disorders, or both.53,58”
From Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients (2013) · cites this paper as [57]
High impulsivity predicts the development of compulsive drug-taking, whereas high reactivity to novelty predicts the propensity to initiate cocaine self-administration.
“Using a similar approach, Belin et al. (Belin et al., 2008) further showed that high impulsivity predicts the development of compulsive drug-taking, whereas high reactivity to novelty predicts the propensity to initiate cocaine self-administration.”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Belin et al., 2008
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Personality and the acute subjective effects of <i>d</i> -amphetamine in humans
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- Authors
- Belin, D., Mar, A. C., Dalley, J. W., Robbins, T. W., & Everitt, B. J.
- Affiliations
- University of Cambridge (GB)
- Venue
- Science
- Published
- 2008-06-06
- Volume
- 320
- Issue
- 5881
- Pages
- 1352-1355
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2478705
- OpenAlex
- W2029087047
- Cited by
- 989
- References
- 28
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 19 · 2023: 26 · 2022: 38 · 2021: 48 · 2020: 120 · 2019: 50 · 2018: 50 · 2017: 58 · 2016: 51 · 2015: 64 · 2014: 69 · 2013: 84 · 2012: 66
- FWCI
- 30.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- impulsivity, compulsive drug taking, cocaine self-administration, novelty seeking, addiction, compulsive behavior, aversive outcomes, drug addiction vulnerability, rats
- MeSH terms
- Animals, Cocaine, Compulsive Behavior, Exploratory Behavior, Impulsive Behavior, Male, Motor Activity, Self Administration, Behavior, Addictive, Cocaine-Related Disorders, Models, Animal, Rats
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