Spectrum of memory dysfunction in degenerative disease
Abstract
We have summarized relevant literature on the patterns of memory deficit found in Alzheimer's disease, the focal lobar atrophies (semantic dementia and dementia of frontal type) and three forms of subcortical dementia (progressive supranuclear palsy, Huntington's and Parkinson's disease). We have stressed an approach based on the joint principals of cognitive neuropsychology and applied neuroanatomy. Alzheimer's disease results in a severe deficit in the establishment of new episodic memories which reflects the perihippocampal locus of the early pathology. In semantic dementia, there is profound progressive and relatively pure loss of semantic memory associated with focal left temporal neocortical atrophy. By contrast, in the subcortical dementias the major impairments are in working (immediate) memory and retrieval of information from longer term memory stores, deficits which reflect dysfunction of frontostriatal systems.
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Severe episodic memory problems are not a symptom of early PD.
“It is thus understandable that severe episodic memory problems are not a symptom of early PD [80].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [80]
At late stages of PD, when all types of dopaminergic projection neurons are affected, memory problems become severe.
“However, at late stages, when all types of dopaminergic projection neurons are affected, memory problems do become severe.”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [80]
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- Authors
- Perry, R. J., & Hodges, J. R.
- Affiliations
- University of Cambridge (GB)
- Venue
- Current Opinion in Neurology
- Published
- 1996-08
- Volume
- 9
- Issue
- 4
- Pages
- 281-286
- ISSN
- 1350-7540 (ISSN-L)
- OpenAlex
- W2017105331
- Cited by
- 59
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- memory impairment, degenerative diseases, Alzheimer's disease, semantic dementia, frontal lobe dementia, progressive supranuclear palsy, Huntington's disease, Parkinson's disease, episodic memory, semantic memory, working memory, long-term memory retrieval, hippocampus, frontostriatal dysfunction
- MeSH terms
- Aged, Alzheimer Disease, Amnesia, Atrophy, Corpus Striatum, Dementia, Frontal Lobe, Hippocampus, Humans, Huntington Disease, Neural Pathways, Neuropsychological Tests, Parkinson Disease, Supranuclear Palsy, Progressive, Temporal Lobe
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