Non-pharmacological intervention for memory decline
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Non-pharmacological intervention of memory difficulties in healthy older adults, as well as those with brain damage and neurodegenerative disorders, has gained much attention in recent years. The two main reasons that explain this growing interest in memory rehabilitation are the limited efficacy of current drug therapies and the plasticity of the human central nervous and the discovery that during aging, the connections in the brain are not fixed but retain the capacity to change with learning. Moreover, several studies have reported enhanced cognitive performance in patients with neurological disease, following non-invasive brain stimulation [i.e., repetitive transcranial magnetic stimulation and transcranial direct current stimulation to specific cortical areas]. The present review provides an overview of memory rehabilitation in individuals with mild cognitive impairment and in patients with Alzheimer's disease with particular regard to cognitive rehabilitation interventions focused on memory and non-invasive brain stimulation. Reviewed data suggest that in patients with memory deficits, memory intervention therapy could lead to performance improvements in memory, nevertheless further studies need to be conducted in order to establish the real value of this approach.
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“The potential applications of VR systems to assess and train AD patients has been reported by several studies (315–320).”
From The Multidisciplinary Approach to Alzheimer’s Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment (2018) · cites this paper as [316]
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- Authors
- Cotelli, M., Manenti, R., Zanetti, O., & Miniussi, C.
- Affiliations
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Corresponding author
- Cotelli, Maria
- Venue
- Frontiers in Human Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2012
- Volume
- 6
- Pages
- 46-46
- ISSN
- 1662-5161 (ISSN-L)
- PMC
- PMC3297818
- OpenAlex
- W1964532996
- Cited by
- 76
- References
- 186
- Citations by year
- 2026: 2 · 2025: 5 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 5 · 2019: 8 · 2018: 8 · 2017: 4 · 2016: 10 · 2015: 11 · 2014: 7 · 2013: 5 · 2012: 1
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Frontiers in Human Neuroscience (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Iris (University of Trento) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Funders
- Alzheimer's Association (NIRG-11-205099)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- memory rehabilitation, non-pharmacological treatment, non-invasive brain stimulation, repetitive transcranial magnetic stimulation, transcranial direct current stimulation, mild cognitive impairment, Alzheimer's disease, memory decline, neuroplasticity, cognitive rehabilitation, brain aging
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