Cited by 309Lipid metabolism and disordersCholesterol and Lipid MetabolismLipid metabolism and biosynthesis

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

Very-low-density lipoprotein assembly and secretion

Shelness, Gregory S., Sellers, Jeremy A.·2001·Current Opinion in Lipidology

DOI 10.1097/00041433-200104000-00008

Open this paper in CoChat — free account

Abstract

The assembly of apolipoprotein B (apoB) into VLDL is broadly divided into two steps. The first involves transfer of lipid by the microsomal triglyceride transfer protein (MTP) to apoB during translation. The second involves fusion of apoB-containing precursor particles with triglyceride droplets to form mature VLDL. ApoB and MTP are homologs of the egg yolk storage protein, lipovitellin. Homodimerization surfaces in lipovitellin are reutilized in apoB and MTP to achieve apoB-MTP interactions necessary for first step assembly. Structural modeling predicts a small lipovitellin-like lipid binding cavity in MTP and a transient lipovitellin-like cavity in apoB important for nucleation of lipid sequestration. The formation of triglyceride droplets in the endoplasmic reticulum requires MTP however, their fusion with apoB may be MTP-independent. Second step assembly is modulated by phospholipase D and A2. Phospholipases may prime membrane transport steps required for second step fusion and/or channel phospholipids into a pathway for VLDL triglyceride production. The enzymology of VLDL triglyceride synthesis is still poorly understood; however, it appears that ACAT2 is the sole source of cholesterol esters for VLDL and chylomicron assembly. VLDL production is controlled primarily at the level of presecretory degradation. Recently, it was discovered that the LDL receptor modulates VLDL production through its interactions with nascent VLDL in the secretory pathway.

Integrity signals

Registry

Crossref · 10.1097/00041433-200104000-00008

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
Cases, S., Smith, S. J., Zheng, Y.-W., Myers, H. M., Lear, S. R., Sande, E., Novak, S., Collins, C. C., Welch, C. L., Lusis, A. J., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13018 · Cited by 1,138
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
Smith, S. J., Cases, S., Jensen, D. R., Chen, H. C., Sande, E., Tow, B., Sanan, D. A., Raber, J., Eckel, R. H., & Farese, R. V. (2000) · Nature Genetics · doi:10.1038/75651 · Cited by 895
Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice
Raabe, M., Véniant, M. M., Sullivan, M. A., Zlot, C. H., Björkegren, J., Nielsen, L. B., Wong, J. S., Hamilton, R. L., & Young, S. G. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6576 · Cited by 395
Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells.
Chang, C. C., Huh, H. Y., Cadigan, K. M., & Chang, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36846-2 · Cited by 389
Characterization of Two Human Genes Encoding Acyl Coenzyme A:Cholesterol Acyltransferase-related Enzymes
Oelkers, P. M., Behari, A., Cromley, D. A., Billheimer, J. T., & Sturley, S. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26765 · Cited by 377
Subcellular localization of B apoprotein of plasma lipoproteins in rat liver.
Alexander, C. A., Hamilton, R. L., & Havel, R. J. (1976) · The Journal of Cell Biology · doi:10.1083/jcb.69.2.241 · Cited by 361
ACAT-2, A Second Mammalian Acyl-CoA:Cholesterol Acyltransferase
Cases, S., Novak, S., Zheng, Y.-W., Myers, H. M., Lear, S. R., Sande, E., Welch, C. B., Lusis, A. J., Spencer, T. A., Krause, B. R., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26755 · Cited by 344
A proposed model for the assembly of chylomicrons
Hussain, M. M. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00397-4 · Cited by 316
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice
Buhman, K. K., Accad, M., Novak, S., Choi, R. S., Wong, J. S., Hamilton, R. L., Turley, S., & Farese, R. V. (2000) · Nature Medicine · doi:10.1038/82153 · Cited by 312
Apolipoprotein B: mRNA Editing, Lipoprotein Assembly, and Presecretory Degradation
Davidson, N. O., & Shelness, G. S. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.169 · Cited by 311
Self-citation
The Role of the Microsomal Triglygeride Transfer Protein in Abetalipoproteinemia
Varoqueaux, N., Aggerbeck, L. P., Bouma, M. E., & Wetterau, J. R. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.663 · Cited by 308
Identification of a Form of Acyl-CoA:Cholesterol Acyltransferase Specific to Liver and Intestine in Nonhuman Primates
Anderson, R. A., Joyce, C. W., Davis, M., Reagan, J. W., Clark, M. A., Shelness, G. S., & Rudel, L. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26747 · Cited by 302
Self-citation
A Lecithin Cholesterol Acyltransferase-like Gene Mediates Diacylglycerol Esterification in Yeast
Oelkers, P. M., Tinkelenberg, A. H., Erdeniz, N., Cromley, D. A., Billheimer, J. T., & Sturley, S. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000144200 · Cited by 269
Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals
Meiner, V., Cases, S., Myers, H. M., Sande, E., Bellosta, S., Schambelan, M., Pitas, R. E., McGuire, J., Herz, J., & Farese, R. V. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14041 · Cited by 261
The role of the LDL receptor in apolipoprotein B secretion
Twisk, J., Gillian‐Daniel, D. L., Oler, A. T., Wang, L., Barrett, P. H. R., & Attie, A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8623 · Cited by 245
Immunological Quantitation and Localization of ACAT-1 and ACAT-2 in Human Liver and Small Intestine
Chang, C. C. Y., Sakashita, N., Ørnvold, K., Lee, O., Chang, E. T., Dong, R., Lin, S., Lee, C. G., Strom, S. C., Kashyap, R., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003927200 · Cited by 228
Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly
Gordon, D. A., & Jamil, H. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00049-4 · Cited by 215
Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates
Lee, R. G., Willingham, M. C., Davis, M. A., Skinner, K. A., & Rudel, L. L. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32360-9 · Cited by 196
Cell and molecular biology of the assembly and secretion of apolipoprotein B-containing lipoproteins by the liver
Davis, R. A. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00083-9 · Cited by 175
apoB-100 has a pentapartite structure composed of three amphipathic alpha-helical domains alternating with two amphipathic beta-strand domains. Detection by the computer program LOCATE.
Segrest, J. P., Jones, M. K., Mishra, V., Anantharamaiah, G. M., & Garber, D. W. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.10.1674 · Cited by 174
The structure of vitellogenin provides a molecular model for the assembly and secretion of atherogenic lipoproteins 1 1Edited by A. R. Fersht
Mann, C. J., Anderson, T. A., Read, J., Chester, S. A., Harrison, G. B., Köchl, S., Ritchie, P. J., Bradbury, P., Hussain, F., Amey, J. S., et al. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2298 · Cited by 174
Is vitellogenin an ancestor of apolipoprotein B-100 of human low-density lipoprotein and human lipoprotein lipase?
Baker, M. E. (1988) · Biochemical Journal · doi:10.1042/bj2551057 · Cited by 174
Expression of carboxyl-terminally truncated forms of human apolipoprotein B in rat hepatoma cells. Evidence that the length of apolipoprotein B has a major effect on the buoyant density of the secreted lipoproteins.
Yao, Z., Blackhart, B. D., Linton, M. F., Taylor, S., Young, S. G., & McCarthy, B. J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)49988-7 · Cited by 171
Inhibition of the Microsomal Triglyceride Transfer Protein Blocks the First Step of Apolipoprotein B Lipoprotein Assembly but Not the Addition of Bulk Core Lipids in the Second Step
Gordon, D. A., Jamil, H., Gregg, R. E., Olofsson, S., & Borén, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.33047 · Cited by 165
The structural basis of lipid interactions in lipovitellin, a soluble lipoprotein
Anderson, T. A., Levitt, D., & Banaszak, L. J. (1998) · Structure · doi:10.1016/s0969-2126(98)00091-4 · Cited by 155
Apolipoprotein B and Low-Density Lipoprotein Structure: Implications for Biosynthesis of Triglyceride-Rich Lipoproteins
Schumaker, V. N., Phillips, M. L., & Chatterton, J. E. (1994) · Advances in protein chemistry · doi:10.1016/s0065-3233(08)60641-5 · Cited by 138
Demonstration of a Physical Interaction between Microsomal Triglyceride Transfer Protein and Apolipoprotein B during the Assembly of ApoB-containing Lipoproteins
Wu, X., Zhou, M., Huang, L., Wetterau, J. R., & Ginsberg, H. N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.10277 · Cited by 131
Lipoprotein assembly. Apolipoprotein B size determines lipoprotein core circumference.
Spring, D. J., Chen-Liu, L. W., Chatterton, J. E., Elovson, J., & Schumaker, V. N. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42116-3 · Cited by 130
N-terminal domain of apolipoprotein B has structural homology to lipovitellin and microsomal triglyceride transfer protein: a “lipid pocket” model for self-assembly of apoB-containing lipoprotein particles
Segrest, J. P., Jones, M. K., & Dashti, N. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33382-4 · Cited by 128
The Activity of Microsomal Triglyceride Transfer Protein Is Essential for Accumulation of Triglyceride within Microsomes in McA-RH7777 Cells
Wang, Y., Tran, K. T., & Yao, Z. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27793 · Cited by 128
The Microsomal Triglyceride Transfer Protein Catalyzes the Post-translational Assembly of Apolipoprotein B-100 Very Low Density Lipoprotein in McA-RH7777 Cells
Rustaeus, S., Stillemark-Billton, P., Lindberg, K., Gordon, D., & Olofsson, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5196 · Cited by 126
Overt and latent activities of diacylglycerol acytransferase in rat liver microsomes: possible roles in very-low-density lipoprotein triacylglycerol secretion
Owen, M. R., Corstorphine, C. G., & Zammit, V. A. (1997) · Biochemical Journal · doi:10.1042/bj3230017 · Cited by 125
Triacylglycerol synthesis by an sn-1,2(2,3)-diacylglycerol transacylase from rat intestinal microsomes.
Lehner, R. S., & Kuksis, A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52942-2 · Cited by 106
Proteasome-mediated Degradation of Apolipoprotein B Targets Both Nascent Peptides Cotranslationally Before Translocation and Full-length Apolipoprotein B After Translocation into the Endoplasmic Reticulum
Liao, W., Yeung, S. J., & Chan, L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27225 · Cited by 100
Assembly of very low density lipoproteins in rat liver: a study of nascent particles recovered from the rough endoplasmic reticulum.
Swift, L. L. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39874-6 · Cited by 99
Amino Acids 430–570 in Apolipoprotein B Are Critical for Its Binding to Microsomal Triglyceride Transfer Protein
Hussain, M. M., Bakillah, A., Nayak, N., & Shelness, G. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.25612 · Cited by 97
Self-citation
A Common Binding Site on the Microsomal Triglyceride Transfer Protein for Apolipoprotein B and Protein Disulfide Isomerase
Bradbury, P., Mann, C. J., Köchl, S., Anderson, T. A., Chester, S. A., Hancock, J. M., Ritchie, P. J., Amey, J. S., Harrison, G. B., Levitt, D. G., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.3159 · Cited by 95
Co-translational Interactions of Apoprotein B with the Ribosome and Translocon during Lipoprotein Assembly or Targeting to the Proteasome
Pariyarath, R., Wang, H., Aitchison, J. D., Ginsberg, H. N., Welch, W. J., Johnson, A. E., & Fisher, E. A. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007944200 · Cited by 93
Mechanism of microsomal triglyceride transfer protein catalyzed lipid transport
Atzel, A., & Wetterau, J. R. (1993) · Biochemistry · doi:10.1021/bi00090a021 · Cited by 91
Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia
Ohashi, K., Ishibashi, S., Osuga, J.-I., Tozawa, R., Harada, K., Yahagi, N., Shionoiri, F., Iizuka, Y., Tamura, Y., Nagai, R., et al. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33426-x · Cited by 91
ADP-ribosylation Factor 1 and Its Activation of Phospholipase D Are Important for the Assembly of Very Low Density Lipoproteins
Asp, L., Claesson, C., Borén, J., & Olofsson, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003520200 · Cited by 86
The ER Translocon and Retrotranslocation
Johnson, A. E., & Haigh, N. G. (2000) · Cell · doi:10.1016/s0092-8674(00)00059-3 · Cited by 86
The Amino Terminus of Apolipoprotein B Is Necessary but Not Sufficient for Microsomal Triglyceride Transfer Protein Responsiveness
Gretch, D. G., Sturley, S. L., Wang, L., Lipton, B. A., Dunning, A. M., Grunwald, K. A. A., Wetterau, J. R., Yao, Z., Talmud, P. J., & Attie, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.8682 · Cited by 76
The Assembly and Secretion of Apolipoprotein B-48-containing Very Low Density Lipoproteins in McA-RH7777 Cells
Stillemark-Billton, P., Borén, J., Andersson, M., Larsson, T. P., Rustaeus, S., Karlsson, K., & Olofsson, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10506 · Cited by 76
Carboxyl-terminal truncation of apolipoprotein B results in gradual loss of the ability to form buoyant lipoproteins in cultured human and rat liver cell lines
Graham, D. L., Knott, T. J., Jones, T. C., Pease, R. J., Pullinger, C. R., & Scott, J. (1991) · Biochemistry · doi:10.1021/bi00236a040 · Cited by 73
Brefeldin A Reversibly Inhibits the Assembly of ApoB Containing Lipoproteins in McA-RH7777 Cells
Rustaeus, S., Lindberg, K., Borén, J., & Olofsson, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.48.28879 · Cited by 72
Origin of hepatic very-low-density lipoprotein triacylglycerol: the contribution of cellular phospholipid
Wiggins, D. K., & Gibbons, G. F. (1996) · Biochemical Journal · doi:10.1042/bj3200673 · Cited by 67
Role of intramolecular disulfide bond formation in the assembly and secretion of apolipoprotein B-100-containing lipoproteins
Shelness, G. S., & Thornburg, J. T. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37627-6 · Cited by 63
Self-citation
Decreased Secretion of ApoB Follows Inhibition of ApoB−MTP Binding by a Novel Antagonist
Bakillah, A., Nayak, N., Saxena, U., Medford, R. M., & Hussain, M. M. (2000) · Biochemistry · doi:10.1021/bi9924009 · Cited by 58
A Mechanism of Membrane Neutral Lipid Acquisition by the Microsomal Triglyceride Transfer Protein
Read, J., Anderson, T. A., Ritchie, P. J., Vanloo, B., Amey, J. S., Levitt, D. G., Rosseneu, M., Scott, J., & Shoulders, C. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000364200 · Cited by 55
The Assembly of Very Low Density Lipoproteins in Rat Hepatoma McA-RH7777 Cells Is Inhibited by Phospholipase A2Antagonists
Tran, K. T., Wang, Y., DeLong, C. J., Cui, Z., & Yao, Z. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m908971199 · Cited by 49
Functional Analysis of Disulfide Linkages Clustered within the Amino Terminus of Human Apolipoprotein B
Tran, K. T., Borén, J., Macri, J., Wang, Y., McLeod, R. S., Avramoglu, R. K., Adeli, K., & Yao, Z. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.13.7244 · Cited by 47
The abetalipoproteinemia gene is a member of the vitellogenin family and encodes an α–helical domain
Shoulders, C. C., Narcisi, T. M. E., Read, J., Chester, S. A., Brett, D. J., Scott, J., Anderson, T. A., Levitt, D. G., & Banaszak, L. J. (1994) · Nature Structural & Molecular Biology · doi:10.1038/nsb0594-285 · Cited by 46
The Amino-terminal Domain of Apolipoprotein B Does Not Undergo Retrograde Translocation from the Endoplasmic Reticulum to the Cytosol
Liang, J.-S., Wu, X., Fisher, E. A. A., & Ginsberg, H. N. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004646200 · Cited by 45
Role of Cholesterol Ester Mass in Regulation of Secretion of ApoB100 Lipoprotein Particles by Hamster Hepatocytes and Effects of Statins on That Relationship
Zhang, Z., Cianflone, K., & Sniderman, A. D. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.3.743 · Cited by 45
Role of Acyl-Coenzyme A:Cholesterol Acyltransferase-1 in the Control of Hepatic VLDL Secretion and LDL Receptor Expression in the Mouse and Hamster
Spady, D. K., Willard, M. N., & Meidell, R. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005097200 · Cited by 43
Identification of Cysteine Pairs within the Amino-terminal 5% of Apolipoprotein B Essential for Hepatic Lipoprotein Assembly and Secretion
Huang, X. F., & Shelness, G. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31872 · Cited by 40
Self-citation
Palmitoylation of Apolipoprotein B Is Required for Proper Intracellular Sorting and Transport of Cholesteroyl Esters and Triglycerides
Zhao, Y., McCabe, J. B., Vance, J. E., & Berthiaume, L. G. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.2.721 · Cited by 38
Disulfide Bonds Are Required for Folding and Secretion of Apolipoprotein B Regardless of Its Lipidation State
Burch, W. L., & Herscovitz, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000446200 · Cited by 32
In Vitro Reconstitution of Assembly of Apolipoprotein B48-containing Lipoproteins
Rusiñol, A. E., Jamil, H., & Vance, J. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.8019 · Cited by 29
Apolipoprotein B-100 destined for lipoprotein assembly and intracellular degradation undergoes efficient translocation across the endoplasmic reticulum membrane
Ingram, M. F., & Shelness, G. S. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37302-8 · Cited by 28
Self-citation
Specificity of Lipid Incorporation Is Determined by Sequences in the N-Terminal 37 of ApoB
Carraway, M., Herscovitz, H., Zannis, V. I., & SMALL, D. M. (2000) · Biochemistry · doi:10.1021/bi000791h · Cited by 27
Inhibition of translocation of nascent apolipoprotein B across the endoplasmic reticulum membrane Is associated with selective inhibition of the synthesis of apolipoprotein B*
Pan, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000554200 · Cited by 26
Chinese Hamster Ovary Cells Require the Coexpression of Microsomal Triglyceride Transfer Protein and Cholesterol 7α-Hydroxylase for the Assembly and Secretion of Apolipoprotein B-containing Lipoproteins
Fleming, J. F., Spitsen, G. M., Hui, T. Y., Olivier, L. M., Du, E. Z., Raabe, M., & Davis, R. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.14.9509 · Cited by 26
Inhibition of Translocation of Nascent Apolipoprotein B across the Endoplasmic Reticulum Membrane Is Associated with Selective Inhibition of the Synthesis of Apolipoprotein B
Pan, M., Liang, J.-S., Fisher, E. A. A., et al. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61524-3 · Cited by 23
Efficient glycosylation site utilization by intracellular apolipoprotein B: implications for proteasomal degradation
Huang, X. F., & Shelness, G. S. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32096-4 · Cited by 20
Self-citation

Research works printed but not linked: 1

Spady, 2000, J Biol Chem, 275, 27005, 10.1016/S0021-9258(19)61472-9 · DOI

Sorted by citations

Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis
Yen, C.-L. E., Stone, S. J., Koliwad, S., Harris, C., & Farese, R. V. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800018-jlr200 · Cited by 1,105
Metabolic origins and clinical significance of LDL heterogeneity
Berneis, K. K., & Krauss, R. M. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200004-jlr200 · Cited by 896
Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly
Hussain, M. M., Shi, J., & Dreizen, P. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r200014-jlr200 · Cited by 591
Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins
Huang, H., Sun, F., Owen, D. M., Li, W., Chen, Y., Gale, M., & Ye, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700760104 · Cited by 532
Assembly of infectious hepatitis C virus particles
Bartenschlager, R. F. W., Pénin, F., Lohmann, V., & André, P. (2010) · Trends in Microbiology · doi:10.1016/j.tim.2010.11.005 · Cited by 454

See all 309

Authors: Shelness, G. S., & Sellers, J. A.
Affiliations: Wake Forest University Health Sciences (US)
Corresponding author: Shelness, Gregory S.
Venue: Current Opinion in Lipidology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-04
Volume: 12
Issue: 2
Pages: 151-157
ISSN: 0957-9672 (ISSN-L)
DOI: 10.1097/00041433-200104000-00008
OpenAlex: W1993281511
Cited by: 309
References: 66
Citations by year: 2026: 8 · 2025: 5 · 2024: 9 · 2023: 11 · 2022: 7 · 2021: 9 · 2020: 16 · 2019: 3 · 2018: 12 · 2017: 14 · 2016: 7 · 2015: 6 · 2014: 10 · 2013: 9 · 2012: 13
FWCI: 3.45
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Lipidology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL 49373, P01HL049373)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: very low density lipoprotein assembly, apolipoprotein B, microsomal triglyceride transfer protein, lipovitellin, VLDL secretion, phospholipase D, phospholipase A2, ACAT2, cholesteryl ester synthesis, LDL receptor, chylomicron assembly, endoplasmic reticulum, lipoprotein secretion
MeSH terms: Animals, Apolipoproteins B, Carrier Proteins, Humans, Lipoproteins, VLDL, Phospholipases, Receptors, LDL, Triglycerides, Vitellogenins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Very-low-density lipoprotein assembly and secretion

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks