Cited by 309Lipid metabolism and disordersCholesterol and Lipid MetabolismLipid metabolism and biosynthesis

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

Very-low-density lipoprotein assembly and secretion

Shelness, Gregory S., Sellers, Jeremy A.·2001·Current Opinion in Lipidology

DOI 10.1097/00041433-200104000-00008

Open this paper in CoChat — free account

Abstract

The assembly of apolipoprotein B (apoB) into VLDL is broadly divided into two steps. The first involves transfer of lipid by the microsomal triglyceride transfer protein (MTP) to apoB during translation. The second involves fusion of apoB-containing precursor particles with triglyceride droplets to form mature VLDL. ApoB and MTP are homologs of the egg yolk storage protein, lipovitellin. Homodimerization surfaces in lipovitellin are reutilized in apoB and MTP to achieve apoB-MTP interactions necessary for first step assembly. Structural modeling predicts a small lipovitellin-like lipid binding cavity in MTP and a transient lipovitellin-like cavity in apoB important for nucleation of lipid sequestration. The formation of triglyceride droplets in the endoplasmic reticulum requires MTP however, their fusion with apoB may be MTP-independent. Second step assembly is modulated by phospholipase D and A2. Phospholipases may prime membrane transport steps required for second step fusion and/or channel phospholipids into a pathway for VLDL triglyceride production. The enzymology of VLDL triglyceride synthesis is still poorly understood; however, it appears that ACAT2 is the sole source of cholesterol esters for VLDL and chylomicron assembly. VLDL production is controlled primarily at the level of presecretory degradation. Recently, it was discovered that the LDL receptor modulates VLDL production through its interactions with nascent VLDL in the secretory pathway.

Integrity signals

Registry

Crossref · 10.1097/00041433-200104000-00008

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
Cases, S., Smith, S. J., Zheng, Y.-W., Myers, H. M., Lear, S. R., Sande, E., Novak, S., Collins, C. C., Welch, C. L., Lusis, A. J., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13018 · Cited by 1,138
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
Smith, S. J., Cases, S., Jensen, D. R., Chen, H. C., Sande, E., Tow, B., Sanan, D. A., Raber, J., Eckel, R. H., & Farese, R. V. (2000) · Nature Genetics · doi:10.1038/75651 · Cited by 895
Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice
Raabe, M., Véniant, M. M., Sullivan, M. A., Zlot, C. H., Björkegren, J., Nielsen, L. B., Wong, J. S., Hamilton, R. L., & Young, S. G. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6576 · Cited by 395
Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells.
Chang, C. C., Huh, H. Y., Cadigan, K. M., & Chang, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36846-2 · Cited by 389
Characterization of Two Human Genes Encoding Acyl Coenzyme A:Cholesterol Acyltransferase-related Enzymes
Oelkers, P. M., Behari, A., Cromley, D. A., Billheimer, J. T., & Sturley, S. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26765 · Cited by 377
Subcellular localization of B apoprotein of plasma lipoproteins in rat liver.
Alexander, C. A., Hamilton, R. L., & Havel, R. J. (1976) · The Journal of Cell Biology · doi:10.1083/jcb.69.2.241 · Cited by 361
ACAT-2, A Second Mammalian Acyl-CoA:Cholesterol Acyltransferase
Cases, S., Novak, S., Zheng, Y.-W., Myers, H. M., Lear, S. R., Sande, E., Welch, C. B., Lusis, A. J., Spencer, T. A., Krause, B. R., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26755 · Cited by 344
A proposed model for the assembly of chylomicrons
Hussain, M. M. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00397-4 · Cited by 316
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice
Buhman, K. K., Accad, M., Novak, S., Choi, R. S., Wong, J. S., Hamilton, R. L., Turley, S., & Farese, R. V. (2000) · Nature Medicine · doi:10.1038/82153 · Cited by 312
Apolipoprotein B: mRNA Editing, Lipoprotein Assembly, and Presecretory Degradation
Davidson, N. O., & Shelness, G. S. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.169 · Cited by 311
Self-citation

Show all 66 references

Research works printed but not linked: 1

Spady, 2000, J Biol Chem, 275, 27005, 10.1016/S0021-9258(19)61472-9 · DOI

Sorted by citations

Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis
Yen, C.-L. E., Stone, S. J., Koliwad, S., Harris, C., & Farese, R. V. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800018-jlr200 · Cited by 1,105
Metabolic origins and clinical significance of LDL heterogeneity
Berneis, K. K., & Krauss, R. M. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200004-jlr200 · Cited by 896
Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly
Hussain, M. M., Shi, J., & Dreizen, P. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r200014-jlr200 · Cited by 591
Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins
Huang, H., Sun, F., Owen, D. M., Li, W., Chen, Y., Gale, M., & Ye, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700760104 · Cited by 532
Assembly of infectious hepatitis C virus particles
Bartenschlager, R. F. W., Pénin, F., Lohmann, V., & André, P. (2010) · Trends in Microbiology · doi:10.1016/j.tim.2010.11.005 · Cited by 454
Effects of aerobic exercise on lipids and lipoproteins
Wang, Y., & Xu, D. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0515-5 · Cited by 436
Cardiac Lipid Accumulation Associated with Diastolic Dysfunction in Obese Mice
Christoffersen, C., Bollano, E., Lindegaard, M. L. S., Bartels, E. D., Goetze, J. P., Andersen, C. B., & Nielsen, L. B. (2003) · Endocrinology · doi:10.1210/en.2003-0242 · Cited by 375
Mechanisms for the Hypotriglyceridemic Effect of Marine Omega-3 Fatty Acids
Davidson, M. H. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.12.024 · Cited by 383
The unfolded protein response transducer IRE1α prevents ER stress‐induced hepatic steatosis
Zhang, K., Wang, S., Malhotra, J. D., Hassler, J. R., Back, S. H., Wang, G., Chang, L., Xu, W., Miao, H. Z., Leonardi, R., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.52 · Cited by 368
Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis
Olofsson, S. ‐., & Borén, J. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01556.x · Cited by 342
Carboxylesterases in lipid metabolism: from mouse to human
Lian, J., Nelson, R., & Lehner, R. S. (2017) · Protein & Cell · doi:10.1007/s13238-017-0437-z · Cited by 313
PPARδ is a very low-density lipoprotein sensor in macrophages
Chawla, A., Lee, C.-H., Barak, Y., He, W., Rosenfeld, J., Liao, D., Han, J., Kang, H., & Evans, R. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337331100 · Cited by 305
ApoAV Reduces Plasma Triglycerides by Inhibiting Very Low Density Lipoprotein-Triglyceride (VLDL-TG) Production and Stimulating Lipoprotein Lipase-mediated VLDL-TG Hydrolysis
Schaap, F. G., Rensen, P. C. N., Voshol, P. J., Vrins, C. L. J., van der Vliet, H. N., Chamuleau, R. A. F. M., Havekes, L. M., Groen, A. K., & van Dijk, K. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403240200 · Cited by 307
PCSK9 inhibitors: A new era of lipid lowering therapy
Chaudhary, R., Garg, J., Shah, N., & Sumner, A. (2017) · World Journal of Cardiology · doi:10.4330/wjc.v9.i2.76 · Cited by 299
Bioactivity of genistein: A review of in vitro and in vivo studies
Ganai, A. A., & Farooqi, H. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.10.026 · Cited by 274
Control of Cholesterol Turnover in the Mouse
Dietschy, J. M., & Turley, S. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100057200 · Cited by 265
Lipid droplets as dynamic organelles connecting storage and efflux of lipids
Olofsson, S., Boström, P., Andersson, L. K., Rutberg, M., Perman, J., & Borén, J. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.08.001 · Cited by 273
HIV protease inhibitors protect apolipoprotein B from degradation by the proteasome: A potential mechanism for protease inhibitor-induced hyperlipidemia
Liang, J.-S., Distler, O., Cooper, D. A., Jamil, H., Deckelbaum, R. J., Ginsberg, H. N., & Sturley, S. L. (2001) · Nature Medicine · doi:10.1038/nm1201-1327 · Cited by 260
An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis
Crooke, R. M., Graham, M. J., Lemonidis, K. M., Whipple, C. P., Koo, S., & Perera, R. J. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400492-jlr200 · Cited by 227
Increasing dietary linoleic acid does not increase tissue arachidonic acid content in adults consuming Western-type diets: a systematic review
Rett, B. S., & Whelan, J. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-36 · Cited by 210
Hepatitis C virus cell entry: role of lipoproteins and cellular receptors
Burlone, M. E., & Budkowska, A. (2009) · Journal of General Virology · doi:10.1099/vir.0.008300-0 · Cited by 206
Hepatic Steatosis as a Marker of Metabolic Dysfunction
Fabbrini, E., & Magkos, F. (2015) · Nutrients · doi:10.3390/nu7064995 · Cited by 192
Hepatitis C Virus Entry
Zeisel, M. B., Felmlee, D. J., & Baumert, T. F. (2013) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-27340-7_4 · Cited by 181
Molecular diversity and evolution of the large lipid transfer protein superfamily
Smolenaars, M. M. W., Madsen, O., Rodenburg, K. W., & HORST, D. J. V. D. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r600028-jlr200 · Cited by 172
Diabetic dyslipidaemia
Adiels, M., Olofsson, S., Taskinen, M., & Borén, J. (2006) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000226115.97436.c0 · Cited by 179
Coactivation of Foxa2 through Pgc-1β promotes liver fatty acid oxidation and triglyceride/VLDL secretion
Wolfrum, C., & Stoffel, M. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.001 · Cited by 172
Statins and PCSK9 inhibitors: A new lipid-lowering therapy
Gallego-Colon, E., Daum, A., & Yosefy, C. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173114 · Cited by 156
Astaxanthin-Rich Extract from the Green Alga Haematococcus pluvialis Lowers Plasma Lipid Concentrations and Enhances Antioxidant Defense in Apolipoprotein E Knockout Mice
Yang, Y. J., Seo, J. M., Nguyen, A. T. H., Pham, T. X., Park, H. J., Park, Y., Kim, B., Bruno, R. S., & Lee, J. (2011) · Journal of Nutrition · doi:10.3945/jn.111.142109 · Cited by 160
The interaction of natural hepatitis C virus with human scavenger receptor SR‐BI/Cla1 is mediated by ApoB‐containing lipoproteins
Maillard, P., Huby, T., Andréo, U., Moreau, M., Chapman, J., & Budkowska, A. (2006) · The FASEB Journal · doi:10.1096/fj.05-4728fje · Cited by 158
Lipoprotein Lipase S447X: A Naturally Occurring Gain-of-Function Mutation
Rip, J., Nierman, M. C., Ross, C. J., Jukema, J. W., Hayden, M. R., Kastelein, J. J. P., Stroes, E. S. G., & Kuivenhoven, J. A. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000219283.10832.43 · Cited by 157
Apolipoprotein B Is an Innate Barrier against Invasive Staphylococcus aureus Infection
Peterson, M. M., Mack, J. L., Hall, P. R., Alsup, A. A., Alexander, S. M., Sully, E. K., Sawires, Y. S., Cheung, A. L., Otto, M. J., & Gresham, H. D. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.10.001 · Cited by 159
Metabolism and Modification of Apolipoprotein B-Containing Lipoproteins Involved in Dyslipidemia and Atherosclerosis
Morita, S. (2015) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00716 · Cited by 161
Adipocyte Differentiation-Related Protein Promotes Fatty Acid Storage in Cytosolic Triglycerides and Inhibits Secretion of Very Low–Density Lipoproteins
Magnusson, B., Asp, L., Boström, P., Ruiz, M., Stillemark-Billton, P., Lindén, D., Borén, J., & Olofsson, S. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000223345.11820.da · Cited by 152
Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan
Geesaman, B. J., Benson, E. K., Brewster, S. J., Kunkel, L. M., Blanché, H., Thomas, G. D., Perls, T. T., Daly, M. J., & Puca, A. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1936249100 · Cited by 149
Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis
Anastasia, I., Ilacqua, N., Raimondi, A., Lemieux, P., Ghandehari‐Alavijeh, R., Faure, G., Mekhedov, S., Williams, K. J., Caicci, F., Valle, G., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108873 · Cited by 157
Diurnal Regulation of Microsomal Triglyceride Transfer Protein and Plasma Lipid Levels
Pan, X., & Hussain, M. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701305200 · Cited by 144
Secretion of Hepatitis C Virus Envelope Glycoproteins Depends on Assembly of Apolipoprotein B Positive Lipoproteins
Icard, V., Diaz, O., Scholtès, C., Perrin‐Cocon, L., Ramière, C., Bartenschlager, R. F. W., Pénin, F., Lotteau, V., & André, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004233 · Cited by 155
Lipoproteins and lipoprotein mimetics for imaging and drug delivery
Thaxton, C. S., Rink, J. S., Naha, P. C., & Cormode, D. P. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.020 · Cited by 142
Role of lipid metabolism in hepatitis C virus assembly and entry
Popescu, C.-I., & Dubuisson, J. (2009) · Biology of the Cell · doi:10.1042/bc20090125 · Cited by 130
Interaction of hepatitis C virus proteins with host cell membranes and lipids
Dubuisson, J., Pénin, F., & Moradpour, D. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02383-8 · Cited by 130
The Role of Lipid and Lipoprotein Metabolism in Non‐Alcoholic Fatty Liver Disease
Perla, F. M., Prelati, M., Lavorato, M., Visicchio, D., & Anania, C. (2017) · Children · doi:10.3390/children4060046 · Cited by 144
Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms
Borradaile, N. M., de Dreu, L. E., Wilcox, L. J., Edwards, J. Y., & Huff, M. W. (2002) · Biochemical Journal · doi:10.1042/bj20020046 · Cited by 123
Triacylglycerol hydrolase: role in intracellular lipid metabolism
Dolinsky, V. W., Gilham, D., Alam, M., Vance, D. E., & Lehner, R. S. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-3426-3 · Cited by 123
Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion
Gilham, D., Ho, S. B., Rasouli, M., Martres, P., Vance, D. E., & Lehner, R. S. (2003) · The FASEB Journal · doi:10.1096/fj.02-0728fje · Cited by 115
Intracellular Assembly of Very Low Density Lipoproteins Containing Apolipoprotein B100 in Rat Hepatoma McA-RH7777 Cells
Tran, K. T., Thorne‐Tjomsland, G., DeLong, C. J., Cui, Z., Shan, J., Burton, L., Jamieson, J. C., & Yao, Z. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200249200 · Cited by 107
Effects of insulin resistance and hepatic lipid accumulation on hepatic mRNA expression levels of apoB, MTP and L-FABP in non-alcoholic fatty liver disease
Higuchi, N., Kato, M., Tanaka, M., MIYAZAKI, M., TAKAO, S., Kohjima, M., Kotoh, K., Enjoji, M., Nakamuta, M., & Takayanagi, R. (2011) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2011.328 · Cited by 111
CD36 deletion reduces VLDL secretion, modulates liver prostaglandins, and exacerbates hepatic steatosis in ob/ob mice
Nassir, F., Okunade, A. L., Brunt, E. M., & Abumrad, N. A. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m037812 · Cited by 105
Long Chain Acyl-CoA Synthetase 3-mediated Phosphatidylcholine Synthesis Is Required for Assembly of Very Low Density Lipoproteins in Human Hepatoma Huh7 Cells
Yao, H., & Ye, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706160200 · Cited by 107
COPII-coated vesicles: flexible enough for large cargo?
Fromme, J. C., & Schekman, R. W. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.06.004 · Cited by 103
Altered Lipid Droplet Dynamics in Hepatocytes Lacking Triacylglycerol Hydrolase Expression
Wang, H., Wei, E., Quiroga, A. D., Sun, X., Touret, N., & Lehner, R. S. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-05-0364 · Cited by 101
HIV Replication Enhances Production of Free Fatty Acids, Low Density Lipoproteins and Many Key Proteins Involved in Lipid Metabolism: A Proteomics Study
Rasheed, S., Yan, J. S., Lau, A., & Chan, A. S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003003 · Cited by 101
Lipid droplets and hepatitis C virus infection
McLauchlan, J. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.12.012 · Cited by 103
A simple, rapid, and sensitive fluorescence assay for microsomal triglyceride transfer protein
Athar, H., Iqbal, J., Jiang, X., & Hussain, M. M. (2004) · Journal of Lipid Research · doi:10.1194/jlr.d300026-jlr200 · Cited by 98
Lipoproteins: When size really matters
German, J. B., Smilowitz, J. T., & Zivkovic, A. M. (2006) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2005.11.006 · Cited by 97
Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: Studies using genetically engineered mouse models
Voshol, P. J., Rensen, P. C. N., van Dijk, K. W., Romijn, J. A., & Havekes, L. M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.12.015 · Cited by 100
Lumenal Lipid Metabolism
Lehner, R. S., Lian, J., & Quiroga, A. D. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.241497 · Cited by 95
Gender Differences in Lipid Metabolism and the Effect of Obesity
Magkos, F., & Mittendorfer, B. (2009) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2009.03.001 · Cited by 89
Proteomic and Lipid Characterization of Apolipoprotein B-free Luminal Lipid Droplets from Mouse Liver Microsomes
Wang, H., Gilham, D., & Lehner, R. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706841200 · Cited by 88
New therapeutic strategies in nonalcoholic fatty liver disease: a focus on promising drugs for nonalcoholic steatohepatitis
Pydyn, N., Miękus, K., Jura, J., & Kotlinowski, J. (2020) · Pharmacological Reports · doi:10.1007/s43440-019-00020-1 · Cited by 89
Reducing shell egg cholesterol content. I. Overview, genetic approaches, and nutritional strategies
Elkin, R. G. (2006) · World s Poultry Science Journal · doi:10.1017/s0043933906001206 · Cited by 88
Microsomal triglyceride transfer protein a multifunctional protein
Hussain, M. M. (2003) · Frontiers in bioscience · doi:10.2741/1071 · Cited by 84
Hepatic steatosis and very low density lipoprotein secretion: the involvement of apolipoprotein E
Mensenkamp, A. R., Havekes, L. M., Romijn, J. A., & Kuipers, F. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00249-5 · Cited by 86
Triacylglycerol Hydrolase Is Localized to the Endoplasmic Reticulum by an Unusual Retrieval Sequence where It Participates in VLDL Assembly without Utilizing VLDL Lipids as Substrates
Gilham, D., Alam, M., Gao, W., Vance, D. E., & Lehner, R. S. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-03-0224 · Cited by 83
Bionanoparticles in cancer imaging, diagnosis, and treatment
Li, Y., Bao, Q., Yang, S., Yang, M., & Mao, C. (2022) · Open Research (University of Surrey) · doi:10.1002/viw.20200027 · Cited by 85
Phospholipid Transfer Activity of Microsomal Triacylglycerol Transfer Protein Is Sufficient for the Assembly and Secretion of Apolipoprotein B Lipoproteins
Rava, P., Ojakian, G. K., Shelness, G. S., & Hussain, M. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512823200 · Cited by 81
Self-citation
Hepatic scavenger receptor class B, type I is stimulated by peroxisome proliferator-activated receptor γ and hepatocyte nuclear factor 4α
Malerød, L., Sporstøl, M., Juvet, L. K., Mousavi, A., Gjøen, T., & Berg, T. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00819-2 · Cited by 81
Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis: Current Issues and Future Perspectives in Preclinical and Clinical Research
Berardo, C., Pasqua, L. G. D., Cagna, M., Richelmi, P., Vairetti, M., & Ferrigno, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249646 · Cited by 89
Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia
Mészáros, M., & Bikov, A. (2022) · Biomedicines · doi:10.3390/biomedicines10112754 · Cited by 83
Pharmacology of the AC AT Inhibitor Avasimibe (CI‐1011)
Llaverías, G., Laguna, J. C., & Alegret, M. (2003) · Cardiovascular Drug Reviews · doi:10.1111/j.1527-3466.2003.tb00104.x · Cited by 77
The intracellular transport of chylomicrons requires the small GTPase, Sar1b
Shoulders, C. C., Stephens, D. J., & Jones, B. (2004) · Current Opinion in Lipidology · doi:10.1097/00041433-200404000-00012 · Cited by 79
Circulatory lipid transport: lipoprotein assembly and function from an evolutionary perspective
HORST, D. J. V. D., Roosendaal, S. D., & Rodenburg, K. W. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-0011-3 · Cited by 79
Inhibition of hepatocyte apoB secretion by naringenin
Borradaile, N. M., de Dreu, L. E., Barrett, P. H. R., & Huff, M. W. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200115-jlr200 · Cited by 79
The evolution of plasma cholesterol: Direct utility or a “spandrel” of hepatic lipid metabolism?
Babin, P. J., & Gibbons, G. F. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.11.002 · Cited by 81
Apolipoproteins A-I and B: biosynthesis, role in the development of atherosclerosis and targets for intervention against cardiovascular disease.
Olofsson, S., Wiklund, O., & Borén, J. (2007) · PubMed Central · Cited by 73
Basal very low-density lipoprotein metabolism in response to exercise: Mechanisms of hypotriacylglycerolemia
Magkos, F. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.02.003 · Cited by 71
Hepatitis C Virus Nonstructural Proteins Inhibit Apolipoprotein B100 Secretion
Domitrovich, A. M., Felmlee, D. J., & Siddiqui, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510391200 · Cited by 70
Abundance of mRNA of Apolipoprotein B100, Apolipoprotein E, and Microsomal Triglyceride Transfer Protein in Liver from Periparturient Dairy Cows
Bernabucci, U., Ronchi, B., Basiricò, L., Pirazzi, D., Rueca, F., Lacetera, N., & Nardone, A. (2004) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(04)73418-9 · Cited by 69
Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B
Gillian-Daniel, D. L., Bates, P. W., Tebon, A., & Attie, A. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072557199 · Cited by 61
Lipid micelles stimulate the secretion of triglyceride‐enriched apolipoprotein B48‐containing lipoproteins by Caco‐2 cells
Château, D., Pauquai, T., Delers, F., Rousset, M., Chambaz, J., & Demignot, S. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20173 · Cited by 66
Human liver cholesteryl ester hydrolase: cloning, molecular characterization, and role in cellular cholesterol homeostasis
Zhao, B., Natarajan, R., & Ghosh, S. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00187.2005 · Cited by 65
Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients
Gerl, M. J., Vaz, W. L. C., Domingues, N. S., Klose, C. D., Surma, M. A., Sampaio, J. L., Almeida, M. S., Rodrigues, G., Gonçalves, P. D. A., Ferreira, J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33116-4 · Cited by 66
Taurine ameliorates cholesterol metabolism by stimulating bile acid production in high‐cholesterol‐fed rats
Murakami, S., Fujita, M., Nakamura, M., Sakono, M., Nishizono, S., Sato, M., Imaizumi, K., Mori, M., & Fukuda, N. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12534 · Cited by 64
Effects of dietary soybean lecithin on plasma lipid transport and hepatic cholesterol metabolism in rats
Leblanc, M.-J., Brunet, S., Bouchard, G., Lamireau, T., Yousef, I. M., Gavino, V. C., Levy, E. H., & Tuchweber, B. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00253-x · Cited by 59
ApoA-IV modulates the secretory trafficking of apoB and the size of triglyceride-rich lipoproteins
Weinberg, R. B., Gallagher, J. W., Fabritius, M. A., & Shelness, G. S. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m019992 · Cited by 58
Self-citation
Apolipoprotein B and triacylglycerol secretion in human triacylglycerol hydrolase transgenic mice
Wei, E., Alam, M., Sun, F., Agellon, L. B., Vance, D. E., & Lehner, R. S. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700320-jlr200 · Cited by 57
Inhibition of protein arginine methyltransferase 5 enhances hepatic mitochondrial biogenesis
Huang, L., Liu, J., Zhang, X.-O., Sibley, K. J., Najjar, S. M., Lee, M., & Wu, Q. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002377 · Cited by 58
Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion
Casaschi, A., Rubio, B. K., Maiyoh, G. K., & Theriault, A. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.05.020 · Cited by 57
Familial Dyslipidaemias
Hachem, S. B., & Mooradian, A. D. (2006) · Drugs · doi:10.2165/00003495-200666150-00005 · Cited by 60
Identification of the Lipoprotein Initiating Domain of Apolipoprotein B
Shelness, G. S., Hou, L., Ledford, A. S., Parks, J. S., & Weinberg, R. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307562200 · Cited by 57
Self-citation
Rice protein improves adiposity, body weight and reduces lipids level in rats through modification of triglyceride metabolism
Yang, L., Chen, J.-H., Lv, J., Wu, Q., Xu, T., Zhang, H., Liu, Q., & Yang, H.-K. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-24 · Cited by 56
Insect lipoprotein follows a transferrin-like recycling pathway that is mediated by the insect LDL receptor homologue
Van Hoof, D., Rodenburg, K. W., & Van der Horst, D. J. (2002) · Journal of Cell Science · doi:10.1242/jcs.00113 · Cited by 53
Pathophysiology of diabetic dyslipidemia:implications for atherogenesis and treatment
Sugden, M., & Holness, M. (2011) · Clinical Lipidology · doi:10.2217/clp.11.32 · Cited by 55
Stable isotope-labeled tracers for the investigation of fatty acid and triglyceride metabolism in humansin vivo
Magkos, F., & Mittendorfer, B. (2009) · Clinical Lipidology · doi:10.2217/clp.09.9 · Cited by 54
Hepatitis C Virus Lipoviroparticles Assemble in the Endoplasmic Reticulum (ER) and Bud off from the ER to the Golgi Compartment in COPII Vesicles
Syed, G. H., Khan, M. A., Yang, S. T., & Siddiqui, A. (2017) · Journal of Virology · doi:10.1128/jvi.00499-17 · Cited by 59
The Low Density Lipoprotein Receptor Prevents Secretion of Dense ApoB100-containing Lipoproteins from the Liver
Larsson, S. L., Skogsberg, J., & Björkegren, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m303057200 · Cited by 54
Computationally Modeling Lipid Metabolism and Aging: A Mini-review
Auley, M. T. M., & Mooney, K. M. (2014) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2014.11.006 · Cited by 53
Effects of obesity on cholesterol metabolism and its implications for healthy ageing
Auley, M. T. M. (2020) · Nutrition Research Reviews · doi:10.1017/s0954422419000258 · Cited by 55
A unified model for regulating lipoprotein lipase activity
Zhang, R., & Zhang, K. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.02.016 · Cited by 52
Up-Regulation of the ATP-Binding Cassette Transporter A1 Inhibits Hepatitis C Virus Infection
Bocchetta, S., Maillard, P., Yamamoto, M., Gondeau, C., Douam, F., Lebreton, S., Lagaye, S., Pol, S., Helle, F., Plengpanich, W., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092140 · Cited by 52
Reducing shell egg cholesterol content. II. Review of approaches utilizing non-nutritive dietary factors or pharmacological agents and an examination of emerging strategies
Elkin, R. G. (2007) · World s Poultry Science Journal · doi:10.1017/s0043933907001249 · Cited by 50

Authors: Shelness, G. S., & Sellers, J. A.
Affiliations: Wake Forest University Health Sciences (US)
Corresponding author: Shelness, Gregory S.
Venue: Current Opinion in Lipidology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-04
Volume: 12
Issue: 2
Pages: 151-157
ISSN: 0957-9672 (ISSN-L)
DOI: 10.1097/00041433-200104000-00008
OpenAlex: W1993281511
Cited by: 309
References: 66
Citations by year: 2026: 8 · 2025: 5 · 2024: 9 · 2023: 11 · 2022: 7 · 2021: 9 · 2020: 16 · 2019: 3 · 2018: 12 · 2017: 14 · 2016: 7 · 2015: 6 · 2014: 10 · 2013: 9 · 2012: 13
FWCI: 3.45
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Lipidology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL 49373, P01HL049373)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: very low density lipoprotein assembly, apolipoprotein B, microsomal triglyceride transfer protein, lipovitellin, VLDL secretion, phospholipase D, phospholipase A2, ACAT2, cholesteryl ester synthesis, LDL receptor, chylomicron assembly, endoplasmic reticulum, lipoprotein secretion
MeSH terms: Animals, Apolipoproteins B, Carrier Proteins, Humans, Lipoproteins, VLDL, Phospholipases, Receptors, LDL, Triglycerides, Vitellogenins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Very-low-density lipoprotein assembly and secretion

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks