Cited by 114Blood Coagulation and Thrombosis MechanismsLipoproteins and Cardiovascular HealthBlood properties and coagulation

Evaluation of lipoprotein(a) as a prothrombotic factor: progress from bench to bedside

Marcovina, Santica M., Koschinsky, Marlys L.·2003·Current Opinion in Lipidology

Abstract

PURPOSE OF REVIEW: Since the homology between apolipoprotein(a) (apo(a)) and plasminogen was discovered in 1987, the role of lipoprotein(a) (Lp(a)) as an inhibitor of the normal fibrinolytic role of plasmin(ogen) has been a major research focus. In this review we summarize recent basic research aimed at identifying mechanisms by which Lp(a) can either inhibit fibrinolysis or promote coagulation, as well as recent clinical studies of Lp(a) as a risk factor for thrombosis either in the presence or absence of atherosclerosis. RECENT FINDINGS: It has recently been reported that the inhibition of plasminogen activation by apo(a) results from the interaction of apo(a) with the ternary complex of tissue-type plasminogen activator, plasminogen and fibrin, rather than competition of apo(a) and plasminogen for binding sites on fibrin. Lp(a) species containing smaller apo(a) isoforms bind more avidly to fibrin and are better inhibitors of plasminogen activation. Recent clinical studies have provided strong evidence that Lp(a), either alone or in synergy with other thrombotic risk factors, significantly increases the risk of venous thromboembolism and ischemic stroke. SUMMARY: Lp(a) both attenuates fibrinolysis, through inhibition of plasminogen activation, and promotes coagulation, through alleviation of extrinsic pathway inhibition. Further basic and clinical studies are required to more clearly define the role of Lp(a) in thrombotic disorders, and to determine the extent to which thrombotic risk is dependent on apo(a) isoform size.

Integrity signals

Registry

Crossref · 10.1097/00041433-200308000-00004

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Marcovina, S. M., & Koschinsky, M. L.
Affiliations
  • University of Washington (US)
  • Queen's University (CA)
Corresponding author
Marcovina, Santica M.
Venue
Current Opinion in Lipidology
Published
2003-08
Volume
14
Issue
4
Pages
361-366
ISSN
0957-9672 (ISSN-L)
OpenAlex
W2325006626
Cited by
114
References
47
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 2
FWCI
1.84
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Lipidology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
Keywords
lipoprotein(a), apolipoprotein(a), plasminogen activation inhibition, fibrinolysis, tissue plasminogen activator, fibrin, coagulation, venous thromboembolism, ischemic stroke, thrombosis risk, atherosclerosis
MeSH terms
Animals, Blood Coagulation Factors, Clinical Trials as Topic, Fibrinolysis, Humans, Plasminogen, Tissue Plasminogen Activator, Thrombosis, Lipoprotein(a)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review