Association study of catechol-O-methyltransferase gene polymorphism in Korean male alcoholics
Abstract
OBJECTIVE: Catechol-O-methyltransferase, which has a functional genetic polymorphism, plays an important role in dopamine metabolism. The study analyzed the association between the catechol-O-methyltransferase gene polymorphism and alcohol dependence in the Korean population. METHODS: Ninety-seven male alcoholics and 94 male age-matched normal controls were enrolled in this study. Polymerase chain reaction-based genotyping was used to verify the presence of the catechol-O-methyltransferase gene polymorphism. The patients were divided into two subtypes (violent group and non-violent group) according to their history of violent behavior. RESULTS: No difference in the distribution of the catechol-O-methyltransferase genotypes (H/H, H/L, L/L) and alleles (H, L) was observed between the patients and the controls. However, the differences between the violent and non-violent groups were significant in terms of the frequencies of the COMT genotypes (chi=7.977, df=2, P=0.019) and the alleles (chi=6.832, df=1, P=0.012). In addition, significant differences in the frequencies of the catechol-O-methyltransferase allele (chi=4.481, df=1, P=0.040) were observed between the non-violent group and the controls. CONCLUSIONS: This suggests that the catechol-O-methyltransferase gene polymorphism is not associated with the development of alcohol dependence, but may affect the susceptibility to a clinical heterogeneity of alcohol dependence, at least in the Korean population.
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Some data suggest alcoholic sub-phenotypes may associate with specific COMT diplotypes.
“some data suggest that alcoholic sub-phenotypes may associate with specific COMT diplotypes (Enoch et al., 2006; Kweon et al., 2005; Tiihonen et al., 1999; Wang et al., 2001).”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Kweon et al., 2005
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Impulsivity, frontal lobes and risk for addiction
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- Authors
- Kweon, Y.-S., Lee, H. K., Lee, C. T., & Pae, C.-U.
- Affiliations
- The Catholic University of Korea Uijeongbu St. Mary's Hospital (KR)
- Corresponding author
- Lee, Hae Kook
- Lee, Chung Tai
- Venue
- Psychiatric Genetics
- Published
- 2005-06
- Volume
- 15
- Issue
- 2
- Pages
- 151-154
- ISSN
- 0955-8829 (ISSN-L)
- OpenAlex
- W2050244228
- Cited by
- 23
- References
- 16
- Citations by year
- 2025: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 2 · 2015: 1 · 2014: 1 · 2012: 4
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- catechol-O-methyltransferase, COMT gene polymorphism, alcoholism, violent behavior, dopamine metabolism, genetic susceptibility, clinical heterogeneity, Korean men
- MeSH terms
- Alcoholism, Catechol O-Methyltransferase, Gene Frequency, Genotype, Humans, Korea, Male, Polymorphism, Genetic, Sex Characteristics, Violence
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