Immediate Reward Bias in Humans: Fronto-Parietal Networks and a Role for the Catechol-O-Methyltransferase 158Val/ValGenotype
Open accessAbstract
The tendency to choose lesser immediate benefits over greater long-term benefits characterizes alcoholism and other addictive disorders. However, despite its medical and socioeconomic importance, little is known about its neurobiological mechanisms. Brain regions that are activated when deciding between immediate or delayed rewards have been identified (McClure et al., 2004, 2007), as have areas in which responses to reward stimuli predict a paper-and-pencil measure of temporal discounting (Hariri et al., 2006). These studies assume "hot" and "cool" response selection systems, with the hot system proposed to generate impulsive choices in the presence of a proximate reward. However, to date, brain regions in which the magnitude of activity during decision making reliably predicts intertemporal choice behavior have not been identified. Here we address this question in sober alcoholics and non-substance-abusing control subjects and show that immediate reward bias directly scales with the magnitude of functional magnetic resonance imaging bold oxygen level-dependent (BOLD) signal during decision making at sites within the posterior parietal cortex (PPC), dorsal prefrontal cortex (dPFC), and rostral parahippocampal gyrus regions. Conversely, the tendency of an individual to wait for a larger, delayed reward correlates directly with BOLD signal in the lateral orbitofrontal cortex. In addition, genotype at the Val158Met polymorphism of the catechol-O-methyltransferase gene predicts both impulsive choice behavior and activity levels in the dPFC and PPC during decision making. These genotype effects remained significant after controlling for alcohol abuse history. These results shed new light on the neurobiological underpinnings of temporal discounting behavior and identify novel behavioral and neural consequences of genetic variation in dopamine metabolism.
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Genetic variation at the Val158Met polymorphism of COMT influences decision-making behavior and brain activity associated with impulsive choice.
“genetic variation at the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene influences decision-making behavior and underlying activity in brain activity associated with impulsive choice (Boettiger et al., 2007).”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Boettiger et al., 2007
Neuroimaging studies have found abnormal orbitofrontal cortex function associated with substance abuse.
“numerous neuroimaging studies have found abnormal OFC function associated with substance abuse (Boettiger et al., 2007; Dom et al., 2005; Ersche et al., 2005; London et al., 2000; Volkow and Fowler, 2000).”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Boettiger et al., 2007
Reduced orbitofrontal cortex activity during decision-making among abstinent alcoholics correlates with tendency to choose immediate over delayed rewards.
“we have found that reduced OFC activity during decision-making among abstinent alcoholics is correlated with their tendency to choose immediate over delayed rewards (Boettiger et al., 2007)”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Boettiger et al., 2007
A single study has examined the effects of COMT Val158Met in an adult sample of abstinent alcoholics and healthy participants.
“while a single study has examined the effects of COMTVal158Met in an adult sample of abstinent alcoholics and healthy participants (Boettiger et al, 2007)”
From DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls (2010) · cites this paper as Boettiger et al, 2007
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SAUNDERS, J. B., AASLAND, O. G., BABOR, T. F., DE LA FUENTE, J. R., & GRANT, M. (1993) · Addiction · doi:10.1111/j.1360-0443.1993.tb02093.x · Cited by 13,482 · see citing works
Nonparametric permutation tests for functional neuroimaging: A primer with examples
Nichols, T. E., & Holmes, A. P. (2002) · Human Brain Mapping · doi:10.1002/hbm.1058 · Cited by 6,256 · see citing works
Spatial registration and normalization of images
Friston, K. J., Ashburner, J., Frith, C., Poline, J.-B., Heather, J. D., & Frackowiak, R. S. J. (1995) · Human Brain Mapping · doi:10.1002/hbm.460030303 · Cited by 3,744 · see citing works
Separate neural systems value immediate and delayed monetary rewards
McClure, S. M., Laibson, D. I., Loewenstein, G., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1100907 · Cited by 3,089 · see citing works
Trope, Y., & Liberman, N. (2003) · Psychological Review · doi:10.1037/0033-295x.110.3.403 · Cited by 3,006 · see citing works
Out of Control: Visceral Influences on Behavior
Loewenstein, G. (1996) · Organizational Behavior and Human Decision Processes · doi:10.1006/obhd.1996.0028 · Cited by 2,610 · see citing works
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,374 · see citing works
Evenden, J. L. (1999) · Psychopharmacology · doi:10.1007/pl00005481 · Cited by 2,044 · see citing works
Dopamine in schizophrenia: a review and reconceptualization
Davis, K. L., Kahn, R. S., Ko, G., & Davidson, M. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.11.1474 · Cited by 2,021 · see citing works
Uneven Pattern of Dopamine Loss in the Striatum of Patients with Idiopathic Parkinson's Disease
Kish, S. J., Shannak, K. S., & Hornykiewicz, O. (1988) · New England Journal of Medicine · doi:10.1056/nejm198804073181402 · Cited by 1,945 · see citing works
THE BEHAVIORAL LIFE‐CYCLE HYPOTHESIS
Shefrin, H., & Thaler, R. H. (1988) · Economic Inquiry · doi:10.1111/j.1465-7295.1988.tb01520.x · Cited by 1,704 · see citing works
Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Kolachana, B. S., Hyde, T. M., Herman, M. M., Apud, J., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/425589 · Cited by 1,675 · see citing works
Frames, Biases, and Rational Decision-Making in the Human Brain
de Martino, B., Kumaran, D., Seymour, B., & Dolan, R. (2006) · Science · doi:10.1126/science.1128356 · Cited by 1,623 · see citing works
Neurons in the orbitofrontal cortex encode economic value
Padoa-Schioppa, C., & Assad, J. A. (2006) · Nature · doi:10.1038/nature04676 · Cited by 1,598 · see citing works
Neural systems responding to degrees of uncertainty in human decision-making
Hsu, M., Bhatt, M., Adolphs, R., Tranel, D., & Camerer, C. F. (2005) · Science · doi:10.1126/science.1115327 · Cited by 1,411 · see citing works
Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex
Volkow, N. D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.318 · Cited by 1,240 · see citing works
Controlling the familywise error rate in functional neuroimaging: a comparative review
Nichols, T. E., & Hayasaka, S. (2003) · Statistical Methods in Medical Research · doi:10.1191/0962280203sm341ra · Cited by 1,210 · see citing works
Baxter, M. G., & Murray, E. A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn875 · Cited by 1,200 · see citing works
Matching Behavior and the Representation of Value in the Parietal Cortex
Sugrue, L. P., Corrado, G. S., & Newsome, W. T. (2004) · Science · doi:10.1126/science.1094765 · Cited by 1,030 · see citing works
Kreek, M. J., Nielsen, D. A., Butelman, E. R., & LaForge, K. S. (2005) · Nature Neuroscience · doi:10.1038/nn1583 · Cited by 1,024 · see citing works
Time Discounting for Primary Rewards
McClure, S. M., Ericson, K. M., Laibson, D. I., Loewenstein, G., & Cohen, J. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4246-06.2007 · Cited by 971 · see citing works
Distributed Neural Representation of Expected Value
Knutson, B., Taylor, J., Kaufman, M., Peterson, R., & Glover, G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0642-05.2005 · Cited by 955 · see citing works
Impulsive choice induced in rats by lesions of the nucleus accumbens core
Cardinal, R. N., Pennicott, D. R., Lakmali, C., Sugathapala, Robbins, T. W., & Everitt, B. J. (2001) · Science · doi:10.1126/science.1060818 · Cited by 923 · see citing works
D1 receptors in prefrontal cells and circuits
Goldman-Rakic, P. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00045-4 · Cited by 807 · see citing works
From cognitive to neural models of working memory
D’Esposito, M. (2007) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2007.2086 · Cited by 792 · see citing works
Bilder, R. M., Volavka, J., Lachman, H. M., & Grace, A. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300542 · Cited by 769 · see citing works
A review of delay-discounting research with humans: relations to drug use and gambling
Reynolds, B. (2006) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3280115f99 · Cited by 711 · see citing works
Catechol-o-Methyltransferase, Cognition, and Psychosis: Val158Met and Beyond
Tunbridge, E. M., Harrison, P. J., & Weinberger, D. R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.024 · Cited by 685 · see citing works
Modulation of Parietal Activation by Semantic Distance in a Number Comparison Task
Pinel, P., Dehaene, S., Rivière, D., & Bihan, D. L. (2001) · NeuroImage · doi:10.1006/nimg.2001.0913 · Cited by 680 · see citing works
Prefrontal cortex and decision making in a mixed-strategy game
Barraclough, D. J., Conroy, M. L., & Lee, D. (2004) · Nature Neuroscience · doi:10.1038/nn1209 · Cited by 678 · see citing works
Contrasting Roles of Basolateral Amygdala and Orbitofrontal Cortex in Impulsive Choice
Winstanley, C. A., Theobald, D. E. H., Cardinal, R. N., & Robbins, T. W. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5606-03.2004 · Cited by 675 · see citing works
Parallel incentive processing: an integrated view of amygdala function
Balleine, B. W., & Killcross, S. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.03.002 · Cited by 622 · see citing works
Izquierdo, A., Suda, R. K., & Murray, E. A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1921-04.2004 · Cited by 588 · see citing works
Separate neural pathways process different decision costs
Rudebeck, P. H., Walton, M. E., Smyth, A. N., Bannerman, D. M., & Rushworth, M. F. S. (2006) · Nature Neuroscience · doi:10.1038/nn1756 · Cited by 580 · see citing works
Hariri, A. R., Brown, S. M., Williamson, D. E., Flory, J. D., de Wit, H., & Manuck, S. B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3446-06.2006 · Cited by 557 · see citing works
Berlin, H. A. (2004) · Brain · doi:10.1093/brain/awh135 · Cited by 541 · see citing works
Yacubian, J., Gläscher, J., Schroeder, K., Sommer, T., Braus, D. F., & Büchel, C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2915-06.2006 · Cited by 537 · see citing works
Neuronal Activity Related to Reward Value and Motivation in Primate Frontal Cortex
Roesch, M. R., & Olson, C. R. (2004) · Science · doi:10.1126/science.1093223 · Cited by 535 · see citing works
Elliott, R., Newman, J. L., Longe, O. A., & Deakin, J. F. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00303.2003 · Cited by 515 · see citing works
“Economics and Psychology”? The Case of Hyperbolic Discounting*
Rubinstein, A. (2003) · International Economic Review · doi:10.1111/1468-2354.t01-1-00106 · Cited by 506 · see citing works
Frontal Lobe Volume Loss Observed with Magnetic Resonance Imaging in Older Chronic Alcoholics
Pfefferbaum, A., Sullivan, E. V., Mathalon, D. H., & Lim, K. O. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb03798.x · Cited by 492 · see citing works
Acute administration of d-amphetamine decreases impulsivity in healthy volunteers
de Wit, H. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00343-3 · Cited by 436 · see citing works
Dorris, M. C., & Glimcher, P. W. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.009 · Cited by 428 · see citing works
S., M., S., B., M.-Y., H., C., B., E., S., J., D., & I., A. (2002) · Psychopharmacology · doi:10.1007/s00213-001-0983-0 · Cited by 409 · see citing works
Orbitofrontal cortex, associative learning and expectancies
Schoenbaum, G., & Roesch, M. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.018 · Cited by 404 · see citing works
Resource Slack and Propensity to Discount Delayed Investments of Time Versus Money.
Zauberman, G. S., & Lynch, J. G. (2005) · Journal of Experimental Psychology General · doi:10.1037/0096-3445.134.1.23 · Cited by 400 · see citing works
IMAGING VALUATION MODELS IN HUMAN CHOICE
Montague, P. R., King‐Casas, B., & Cohen, J. D. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112903 · Cited by 371 · see citing works
Orbitofrontal Cortex and Human Drug Abuse: Functional Imaging
London, E. D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.334 · Cited by 360 · see citing works
Impulsive Responding in Alcoholics
Mitchell, J. M., Fields, H. L., D'Esposito, M., & Boettiger, C. A. (2005) · Alcoholism: Clinical and Experimental Research · doi:10.1097/01.alc.0000191755.63639.4a · Cited by 331 · see citing works
Frontal Brain Asymmetry and Reward Responsiveness
Pizzagalli, D. A., Sherwood, R., Henriques, J. B., & Davidson, R. J. (2005) · Psychological Science · doi:10.1111/j.1467-9280.2005.01618.x · Cited by 326 · see citing works
Molecular imaging of the dopaminergic system and its association with human cognitive function.
Cropley, V., Fujita, M., Innis, R., & Nathan, P. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.004 · Cited by 299 · see citing works
Blasi, G., Mattay, V. S., Bertolino, A., Elvevåg, B., Callicott, J. H., Das, S., Kolachana, B. S., Egan, M. F., Goldberg, T. E., & Weinberger, D. R. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0476-05.2005 · Cited by 294 · see citing works
Chemistry of the adaptive mind
Cools, R., & Robbins, T. W. (2004) · Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences · doi:10.1098/rsta.2004.1468 · Cited by 257 · see citing works
Dom, G., Sabbe, B., Hulstijn, W., & van Den Brink, W. (2005) · British Journal of Psychiatry · doi:10.1192/bjp.187.3.209 · Cited by 231 · cited 1× · see citing works
“Our finding of reduced OFC activity during decision making among AA subjects is consistent with the common finding of OFC dysfunction in substance abusers (London et al., 2000; Volkow and Fowler, 2000; Dom et al., 2005).”
ResultNolan, K. A., Bilder, R. M., Lachman, H. M., & Volavka, J. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.359 · Cited by 222 · see citing works
Ersche, K. D., Fletcher, P. C., Lewis, S. J. G., Clark, L., Stocks-Gee, G., London, M., Deakin, J. B., Robbins, T. W., & Sahakian, B. J. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2205-7 · Cited by 199 · see citing works
Simon, H. A. (2004) · McGraw-Hill eBooks · doi:10.1037/10590-014 · Cited by 198 · see citing works
Tiihonen, J., Hallikainen, T., Lachman, H., Saito, T., Volavka, J., Kauhanen, J., Salonen, J. T., Ryynänen, O.-P., Koulu, M., Karvonen, M. K., et al. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000509 · Cited by 189 · see citing works
Williams‐Gray, C. H., Hampshire, A., Robbins, T. W., Owen, A. M., & Barker, R. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0774-07.2007 · Cited by 180 · see citing works
Fellows, L. K., & Farah, M. J. (2005) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.07.018 · Cited by 172 · see citing works
Predicting the near and distant future.
Nussbaum, S., Liberman, N., & Yaacov Trope, B. (2006) · Journal of Experimental Psychology General · doi:10.1037/0096-3445.135.2.152 · Cited by 166 · see citing works
Homovanillic Acid Measurement in Clinical Research: A Review of Methodology
Amin, F., Davidson, M., & Davis, K. L. (1992) · Schizophrenia Bulletin · doi:10.1093/schbul/18.1.123 · Cited by 153 · see citing works
Cheung, T. H. C., & Cardinal, R. N. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-36 · Cited by 147 · see citing works
Malkoc, S. A., & Zauberman, G. S. (2006) · Journal of Marketing Research · doi:10.1509/jmkr.43.4.618 · Cited by 147 · see citing works
The Role of the Amygdala in Signaling Prospective Outcome of Choice
Kahn, I., Yeshurun, Y., Rotshtein, P., Fried, I., Ben-Bashat, D., & Hendler, T. (2002) · Neuron · doi:10.1016/s0896-6273(02)00626-8 · Cited by 141 · see citing works
COMT genotype predicts BOLD signal and noise characteristics in prefrontal circuits
Winterer, G., Musso, F., Vučurević, G., Stoeter, P., Konrad, A., Seker, B., Gallinat, J., Dahmen, N., & Weinberger, D. R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.05.058 · Cited by 122 · see citing works
Congdon, E., & Canli, T. (2005) · Behavioral & Cognitive Neuroscience Reviews · doi:10.1177/1534582305285980 · Cited by 110 · see citing works
Kauhanen, J., Hallikainen, T., Tuomainen, T., Koulu, M., Karvonen, M. K., Salonen, J. T., & Tiihonen, J. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb04582.x · Cited by 96 · see citing works
Samochowiec, J., Kucharska–Mazur, J., Grzywacz, A., Jabłoński, M., Rommelspacher, H., Samochowiec, A., Sznabowicz, M., Horodnicki, J., Sagan, L. M., & Pełka-Wysiecka, J. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.05.005 · Cited by 88 · see citing works
Endogenous Opioid Blockade and Impulsive Responding in Alcoholics and Healthy Controls
Mitchell, J., Tavares, V. C., Fields, H. L., D’Esposito, M., & Boettiger, C. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301226 · Cited by 88 · see citing works
Wang, T., Franke, P. E., Neidt, H., Cichon, S., Knapp, M., Lichtermann, D., Maier, W., Propping, P., & Nöthen, M. M. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000803 · Cited by 74 · see citing works
Enoch, M., Waheed, J. F., Harris, C. R., Albaugh, B., & Goldman, D. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00045.x · Cited by 70 · see citing works
Prefrontal Electrophysiologic “Noise” and Catechol-O-Methyltransferase Genotype in Schizophrenia
Winterer, G., Egan, M. F., Kolachana, B. S., Goldberg, T. E., Coppola, R., & Weinberger, D. R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.023 · Cited by 69 · see citing works
Panfilis, C. D., & Schwarzbauer, C. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.11.014 · Cited by 64 · see citing works
lshiguro, H., Shibuya, T. H., Toru, M., Saito, T., & Arinami, T. (1999) · Psychiatric Genetics · doi:10.1097/00041444-199909000-00004 · Cited by 52 · see citing works
Minzenberg, M., Xu, K., Mitropoulou, V., Harvey, P. D., Finch, T., Flory, J. D., New, A. S., Goldman, D. A., & Siever, L. J. (2006) · Psychiatric Genetics · doi:10.1097/01.ypg.0000199448.00163.e6 · Cited by 45 · see citing works
KIM, J.-W., PARK, C.-S., HWANG, J.-W., SHIN, M.-S., HONG, K.-E., CHO, S.-C., & KIM, B.-N. (2006) · Alcohol and Alcoholism · doi:10.1093/alcalc/agl034 · Cited by 43 · see citing works
The association between high-activity COMT allele and alcoholism.
Šerý, O., Didden, W., Mikeš, V., Pitelová, R., Znojil, V., & Zvolský, P. (2006) · PubMed · Cited by 41 · see citing works
Köhnke, M. D., Wiatr, G., Kolb, W., Köhnke, A. M., Schick, S., Lutz, U. C., Vonthein, R., & Gaertner, I. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300107 · Cited by 34 · see citing works
Association study of catechol-O-methyltransferase gene polymorphism in Korean male alcoholics
Kweon, Y.-S., Lee, H. K., Lee, C. T., & Pae, C.-U. (2005) · Psychiatric Genetics · doi:10.1097/00041444-200506000-00014 · Cited by 23 · see citing works
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MacKillop, J., Amlung, M. T., Few, L. R., Ray, L. A., Sweet, L. H., & Munafò, M. R. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2229-0 · Cited by 1,021 · see citing works
The neural mechanisms of inter-temporal decision-making: understanding variability
Peters, J., & Büchel, C. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.03.002 · Cited by 693 · see citing works
Neural correlates of food addiction
Gearhardt, A. N. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.32 · Cited by 707 · see citing works
Impulsivity, frontal lobes and risk for addiction
Crews, F. T., & Boettiger, C. A. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.04.018 · Cited by 679 · see citing works
The behavioral economics of substance use disorders: reinforcement pathologies and their repair
Bickel, W. K., Johnson, M. W., Koffarnus, M. N., MacKillop, J., & Murphy, J. G. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032813-153724 · Cited by 655 · see citing works
Alcoholism: A Systems Approach From Molecular Physiology to Addictive Behavior
Spanagel, R. (2009) · Physiological Reviews · doi:10.1152/physrev.00013.2008 · Cited by 636 · see citing works
Obese women show greater delay discounting than healthy-weight women
Weller, R. E., Cook, E. W., Avsar, K. B., & Cox, J. E. (2008) · Appetite · doi:10.1016/j.appet.2008.04.010 · Cited by 544 · see citing works
Ventral striatal activation during reward anticipation correlates with impulsivity in alcoholics
Beck, A., Schlagenhauf, F., Wüstenberg, T., Hein, J., Kienast, T., Kahnt, T., Schmack, K., Hägele, C., Knutson, B., Heinz, A., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.035 · Cited by 461 · see citing works
Dissociable neural representations of future reward magnitude and delay during temporal discounting
Ballard, K., & Knutson, B. D. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.11.004 · Cited by 450 · see citing works
A neural mechanism mediating the impact of episodic prospection on farsighted decisions
Benoit, R. G., Gilbert, S. J., & Burgess, P. W. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6559-10.2011 · Cited by 422 · see citing works
Bias in the Brain: A Diffusion Model Analysis of Prior Probability and Potential Payoff
Mulder, M., Wagenmakers, E., Ratcliff, R., Boekel, W., & Forstmann, B. U. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4156-11.2012 · Cited by 427 · see citing works
Bickel, W. K., Koffarnus, M. N., Moody, L., & Wilson, A. G. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.013 · Cited by 386 · see citing works
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Frank, G. K. W., Reynolds, J. R., Shott, M. E., Jappe, L., Yang, T. T., Tregellas, J. R., & O'Reilly, R. C. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.51 · Cited by 311 · see citing works
Dissecting impulsivity and its relationships to drug addictions
Jentsch, J. D., Ashenhurst, J. R., Cervantes, M. C., Groman, S. M., James, A. S., & Pennington, Z. T. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12388 · Cited by 281 · see citing works
Relation of obesity to consummatory and anticipatory food reward
Stice, E. M., Spoor, S. T. P., Ng, J., & Zald, D. H. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.03.020 · Cited by 289 · see citing works
Dorsolateral Prefrontal Cortex Drives Mesolimbic Dopaminergic Regions to Initiate Motivated Behavior
Ballard, I. C., Murty, V. P., Carter, R. M., MacInnes, J., Huettel, S. A., & Adcock, R. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0895-11.2011 · Cited by 284 · see citing works
Story, G. W., Vlaev, I., Seymour, B., Darzi, A. W., & Dolan, R. J. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00076 · Cited by 284 · see citing works
Bickel, W. K., Pitcock, J. A., Yi, R., & Angtuaco, E. J. C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5319-08.2009 · Cited by 278 · see citing works
MacKillop, J., Miranda, R., Monti, P. M., Ray, L. A., Murphy, J. G., Rohsenow, D. J., McGeary, J. E., Swift, R. M., Tidey, J. W., & Gwaltney, C. J. (2010) · Journal of Abnormal Psychology · doi:10.1037/a0017513 · Cited by 278 · see citing works
Nucleus accumbens and impulsivity
Başar, K., Sesia, T., Groenewegen, H. J., Steinbusch, H. W. M., Visser-Vandewalle, V. E. R. M., & Temel, Y. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.08.007 · Cited by 276 · see citing works
Determinants of takeaway and fast food consumption: a narrative review
Janssen, H. G., Davies, I. G., Richardson, L. D., & Stevenson, L. (2017) · Nutrition Research Reviews · doi:10.1017/s0954422417000178 · Cited by 279 · see citing works
Maier, S. U., Makwana, A. B., & Hare, T. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.005 · Cited by 270 · see citing works
Steep discounting of delayed monetary and food rewards in obesity: a meta-analysis
Amlung, M., Petker, T., Jackson, J., Balodis, I., & MacKillop, J. (2016) · Psychological Medicine · doi:10.1017/s0033291716000866 · Cited by 274 · see citing works
Gould, T. J. (2010) · PubMed Central · Cited by 245 · see citing works
Shenhav, A., & Greene, J. D. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.020 · Cited by 243 · see citing works
Mitchell, J. M., O’Neil, J. P., Janabi, M., Marks, S. M., Jagust, W. J., & Fields, H. L. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3002902 · Cited by 237 · see citing works
NOW vs LATER brain circuits: implications for obesity and addiction
Volkow, N. D., & Baler, R. D. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.04.002 · Cited by 237 · see citing works
Meeks, T. W., & Jeste, D. V. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.8 · Cited by 233 · see citing works
MacKillop, J., & Kahler, C. W. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.04.020 · Cited by 232 · see citing works
Miedl, S. F. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1552 · Cited by 229 · see citing works
Cortical activation during delay discounting in abstinent methamphetamine dependent individuals
Hoffman, W. F., Schwartz, D. L., Huckans, M. S., McFarland, B. H., Meiri, G., Stevens, A. A., & Mitchell, S. H. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1261-1 · Cited by 210 · see citing works
Dissociable effects of lesions to orbitofrontal cortex subregions on impulsive choice in the rat
Mar, A. C., Walker, A. L. J., Theobald, D. E., Eagle, D. M., & Robbins, T. W. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6620-10.2011 · Cited by 206 · see citing works
Remember the future II: Meta-analyses and functional overlap of working memory and delay discounting
Wesley, M. J., & Bickel, W. K. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.08.008 · Cited by 205 · see citing works
Activity in dlPFC and its effective connectivity to vmPFC are associated with temporal discounting
Hare, T. A., Hakimi, S., & Rangel, A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00050 · Cited by 206 · see citing works
A dual‐systems perspective on addiction: contributions from neuroimaging and cognitive training
McClure, S. M., & Bickel, W. K. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12561 · Cited by 201 · see citing works
van den Bos, W., Rodriguez, C. A., Schweitzer, J. B., & McClure, S. M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4105-13.2014 · Cited by 178 · see citing works
Moral Enhancement, Freedom, and the God Machine
Savulescu, J., & Persson, I. (2012) · The Monist · doi:10.5840/monist201295321 · Cited by 197 · see citing works
fMRI reactivity on a delay discounting task predicts weight gain in obese women
Kishinevsky, F. I., Cox, J. E., Murdaugh, D. L., Stoeckel, L. E., Cook, E. W., & Weller, R. E. (2012) · Appetite · doi:10.1016/j.appet.2011.11.029 · Cited by 191 · see citing works
Blum, K., Chen, A. L., Chen, T. J. H., Braverman, E. R., Reinking, J. L., Blum, S. H., Cassel, K., Downs, B. W., Waite, R. L., Williams, L., et al. (2008) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-5-24 · Cited by 186 · see citing works
Resting-State Functional Connectivity Predicts Impulsivity in Economic Decision-Making
Li, N., Ma, N., Liu, Y., He, X., Sun, D., Fu, X., Zhang, X., Han, S., & Zhang, D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1342-12.2013 · Cited by 183 · see citing works
Paloyelis, Y., Asherson, P., Mehta, M. A., Faraone, S. V., & Kuntsi, J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.124 · Cited by 180 · see citing works
Housden, C. R., O’Sullivan, S. S., Joyce, E. M., Lees, A. J., & Roiser, J. P. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.84 · Cited by 176 · see citing works
Jackson, J. N. S., & MacKillop, J. (2016) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.01.007 · Cited by 167 · see citing works
“For example, alcohol misuse has been implicated with distinct patterns of neural activity in subunits of the prefrontal cortex, parietal cortex, anterior cingulate and anterior insula, among others, during delay discounting decision making (57-59).”
BackgroundRenteria, R., Baltz, E. T., & Gremel, C. M. (2018) · Nature Communications · doi:10.1038/s41467-017-02615-9 · Cited by 161 · see citing works
Neural mechanism of intertemporal choice: From discounting future gains to future losses
Xu, L., Liang, Z.-Y., Wang, K., Li, S., & Jiang, T. (2009) · Brain Research · doi:10.1016/j.brainres.2008.12.061 · Cited by 161 · see citing works
The Genetics of Impulsivity: Evidence for the Heritability of Delay Discounting
Anokhin, A. P., Grant, J. D., Mulligan, R. C., & Heath, A. C. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.022 · Cited by 144 · see citing works
The Behavioral Economics and Neuroeconomics of Alcohol Use Disorders
MacKillop, J. M. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13004 · Cited by 152 · see citing works
Dopamine, Corticostriatal Connectivity, and Intertemporal Choice
Kayser, A. S., Allen, D. C., Cebrian, A. N., Mitchell, J., & Fields, H. L. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1180-12.2012 · Cited by 146 · see citing works
Fronto‐striatal functional connectivity during response inhibition in alcohol dependence
Courtney, K. E., Ghahremani, D. G., & Ray, L. A. (2012) · Addiction Biology · doi:10.1111/adb.12013 · Cited by 143 · see citing works
Neural and Behavioral Mechanisms of Impulsive Choice in Alcohol Use Disorder
Claus, E. D., Kiehl, K. A., & Hutchison, K. E. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01455.x · Cited by 130 · see citing works
Time preference and its relationship with age, health, and survival probability
Chao, L., Szrek, H., Pereira, N. S., & Pauly, M. V. (2009) · Judgment and Decision Making · doi:10.1017/s1930297500000668 · Cited by 128 · see citing works
MacKillop, J. (2012) · Journal of the Experimental Analysis of Behavior · doi:10.1002/jeab.4 · Cited by 120 · see citing works
NEUROBEHAVIORAL EVIDENCE FOR THE “NEAR‐MISS” EFFECT IN PATHOLOGICAL GAMBLERS
Habib, R., & Dixon, M. R. (2010) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.2010.93-313 · Cited by 115 · see citing works
He, Q., Xue, G., Chen, C., Lu, Z., Dong, Q., Lei, X., Ding, N., Li, J., Li, H., Chen, C., et al. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.07.008 · Cited by 111 · see citing works
The role of the orbitofrontal cortex in alcohol use, abuse, and dependence
Moorman, D. E. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.010 · Cited by 109 · see citing works
Clewett, D., LUO, S. H., Hsu, E., Ainslie, G. W., Mather, M., & Monterosso, J. R. (2014) · Human Brain Mapping · doi:10.1002/hbm.22436 · Cited by 105 · see citing works
Individual Differences in Delay Discounting Under Acute Stress: The Role of Trait Perceived Stress
Lempert, K. M., Porcelli, A. J., Delgado, M. R., & Tricomi, E. M. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00251 · Cited by 101 · see citing works
Monterosso, J. R., & Luo, S. (2010) · Journal of Neuroscience, Psychology, and Economics · doi:10.1037/a0016827 · Cited by 100 · see citing works
Visual Decision-Making in an Uncertain and Dynamic World
Gold, J. I., & Stocker, A. A. (2017) · Annual Review of Vision Science · doi:10.1146/annurev-vision-111815-114511 · Cited by 100 · see citing works
Conversano, C., Marazziti, D., Carmassi, C., Baldini, S., Barnabei, G., & Dell'Osso, L. (2012) · Harvard Review of Psychiatry · doi:10.3109/10673229.2012.694318 · Cited by 110 · see citing works
Ovarian Cycle Effects on Immediate Reward Selection Bias in Humans: A Role for Estradiol
Smith, C. T., Sierra, Y., Oppler, S. H., & Boettiger, C. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0014-14.2014 · Cited by 91 · see citing works
Why We Should Use Animals to Study Economic Decision Making – A Perspective
Kalenscher, T., & van Wingerden, M. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00082 · Cited by 87 · see citing works
Winstanley, C. A., Zeeb, F. D., Bedard, A., Fu, K., Lai, B., Steele, C., & Wong, A. C. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.02.044 · Cited by 84 · see citing works
Garland, E. L., Boettiger, C. A., & Howard, M. O. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.02.014 · Cited by 85 · see citing works
Bechara, A., Berridge, K. C., Bickel, W. K., Morón, J. A., Williams, S. B., & Stein, J. S. (2019) · Psychological Science in the Public Interest · doi:10.1177/1529100619860513 · Cited by 82 · see citing works
Dopamine-Based Reward Circuitry Responsivity, Genetics, and Overeating
Stice, E. M., Yokum, S., Zald, D. H., & Dagher, A. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_89 · Cited by 81 · see citing works
Impulsivity and Fast-Food Consumption: A Cross-Sectional Study among Working Adults
Garza, K. B., Ding, M., Owensby, J. K., & Zizza, C. A. (2015) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2015.05.003 · Cited by 82 · see citing works
MacKillop, J. M., Amlung, M. T., Acker, J. D., Gray, J. C., Brown, C. L., Murphy, J. G., Ray, L. A., & Sweet, L. H. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.47 · Cited by 79 · see citing works
Boettiger, C. A., Kelley, E. A., Mitchell, J., D’Esposito, M., & Fields, H. L. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.02.008 · Cited by 77 · see citing works
Amlung, M. T., Sweet, L. H., Acker, J. D., Brown, C. L., & MacKillop, J. M. (2012) · Addiction Biology · doi:10.1111/adb.12017 · Cited by 76 · see citing works
Badanich, K. A., Mulholland, P. J., Beckley, J. T., Trantham‐Davidson, H., & Woodward, J. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.12 · Cited by 74 · see citing works
The neural correlates of temporal reward discounting
Scheres, A., de Water, E., & Mies, G. W. (2013) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1246 · Cited by 74 · see citing works
Stoeckel, L. E., Murdaugh, D. L., Cox, J. E., Cook, E. W., & Weller, R. E. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-012-9201-4 · Cited by 73 · see citing works
MacKillop, J., Amlung, M. T., Wier, L. M., David, S. P., Ray, L. A., Bickel, W. K., & Sweet, L. H. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.10.003 · Cited by 70 · see citing works
Frontoparietal connectivity in substance-naïve youth with and without a family history of alcoholism
Wetherill, R. R., Bava, S., Thompson, W. K., Boucquey, V., Pulido, C., Yang, T. T., & Tapert, S. F. (2011) · Brain Research · doi:10.1016/j.brainres.2011.11.013 · Cited by 70 · see citing works
Current hypotheses on the mechanisms of alcoholism
Vetreno, R. P., & Crews, F. T. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00027-6 · Cited by 71 · see citing works
Brain activations reflect individual discount rates in intertemporal choice
Marco‐Pallarés, J., Mohammadi, B., Samii, A., & Münte, T. F. (2010) · Brain Research · doi:10.1016/j.brainres.2010.01.025 · Cited by 68 · see citing works
Ripke, S., Hübner, T., Mennigen, E., Müller, K. U., Rodehacke, S., Schmidt, D., Jacob, M. J., & Smolka, M. N. (2012) · Brain Research · doi:10.1016/j.brainres.2012.08.034 · Cited by 65 · see citing works
Are genetic variants of COMT associated with addiction?
Tammimäki, A., & Männistö, P. T. (2010) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e328340bdf2 · Cited by 67 · see citing works
Moderators of the association between brain activation and farsighted choice
LUO, S. H., Ainslie, G. W., Pollini, D., Giragosian, L., & Monterosso, J. R. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.08.004 · Cited by 65 · see citing works
Diekhof, E. K. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.001 · Cited by 62 · see citing works
Decision neuroscience: neuroeconomics
Smith, D. V., & Huettel, S. A. (2010) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.73 · Cited by 62 · see citing works
Patients’ impatience is an independent determinant of poor diabetes control
Reach, G., Michault, A., Bihan, H., Paulino, C., Cohen, R., & Clésiau, H. L. (2011) · Diabetes & Metabolism · doi:10.1016/j.diabet.2011.03.004 · Cited by 61 · see citing works
Moallem, N. R., & Ray, L. A. (2012) · Addictive Behaviors · doi:10.1016/j.addbeh.2012.03.002 · Cited by 60 · see citing works
Genetic associations with performance on a behavioral measure of distress intolerance
Amstadter, A. B., Daughters, S. B., MacPherson, L., Reynolds, E. K., Danielson, C. K., Wang, F. M., Potenza, M. N., Gelernter, J. E., & Lejuez, C. W. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.09.017 · Cited by 60 · see citing works
The genetic basis of delay discounting and its genetic relationship to alcohol dependence
Mitchell, S. H. (2011) · Behavioural Processes · doi:10.1016/j.beproc.2011.02.008 · Cited by 58 · see citing works
Age modulates the effect of COMT genotype on delay discounting behavior
Smith, C. T., & Boettiger, C. A. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2653-9 · Cited by 59 · see citing works
Individual Differences in Intertemporal Choice
Keidel, K., Rramani, Q., Weber, B., Murawski, C., & Ettinger, U. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.643670 · Cited by 63 · see citing works
Gianotti, L. R. R. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00054 · Cited by 58 · see citing works
Neuroeconomic dissociation of semantic dementia and behavioural variant frontotemporal dementia
Chiong, W., Wood, K., Beagle, A. J., Hsu, M., Kayser, A. S., Miller, B. L., & Kramer, J. H. (2015) · Brain · doi:10.1093/brain/awv344 · Cited by 55 · see citing works
Association of the COMT Met158 allele with trait impulsivity in healthy young adults
Soeiro‐de‐Souza, M. G., Stanford, M. S., Bio, D. S., Machado‐Vieira, R., & Moreno, R. A. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1336 · Cited by 53 · see citing works
Saddoris, M. P., Wang, X., Sugam, J. A., & Carelli, R. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3468-15.2016 · Cited by 54 · see citing works
Gray, J. C., & MacKillop, J. M. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01104 · Cited by 53 · see citing works
Pornpattananangkul, N., & Nusslock, R. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.07.037 · Cited by 52 · see citing works
The Role of Working Memory for Cognitive Control in Anorexia Nervosa versus Substance Use Disorder
Brooks, S. J., Funk, S. G., Young, S. Y., & Schiöth, H. B. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01651 · Cited by 51 · see citing works
Schmaal, L., Goudriaan, A. E., van der Meer, J. N., van den Brink, W., & Veltman, D. J. (2012) · Brain and Behavior · doi:10.1002/brb3.74 · Cited by 51 · see citing works
A developmental perspective on neuroeconomic mechanisms of contingency management.
Stanger, C., Budney, A. J., & Bickel, W. K. (2013) · Psychology of Addictive Behaviors · doi:10.1037/a0028748 · Cited by 50 · see citing works
Valuation, Intertemporal Choice, and Self-Control
Kable, J. W. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-416008-8.00010-3 · Cited by 50 · see citing works
Hill, P. F., Yi, R., Spreng, R. N., & Diana, R. A. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.08.071 · Cited by 48 · see citing works
Increased impulsivity in rats as a result of repeated cycles of alcohol intoxication and abstinence
Irimia, C., Wiskerke, J., Natividad, L. A., Polis, I. Y., Vries, T. J. D., Pattij, T., & Parsons, L. H. (2013) · Addiction Biology · doi:10.1111/adb.12119 · Cited by 45 · see citing works
- Authors
- Boettiger, C. A., Mitchell, J. M., Tavares, V. C., Robertson, M., Joslyn, G., D'Esposito, M., & Fields, H. L.
- Affiliations
- Ernest Gallo Clinic and Research Center (US)
- University of California, San Francisco (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-12-26
- Volume
- 27
- Issue
- 52
- Pages
- 14383-14391
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673461
- OpenAlex
- W2032471892
- Cited by
- 300
- References
- 80
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3 · 2023: 12 · 2022: 6 · 2021: 8 · 2020: 16 · 2019: 13 · 2018: 15 · 2017: 17 · 2016: 18 · 2015: 24 · 2014: 24 · 2013: 22 · 2012: 34
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- delay discounting, intertemporal choice, impulsive decision-making, alcoholism, catechol-O-methyltransferase, COMT Val158Met polymorphism, dopamine metabolism, posterior parietal cortex, dorsal prefrontal cortex, lateral orbitofrontal cortex
- MeSH terms
- Adult, Alcoholism, Brain Mapping, Catechol O-Methyltransferase, Decision Making, Female, Humans, Image Processing, Computer-Assisted, Luria-Nebraska Neuropsychological Battery, Magnetic Resonance Imaging, Male, Nerve Net, Oxygen, Parietal Lobe, Polymorphism, Genetic, Reward, Valine, Bias, Prefrontal Cortex
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