The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Comorbidity of Irritable Bowel Syndrome in Psychiatric Patients: A Review
Abstract
Irritable bowel syndrome (IBS), a functional gastrointestinal disorder, is present in 10% to 20% of the U.S. adult population. The syndrome is best defined as chronic abdominal discomfort with changes in stool frequency, consistency, and passage, with associated symptoms such as abdominal bloating or presence of mucus in stools. Several studies have shown that up to 70% to 90% of patients with IBS who seek treatment have psychiatric comorbidity, most notably mood and anxiety disorders. Recent studies have shown a high prevalence of IBS in psychiatric patients who seek treatment, with a prevalence of 19% in schizophrenia, 29% in major depression, and 46% in panic disorder among other disorders. Our article reviews the comorbidity of IBS in psychiatric patients and discusses implications for treatment.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There is a high prevalence of co-morbidity between psychiatric and gastrointestinal symptoms, e.g., 40–60% of patients with functional gastrointestinal disorders experience psychiatric symptoms [35] and up to 50% of psychiatric patients are diagnosed with irritable bowel syndrome [36], which clearly suggests broader implications of this axis on gastrointestinal and brain functions.”
Citations
Cites
Drossman, D. A., Li, Z., Andruzzi, E., Temple, R. D., Talley, N. J., Grant Thompson, W., Whitehead, W. E., Janssens, J., Funch-Jensen, P., Corazziari, E., et al. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303162 · Cited by 2,198
Liu, Y., Zhou, Z., Chen, K.-L., Zhou, B., Yang, L., Yan, H., & Li, Y. (2012) · Hepatogastroenterology · doi:10.5754/hge12281 · Cited by 2,097
Basic and clinical aspects of visceral hyperalgesia
Mayer, E. A., & Gebhart, G. F. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90086-8 · Cited by 920
Psychosocial Factors in the Irritable Bowel Syndrome
Drossman, D. A., McKee, D. C., Sandler, R. S., Mitchell, C. M., Cramer, E. M., Lowman, B. C., & Burger, A. L. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80017-9 · Cited by 757
Tolerance for Rectosigmoid Distention in Irritable Bowel Syndrome
Whitehead, W. E., Holtkötter, B., Enck, P., Hoelzl, R., Holmes, K. D., Anthony, J. C., Shabsin, H. S., & Schuster, M. M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90332-u · Cited by 592
Irritable bowel syndrome: A technical review for practice guideline development
Drossman, D. A., Whitehead, W. E., & Camilleri, M. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.agast972120 · Cited by 571
Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis
Jackson, J. L., O’Malley, P. G., Tomkins, G., Balden, E., Santoro, J., & Kroenke, K. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00299-5 · Cited by 466
Altered small bowel motility in irritable bowel syndrome is correlated with symptoms
Kellow, J. E., & Phillips, S. F. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90620-2 · Cited by 464
A controlled trial of psychological treatment for the irritable bowel syndrome
Guthrie, E., Creed, F. H., Dawson, D., & Tomenson, B. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90215-7 · Cited by 461
Treatment of Irritable Bowel Syndrome With Chinese Herbal Medicine
Bensoussan, A., Talley, N. J., Hing, M. C., Menzies, R. G., Guo, A., & Ngu, M. (1998) · JAMA · doi:10.1001/jama.280.18.1585 · Cited by 415
Research works printed but not linked: 6
- Norton, 1997, Participate, 6, 1
- Thompson, 1992, Gastroenterol Int, 5, 75
- Masand, 1995, J Clin Psychiatry, 56, 363
- Lydiard, 1986, J Clin Psychiatry, 47, 470
- Emmanuel, 1997, Am J Psychiatry, 154, 711
- Drossman, 1995, Gastroenterol Int, 8, 47
Cited by
Sorted by citations
Items 101–146 of 146
The contribution of brain imaging to the study of panic disorder
Volpe, U., Merlotti, E., Mucci, A., & Galderisi, S. (2004) · Epidemiology and Psychiatric Sciences · doi:10.1017/s1121189x00001755 · Cited by 7
Easing the Burden of Panic Disorder: Comorbidity, Diagnosis, and Implications for Treatment
Baldwin, D. S. (2005) · CNS Spectrums · doi:10.1017/s1092852900026493 · Cited by 7
Alhazmi, A., Darraj, H., Abdali, H., Hakami, S. M., Alatiyyah, A., Dalak, M., Hakami, K., Ghalibi, A., Abdulwali, H. M., Jali, A., et al. (2024) · Cureus · doi:10.7759/cureus.53549 · Cited by 7
Tamannaifar, M. R., & Akhavan-Hejazi, Z. S. (2013) · Fiyz̤. · Cited by 6
Stress and the Gastrointestinal System
Bonaz, B. L. (2016) · Springer eBooks · doi:10.1007/978-3-319-28609-9_7 · Cited by 6
Irritable Bowel Syndrome in Dialysis Patients and Symptom Check List Revised (SCL 90-R) Screening
Yılmaz, A., Gökçen, P., Yılmaz, H., Hüzmeli, C., & Yılmaz, A. (2021) · Eurasian Journal of Medicine · doi:10.5152/eurasianjmed.2021.20412 · Cited by 7
Fakhraei, B., Ali, F., Farjam, M., Fattahi, M. R., Kazemi, M. H., Naini, M. A., & Moini, M. (2015) · Annals of Colorectal Research · doi:10.17795/acr-27621 · Cited by 5
Kashani, S. A. (2017) · Journal of Psychology & Clinical Psychiatry · doi:10.15406/jpcpy.2017.07.00458 · Cited by 5
Aydın, O., & Ünal‐Aydın, P. (2017) · Psychiatry and Clinical Psychopharmacology · doi:10.1080/24750573.2017.1387403 · Cited by 5
A Microbial Relationship Between Irritable Bowel Syndrome and Depressive Symptoms
Perez, N. B., Wright, F., & Vorderstrasse, A. A. (2020) · Biological Research For Nursing · doi:10.1177/1099800420940787 · Cited by 5
Gender Differences in Irritable Bowel Syndrome
Pickett‐Blakely, O., Lee, L. A., & Mullin, G. E. (2010) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-12-374271-1.00032-0 · Cited by 5
Ismaiel, A., Foucambert, P., Ismaiel, M., Leucuta, D., Popa, S., Băban, A., & Dumitrascu, D. L. (2024) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm23159 · Cited by 5
Irritable Bowel Syndrome, Depression and Anxiety
Alhan, C., & Okan, A. (2017) · Eastern Journal Of Medicine · doi:10.5505/ejm.2017.08208 · Cited by 3
Bajic, J. E., Howarth, G. S., Johnston, I. N., & Hutchinson, M. R. (2018) · Journal of Cancer Science and Research · doi:10.4172/2576-1447.1000105 · Cited by 3
Saade-Cleves, N., & Rosselli, D. (2025) · Revista Colombiana de Gastroenterología · doi:10.22516/25007440.1289 · Cited by 3
Abbasi, M., Safizadeh, H., Zahedi, M. J., Moghadam, S. D., Shafieipour, S., Rafsanjani, A. M. B., & Rafsanjani, N. M. B. (2015) · GOVARESH · Cited by 2
Depressive Störungen bei internistischen und neurologischen Erkrankungen
Norra, C., Herpertz, S., Baghai, T. C., Lieb, M., Schäfer, M. K.-H., & Juckel, G. (2013) · Nervenheilkunde · doi:10.1055/s-0038-1628508 · Cited by 2
Psychiatric Comorbidities in Irritable Bowel Syndrome (IBS)
Stănculete, M. F. (2016) · InTech eBooks · doi:10.5772/66301 · Cited by 2
VNS for the Treatment of Inflammatory Disorders of the Gastrointestinal Tract
Bonaz, B. L., Sinniger, V., Sonia Pellissier, A., & Clarençon, D. (2017) · Springer eBooks · doi:10.1007/978-3-319-28612-9_9 · Cited by 3
Pickett‐Blakely, O., & Lee, L. (2009) · CRC Press eBooks · doi:10.1201/9781420067637.ch13 · Cited by 2
Abdominal pain models: mechanisms and therapies and experimental models
Lucarini, E., Mannelli, L. D. C., & Ghelardini, C. (2020) · doi:10.36118/pharmadvances.03.2020.04 · Cited by 1
Mechanical prosthetic valve disease is related with an increase in depression and anxiety disorder.
Türker, Y., Öngel, K., Özaydın, M., Türker, Y., BAŞ, F. Y., & Akkaya, M. (2015) · PubMed · Cited by 1
Psychimmunological Aspects and Quality of Life in Patients with Irritable Bowel Syndrome
El-Mrasey, I. M., Shama, G., Issa, M. A. E.-R., Hussein, M. Z., & Selim, A. F. (2023) · International Neuropsychiatric Disease Journal · doi:10.9734/indj/2023/v20i3404 · Cited by 1
Verma, N., Arora, A., Wal, A., Singh, C., Shankara, R. K., Singh, B., & Sharma, M. C. (2025) · Current Psychiatry Research and Reviews · doi:10.2174/0126660822325668241118073750 · Cited by 1
Depresyon ve İrritabl Barsak Sendromu Birlikteliğinin Nörobiyolojisi
Eker, M. C., & Eker, Ö. D. (2009) · DergiPark (Istanbul University) · doi:10.18863/pgy.17409 · Cited by 5
Gut Microbiota and its Role in Human Health
Rajilić-Stojanović, M. D. (2018) · Psihologijske teme · doi:10.31820/pt.27.1.2 · Cited by 1
Bhatti, N. A. A. (2018) · The Professional Medical Journal · doi:10.29309/tpmj/18.4737 · Cited by 1
Peripheral and central factors in the pathophysiology of irritable bowel syndrome
Posserud, I. (2007) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 1
Halliez, M. C. M. (2014) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/27133 · Cited by 1
Omar, M., Omar, M., Agbareia, R., & Nassar, S. (2024) · medRxiv · doi:10.1101/2024.02.09.24302578 · Cited by 1
Collins, S., Bercik, P., Denou, E., & Verdú, E. (2010) · Bioscience and Microflora · doi:10.12938/bifidus.29.179
THE EMOTIONAL MOTOR SYSTEM AND GASTROINTESTINAL SYMPTOMS
Karling, P. (2008) · DiVA at Umeå University (Umeå University)
Controlled trial of hypnotherapy as a treatment for irritable bowel syndrome.
Phillips-Moore, J. (2009) · The Sydney eScholarship Repository (The University of Sydney)
Microbiota, the brain and epigenetics
Louwies, T., Johnson, A. C., Orock, A. M., Yuan, T., & Meerveld, B. G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816843-1.00026-6
Correlation of irritable bowel syndrome with psychiatric disorders
Caban, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821324-7.00015-0
Bhatti, N. A. A. (2018) · The Professional Medical Journal · doi:10.29309/tpmj/2018.25.08.81
Valkenburg, C. V. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-252-6_24
Valkenburg, C. V. (2016) · Springer eBooks · doi:10.1007/978-1-4939-2528-5_24
Levant, B. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.04854-6
Méndez‐Ferrer, S. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732146442.793575333
Marcil, W., & Petty, F. (2007) · xPharm: The Comprehensive Pharmacology Reference · doi:10.1016/b978-008055232-3.60650-6
Complementary and alternative medicine in patients with irritable bowel syndrome: A Pilot Study
Porwal, A. D., Gandhi, P. M., Kulkarni, D. K., Bhagwat, G. B., & Kamble, P. P. (2023) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2023.19.3.1808
Особливості клінічних проявів у дітей із синдромом подразненого кишечника
Buryak, V. M., & Bessarab, P. O. (2012) · Likarska sprava · doi:10.31640/ls-2012-8-10
Söderquist, F., Syk, M., Just, D., Kurbalija Novicic, Z., Rasmusson, A. J., Hellström, P. M., Ramklint, M., & Cunningham, J. L. (2020) · Figshare · doi:10.6084/m9.figshare.13226348
The gut–brain–epigenetic axis in brain health
Louwies, T. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-15572-7.00057-7
Metadata
- Authors
- Garakani, A., Win, T., Virk, S., Gupta, S., Kaplan, D., & Masand, P. S.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Olean General Hospital (US)
- Corresponding author
- Masand, Prakash S.
- Venue
- American Journal of Therapeutics
- Published
- 2003-01
- Volume
- 10
- Issue
- 1
- Pages
- 61-67
- ISSN
- 1075-2765 (ISSN-L)
- OpenAlex
- W2041184383
- Cited by
- 149
- References
- 49
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 7 · 2017: 12 · 2016: 14 · 2015: 12 · 2014: 8 · 2013: 3 · 2012: 8
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
- Keywords
- irritable bowel syndrome, psychiatric comorbidity, mood disorders, anxiety disorders, schizophrenia, major depressive disorder, panic disorder, functional gastrointestinal disorders, prevalence, therapeutic implications
- MeSH terms
- Colonic Diseases, Functional, Depressive Disorder, Humans, Schizophrenia, United States, Comorbidity, Prevalence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review