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Comorbidity of Irritable Bowel Syndrome in Psychiatric Patients: A Review
Abstract
Irritable bowel syndrome (IBS), a functional gastrointestinal disorder, is present in 10% to 20% of the U.S. adult population. The syndrome is best defined as chronic abdominal discomfort with changes in stool frequency, consistency, and passage, with associated symptoms such as abdominal bloating or presence of mucus in stools. Several studies have shown that up to 70% to 90% of patients with IBS who seek treatment have psychiatric comorbidity, most notably mood and anxiety disorders. Recent studies have shown a high prevalence of IBS in psychiatric patients who seek treatment, with a prevalence of 19% in schizophrenia, 29% in major depression, and 46% in panic disorder among other disorders. Our article reviews the comorbidity of IBS in psychiatric patients and discusses implications for treatment.
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“There is a high prevalence of co-morbidity between psychiatric and gastrointestinal symptoms, e.g., 40–60% of patients with functional gastrointestinal disorders experience psychiatric symptoms [35] and up to 50% of psychiatric patients are diagnosed with irritable bowel syndrome [36], which clearly suggests broader implications of this axis on gastrointestinal and brain functions.”
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Cites
Drossman, D. A., Li, Z., Andruzzi, E., Temple, R. D., Talley, N. J., Grant Thompson, W., Whitehead, W. E., Janssens, J., Funch-Jensen, P., Corazziari, E., et al. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303162 · Cited by 2,198
Liu, Y., Zhou, Z., Chen, K.-L., Zhou, B., Yang, L., Yan, H., & Li, Y. (2012) · Hepatogastroenterology · doi:10.5754/hge12281 · Cited by 2,097
Basic and clinical aspects of visceral hyperalgesia
Mayer, E. A., & Gebhart, G. F. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90086-8 · Cited by 920
Psychosocial Factors in the Irritable Bowel Syndrome
Drossman, D. A., McKee, D. C., Sandler, R. S., Mitchell, C. M., Cramer, E. M., Lowman, B. C., & Burger, A. L. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80017-9 · Cited by 757
Tolerance for Rectosigmoid Distention in Irritable Bowel Syndrome
Whitehead, W. E., Holtkötter, B., Enck, P., Hoelzl, R., Holmes, K. D., Anthony, J. C., Shabsin, H. S., & Schuster, M. M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90332-u · Cited by 592
Irritable bowel syndrome: A technical review for practice guideline development
Drossman, D. A., Whitehead, W. E., & Camilleri, M. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.agast972120 · Cited by 571
Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis
Jackson, J. L., O’Malley, P. G., Tomkins, G., Balden, E., Santoro, J., & Kroenke, K. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00299-5 · Cited by 466
Altered small bowel motility in irritable bowel syndrome is correlated with symptoms
Kellow, J. E., & Phillips, S. F. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90620-2 · Cited by 464
A controlled trial of psychological treatment for the irritable bowel syndrome
Guthrie, E., Creed, F. H., Dawson, D., & Tomenson, B. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90215-7 · Cited by 461
Treatment of Irritable Bowel Syndrome With Chinese Herbal Medicine
Bensoussan, A., Talley, N. J., Hing, M. C., Menzies, R. G., Guo, A., & Ngu, M. (1998) · JAMA · doi:10.1001/jama.280.18.1585 · Cited by 415
Pharmacologic Treatment of the Irritable Bowel Syndrome
Jailwala, J., Imperiale, T. F., & Kroenke, K. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-2-200007180-00013 · Cited by 374
The Irritable Bowel Syndrome: Long-Term Prognosis and the Physician-Patient Interaction
Owens, D. M., Nelson, D. K., & Talley, N. J. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-2-199501150-00005 · Cited by 349
Survey of the AGA Membership Relating to Patients With Functional Gastrointestinal Disorders
Mitchell, C. M., & Drossman, D. A. (1987) · Gastroenterology · doi:10.1016/s0016-5085(87)91099-7 · Cited by 292
Colonic Myoelectrical Activity in Irritable-Bowel Syndrome
Sullivan, M. A., Cohen, S., & Snape, W. J. (1978) · New England Journal of Medicine · doi:10.1056/nejm197804202981604 · Cited by 263
Evidence for exacerbation of irritable bowel syndrome during menses
Whitehead, W. E., Cheskin, L. J., Heller, B. R., Robinson, J. C., Crowell, M. D., Benjamin, C., & Schuster, M. M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)91079-l · Cited by 262
Patients with irritable bowel syndrome have greater pain tolerance than normal subjects
Cook, I. J., van Eeden, A., & Collins, S. M. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90434-3 · Cited by 233
PROGNOSIS IN THE IRRITABLE BOWEL SYNDROME: A 5-YEAR PROSPECTIVE STUDY
Harvey, R. F., Mauad, E. C., & Brown, A. M. (1987) · The Lancet · doi:10.1016/s0140-6736(87)90304-7 · Cited by 212
Selective Serotonin-Reuptake Inhibitors: An Update
Masand, P. S., & Gupta, S. (1999) · Harvard Review of Psychiatry · doi:10.3109/hrp.7.2.69 · Cited by 211
A Double-Blind Placebo-Controlled Trial with Loperamide in Irritable Bowel Syndrome
Efskind, P., Bernklev, T., & Vatn, M. H. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609006766 · Cited by 206
Prior, A., & Read, N. W. (1993) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1993.tb00087.x · Cited by 178
A Randomised Controlled Trial of Psychotherapy in Patients with Refractory Irritable Bowel Syndrome
Guthrie, E., Creed, F. H., Dawson, D., & Tomenson, B. (1993) · The British Journal of Psychiatry · doi:10.1192/bjp.163.3.315 · Cited by 155
Lynn, R. B., & Friedman, L. S. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312233292608 · Cited by 139
The Irritable Bowel Syndrome: Mechanisms and a Practical Approach to Management
Camilleri, M., & Prather, C. M. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-12-1001 · Cited by 131
Antidepressants for functional gastrointestinal syndromes
Clouse, R. E. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02087651 · Cited by 124
Bradette, M., Delvaux, M. M., Staumont, G., Fioramonti, J., Bueno, L. P., & Frexinos, J. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02093780 · Cited by 106
Abnormal REM sleep in the irritable bowel syndrome
Kumar, D., Thompson, P. D., Wingate, D. L., Vesselinova-Jenkins, C. K., & Libby, G. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91089-m · Cited by 105
Major depression and irritable bowel syndrome: is there a relationship?
Masand, P. S., Kaplan, D., Gupta, S. B., Bhandary, A. N., Nasra, G. S., Kline, M. D., & Margo, K. L. (1995) · PubMed · Cited by 100
Psyllium Therapy in the Irritable Bowel Syndrome
Longstreth, G. F., FOX, D. D., YOUKELES, L., FORSYTHE, A. B., & WOLOCHOW, D. A. (1981) · Annals of Internal Medicine · doi:10.7326/0003-4819-95-1-53 · Cited by 99
Lydiard, R. B., & Falsetti, S. A. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00082-0 · Cited by 97
Cook, I. J., Irvine, E. J., Campbell, D., Shannon, S., Reddy, S. N., & Collins, S. M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)91292-e · Cited by 96
Maxton, D. G., Morris, J. A., & Whorwell, P. J. (1996) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1996.30172000.x · Cited by 96
Goldberg, P. A., Kamm, M. A., Setti-Carraro, P., van der Sijp, J. R. M., & Roth, C. (2009) · Digestion · doi:10.1159/000201377 · Cited by 94
Irritable Bowel Syndrome–Prognosis and Diagnostic Safety
Svendsen, J. H., Munck, L. K., & Andersen, J. R. (1985) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528509089673 · Cited by 90
Diagnosing and Treating Patients with Refractory Functional Gastrointestinal Disorders
Drossman, D. A. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-123-9-199511010-00008 · Cited by 89
The relationship between schizophrenia and irritable bowel syndrome (IBS)
Gupta, S., Masand, P. S., Kaplan, D. S., Bhandary, A. N., & Hendricks, S. E. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(96)00099-0 · Cited by 85
Can panic disorder present as irritable bowel syndrome?
Lydiard, R. B., Mt, L., Ef, H., & Jc, B. (1986) · PubMed · Cited by 75
Dobrilla, G., Imbimbo, B. P., Piazzi, L., & Bensi, G. (1990) · Gut · doi:10.1136/gut.31.3.355 · Cited by 66
Reduction of Gastrointestinal Symptoms Following Treatment for Panic Disorder
Noyes, R., Cook, B. L., Garvey, M. J., & Summers, R. W. (1990) · Psychosomatics · doi:10.1016/s0033-3182(90)72220-7 · Cited by 63
The Relationship of Irritable Bowel Syndrome (IBS) and Panic Disorder1
Kaplan, D. S., Masand, P. M., & Gupta, S. (1996) · Annals of Clinical Psychiatry · doi:10.3109/10401239609148805 · Cited by 62
Comorbid Irritable Bowel Syndrome in Patients with Generalized Anxiety and Major Depression
Tollefson, G. D., Tollefson, S. L., Pederson, M. W., Luxenberg, M. G., & Dunsmore, G. (1991) · Annals of Clinical Psychiatry · doi:10.3109/10401239109147994 · Cited by 60
O'DONNELL, L. J. D., Watson, A. J. M., CAMERON, D., & Farthing, M. J. G. (1990) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1990.tb00463.x · Cited by 53
New Drugs in the Management of the Irritable Bowel Syndrome
Farthing, M. J. G. (1998) · Drugs · doi:10.2165/00003495-199856010-00002 · Cited by 50
Irritable Bowel Syndrome and Dysthymia
Masand, P. S., Kaplan, D. S., Gupta, S., & Bhandary, A. N. (1997) · Psychosomatics · doi:10.1016/s0033-3182(97)71505-6 · Cited by 34
Anxiety and the Irritable Bowel Syndrome
Lydiard, R. B. (1992) · Psychiatric Annals · doi:10.3928/0048-5713-19921201-09 · Cited by 31
Irritable Bowel Syndrome and Mirtazapine
Thomas, S. G. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.8.1341-a · Cited by 30
Brief Note: Irritable Bowel Syndrome (IBS) and Alcohol Abuse or Dependence
Masand, P. S., Sousou, A. J., Gupta, S., & Kaplan, D. S. (1998) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952999809016913 · Cited by 23
Paroxetine and Irritable Bowel Syndrome
Kirsch, M. A., & Louie, A. K. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.9.1523-a · Cited by 20
Treatment of irritable bowel syndrome with fluvoxamine
Emmanuel, N. P., Lydiard, R. B., & Crawford, M. A. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.5.711b · Cited by 14
Masand, P. S., Kaplan, D., Gupta, S. B., & Bhandary, A. N. (1995) · Depression · doi:10.1002/depr.3050030608 · Cited by 11
Research works printed but not linked: 6
- Norton, 1997, Participate, 6, 1
- Thompson, 1992, Gastroenterol Int, 5, 75
- Masand, 1995, J Clin Psychiatry, 56, 363
- Lydiard, 1986, J Clin Psychiatry, 47, 470
- Emmanuel, 1997, Am J Psychiatry, 154, 711
- Drossman, 1995, Gastroenterol Int, 8, 47
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Metadata
- Authors
- Garakani, A., Win, T., Virk, S., Gupta, S., Kaplan, D., & Masand, P. S.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Olean General Hospital (US)
- Corresponding author
- Masand, Prakash S.
- Venue
- American Journal of Therapeutics
- Published
- 2003-01
- Volume
- 10
- Issue
- 1
- Pages
- 61-67
- ISSN
- 1075-2765 (ISSN-L)
- OpenAlex
- W2041184383
- Cited by
- 149
- References
- 49
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 7 · 2017: 12 · 2016: 14 · 2015: 12 · 2014: 8 · 2013: 3 · 2012: 8
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
- Keywords
- irritable bowel syndrome, psychiatric comorbidity, mood disorders, anxiety disorders, schizophrenia, major depressive disorder, panic disorder, functional gastrointestinal disorders, prevalence, therapeutic implications
- MeSH terms
- Colonic Diseases, Functional, Depressive Disorder, Humans, Schizophrenia, United States, Comorbidity, Prevalence
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