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Cited by 464Gastrointestinal motility and disordersGut microbiota and healthGastroesophageal reflux and treatments

Altered small bowel motility in irritable bowel syndrome is correlated with symptoms

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Kellow, John E., Phillips, Sidney F.·1987·Gastroenterology
DOI 10.1016/0016-5085(87)90620-2
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Abstract

The pathogenesis of irritable bowel syndrome (IBS) has been related more to dysmotility of the colon than to abnormalities of the small intestine. To look for small bowel abnormalities, we recorded ultraluminal pressures in 16 patients with IBS. All patients complained of abdominal pain, and diarrhea (n = 8) or constipation (n = 8) were also prominent symptoms. Comparable studies were performed on 16 age-matched controls. The observations include diurnal and nocturnal fasting recordings and the response to a fatty meal. Periodicities of the interdigestive migrating myoelectric complexes were shorter in IBS (p less than 0.05); this was due to much shorter diurnal cycles in patients with diarrhea (77 +/- 10 min) than those with constipation (118 +/- 15 min) or controls (113 +/- 10 min, both p less than 0.05). All groups exhibited circadian changes, with nocturnal cycles being more frequent. Two specific patterns of small bowel motor activity were more common in IBS--ileal propulsive waves and clusters of jejunal pressure activity (both p less than 0.05 compared to controls). Moreover, cramping abdominal pain was usually noted in IBS when ileal motility was propulsive; jejunal bursts were also sometimes associated with abdominal symptoms. We conclude that motility of the small intestine is modified in some patients with IBS and that certain motor patterns are related to their symptoms.

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  • So far, randomised controlled trials have not confirmed symptom generation by a specific food.

    “Although randomised controlled trials (RCTs) have confirmed that dietary modification can affect IBS symptoms, so far, they have not confirmed symptom generation by a specific food.”

    From Irritable bowel syndrome (2020) · cites this paper as [34]

    The Test Meals section describes a standardized high-fat meal used while recording motility, and the Discussion links abdominal pain to intestinal motor patterns. Neither passage assesses randomized controlled trials or whether a specific food has been confirmed to generate IBS symptoms; searches for dietary modification and food trials found no such assessment in our copy. Page numbers were not available. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • FODMAPs have fermentative and osmotic effects, which may contribute to symptoms in some patients.

    “They have fermentative and osmotic effects, which may contribute to symptoms in some patients. 34”

    From Irritable bowel syndrome (2020) · cites this paper as [34]

    The Test Meals section describes a meal used to measure motility, and the Discussion links intestinal motor patterns with symptoms. Neither passage addresses FODMAPs or their fermentative and osmotic effects; searches for those mechanisms found no supporting passage in our copy. Page numbers were not provided. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • Randomised controlled trials have confirmed that dietary modification can affect IBS symptoms.

    “Although randomised controlled trials (RCTs) have confirmed that dietary modification can affect IBS symptoms, so far, they have not confirmed symptom generation by a specific food.”

    From Irritable bowel syndrome (2020) · cites this paper as [34]

    The Test Meals section describes a high-fat meal used to measure motility, not a randomized trial of dietary modification. The Discussion mentions food as a stimulus for IBS symptoms, but our copy does not report RCTs confirming that dietary changes affect symptoms. Searched for randomized trials, dietary modification, food, and meal-related symptoms; page numbers were unavailable. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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Cites

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Research works printed but not linked: 38

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Authors
Kellow, J. E., & Phillips, S. F.
Affiliations
Mayo Clinic (US)
Venue
Gastroenterology
Publisher
Elsevier BV
Published
1987-06
Volume
92
Issue
6
Pages
1885-1893
ISSN
0016-5085 (ISSN-L)
DOI
10.1016/0016-5085(87)90620-2
OpenAlex
W130502936
Cited by
464
References
0
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 5 · 2016: 6 · 2015: 10 · 2014: 12 · 2013: 6 · 2012: 9
FWCI
15.50
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01am032121-03, 3p30am034988-01s1)
  • National Center for Research Resources (RR-585)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords
irritable bowel syndrome, small intestine motility, migrating motor complex, abdominal pain, diarrhea, constipation
MeSH terms
Abdomen, Adult, Circadian Rhythm, Colonic Diseases, Functional, Female, Food, Gastrointestinal Motility, Humans, Ileum, Male, Middle Aged, Muscle Contraction, Pain

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