The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Interleukin-13 in asthma
Abstract
Some time ago, the Th2 cytokine, interleukin (IL)-13, was identified as a critical regulator of the allergic response. Initial studies in animal models of disease provided compelling evidence that IL-13, independent from other Th2 cytokines, was necessary and sufficient to induce all features of allergic asthma. This contention was supported in human disease when strong associations between IL-13 levels and genetic polymorphisms in the IL-13 gene and disease correlates were found. With the preponderance of evidence continuing to support the importance of IL-13 in allergic disorders, attention is now turned towards understanding the mechanisms by which this cytokine may mediate the pathophysiologic features of allergic disease. The emerging paradigm is that IL-13 induces features of the allergic response via its actions on epithelial and smooth muscle cells not through traditional effector pathways involving eosinophils and IgE-mediated events. In light of recent developments, this review will explore our current understanding of the role of IL-13 in the pathogenesis of allergy and asthma with a particular focus on new insights into the mechanisms by which IL-13 induces the features of asthma.
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Hurst, S. D., Muchamuel, T., Gorman, D. M., Gilbert, J. M., Clifford, T., Kwan, S., Menon, S., Seymour, B., Jackson, C., Kung, T. T., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.443 · Cited by 619
Chiaramonte, M. G., Donaldson, D. D., Cheever, A. W., & Wynn, T. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7325 · Cited by 603
Self-citationTemann, U.-A., Geba, G. P., Rankin, J. A., & Flavell, R. A. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.7.1307 · Cited by 452
Modulation of murine macrophage function by IL-13
Doherty, T. M., Kastelein, R., Menon, S., Andrade, S., & Coffman, R. L. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.12.7151 · Cited by 249
Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology
Temann, U.-A., Ray, P., & Flavell, R. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213696 · Cited by 201
IL-13 and IL-4 cause eotaxin release in human airway smooth muscle cells: a role for ERK
Moore, P. E., Church, T. L., Chism, D. D., Panettieri, R. A., & Shore, S. A. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00245.2001 · Cited by 166
Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells
Liu, X., Kohyama, T., Wang, H., Zhu, Y. K., Wen, F.-Q., Kim, H. J., Romberger, D. J., & Rennard, S. I. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00321.2001 · Cited by 77
Cited by
The cytokine network in asthma and chronic obstructive pulmonary disease
Barnes, P. J. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36130 · Cited by 982
Interleukin‐13 in asthma pathogenesis
Wills‐Karp, M. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00215.x · Cited by 683
Self-citationLee, C. G., Link, H., Baluk, P., Homer, R. J., Chapoval, S., Bhandari, V., Kang, M. J., Cohn, L., Kim, Y. K., McDonald, D. M., et al. (2004) · Nature Medicine · doi:10.1038/nm1105 · Cited by 594
CD4 + T-cell subsets in inflammatory diseases: beyond the T h 1/T h 2 paradigm
Hirahara, K., & Nakayama, T. (2016) · International Immunology · doi:10.1093/intimm/dxw006 · Cited by 417
Hamid, Q., & Tulic, M. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163200 · Cited by 371
Metadata
- Authors
- Wills-Karp, M., & Chiaramonte, M.
- Venue
- Current Opinion in Pulmonary Medicine
- Published
- 2003-01
- Volume
- 9
- Issue
- 1
- Pages
- 21-27
- ISSN
- 1070-5287 (ISSN-L)
- OpenAlex
- W2323399409
- Cited by
- 179
- References
- 7
- FWCI
- 14.11
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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