The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Regulation of skeletal muscle protein metabolism in catabolic states
Abstract
PURPOSE OF REVIEW: This review highlights recent publications dealing with the nature of the in-vivo response of skeletal muscle to critical illness and approaches to attenuating this response. Studies focused on molecular mechanisms of muscle catabolism are not reviewed. RECENT FINDINGS: The general areas covered are the metabolic response to stress, particularly regarding the relationship between muscle protein breakdown, amino acid availability, and muscle protein synthesis. The impact of the profile of amino acids in the context of protein/amino acid intake is also discussed. Advances in our understanding of the hormonal response are considered, and use of insulin therapy to slow muscle catabolism is discussed. SUMMARY: Muscle catabolism is a fundamental response to severe stress, and the resulting amino acid efflux from muscle provides important precursors for protein synthesis in other parts of the body. The nature of this response (i.e. transport kinetics favoring efflux of amino acids from muscle) makes amelioration of the catabolic response of muscle with nutrition alone very difficult. Many approaches have been used to reverse catabolism, mostly involving various anabolic hormones. Recent studies using insulin therapy are particularly intriguing because of the low cost and powerful anabolic stimulus of insulin.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Simultaneously, muscle cells benefit from this response despite net catabolism of muscle mass.89, 90”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [89]
Citations
Cites
1 retracted
RETRACTED: Effect of burn injury on glucocorticoid receptor binding activity in rat muscle
Sun, X., Fischer, D. R., Yang, M., & Tian, T. (2004) · Journal of Surgical Research · doi:10.1016/s0022-4804(03)00285-3 · Cited by 2
RetractedIntensive insulin therapy in critically ill patients.
Van den Berghe, G., Wouters, P., Weekers, F., Verwaest, C., Bruyninckx, F., Schetz, M., Vlasselaers, D., Ferdinande, P., Lauwers, P., & Bouillon, R. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011300 · Cited by 9,977
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
Lecker, S. H., Jagoe, R. T., Gilbert, A., Gomes, M., Baracos, V., Bailey, J., Price, S. R., Mitch, W. E., & Goldberg, A. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-0610com · Cited by 1,539
Reversal of Catabolism by Beta-Blockade after Severe Burns
Herndon, D. N., Hart, D. W., Wolf, S. E., Chinkes, D. L., & Wolfe, R. R. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010342 · Cited by 638
Self-citationAnthony, J. C., Anthony, T. G., Kimball, S. R., Vary, T. C., & Jefferson, L. S. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.139 · Cited by 469
Biolo, G., Declan Fleming, R. Y., & Wolfe, R. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117731 · Cited by 442
Self-citationResponse of Protein and Urea Kinetics in Burn Patients to Different Levels of Protein Intake
Wolfe, R. R., Goodenough, R. D., Burke, J. F., & WOLFE, M. H. (1983) · Annals of Surgery · doi:10.1097/00000658-198302000-00007 · Cited by 270
Self-citationStimulation of Muscle Protein Synthesis by Long-Term Insulin Infusion in Severely Burned Patients
Sakurai, Y., Aarsland, A. A., Herndon, D. N., Chinkes, D. L., Pierre, E. J., Nguyen, T. T., Patterson, B. W., & Wolfe, R. R. (1995) · Annals of Surgery · doi:10.1097/00000658-199509000-00007 · Cited by 234
Self-citationInsulin Treatment Improves the Systemic Inflammatory Reaction to Severe Trauma
Jeschke, M. G., Klein, D., & Herndon, D. N. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000118569.10289.ad · Cited by 232
Hyperglycemia exacerbates muscle protein catabolism in burn-injured patients
Gore, D. C., Chinkes, D. L., Hart, D. W., Wolf, S. E., Herndon, D. N., & Sanford, A. P. (2002) · Critical Care Medicine · doi:10.1097/00003246-200211000-00006 · Cited by 194
Research works printed but not linked: 3
- Costelli, 2003, Curr Opin Clin Nutr Metab Care, 6, 407
- Bergstrom, 1992, Miner Electrolyte Metab, 18, 280
- Flakoll, 1993, Am J Physiol, 265, E715
Cited by
Sorted by citations
Hypoalbuminemia: Pathogenesis and Clinical Significance
Soeters, P. B., Wolfe, R. R., & Shenkin, A. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1451 · Cited by 1,448
Self-citationHuman amyloid-β synthesis and clearance rates as measured in cerebrospinal fluid in vivo
Bateman, R. J., Munsell, L. Y., Morris, J. C., Swarm, R., Yarasheski, K. E., & Holtzman, D. M. (2006) · Nature Medicine · doi:10.1038/nm1438 · Cited by 599
Intensive care unit-acquired weakness
Griffiths, R., & Hall, J. B. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181cc4b53 · Cited by 277
Atrophy and Impaired Muscle Protein Synthesis during Prolonged Inactivity and Stress
Paddon-Jones, D., Sheffield-Moore, M., Cree, M. G., Hewlings, S. J., Aarsland, A., Wolfe, R. R., & Ferrando, A. A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0651 · Cited by 254
Self-citationGender Differences in Pediatric Burn Patients
Jeschke, M. G., Mlcak, R. P., Finnerty, C. C., Norbury, W. B., Przkora, R., Kulp, G. A., Gauglitz, G. G., Zhang, X., & Herndon, D. N. (2008) · Annals of Surgery · doi:10.1097/sla.0b013e318176c4b3 · Cited by 172
Metadata
- Authors
- Wolfe, R. R.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Wolfe, Robert R
- ORCID
- Wolfe, Robert R
- Venue
- Current Opinion in Clinical Nutrition and Metabolic Care
- Published
- 2005-01
- Volume
- 8
- Issue
- 1
- Pages
- 61-65
- ISSN
- 1363-1950 (ISSN-L)
- OpenAlex
- W2016803694
- Cited by
- 108
- References
- 33
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 12 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 4 · 2014: 11 · 2013: 1 · 2012: 9
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- skeletal muscle protein metabolism, muscle catabolism, critical illness, amino acid availability, muscle protein synthesis, amino acid efflux, insulin therapy, anabolic hormones, stress response, nutritional support, catabolic state
- MeSH terms
- Amino Acids, Humans, Insulin, Muscle Proteins, Stress, Physiological, Muscle, Skeletal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
