The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Anal intraepithelial neoplasia in the highly active antiretroviral therapy era among HIV-positive men who have sex with men
Abstract
OBJECTIVES: The incidence of anal cancer among men who have sex with men (MSM) has continued to increase since the introduction of highly active antiretroviral therapy (HAART). The prevalence of the putative anal cancer precursor, anal intraepithelial neoplasia (AIN) was high among HIV-positive MSM prior to the availability of HAART but little is known about AIN since HAART was introduced. We characterized the prevalence of AIN among HIV-positive MSM and examined the association between AIN and various factors including use of HAART. DESIGN AND METHODS: A baseline point-prevalence analyses in a prospective cohort study of AIN was performed at a university-based research clinic. A total of 357 HIV-positive MSM with no history of anal cancer completed a questionnaire detailing behaviors and medical history, anal cytology and human papillomavirus (HPV) testing, and high-resolution anoscopy with biopsy for detection of AIN. RESULTS: Eighty-one percent of participants with available CD4+ cell counts at baseline had AIN of any grade; 52% had AIN 2 or 3; and 95% had anal HPV infection. In multivariate analysis, detection of > or = 6 HPV types [odds ratio (OR), 36; 95% confidence interval (CI), 7.4-171) and use of HAART (OR, 10; 95% CI, 2.6-38) were associated with AIN after adjustment for length of time participants were HIV-positive, CD4+ cell count and HIV viral load. CONCLUSIONS: The prevalence of AIN has remained high among HIV-positive MSM after the introduction of HAART. Our data indicate that HAART is not associated with a reduced prevalence of AIN and support measures to prevent anal cancer among HIV-positive MSM whether or not they are using HAART.
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Cites
Frisch, M. (2000) · Journal of the National Cancer Institute · doi:10.1093/jnci/92.18.1500 · Cited by 885
Spectrum of AIDS-associated malignant disorders
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Sexual Practices, Sexually Transmitted Diseases, and the Incidence of Anal Cancer
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Machalek, D. A., Poynten, M., Jin, F., Fairley, C. K., Farnsworth, A., Garland, S. M., Hillman, R. J., Petoumenos, K., Roberts, J., Tabrizi, S. N., et al. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70080-3 · Cited by 963
Risk of Human Papillomavirus–Associated Cancers Among Persons With AIDS
Chaturvedi, A. K., Madeleine, M. M., Biggar, R. J., & Engels, E. A. (2009) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djp205 · Cited by 523
Richel, O., de Vries, H. J., van Noesel, C. J., Dijkgraaf, M. G., & Prins, J. M. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70067-6 · Cited by 181
Canfell, K., Kim, J. J., Kulasingam, S., Berkhof, J., Barnabas, R., Bogaards, J. A., Campos, N., Jennett, C., Sharma, M., Simms, K. T., et al. (2019) · Papillomavirus Research · doi:10.1016/j.pvr.2019.100184 · Cited by 68
The performance of anal cytology as a screening test for anal HSILs in homosexual men.
Jin, F., Grulich, A. E., Poynten, I. M., Hillman, R. J., Templeton, D. J., Law, C. L. H., Farnsworth, A., Garland, S. M., Fairley, C. K., Roberts, J. M., et al. (2016) · Cancer Cytopathology · doi:10.1002/cncy.21702 · Cited by 45
Metadata
- Authors
- Palefsky, J. M., Holly, E. A., Efirdc, J. T., Da Costa, M., Jay, N., Berry, J. M., & Darragh, T. M.
- Venue
- AIDS
- Published
- 2005-09-02
- Volume
- 19
- Issue
- 13
- Pages
- 1407-1414
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2093150743
- Cited by
- 386
- References
- 22
- FWCI
- 15.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Palefsky, J. M., Holly, E. A., Efirdc, J. T., Da Costa, M., Jay, N., Berry, J. M., & Darragh, T. M. (2005). Anal intraepithelial neoplasia in the highly active antiretroviral therapy era among HIV-positive men who have sex with men. AIDS. https://doi.org/10.1097/01.aids.0000181012.62385.4a
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