The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Mortality and causes of death in adults receiving highly active antiretroviral therapy in Senegal: a 7-year cohort study
Abstract
OBJECTIVES: To evaluate survival and investigate causes of death among HIV-1 infected adults receiving HAART in Senegal. DESIGN: An observational prospective cohort. METHODS: Mortality was assessed in the first patients enrolled between August 1998 and April 2002 in the Senegalese antiretroviral drug access initiative. First-line regimen combined two nucleoside reverse transcriptase inhibitors and either a non-nucleoside reverse transcriptase inhibitor or a protease inhibitor. The most likely causes of death were ascertained through medical records or post-mortem interviews (verbal autopsy). RESULTS: Four hundred and four patients (54.7% women) were enrolled in the study and were followed for a median of 46 months (interquartile range: 32-57 months) after HAART initiation. At baseline, 5% were antiretroviral therapy (ART) non-naive, 39 and 55% were respectively at CDC stage B and C, median age, CD4 cell count and viral load were 37 years, 128 cells/microl and 5.2 log cp/ml, respectively. Ninety-three patients died during follow-up and the overall incidence rate of death was 6.3/100 person-years [95% confidence interval (CI), 5.2-7.7]. During the first year after HAART initiation, 47 patients died and seven were lost to follow-up, yielding to a probability of dying of 11.7% (95% CI, 8.9-15.3%). The death rate, which was highest during the first year after HAART initiation, decreased with time yielding a cumulative probability of dying of 17.4% (95% CI, 13.9-21.5%) and 24.6% (95% CI, 20.4-29.4%) at 2 and 5 years. Causes of death were ascertained in 76 deaths. Mycobacterial infections, neurotropic infections and septicaemia were the most frequent likely causes of death. CONCLUSIONS: This study underlines the early mortality pattern after HAART initiation and highlights the leading role of mycobacterial infections in the causes of death.
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Decline in the AIDS and death rates in the EuroSIDA study: an observational study
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Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa
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Metadata
- Authors
- Etard, J.-F., Ndiaye, I., Thierry-Mieg, M., Guèye, N. F. N., Guèye, P. M., Lanièce, I., Dieng, A. B., Diouf, A., Laurent, C., Mboup, S., Sow, P. S., & Delaporte, E.
- Venue
- AIDS
- Published
- 2006-05-12
- Volume
- 20
- Issue
- 8
- Pages
- 1181-1189
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2056581462
- Cited by
- 278
- References
- 16
- FWCI
- 16.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Etard, J.-F., Ndiaye, I., Thierry-Mieg, M., Guèye, N. F. N., Guèye, P. M., Lanièce, I., Dieng, A. B., Diouf, A., Laurent, C., Mboup, S., Sow, P. S., & Delaporte, E. (2006). Mortality and causes of death in adults receiving highly active antiretroviral therapy in Senegal: a 7-year cohort study. AIDS. https://doi.org/10.1097/01.aids.0000226959.87471.01
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