Cited by 78Anesthesia and Sedative AgentsDrug-Induced Adverse ReactionsFood Allergy and Anaphylaxis Research

Skin Reactions to Intradermal Neuromuscular Blocking Agent Injections: A Randomized Multicenter Trial in Healthy Volunteers

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Mertes, Paul Michel, Moneret-Vautrin, Denise Anne, Leynadier, Francisque, Laxenaire, Marie-Claire·2007·Anesthesiology

Abstract

Background: Numerous reports confirm the performance of intradermal tests for the diagnosis of anaphylaxis during anesthesia; however, there is controversy over their diagnostic value regarding the newer neuromuscular blocking agents (NMBAs). Methods: One hundred eleven healthy volunteers were randomly assigned to receive intradermal injections of two NMBAs, at five increasing concentrations. A concentration was considered as a reactive concentration when it led to a positive reaction in more than 5% of the subjects. These concentrations were compared with the maximal concentration recommended for the diagnosis of sensitization to NMBAs. Results: The maximal nonreactive concentrations were 10 m for suxamethonium; 10 m for pancuronium, vecuronium, rocuronium, and cisatracurium; and 10 m for atracurium and mivacurium. Except for mivacurium, these nonreactive concentrations were close to the maximal concentrations used for the diagnosis of sensitization against NMBAs. For mivacurium, the nonreactive concentrations were higher than the maximal concentration currently recommended in clinical practice. Conclusion: The aminosteroidal NMBAs pancuronium, vecuronium, and rocuronium and the benzylisoquinoline cisatracurium have a similar potency to induce a nonspecific skin reactivity. If the criteria for positivity and the maximal concentrations of the commercially available compounds recommended by French practice guidelines are used, the risk of false-positive results is limited, and only minor modifications of these recommendations could be suggested. A slight reduction in the maximal concentration used for rocuronium from 1:100 to 1:200 and an increase from 1:1,000 to 1:200 for mivacurium can be proposed.

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  • Intradermal testing has been used to assess reactions to local anesthetics, muscle relaxants, antibiotics, and contrast dyes.

    “Intradermal testing has also been described in the evaluation of sensitivities to other substances, including local anesthetic agents, neuromuscular blocking agents, antibiotics, and contrast media.837-840”

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Research works printed but not linked: 7

  1. Moneret-Vautrin DA, Laxenaire MC, Moeller R: Anaphylaxis due to succi- nylcholine: Immunoallergological study of thirteen cases. Clin Allergy 1981; 11:175-83
  2. Moneret-Vautrin DA, Laxenaire MC, Widmer S, Hummer M: The value of prick tests in the detection of anaphylaxis caused by muscle relaxants. Ann Fr Anesth Reanim 1987; 6:352-5
  3. Mertes PM, Laxenaire MC: Anaphylactic and anaphylactoid reactions oc- curring during anaesthesia in France: Seventh epidemiologic survey (January 2001-December 2002). Ann Fr Anesth Reanim 2004; 23:1133-43
  4. Fisher MM, Baldo BA: Persistence of allergy to anaesthetic drugs. Anaesth Intensive Care 1992; 20:143-6
  5. Leynadier F, Calinaux C, Dry J: Predictive value of intradermal tests using muscle-relaxing drugs. Ann Fr Anesth Reanim 1989; 8:98-101
  6. Maria Y, Grosdidier R, Haberer JP, Moneret-Vautrin DA: Prospective pre- operative survey of 300 patients using prick tests with muscle relaxants. Ann Fr Anesth Reanim 1989; 8:301-5
  7. Moneret-Vautrin DA, Laxenaire MC: Predictive checkup for risk of anaphy- lactoid shock in anesthesia. Monogr Allergy 1992; 30:156-61

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Authors
Mertes, P. M., Moneret-Vautrin, D. A., Leynadier, F., & Laxenaire, M.-C.
Affiliations
  • Professor and Head of the Department of Anesthesiology, Service d’Anesthésie-Réanimation, Hôpital Central, Centre Hospitalier Universitaire de Nancy, Unité Inserm 684, Faculté de Médecine de Nancy.
  • Professor of Allergology and Head of the Service de Médecine Interne–Immunologie Clinique, Hôpital Central, Centre Hospitalier Universitaire de Nancy.
  • Professor and Head of the Department of Allergology, Hôpital Tenon (AP-HP), Université Pierre et Marie Curie, Faculté de Médecine Saint Antoine, Paris, France.
  • Centre Hospitalier Régional et Universitaire de Nancy (FR)
Venue
Anesthesiology
Published
2007-08-01
Volume
107
Issue
2
Pages
245-252
ISSN
0003-3022 (ISSN-L)
OpenAlex
W1985333315
Cited by
78
References
51
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 2 · 2015: 4 · 2013: 4 · 2012: 1
FWCI
9.59
Type
journal article
Language
en
Open access
Locations
  • Anesthesiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
  • Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Keywords
neuromuscular blocking agents, intradermal test, drug hypersensitivity, anaphylaxis diagnosis, succinylcholine, pancuronium, vecuronium, rocuronium, cisatracurium, atracurium, mivacurium, aminosteroids
MeSH terms
Rocuronium, Mivacurium, Adolescent, Adult, Androstanols, Atracurium, Neuromuscular Nondepolarizing Agents, Dose-Response Relationship, Drug, Drug Hypersensitivity, Female, Humans, Injections, Intradermal, Isoquinolines, Male, Middle Aged, Neuromuscular Blocking Agents, Neuromuscular Depolarizing Agents, Pancuronium, Reference Values, Skin, Skin Tests, Succinylcholine, Vecuronium Bromide

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