The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Effects of Body Size and Body Composition on Survival in Hemodialysis Patients
Abstract
It is unclear whether increased muscle mass or body fat confer the survival advantage in hemodialysis patients with high body-mass index (BMI). Twenty-four-hour urinary creatinine (UCr) excretion was used as a measure of muscle mass. The outcomes of hemodialysis patients with high BMI and normal or high muscle mass (inferred low body fat) and high BMI and low muscle mass (inferred high body fat) were studied to study the effects of body composition on outcomes. In 70,028 patients who initiated hemodialysis in the United States from January 1995 to December 1999 with measured creatinine clearances reported in the Medical Evidence form, all-cause and cardiovascular mortality were examined in Cox and parametric survival models. When compared with normal BMI (18.5 to 24.9 kg/m(2)) group, patients with high BMI (> or = 25 kg/m(2)) had lower hazard of death (hazard ratio [HR], 0.85; P < 0.001). However, when compared with normal BMI patients with UCr >25th percentile (0.55 g/d), high BMI patients with UCr >0.55 g/d had lower hazard of all-cause (HR, 0.85; P < 0.001) and cardiovascular death (HR, 0.89; P < 0.001), and high BMI patients with UCr < or =0.55 g/d had higher hazard of all-cause death (HR, 1.14; P<0.001) and cardiovascular death (HR, 1.19; P <0.001). Both BMI and body composition are strong predictors of death. The protective effect conferred by high BMI is limited to those patients with normal or high muscle mass. High BMI patients with inferred high body fat have increased and not decreased mortality.
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Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients
Kalantar-Zadeh, K., Block, G., Humphreys, M. H., & Kopple, J. D. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00803.x · Cited by 1,247
Atherosclerotic cardiovascular disease risks in chronic hemodialysis patients
Cheung, A. K., Sarnak, M. J., Yan, G., Dwyer, J. T., Heyka, R. J., Rocco, M. V., Teehan, B. P., & Levey, A. S. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00173.x · Cited by 777
Cardiovascular disease and chronic renal disease: A new paradigm
Sarnak, M. J., & Levey, A. S. (2000) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(00)70239-3 · Cited by 586
Influence of excess weight on mortality and hospital stay in 1346 hemodialysis patients
Fleischmann, E., Teal, N., Dudley, J., May, W., Bower, J. D., & Salahudeen, A. K. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00389.x · Cited by 469
Simple nutritional indicators as independent predictors of mortality in hemodialysis patients
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Body weight-for-height relationships predict mortality in maintenance hemodialysis patients
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Dialysis Dose and Body Mass Index Are Strongly Associated with Survival in Hemodialysis Patients
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Cited by
Survival advantages of obesity in dialysis patients
Kalantar-Zadeh, K., Abbott, K. C., Salahudeen, A. K., Kilpatrick, R. D., & Horwich, T. B. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.3.543 · Cited by 610
Uraemic sarcopenia: aetiology and implications
Fahal, I. H. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft070 · Cited by 357
The evaluation of body composition: A useful tool for clinical practice
Thibault, R., & Pichard, C. (2012) · Annals of Nutrition and Metabolism · doi:10.1159/000334879 · Cited by 193
Baria, F., Kamimura, M. A., Aoike, D. T., Ammirati, A., Leister Rocha, M., de Mello, M. T., & Cuppari, L. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft529 · Cited by 110
Schmidt, D., & Salahudeen, A. (2007) · Nutrition in Clinical Practice · doi:10.1177/011542650702200111 · Cited by 62
Metadata
- Authors
- Beddhu, S., Pappas, L. M., Ramkumar, N., & Samore, M.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2003-09
- Volume
- 14
- Issue
- 9
- Pages
- 2366-2372
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2102321386
- Cited by
- 438
- References
- 22
- FWCI
- 9.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Beddhu, S., Pappas, L. M., Ramkumar, N., & Samore, M. (2003). Effects of Body Size and Body Composition on Survival in Hemodialysis Patients. Journal of the American Society of Nephrology. https://doi.org/10.1097/01.asn.0000083905.72794.e6
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