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Cited by 273

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Systemic Safety of High-Dose Antibiotic-Loaded Cement Spacers after Resection of an Infected Total Knee Arthroplasty

Springer, Bryan D, Lee, Gwo-Chin, Osmon, Douglas, Haidukewych, George J, Hanssen, Arlen D, Jacofsky, David J·2004·Clinical Orthopaedics and Related Research
DOI 10.1097/01.blo.0000144476.43661.10
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Abstract

The purpose of this study was to assess the systemic safety and potential adverse effects of using a high-dose antibiotic-impregnated cement spacer after resection arthroplasty of an infected total knee replacement. Between October 2000 and December 2002, 36 knees (34 patients) had a resection arthroplasty of an infected total knee prosthesis with placement of a high-dose antibiotic impregnated cement spacer. There were 24 men and 10 women with a mean age of 66.5 years (range, 48-84 years). All spacers placed contained an average of 3.4 batches of cement with an average total dose of 10.5 g of vancomycin (range, 3-16 g) and 12.5 g of gentamicin (range, 3.6-19.2 g). All patients were followed up post-operatively until reimplantation for evidence of renal failure. The preoperative creatinine ranged from 0.7 to 1.8 mg/dL. All patients were concomitantly treated with 6 weeks of intravenous organism-specific antibiotics. One patient with normal preoperative renal function (Cr 0.7 mg/dL) had a perioperative 1-day transient rise in serum creatinine (1.7 mg/dL) postoperatively that subsequently normalized. No patients showed any clinical evidence of acute renal insufficiency, failure, or other systemic side effects of the antibiotics. Treatment of patients with an infected total knee arthroplasty with high-dose vancomycin and gentamicin antibiotic spacers seems to be clinically safe.

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Metadata

Authors
Springer, B. D., Lee, G.-C., Osmon, D., Haidukewych, G. J., Hanssen, A. D., & Jacofsky, D. J.
Venue
Clinical Orthopaedics and Related Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-10
Volume
427
Issue
427
Pages
47-51
ISSN
0009-921X (ISSN-L)
DOI
10.1097/01.blo.0000144476.43661.10
OpenAlex
W1983589078
Cited by
273
References
24
FWCI
6.66
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Systemic Safety of High-Dose Antibiotic-Loaded Cement Spacers after Resection of an Infected Total Knee Arthroplasty. https://app.cochat.ai/papers/10.1097/01.blo.0000144476.43661.10
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Springer, B. D., Lee, G.-C., Osmon, D., Haidukewych, G. J., Hanssen, A. D., & Jacofsky, D. J. (2004). Systemic Safety of High-Dose Antibiotic-Loaded Cement Spacers after Resection of an Infected Total Knee Arthroplasty. Clinical Orthopaedics and Related Research. https://doi.org/10.1097/01.blo.0000144476.43661.10

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.