The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients*
Abstract
OBJECTIVE: To test for an association between apolipoprotein E (APOE) genotypes and duration of intensive care unit delirium. DESIGN: Prospective, observational cohort study. SETTING: A 541-bed, community-based teaching hospital. PATIENTS: Fifty-three mechanically ventilated intensive care unit patients. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: All patients were managed with standardized sedation and ventilator weaning protocols as part of an ongoing clinical trial and were evaluated prospectively for delirium with the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). DNA was extracted from whole blood samples obtained on enrollment, and APOE genotype was determined using polymerase chain reaction followed by restriction enzyme digestion by investigators blinded to the clinical information. Delirium occurred in 47 (89%) patients at some point during the intensive care unit stay. Of the 53 patients, 12 (23%) had an APOE4 allele (APOE4+) and 41 (77%) had only APOE2 or APOE3 alleles (APOE4-). APOE4+ patients were younger (53.2 +/- 21.9 vs. 65.4 +/- 13.4, p = .08) and less often admitted for pneumonia (0% vs. 29.3%, p = .05) compared with APOE4- patients, yet they had a duration of delirium that was twice as long: median (interquartile range), 4 (3, 4.5) vs. 2 (1, 4) days (p = .05). No other clinical outcomes were significantly different between the APOE4+ and APOE4- patients. Using multivariable regression analysis to adjust for age, admission diagnosis of sepsis or acute respiratory distress syndrome or pneumonia, severity of illness, and duration of coma, the presence of APOE4 allele was the strongest predictor of delirium duration (odds ratio, 7.32; 95% confidence interval, 1.82-29.51, p = .005). CONCLUSIONS: APOE4 allele represents the first demonstrated genetic predisposition to longer duration of delirium in humans.
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Cites
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Sessler, C. N., Gosnell, M. S., Grap, M. J., Brophy, G. M., O'Neal, P. V., Keane, K. A., Tesoro, E. P., & Elswick, R. K. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2107138 · Cited by 3,695
Ely, E. W., Inouye, S. K., Bernard, G. R., Gordon, S., Francis, J., May, L., Truman, B., Speroff, T., Gautam, S., Margolin, R., et al. (2001) · JAMA · doi:10.1001/jama.286.21.2703 · Cited by 3,210
Self-citationDelirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit
Ely, E. W. (2004) · JAMA · doi:10.1001/jama.291.14.1753 · Cited by 3,073
Intensive Care Delirium Screening Checklist: evaluation of a new screening tool
Bergeron, N., Dubois, M.-J., Dumont, M., Dial, S., & Skrobik, Y. (2001) · Intensive Care Medicine · doi:10.1007/s001340100909 · Cited by 1,487
Inouye, S. K., Viscoli, C. M., Horwitz, R. I., Hurst, L. D., & Tinetti, M. E. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-119-6-199309150-00005 · Cited by 854
Delirium in an intensive care unit: a study of risk factors
Dubois, M.-J., Bergeron, N., Dumont, M., Dial, S., & Skrobik, Y. (2001) · Intensive Care Medicine · doi:10.1007/s001340101017 · Cited by 609 · cited 1×
“If coupled with known mechanisms leading to delirium during critical illness such as sepsis or sedative agents, APOE4 could be a particularly hazardous risk factor for a longer duration of delirium (20, 26).”
BackgroundLynch, J. R., Tang, W., Wang, H., Vitek, M. P., Bennett, E. R., Sullivan, P. M., Warner, D. S., & Laskowitz, D. T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306923200 · Cited by 394
Self-citationMotor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury
Chen, Y., Lomnitski, L., Michaelson, D. M., & Shohami, E. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00007-9 · Cited by 214
Micek, S. T., Anand, N. J., Laible, B. R., Shannon, W. D., & Kollef, M. H. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000164540.58515.bf · Cited by 141
Cited by
Neuropathogenesis of Delirium: Review of Current Etiologic Theories and Common Pathways
Maldonado, J. R. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.09.005 · Cited by 745
Delirium in the intensive care unit
Girard, T. D., Pandharipande, P. P., & Ely, E. W. (2008) · Critical Care · doi:10.1186/cc6149 · Cited by 622
Self-citationCholinergic Deficiency Hypothesis in Delirium: A Synthesis of Current Evidence
Hshieh, T. T., Fong, T. G., Marcantonio, E. R., & Inouye, S. K. (2008) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/63.7.764 · Cited by 553
The inter-relationship between delirium and dementia: the importance of delirium prevention
Fong, T. G., & Inouye, S. K. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00698-7 · Cited by 404
Epidemiology and risk factors for delirium across hospital settings
Vasilevskis, E. E., Han, J. H., Hughes, C. G., & Ely, E. W. (2012) · Best Practice & Research Clinical Anaesthesiology · doi:10.1016/j.bpa.2012.07.003 · Cited by 391
Metadata
- Authors
- Ely, W. E., Girard, T. D., Shintani, A. K., Jackson, J. C., Gordon, S. M., Thomason, J. W. W., Pun, B. T., Canonico, A. E., Light, R. W., Pandharipande, P., & Laskowitz, D. T.
- Venue
- Critical Care Medicine
- Published
- 2007-01
- Volume
- 35
- Issue
- 1
- Pages
- 112-117
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W1983988971
- Cited by
- 202
- References
- 12
- FWCI
- 10.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Ely, W. E., Girard, T. D., Shintani, A. K., Jackson, J. C., Gordon, S. M., Thomason, J. W. W., Pun, B. T., Canonico, A. E., Light, R. W., Pandharipande, P., & Laskowitz, D. T. (2007). Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients*. Critical Care Medicine. https://doi.org/10.1097/01.ccm.0000251925.18961.ca
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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