Common and specific genetic influences on aggressive and nonaggressive conduct disorder domains
Abstract
Objective To explore the genetic and environmental influences on DSM-IV conduct disorder (CD) aggressive and nonaggressive subscales, taking into account age and sex differences.Method A community sample of 1,100 twin pairs (ages 11-18) was interviewed using the Diagnostic Interview Schedule for Children. Bivariate analyses, using variable threshold models accounting for age and sex differences, were used to determine the extent to which the genetic and environmental influences on aggressive and nonaggressive CD domains are shared or unique.Results The phenotypic correlation between aggressive and nonaggressive CD domains was 0.32. The most parsimonious bivariate model included additive genetic effects and nonshared environmental effects only (AE model).Conclusions The results of behavior genetic model fitting suggest that the DSM-IV CD domains are influenced by unique genetic and environmental factors, but also share some common genetic and environmental influences. A large percentage of the covariation (61%) is caused by genetic factors. These results are consistent with a previous report on the bivariate heritability of aggressive and nonaggressive antisocial behavior, but extend the findings to DSM-IV domains.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Studies including adolescent twins do not in most cases report finding any shared environmental influences.
“Studies including adolescent twins (∼ younger than 19 years of age) do not in most cases report finding any shared environmental influences (Table 8.2; e.g., Button et al., 2004; Cho et al., 2006; Gelhorn et al., 2006; Tackett et al., 2009).”
From Human Aggression Across the Lifespan (2011) · cites this paper as Gelhorn et al., 2006
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Methodology for Genetic Studies of Twins and Families
Neale, M. C., & Cardon, L. R. (1992) · doi:10.1007/978-94-015-8018-2 · Cited by 4,005 · see citing works
SHAFFER, D., FISHER, P., LUCAS, C. P., DULCAN, M. K., & SCHWAB-STONE, M. E. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200001000-00014 · Cited by 3,505 · see citing works
MOFFITT, T. E., & CASPI, A. (2001) · Development and Psychopathology · doi:10.1017/s0954579401002097 · Cited by 1,669 · cited 2× · see citing works
“However, several researchers have suggested the importance of distinguishing the two forms of ASB (Moffitt and Caspi, 2001; Stanger et al., 1997).”
BackgroundOppositional Defiant and Conduct Disorder: A Review of the Past 10 Years, Part I
LOEBER, R., BURKE, J. D., LAHEY, B. B., WINTERS, A., & ZERA, M. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200012000-00007 · Cited by 1,192 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Preedy, V., & Watson, R. (2010) · Springer eBooks · doi:10.1007/978-0-387-78665-0_5485 · Cited by 1,146 · see citing works
Conduct disorder and oppositional defiant disorder in a national sample: developmental epidemiology
Maughan, B., Rowe, R., Messer, J., Goodman, R., & Meltzer, H. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00250.x · Cited by 743 · see citing works
Cross-National Research in Self-Reported Crime and Delinquency
Klein, M. W. (1989) · Springer eBooks · doi:10.1007/978-94-009-1001-0 · Cited by 374 · see citing works
Eley, T. C., Lichtenstein, P., & Stevenson, J. (1999) · Child Development · doi:10.1111/1467-8624.00012 · Cited by 274 · see citing works
Individual differences in infancy: Reliability, stability, prediction
Plomin, R. J., Campos, J., Corley, R. P., Emde, R. N., Fulker, D., Kagan, J., Reznick, J., Robinson, J. A., Zahn‐Waxler, C., & DeFries, J. C. (1990) · Cited by 233 · see citing works
Self-citationEley, T. C., Lichtenstein, P., & Moffitt, T. E. (2003) · Development and Psychopathology · doi:10.1017/s095457940300021x · Cited by 225 · see citing works
Validity of DSM‐IV Subtypes of Conduct Disorder Based on Age of Onset
Lahey, B. B., Loeber, R., Quay, H. C., Applegate, B. E., Shaffer, D. R., Waldman, I. D., HART, E. L., McBurnett, K., Frick, P. J., Jensen, P. S., et al. (1998) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199804000-00022 · Cited by 209 · see citing works
Accelerated longitudinal comparisons of aggressive versus delinquent syndromes
Stanger, C., Achenbach, T. M., & Verhulst, F. C. (1997) · Development and Psychopathology · doi:10.1017/s0954579497001053 · Cited by 209 · see citing works
Fergusson, D. M., Lynskey, M. T., & Horwood, L. J. (1996) · Research on Child and Adolescent Psychopathology · doi:10.1007/bf01670099 · Cited by 175 · see citing works
Prevalence and Incidence in the Study of Antisocial Behavior: Definitions and Measurements
Olweus, D. (1989) · Springer eBooks · doi:10.1007/978-94-009-1001-0_9 · Cited by 166 · see citing works
Infancy to early childhood: genetic and environmental influences on developmental change
(2001) · Choice Reviews Online · doi:10.5860/choice.39-1240 · Cited by 141 · see citing works
Problem Behavior in Early and Middle Childhood: An Initial Behavior Genetic Analysis
Schmitz, S., Fulker, D. W., & Mrazek, D. A. (1995) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1995.tb01674.x · Cited by 127 · see citing works
Genetic and environmental influences on conduct disorder: symptom, domain and full‐scale analyses
Gelhorn, H. L., Stallings, M. C., Young, S. E., Corley, R. P., Rhee, S. H., & Hewitt, J. K. (2005) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00373.x · Cited by 75 · see citing works
Self-citationHeath, A. C., Todorov, A. A., Nelson, E. C., Madden, P. A. F., Bucholz, K. K., & Martin, N. G. (2002) · Twin Research · doi:10.1375/1369052022875 · Cited by 62 · see citing works
Genetic and environmental influences on subtypes of conduct disorder behavior in boys.
Simonoff, E. A., Pickles, A. R., Meyer, J. M., Silberg, J. L., & Maes, H. (1998) · PubMed · Cited by 41 · see citing works
Button, T. M. M., Scourfield, J., Martin, N., & McGuffin, P. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30045 · Cited by 33 · see citing works
Individual differences during the second year of life: The MacArthur Longitudinal Twin Study.
Plomin, R. J., Campos, J. J., Corley, R., Emde, R. N., Fulker, D. W., Kagan, J., Reznick, J. S., Robinson, J. G., & Zahn‐Waxler, C. (1990) · Cited by 29 · see citing works
Self-citationHeath, A. C., Todorov, A. A., Nelson, E. C., et al. (2002) · Twin Research · doi:10.1375/twin.5.1.30 · Cited by 24 · see citing works
Young (2000) · doi:10.1002/1096-8628(20001009)96:5
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Fairchild, G. F., Hawes, D. J., Frick, P. J., Copeland, W., Odgers, C. L., Franke, B., Freitag, C. M., & Brito, S. A. D. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0095-y · Cited by 426 · see citing works
Ferguson, C. J. (2010) · The Journal of Social Psychology · doi:10.1080/00224540903366503 · Cited by 336 · see citing works
Are there meaningful etiological differences within antisocial behavior? Results of a meta-analysis
Burt, S. A. (2009) · Clinical Psychology Review · doi:10.1016/j.cpr.2008.12.004 · Cited by 305 · see citing works
Burt, S. A. (2012) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.02.006 · Cited by 182 · see citing works
Human Aggression Across the Lifespan
Tuvblad, C., & Baker, L. A. (2011) · Advances in Genetics · doi:10.1016/b978-0-12-380858-5.00007-1 · Cited by 139 · see citing works
“N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript 2006; Gelhorn et al., 2006; Tackett et al., 2009).”
BackgroundSiclari, F., Khatami, R., Urbaniok, F., Nobili, L., Mahowald, M. W., Schenck, C. H., Cramer Bornemann, M. A., & Bassetti, C. L. (2010) · Brain · doi:10.1093/brain/awq296 · Cited by 131 · see citing works
Lahey, B. B., & Waldman, I. D. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02509.x · Cited by 85 · see citing works
Delinquent peer affiliation and conduct problems: A twin study.
Button, T. M. M., Corley, R. P., Rhee, S. H., Hewitt, J. K., Young, S. E., & Stallings, M. C. (2007) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.116.3.554 · Cited by 82 · see citing works
Self-citationGenetic influences on conduct disorder
Salvatore, J. E., & Dick, D. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.034 · Cited by 76 · see citing works
Neurobiological Mechanisms for Impulsive-Aggression: The Role of MAOA
Dorfman, H. M., Meyer‐Lindenberg, A., & Buckholtz, J. W. (2013) · Current topics in behavioral neurosciences · doi:10.1007/7854_2013_272 · Cited by 75 · see citing works
Monuteaux, M. C., Biederman, J., Doyle, A. E., Mick, E. O., & Faraone, S. V. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181a5661b · Cited by 69 · see citing works
Do etiological influences on aggression overlap with those on rule breaking? A meta-analysis
Burt, S. A. (2012) · Psychological Medicine · doi:10.1017/s0033291712001894 · Cited by 49 · see citing works
Baler, R., Volkow, N. D., Fowler, J. S., & Benveniste, H. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0819 · Cited by 39 · see citing works
Rowe, R., Rijsdijk, F. V., Maughan, B., Eley, T. C., Hosang, G. M., & Eley, T. C. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01834.x · Cited by 30 · see citing works
The Development of Comorbid Conduct Problems in Children With ADHD
Danforth, J. S., Connor, D. F., & Doerfler, L. A. (2014) · Journal of Attention Disorders · doi:10.1177/1087054713517546 · Cited by 28 · see citing works
Unger, J. B., Lessov‐Schlaggar, C. N., Pang, Z., Guo, Q., Ning, F., Gallaher, P. E., Lee, L., Cao, W., Conti, D. V., & Johnson, C. A. (2010) · Asia Pacific Journal of Public Health · doi:10.1177/1010539509351052 · Cited by 25 · see citing works
Verweij, K. J. H., Zietsch, B. P., Bailey, J. M., & Martin, N. G. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2008.00456.x · Cited by 25 · see citing works
Comorbid conduct disorder and substance use disorders.
Conner, B. T., & Lochman, J. E. (2010) · Clinical Psychology Science and Practice · doi:10.1111/j.1468-2850.2010.01225.x · Cited by 21 · see citing works
Barker, E. D., Larsson, H., Viding, E. M., Maughan, B., Rijsdijk, F. V., Fontaine, N. M. G., & Plomin, R. J. (2009) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-009-9132-6 · Cited by 21 · see citing works
Genetic and environmental influences on aggression.
Rhee, S. H., & Waldman, I. D. (2010) · American Psychological Association eBooks · doi:10.1037/12346-008 · Cited by 21 · see citing works
Self-citationMcBurnett, K., & Pfiffner, L. J. (2009) · Postgraduate Medicine · doi:10.3810/pgm.2009.11.2084 · Cited by 18 · see citing works
Oppositional Defiant Disorder, Conduct Disorder, and Juvenile Delinquency
Lahey, B. B., & Waldman, I. D. (2017) · Wiley eBooks · doi:10.1002/9781394258932.ch14 · Cited by 18 · see citing works
Womack, S. R., Clifford, S., Wilson, M. N., Shaw, D. S., & Lemery‐Chalfant, K. (2021) · Behavior Genetics · doi:10.1007/s10519-021-10069-5 · Cited by 12 · see citing works
Van Hulle, C. A., Waldman, I., & Lahey, B. B. (2018) · Behavior Genetics · doi:10.1007/s10519-018-9907-1 · Cited by 10 · see citing works
Attention Deficit Hyperactivity Disorder and Blood Lead Levels in Chinese Children
Brondum, J. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0900850 · Cited by 10 · see citing works
Raine, A. (1993) · Elsevier eBooks · doi:10.1016/b978-0-08-057148-5.50007-1 · Cited by 9 · see citing works
Genetic evidence that Darwin was right about criminality: Nature, not nurture
Baschetti, R. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2008.01.005 · Cited by 7 · see citing works
Burt, S. A. (2014) · Springer eBooks · doi:10.1007/978-1-4614-9509-3_4 · Cited by 6 · see citing works
Terranova, C., Tucci, M., Sartore, D., Cavarzeran, F., Barzon, L., Palù, G., & Ferrara, S. D. (2012) · Journal of Forensic Sciences · doi:10.1111/j.1556-4029.2012.02243.x · Cited by 5 · see citing works
Yu, M., Desha, L. N., & Ziviani, J. M. (2013) · Occupational Therapy in Mental Health · doi:10.1080/0164212x.2013.848398 · Cited by 4 · see citing works
Hur, Y. (2022) · Personality and Individual Differences · doi:10.1016/j.paid.2022.112062 · Cited by 2 · see citing works
Cancer Risk and GSTM1 and GSTT1 Polymorphisms
Cetta, F., Dhamo, A., Moltoni, L., & Zangari, R. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0900829 · Cited by 2 · see citing works
Mental Disorders and Violent Crime
Pace, C. M. (2014) · Cited by 1 · see citing works
Externalising Behaviour in Children: An Integrative Model Between Health and EducationPreprint
Rungan, S., Montgomery, A. K., Smith‐Merry, J., Liu, H. M., & Eastwood, J. G. (2021) · Research Square · doi:10.21203/rs.3.rs-723269/v1 · Cited by 1 · see citing works
A developmental neurocognitive perspective on conduct disorder: current status and future directions
Glenn, D. E., & Michalska, K. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91497-0.00233-2 · Cited by 1 · see citing works
Frecuencia de trastorno disocial en adolescentes que en su infancia asistieron a guarderías
Reynoso-Arenas, M. D. P., Soberanes-López, I. C., León-Félix, J., & Sánchez, O. C. (2015) · Atención Familiar · doi:10.1016/s1405-8871(16)30058-x
Childhood environmental neurotoxic exposures and experiences: Major factors in antisocial behavior
Anyanwu, E. C. (2007) · International Journal on Disability and Human Development · doi:10.1515/ijdhd.2007.6.3.231
(2019) · Elsevier eBooks · doi:10.1016/b978-0-12-804417-9.16001-6
Oppositional Defiant Disorder and Conduct Disorder
Corcoran, J., & Wolk, C. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780197653562.003.0007
Grundlagen der Diagnostik und Therapie
(2024) · Elsevier eBooks · doi:10.1016/b978-3-437-22487-4.16001-0
- Authors
- GELHORN, H., STALLINGS, M., YOUNG, S., CORLEY, R., RHEE, S. H., CHRISTIAN, H., & HEWITT, J.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- GELHORN, HEATHER
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 45
- Issue
- 5
- Pages
- 570-577
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W2041445589
- Cited by
- 40
- References
- 24
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA-11015, DA-12845, and DA-015522)
- National Institute of Child Health and Human Development (HD10333)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Social Sciences › Sociology and Political Science › Crime Patterns and Interventions
- Keywords
- conduct disorder, heritability, genetic factors, environmental influences, nonshared environment, additive genetic effects, antisocial behavior, age and sex differences, twin pairs
- MeSH terms
- Adolescent, Aggression, Child, Child Behavior Disorders, Diseases in Twins, Female, Genotype, Humans, Male, Personality Assessment, Phenotype, Psychometrics, Social Environment, Statistics as Topic, Twins, Dizygotic, Twins, Monozygotic, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
