Genetic susceptibility testing versus family history–based risk assessment: Impact on perceived risk of Alzheimer disease
Open accessAbstract
Purpose We examined how an Alzheimer disease (AD) family history assessment as compared to a risk assessment incorporating the absence of a disease-associated susceptibility allele affected risk perception among adult children with a family history of AD. Methods The REVEAL study is a clinical trial in which adult children of patients with AD were randomized to receive a risk assessment based upon family history alone or family history plus apolipoprotein E (APOE) disclosure. In this analysis, two subsets of women were identified, each of whom received identical 29% lifetime risk estimates of developing AD. One group received a risk estimate that incorporated APOE epsilon4-negative genetic test results (Genotype Group, n = 30), whereas the other received a risk estimate based on family history and gender (Family History Group, n = 36). Six weeks after risk disclosure, we surveyed participants regarding the impact of the risk assessment on their perceptions of AD risk. Results 73% of the Genotype Group judged their risk to be lower compared to 25% of the Family History Group (P < 0.0001). 67% of the Genotype Group reported lower anxiety about AD, versus 26% of the Family History Group (P < 0.01). 80% of the Genotype Group indicated that the risk information had a positive impact, versus 36% of the Family History Group (P < 0.001). The Genotype Group was less likely to believe that they would develop AD (13% vs. 36%, P < 0.05) and was more likely to report that the risk assessment removed uncertainty about their chances of developing AD (63% vs. 9%, P < 0.0001). Conclusions These data suggest that risk estimates incorporating negative genetic test results affect perceptions of disease susceptibility more strongly than identical estimates based on family history alone.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Studies on genetic susceptibility testing for Alzheimer's disease show a strong association between family history and genetic risk factors and self-perceived risk of the disease.
“Similarly, studies on genetic susceptibility testing for AD have shown that there is a strong association between family history and genetic risk factor for AD on self-perceived risk of the disease (Hiraki, Chen, Roberts, Cupples, & Green, 2008; Larusse et al., 2005).”
From Correlates of dementia-related anxiety: self-perceived dementia risk and ageism (2020) · cites this paper as Larusse et al., 2005
The Abstract (page unavailable) reports that women given an APOE ε4-negative result perceived lower AD risk than women given the same numerical estimate based on family history alone. This supports an effect of genetic-test information on perceived risk, but all participants had a family history of AD; the study does not establish a separate strong association between family history and perceived risk. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works
Facts and Fears: Understanding Perceived Risk
Slovic, P., Fischhoff, B., & Lichtenstein, S. (1980) · Springer eBooks · doi:10.1007/978-1-4899-0445-4_9 · Cited by 1,301 · see citing works
Risk of Dementia Among White and African American Relatives of Patients With Alzheimer Disease
Green, R. C. (2002) · JAMA · doi:10.1001/jama.287.3.329 · Cited by 391 · see citing works
Self-citationLautenschlager, N. T., Cupples, L. A., Rao, V. S., Auerbach, S. A., Becker, R., Burke, J., Chui, H., Duara, R., Foley, E. J., Glatt, S. L., et al. (1996) · Neurology · doi:10.1212/wnl.46.3.641 · Cited by 298 · see citing works
Self-citationExploring the Etiology of Alzheimer Disease Using Molecular Genetics
Lendon, C. L. (1997) · JAMA · doi:10.1001/jama.1997.03540340059034 · Cited by 272 · see citing works
Statement on Use of Apolipoprotein E Testing for Alzheimer Disease
Farrer, L. A. (1995) · JAMA · doi:10.1001/jama.1995.03530200063039 · Cited by 271 · see citing works
Apolipoprotein E genotyping in Alzheimer's disease
Relkin, N. R. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90284-6 · Cited by 241 · see citing works
Self-citationReluctance to undergo predictive testing: The case of Huntington Disease
Quaid, K. A., & Morris, M. (1993) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320450112 · Cited by 210 · see citing works
Self-citationMarteau, T. M., Senior, V., Humphries, S. E., Bobrow, M., Cranston, T., Crook, M. A., Day, L., Fernandez, M. C., Horne, R., Iversen, A., et al. (2004) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30102 · Cited by 194 · see citing works
Self-citationGenomic profiling to promote a healthy lifestyle: not ready for prime time
Haga, S. B., Khoury, M. J., & Burke, W. (2003) · Nature Genetics · doi:10.1038/ng0803-347 · Cited by 167 · see citing works
Cupples, L. A., Farrer, L. A., Sadovnick, A. S. D., Relkin, N. R., Whitehouse, P. J., & Green, R. C. (2004) · Genetics in Medicine · doi:10.1097/01.gim.0000132679.92238.58 · Cited by 166 · see citing works
Self-citationLerman, C., Gold, K. F., Audrain, J. E., Lin, T. H., Boyd, N. R., Orleans, C. T., Wilfond, B., Louben, G., & Caporaso, N. (1997) · Health Psychology · doi:10.1037//0278-6133.16.1.87 · Cited by 154 · see citing works
Genetic counseling: Provision and reception of information
Lippman-Hand, A., & Fraser, F. C. (1979) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320030202 · Cited by 128 · see citing works
Roberts, J. S. (2000) · The Gerontologist · doi:10.1093/geront/40.1.43 · Cited by 124 · see citing works
Self-citationFarrer, L. A. (1997) · JAMA · doi:10.1001/jama.1997.03550160069041 · Cited by 124 · see citing works
Categorizing genetic tests to identify their ethical, legal, and social implications
Burke, W., Pinsky, L. E., & Press, N. A. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.10011 · Cited by 122 · see citing works
Public Attitudes About Genetic Testing For Alzheimer’s Disease
Neumann, P. J., Hammitt, J. K., Mueller, C. D., Fillit, H. M., Hill, J. W., Tetteh, N. A., & Kosik, K. S. (2001) · Health Affairs · doi:10.1377/hlthaff.20.5.252 · Cited by 117 · see citing works
Roberts, J. S., LaRusse, S., Katzen, H., Whitehouse, P. J., Barber, M., Post, S. G., Relkin, N. R., Quaid, K. A., Pietrzak, R. H., Cupples, L. A., et al. (2003) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200304000-00006 · Cited by 88 · see citing works
Self-citationImpact of genetic testing on causal models of heart disease and arthritis: An analogue study
Senior, V., Marteau, T. M., & Weinman, J. A. (2000) · Psychology and Health · doi:10.1080/08870440008407368 · Cited by 73 · see citing works
Self-citationConsensus Statement on Predictive Testing for Alzheimer Disease
Brodaty, H., Conneally, M., Gauthier, S. G., Jennings, C. D., Lennox, A., & Lovestone, S. (1995) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199509040-00002 · Cited by 63 · see citing works
Lay Attitudes toward Genetic Testing for Susceptibility to Inherited Diseases
Shaw, J. S., & Bassi, K. L. (2001) · Journal of Health Psychology · doi:10.1177/135910530100600404 · Cited by 60 · see citing works
Challenges in communicating genetics: A public health approach
Khoury, M. J., Thrasher, J. F., Burke, W., Gettig, E. A., Fridinger, F., & Jackson, R. (2000) · Genetics in Medicine · doi:10.1097/00125817-200005000-00007 · Cited by 60 · see citing works
Impact of Genetic Counseling and Testing on Colorectal Cancer Screening Behavior
Johnson, K. A., Trimbath, J. D., Petersen, G. M., Griffin, C. A., & Giardiello, F. M. (2002) · Genetic Testing · doi:10.1089/10906570260471831 · Cited by 50 · see citing works
Assessment of risk by pregnant women: Implications for genetic counseling and education
Chase, G. A., Faden, R., Holtzman, N. A., Chwalow, A. J., Leonard, C. O., Lopes, C. E., & Quaid, K. A. (1986) · Biodemography and Social Biology · doi:10.1080/19485565.1986.9988622 · Cited by 43 · see citing works
Self-citation332 Early detection of Alzheimer's disease: Methods, markers and misgivings
Green, R. C., Clarke, V., Thompson, N., Woodard, J. L., & Letz, R. (1996) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)80334-4 · Cited by 28 · see citing works
Self-citationImpact of genetic risk feedback: Perceived risk and motivation for health protective behaviours
Hicken, B. L., & Tucker, D. (2002) · Psychology Health & Medicine · doi:10.1080/13548500120101531 · Cited by 21 · see citing works
Plon, S. E., Peterson, L. E., Friedman, L. C., & Richards, C. S. (2000) · Genetics in Medicine · doi:10.1097/00125817-200011000-00001 · Cited by 18 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Green RC. Genetic testing for Alzheimer's disease: has the moment arrived? Alz Care Quarterly 2002;208 -214.
- Murray TH. Genetic exceptionalism and 'future diaries': Is genetic information different from other medical information? In: Rothstein MA, ed. Genetic secrets: Protecting privacy and confidentiality in the genetic era, vol 1. New Haven: Yale University Press, 1997:60 -72
- LaRusse S, Katzen H, Brown T, Barber M, Whitehouse P, Green RC et al. Participant recall of their own apolipoprotein E (APOE) genotype and risk estimate after six weeks: results from the REVEAL Study. Neurobiol Aging 2002;23:S324.
Cited by
Sorted by citations
Khoury, M. J., McBride, C. M., Schully, S. D., Ioannidis, J. P. A., Feero, W. G., Janssens, A. C. J. W., GWINN, M. L., Simons‐Morton, D. G., Bernhardt, J. M., Cargill, M., et al. (2009) · Genetics in Medicine · doi:10.1097/gim.0b013e3181b13a6c · Cited by 192 · see citing works
Self-citationCommunicating Genetic Risk Information for Common Disorders in the Era of Genomic Medicine
Lautenbach, D. M., Christensen, K. D., Sparks, J. A., & Green, R. C. (2011) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-092010-110722 · Cited by 160 · see citing works
Self-citationRoberts, J. S., Cupples, L. A., Relkin, N. R., Whitehouse, P. J., Green, R. C., & for the REVEAL (Risk Evaluation and Education for Alzheimer’s Disease) Study Group (2005) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988705281883 · Cited by 146 · see citing works
Self-citationLearning one’s genetic risk changes physiology independent of actual genetic risk
Turnwald, B. P., Goyer, J. P., Boles, D. Z., Silder, A., Delp, S. L., & Crum, A. J. (2018) · Nature Human Behaviour · doi:10.1038/s41562-018-0483-4 · Cited by 142 · see citing works
Widén, E., Junna, N., Ruotsalainen, S., Surakka, I. L., Mars, N., Ripatti, P., Partanen, J., Aro, J., Mustonen, P., Tuomi, T., et al. (2022) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.121.003459 · Cited by 141 · see citing works
The Genetics of Alzheimer’s Disease
Barber, R. C. (2012) · Scientifica · doi:10.6064/2012/246210 · Cited by 111 · see citing works
Bemelmans, S. A. S. A., Tromp, K., Bunnik, E. M., Milne, R., Badger, S. J., Brayne, C., Schermer, M., & Richard, E. (2016) · Alzheimer s Research & Therapy · doi:10.1186/s13195-016-0212-z · Cited by 108 · see citing works
Illness Representations, Self‐Regulation, and Genetic Counseling: A Theoretical Review
Shiloh, S. (2006) · Journal of Genetic Counseling · doi:10.1007/s10897-006-9044-5 · Cited by 106 · see citing works
Genetics, Transcriptomics, and Proteomics of Alzheimers Disease
Papassotiropoulos, A., Fountoulakis, M., Dunckley, T. L., Stephan, D. A., & Reiman, E. M. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0418 · Cited by 103 · see citing works
Haga, S. B., Mills, R. A., Pollak, K. I., Rehder, C. W., Buchanan, A. H., Lipkus, I. M., Crow, J. H., & Datto, M. (2014) · Genome Medicine · doi:10.1186/s13073-014-0058-6 · Cited by 98 · see citing works
Using Alzheimer's disease as a model for genetic risk disclosure: implications for personal genomics
Roberts, J., Christensen, K. D., & Green, R. C. (2011) · Clinical Genetics · doi:10.1111/j.1399-0004.2011.01739.x · Cited by 88 · see citing works
Self-citationLinnenbringer, E. L., Roberts, J. S., Hiraki, S. C., Cupples, L. A., & Green, R. C. (2010) · Genetics in Medicine · doi:10.1097/gim.0b013e3181cef9e1 · Cited by 86 · see citing works
Self-citationVears, D. F., Minion, J. T., Roberts, S. J., Cummings, J., Machirori, M., Blell, M. T., Budin‐Ljøsne, I., Cowley, L., Dyke, S. O. M., Gaff, C., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258646 · Cited by 75 · see citing works
Self-citationAnchoring-and-Adjustment Bias in Communication of Disease Risk
Şenay, İ., & Kaphingst, K. A. (2008) · Medical Decision Making · doi:10.1177/0272989x08327395 · Cited by 67 · see citing works
Gooding, H. C., Linnenbringer, E. L., Burack, J. H., Roberts, J. S., Green, R. C., & Biesecker, B. B. (2006) · Patient Education and Counseling · doi:10.1016/j.pec.2006.03.002 · Cited by 66 · see citing works
Self-citationGenetic susceptibility testing for neurodegenerative diseases: Ethical and practice issues
Roberts, J. S., & Uhlmann, W. R. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.02.005 · Cited by 60 · see citing works
Self-citationPredictive Genetic Testing for Alzheimer's Disease: Impact upon Risk Perception
Marteau, T. M., Roberts, J. S., LaRusse, S., & Green, R. C. (2005) · Risk Analysis · doi:10.1111/j.1539-6924.2005.00598.x · Cited by 54 · see citing works
Self-citationLanglois, C. M., Bradbury, A. R., Wood, E. M., Roberts, J. S., Kim, S. Y. H., Riviere, M., Liu, F., Reiman, E. M., Tariot, P. N., Karlawish, J. H., et al. (2019) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2019.09.013 · Cited by 50 · see citing works
Self-citationLaRusse, S., Katzen, H., Roberts, J. S., Barber, M., Ravdin, L., Relkin, N. R., Whitehouse, P. J., & Green, R. C. (2006) · Genetics in Medicine · doi:10.1097/01.gim.0000250197.44245.a3 · Cited by 49 · see citing works
Self-citationGreen, R., Rehm, H., & Kohane, I. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-382227-7.00009-4 · Cited by 55 · see citing works
Self-citationCondit, C. M. (2011) · Sociology Compass · doi:10.1111/j.1751-9020.2011.00385.x · Cited by 41 · see citing works
The future of direct-to-consumer clinical genetic tests
Frueh, F. W., Greely, H. T., Green, R. C., Hogarth, S., & Siegel, S. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3026 · Cited by 41 · see citing works
Self-citationGenetic counseling and ethical issues for autism
McMahon, W. M., Baty, B. J., & Botkin, J. R. (2006) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30082 · Cited by 41 · see citing works
Kaphingst, K. A., Stafford, J. D., McGowan, L. D., Seo, J., Lachance, C. R., & Goodman, M. S. (2015) · Health Psychology · doi:10.1037/hea0000177 · Cited by 39 · see citing works
Beliefs About Heritability of Cancer and Health Information Seeking and Preventive Behaviors
Kaphingst, K. A., Lachance, C. R., & Condit, C. M. (2009) · Journal of Cancer Education · doi:10.1080/08858190902876304 · Cited by 39 · see citing works
Roberts, J. S., Chen, C. A., Uhlmann, W. R., & Green, R. C. (2012) · Genetics in Medicine · doi:10.1038/gim.2012.37 · Cited by 33 · see citing works
Self-citationRahman, B., Meiser, B., Sachdev, P. S., Barlow-Stewart, K. K., Otlowski, M. F. A., Zilliacus, E. M., & Schofield, P. R. (2012) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2011.0300 · Cited by 32 · see citing works
Parents' Concern About Their Own and Their Children's Genetic Disease Risk
Tarini, B. A., Singer, D., Clark, S. J., & Davis, M. M. (2008) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.162.11.1079 · Cited by 32 · see citing works
Roberts, J. S., & Tersegno, S. M. (2010) · Future Neurology · doi:10.2217/fnl.10.31 · Cited by 31 · see citing works
Self-citationEthical Considerations in Psychiatric Genetics
Hoop, J. G. (2008) · Harvard Review of Psychiatry · doi:10.1080/10673220802576859 · Cited by 27 · see citing works
Correlates of dementia-related anxiety: self-perceived dementia risk and ageism
Yun, S., & Maxfield, M. (2020) · Educational Gerontology · doi:10.1080/03601277.2020.1790103 · Cited by 26 · see citing works
Fanshawe, T. R., Prevost, A. T., Roberts, J. S., Green, R. C., Armstrong, D., & Marteau, T. M. (2008) · Genetic Testing · doi:10.1089/gte.2007.0103 · Cited by 23 · see citing works
Self-citationAlber, J., Popescu, D. L., Thompson, L. I., Tonini, G.-M., Arthur, E., Oh, H., Correia, S., Salloway, S., & Lee, A. K. (2021) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988721993575 · Cited by 20 · see citing works
Kim, J. O., Schaid, D. J., Vachon, C. M., Cooke, A. L., Couch, F. J., Kim, C., Sinnwell, J. P., Hasadsri, L., Stan, D. L., Goldenberg, B. A., et al. (2020) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-20-0154 · Cited by 19 · see citing works
Pijl, M., Dondorp, W., Timmermans, D. R. M., Cornel, M. C., & Henneman, L. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-535 · Cited by 19 · see citing works
Moscarillo, T. J., Holt, H. L., Perman, M., Goldberg, S., Cortellini, L., Stoler, J. M., DeJong, W., Miles, B., Albert, M., Go, R. C. P., et al. (2007) · Public Health Genomics · doi:10.1159/000099087 · Cited by 14 · see citing works
Genetic Testing of Children for Predisposition to Mood Disorders: Anticipating the Clinical Issues
Erickson, J. A., Kuzmich, L., Ormond, K. E., Gordon, E. S., Christman, M. F., Cho, M. K., & Levinson, D. F. (2014) · Journal of Genetic Counseling · doi:10.1007/s10897-014-9710-y · Cited by 13 · see citing works
Genomic Risk Information for Common Health Conditions: Maximizing Kinship-Based Health Promotion
Koehly, L. M., & McBride, C. M. (2010) · Issues in clinical child psychology · doi:10.1007/978-1-4419-5800-6_17 · Cited by 12 · see citing works
Risk estimates for complex disorders: comparing personal genome testing and family history
Aiyar, L., Shuman, C. T., Hayeems, R. Z., Dupuis, A., Pu, S., Wodak, S. J., Chitayat, D. A., Velsher, L., & Davies, J. (2013) · Genetics in Medicine · doi:10.1038/gim.2013.115 · Cited by 12 · see citing works
A randomized trial Examining The Impact Of Communicating Genetic And Lifestyle Risks For Obesity
Wang, C., Gordon, E. S., Cunningham, T. N., Wawak, L., Liu, C., Winter, M. R., Kasper, R. S., Christman, M. F., Green, R. C., & Bowen, D. J. (2016) · Obesity · doi:10.1002/oby.21661 · Cited by 11 · see citing works
Self-citationWang, C., Gordon, E. S., Stack, C. B., Liu, C., Cunningham, T. N., Wawak, L., Christman, M. F., Green, R. C., & Bowen, D. J. (2013) · Clinical Trials · doi:10.1177/1740774513508029 · Cited by 10 · see citing works
Self-citationImpacts of apolipoprotein E disclosure on healthy Asian older adults: a cohort study
Sng, W. T., Yeo, S. N., Lin, X. B., & Lee, T.-S. W. (2019) · International Psychogeriatrics · doi:10.1017/s1041610218002089 · Cited by 10 · see citing works
Lee, A. K. W., Collier, M. K., Thompson, L. I., Popescu, D. L., Arthur, E., Correia, S., Salloway, S., & Alber, J. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.12 · Cited by 9 · see citing works
Langbaum, J. B. S., Bradbury, A. R., Egleston, B. L., Wood, E. M., Langlois, C. M., Largent, E. A., Harkins, K. A., Erickson, C. M., Stites, S. D., Oyen, E., et al. (2025) · The Lancet Healthy Longevity · doi:10.1016/j.lanhl.2025.100778 · Cited by 8 · see citing works
Self-citationViews on Genomic Research Result Delivery Methods and Informed Consent: A Review
Vears, D. F., Minion, J. T., Roberts, S. J., Cummings, J., Machirori, M., & Murtagh, M. J. (2021) · Personalized Medicine · doi:10.2217/pme-2020-0139 · Cited by 8 · see citing works
Assessment of the psychological effects of genetic screening for hereditary hemochromatosis
Elsass, P., Pedersen, P. L., Husum, K., & Milman, N. T. (2007) · Annals of Hematology · doi:10.1007/s00277-007-0415-2 · Cited by 6 · see citing works
Erickson, C. M., Langlois, C. M., Wood, E. M., Mim, R., Howe, S., Ofidis, D., Egleston, B. L., Harkins, K. A., Largent, E. A., Roberts, J. S., et al. (2025) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70177 · Cited by 5 · see citing works
Self-citationInterpretation of Melanoma Risk Feedback in First-Degree Relatives of Melanoma Patients
Hay, J. L., Baguer, C., Li, Y., Orlow, I., & Berwick, M. (2012) · Journal of Cancer Epidemiology · doi:10.1155/2012/374842 · Cited by 5 · see citing works
Özdemir, V., Burke, W., Khoury, M. J., Knoppers, B. M., & Zimmern, R. L. (2015) · doi:10.1093/med/9780199661756.003.0010 · Cited by 5 · see citing works
Risk communication: Illusion or reality?
Cabeeza, P. J., Ramisetty, P., Thompson, P. J., & Khan, K. S. (2005) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443610500278162 · Cited by 4 · see citing works
Murthy, V. S. (2005) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 4 · see citing works
Family History and Health Risk Assessment
Rubinstein, W. S. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382227-7.00026-4 · Cited by 3 · see citing works
Disabling Pregnancy: Revealing how prenatal testing messages shape reproductive choices
Truitt, A. R. (2015) · ResearchWorks at the University of Washington (University of Washington) · Cited by 3 · see citing works
Challenges in the Clinical Use of Genome Sequencing
Green, R. C., Rehm, H. L., & Kohane, I. S. (2012) · Cited by 1 · see citing works
Self-citationStewart, A., Burke, W., Khoury, M. J., & Zimmerns, R. (2009) · Oxford University Press eBooks · doi:10.1093/med/9780199218707.003.0008 · Cited by 1 · see citing works
Douglass, B. (2013) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Current awareness in geriatric psychiatry
Gillies, B. (1994) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.930090415
Exposition aux organochlorés et démence dans la population âgée du Canada
Medehouenou, T. C. M. (2013)
Dementia-related Anxiety and Advance Care Planning
Yun, S. W. (2019) · Digital Collections of Colorado (Colorado State University)
Current awareness in geriatric psychiatry
(2005) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1227
Kim, J. O., Schaid, D. J., Vachon, C. M., Cooke, A., Couch, F. J., Kim, C., Sinnwell, J. P., Hasadsri, L., Stan, D. L., Goldenberg, B. A., et al. (2023) · doi:10.1158/1940-6207.22533448
Kim, J. O., Schaid, D. J., Vachon, C. M., Cooke, A., Couch, F. J., Kim, C., Sinnwell, J. P., Hasadsri, L., Stan, D. L., Goldenberg, B. A., et al. (2023) · doi:10.1158/1940-6207.22533448.v1
Kim, J. O., Schaid, D. J., Vachon, C. M., Cooke, A., Couch, F. J., Kim, C., Sinnwell, J. P., Hasadsri, L., Stan, D. L., Goldenberg, B. A., et al. (2023) · doi:10.1158/1940-6207.c.6547102
Apoe genotype knowledge and its impact on cognitive beliefs and performance
Barber, S. J., Menon, M., Shoemaker, K. J., Mather, M., Langbaum, J. B. S., & Karlawish, J. H. (2025) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2025.2587702
APOE and Genetic Counseling for Dementia in Clinical Practice
Rumbaugh, M. C., & Chan, A. K. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_71-1
Returning APOE and pTau-217 Results: the eSMARTER Randomized Noninferiority Clinical TrialPreprint
Langbaum, J. B. S., Erickson, C. M., Langlois, C. M., Wood, E. M., Egleston, B. L., Harkins, K. A., Mim, R., John, S., Brown, C., Brown, S., et al. (2026) · medRxiv · doi:10.64898/2026.08.27.26361535
Self-citation
- Authors
- Larusse, S., Roberts, J. S., Marteau, T. M., Katzen, H., Linnenbringer, E. L., Barber, M., Whitehouse, P., Quaid, K., Brown, T., Green, R. C., & Relkin, N. R.
- Affiliations
- Columbia University (US)
- Boston University (US)
- King's College London (GB)
- Cornell University (US)
- University Hospitals of Cleveland (US)
- ORCID
- Venue
- Genetics in Medicine
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 7
- Issue
- 1
- Pages
- 48-53
- ISSN
- 1098-3600 (ISSN-L)
- OpenAlex
- W2134881136
- Cited by
- 67
- References
- 27
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 7
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Genetics in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- DigitalGeorgetown (Georgetown University Library) (submittedVersion)
- Funders
- National Institute on Aging (P30AG013846)
- National Human Genome Research Institute (R01-HG/AG02213)
- National Center for Research Resources (M01RR000533)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Keywords
- Alzheimer's disease, genetic susceptibility testing, family history (medicine), risk perception, apolipoprotein E, APOE ε4, risk disclosure, anxiety, uncertainty reduction, risk communication
- MeSH terms
- Alzheimer Disease, Apolipoproteins E, Family, Genetic Testing, Genotype, Humans, Pedigree, Risk Factors, Risk Assessment, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
