Cited by 151Cardiovascular Function and Risk FactorsCardiac electrophysiology and arrhythmiasCardiac Fibrosis and Remodeling

The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.

High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis

Relling, David P, Esberg, Lucy B, Fang, Cindy X, Johnson, W Thomas, Murphy, Eric J, Carlson, Edward C, Saari, Jack T, Ren, Jun·2006·Journal of Hypertension

DOI 10.1097/01.hjh.0000203846.34314.94

Open this paper in CoChat — free account

Abstract

BACKGROUND: Obesity is associated with dyslipidemia, which leads to elevated triglyceride and ceramide levels, apoptosis and compromised cardiac function. METHODS: To determine the role of high-fat diet-induced obesity on cardiomyocyte function, weanling male Sprague-Dawley rats were fed diets incorporating 10% of kcal or 45% of kcal from fat. Mechanical function of ventricular myocytes was evaluated including peak shortening (PS), time-to-PS (TPS), time-to-90% relengthening (TR90) and maximal velocity of shortening and relengthening (+/- dl/dt). Intracellular Ca properties were assessed using fluorescent microscopy. RESULTS: High-fat diet induced hyperinsulinemic insulin-resistant obesity with depressed PS, +/- dl/dt, prolonged TPS/TR90 reduced intracellular Ca release and Ca clearing rate in the absence of hypertension, diabetes, lipotoxicity and apoptosis. Myocyte responsiveness to increased stimulus frequency and extracellular Ca was compromised. SERCA2a and phospholamban levels were increased, whereas phosphorylated phospholamban and potassium channel (Kv1,2) were reduced in high-fat diet group. High-fat diet upregulated the forkhead transcription factor Foxo3a, and suppressed mitochondrial aconitase activity without affecting expression of the caloric sensitive gene silent information regulator 2 (Sir2), protein nitrotyrosine formation, lipid peroxidation and apoptosis. Levels of endothelial nitric oxide synthase (NOS), inducible NOS, triglycerides and ceramide were similar between the two groups. CONCLUSIONS: Collectively, our data show that high-fat diet-induced obesity resulted in impaired cardiomyocyte function, upregulated Foxo3a transcription factor and mitochondrial damage without overt lipotoxicity or apoptosis.

Integrity signals

Registry

Crossref · 10.1097/01.hjh.0000203846.34314.94

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190
Cardiac excitation–contraction coupling
Bers, D., & Despa, S. (2002) · Nature · doi:10.1038/415198a · Cited by 4,927
The Disease Burden Associated With Overweight and Obesity
Must, A. (1999) · JAMA · doi:10.1001/jama.282.16.1523 · Cited by 4,827
Prevalence and Trends in Overweight Among US Children and Adolescents, 1999-2000
Ogden, C. L. (2002) · JAMA · doi:10.1001/jama.288.14.1728 · Cited by 4,060
The Continuing Epidemics of Obesity and Diabetes in the United States
Mokdad, A. H. (2001) · JAMA · doi:10.1001/jama.286.10.1195 · Cited by 2,730
Lipotoxic heart disease in obese rats: Implications for human obesity
Zhou, Y.-T., Grayburn, P., Karim, A., Shimabukuro, M., Higa, M., Baetens, D., Orci, L., & Unger, R. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1784 · Cited by 1,265
Trends and Disparities in Coronary Heart Disease, Stroke, and Other Cardiovascular Diseases in the United States
Cooper, R., Cutler, J. A., Desvigne-Nickens, P. M., Fortmann, S. P., Friedman, L., Havlik, R. J., Hogelin, G. C., Marler, J. M., McGovern, P. C., Morosco, G. J., et al. (2000) · Circulation · doi:10.1161/01.cir.102.25.3137 · Cited by 831

Show all 56 references

Sorted by citations

Cardiac remodeling in obesity
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications
Ren, J. T., Wu, N. N., Wang, S., Sowers, J. R., & Zhang, Y. (2021) · Physiological Reviews · doi:10.1152/physrev.00030.2020 · Cited by 388
Self-citation
Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations
Li, Y., Wang, W., Cao, H., Lu, J., Wu, C., Hu, F., Guo, J., Zhao, L., Yang, F., Zhang, Y.-X., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp459 · Cited by 323
Forgotten but Not Gone
Szczepaniak, L. S., Victor, R. G., Orci, L., & Unger, R. H. (2007) · Circulation Research · doi:10.1161/circresaha.107.160457 · Cited by 260
Lipotoxicity in type 2 diabetic cardiomyopathy
van de Weijer, T., Schrauwen‐Hinderling, V. B., & Schrauwen, P. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr212 · Cited by 239
High-fat diet decreases cancellous bone mass but has no effect on cortical bone mass in the tibia in mice
Cao, J., Gregoire, B. R., & Gao, H. (2009) · Bone · doi:10.1016/j.bone.2009.02.017 · Cited by 235
Adiponectin knockout accentuates high fat diet-induced obesity and cardiac dysfunction: Role of autophagy
Guo, R., Zhang, Y., Turdi, S., & Ren, J. T. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.03.013 · Cited by 165
Self-citation
Molecular mechanisms of hypolipidemic effects of curcumin
Zingg, J.-M. A., Hasan, S. T., & Meydani, M. (2013) · BioFactors · doi:10.1002/biof.1072 · Cited by 162
Metallothionein Prevents High-Fat Diet–Induced Cardiac Contractile Dysfunction
Dong, F., Li, Q., Sreejayan, N., Nunn, J. M., & Ren, J. T. (2007) · Diabetes · doi:10.2337/db06-1596 · Cited by 136
Self-citation
Obesity and Bone Health: A Complex Link
Hou, J., He, C., He, W., Yang, M., Luo, X., & Li, C. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.600181 · Cited by 139
RETRACTED ARTICLE: Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3β and mitochondrial function
Zhang, Y., Babcock, S. A., Hu, N., Maris, J. R., Wang, H., & Ren, J. T. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-40 · Cited by 130
Self-citation
Retracted
Cardiac remodeling in a rat model of diet-induced obesity
Leopoldo, A. S., Sugizaki, M. M., Lima‐Leopoldo, A. P., do Nascimento, A. F., Luvizotto, R. D. A. M., de Campos, D. H. S., Okoshi, K., Dal‐Pai‐Silva, M., Padovani, C. R., & Cicogna, A. C. (2010) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(10)70440-2 · Cited by 129
Sodium Butyrate Protects Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice
Zhang, L., Du, J., Yano, N., Wang, H., Zhao, Y., Dubielecka, P. M., Zhuang, S., Chin, Y. E., Qin, G., & Zhao, T. C. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25902 · Cited by 125
Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy
Kandula, V., Kosuru, R., Li, H., Yan, D., Zhu, Q., Lian, Q., Ge, R., Xia, Z., & Irwin, M. G. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0361-1 · Cited by 115
A Hypercaloric pellet-diet cycle induces obesity and co-morbidities in wistar rats
do Nascimento, A. F., Sugizaki, M. M., Leopoldo, A. S., Lima‐Leopoldo, A. P., Luvizotto, R. D. A. M., Nogueira, C. R., & Cicogna, A. C. (2008) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302008000600007 · Cited by 110
Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription
Fang, C. X., Dong, F., Thomas, D. P., Ma, H., He, L., & Ren, J. T. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00319.2008 · Cited by 108
Self-citation
Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction
Turdi, S., Kandadi, M. R., Zhao, J., Huff, A. F., Du, M., & Ren, J. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.12.007 · Cited by 103
Self-citation
Insulin-Like Growth Factor 1 Alleviates High-Fat Diet–Induced Myocardial Contractile Dysfunction
Zhang, Y., Yuan, M., Bradley, K. M., Dong, F., Anversa, P., & Ren, J. T. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.181867 · Cited by 91
Self-citation
Retracted
“SLY AS A FOXO”: New Paths with Forkhead Signaling in the Brain
Maiese, K., Chong, Z. Z., & Shang, Y. (2007) · Current Neurovascular Research · doi:10.2174/156720207782446306 · Cited by 77
Triple play: Promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus
Maiese, K. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.01.009 · Cited by 75
Retracted: Activation of Akt Rescues Endoplasmic Reticulum Stress-Impaired Murine Cardiac Contractile Function via Glycogen Synthase Kinase-3β-Mediated Suppression of Mitochondrial Permeation Pore Opening
Zhang, Y., Xia, Z., LaCour, K. H., & Ren, J. T. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3751 · Cited by 72
Self-citation
Retracted
Ablation of Akt2 prevents paraquat-induced myocardial mitochondrial injury and contractile dysfunction: Role of Nrf2
Wang, S., Zhu, X., Xiong, L., & Ren, J. T. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.01.009 · Cited by 69
Self-citation
Influence of cardiac‐specific overexpression of insulin‐like growth factor 1 on lifespan and aging‐associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression
Li, Q., & Ren, J. T. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00343.x · Cited by 68
Self-citation
Interaction of diet and diabetes on cardiovascular function in rats
Marsh, S. A., Dell’Italia, L. J., & Chatham, J. C. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00421.2008 · Cited by 66
Protective role of Citrus sinensis, Musa paradisiaca, and Punica granatum peels against diet-induced atherosclerosis and thyroid dysfunctions in rats
Parmar, H. S., & Kar, A. (2007) · Nutrition Research · doi:10.1016/j.nutres.2007.09.003 · Cited by 63
Regulatory effects of curcumin on lipid accumulation in monocytes/macrophages
Zingg, J.-M. A., Hasan, S. T., Cowan, D., Ricciarelli, R., Azzi, A., & Meydani, M. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23411 · Cited by 65
Nutritional models of foetal programming and nutrigenomic and epigenomic dysregulations of fatty acid metabolism in the liver and heart
Guéant, J., Akoum, R. E., Ziegler, O., Coelho, D., Feigerlová, E., Daval, J., & Guéant‐Rodriguez, R. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1339-4 · Cited by 69
Long Noncoding RNA Kcna2 Antisense RNA Contributes to Ventricular Arrhythmias via Silencing Kcna2 in Rats With Congestive Heart Failure
Long, Q., Wang, H., Gao, W., Fan, Y., Li, Y., Ma, Y., Yang, Y., Shi, H., Chen, B., Meng, H., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.005965 · Cited by 60
Insulin resistance by TNF-α is associated with mitochondrial dysfunction in 3T3-L1 adipocytes and is ameliorated by punicic acid, a PPARγ agonist
Anusree, S. S., Nisha, V. M., Priyanka, A., & Raghu, K. G. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.06.018 · Cited by 62
Misclassification probability as obese or lean in hypercaloric and normocaloric diet
do Nascimento, A. F., Sugizaki, M. M., Leopoldo, A. S., Lima‐Leopoldo, A. P., Nogueira, C. R., Novelli, E. L. B., Padovani, C. R., & Cicogna, A. C. (2008) · Biological Research · doi:10.4067/s0716-97602008000300002 · Cited by 58
Hearts from Mice Fed a Non-Obesogenic High-Fat Diet Exhibit Changes in Their Oxidative State, Calcium and Mitochondria in Parallel with Increased Susceptibility to Reperfusion Injury
Littlejohns, B., Pasdois, P., Duggan, S. M. J., Bond, A., Heesom, K. J., Jackson, C. L., Angelini, G. D., Halestrap, A. P., & Suleiman, M. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100579 · Cited by 58
Cardiac-Specific Overexpression of Metallothionein Rescues against Cigarette Smoking Exposure-Induced Myocardial Contractile and Mitochondrial Damage
Hu, N., Han, X., Lane, E., Gao, F., Zhang, Y., & Ren, J. T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057151 · Cited by 55
Self-citation
Metallothionein Abrogates GTP Cyclohydrolase I Inhibition–Induced Cardiac Contractile and Morphological Defects
Ceylan‐Isik, A. F., Guo, K. K., Carlson, E. C., Privratsky, J. R., Liao, S.-J., Cai, L. F., Chen, A. F., & Ren, J. T. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.123422 · Cited by 55
Self-citation
Exercise Training and Caloric Restriction Prevent Reduction in Cardiac Ca 2+ -Handling Protein Profile in Obese Rats
Paulino, E. C., Ferreira, J. C. B., Bechara, L. R. G., Tsutsui, J. M., Mathias, W., Lima, F. B., Casarini, D. E., Cicogna, A. C., Brum, P. C., & Negrão, C. E. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.156141 · Cited by 56
Involvement of L‐type calcium channel and serca2a in myocardial dysfunction induced by obesity
Leopoldo, A. S., Lima‐Leopoldo, A. P., Sugizaki, M. M., do Nascimento, A. F., de Campos, D. H. S., Luvizotto, R. D. A. M., Castardeli, É., Alves, C. A. B., Brum, P. C., & Cicogna, A. C. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22643 · Cited by 56
Obesity and hypertensive heart disease: focus on body composition and sex differences
SIMONE, G. D., Mancusi, C., Izzo, R., Losi, M. A., & Ferrara, L. A. (2016) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-016-0193-x · Cited by 50
CARDIAC-SPECIFIC OVEREXPRESSION OF INSULIN-LIKE GROWTH FACTOR I (IGF-1) RESCUES lIPOPOLYSACCHARIDE-INDUCED CARDIAC DYSFUNCTION AND ACTIVATION OF STRESS SIGNALING IN MURINE CARDIOMYOCYTES
Zhao, P., Turdi, S., Dong, F., Xiao, X., Su, G., Zhu, X., Scott, G. I., & Ren, J. T. (2009) · Shock · doi:10.1097/shk.0b013e31818ec609 · Cited by 46
Self-citation
Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats
Bruder-Nascimento, T. B., de Campos, D. H. S., Alves, C. A. B., Thomaz, S., Cicogna, A. C., & Cordellini, S. (2013) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302013000800010 · Cited by 44
Western diet changes cardiac acyl-CoA composition in obese rats: a potential role for hepatic lipogenesis
Harmancey, R., Wilson, C. R., Wright, N. R., & Taegtmeyer, H. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m001230 · Cited by 44
INFLUENCE OF GENDER ON OXIDATIVE STRESS, LIPID PEROXIDATION, PROTEIN DAMAGE AND APOPTOSIS IN HEARTS AND BRAINS FROM SPONTANEOUSLY HYPERTENSIVE RATS
Ren, J. T. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04591.x · Cited by 44
Self-citation
Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity
Martínez-Jiménez, V., Cortez-Espinosa, N., Rodríguez-Varela, E., Vega‐Cárdenas, M., Briones-Espinoza, M., Ruiz-Rodríguez, V. M., López‐López, N., Briseño-Medina, A., Turiján-Espinoza, E., & Portales‐Pérez, D. P. (2018) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2018.11.011 · Cited by 43
High‐fat Diet‐induced Obesity Leads to Resistance to Leptin‐induced Cardiomyocyte Contractile Response
Ren, J. T., Zhu, B., Relling, D. P., Esberg, L. B., & Ceylan‐Isik, A. F. (2008) · Obesity · doi:10.1038/oby.2008.381 · Cited by 43
Self-citation
Long-term obesity promotes alterations in diastolic function induced by reduction of phospholamban phosphorylation at serine-16 without affecting calcium handling
Lima‐Leopoldo, A. P., Leopoldo, A. S., da Silva, D. C. T., do Nascimento, A. F., de Campos, D. H. S., Luvizotto, R. D. A. M., de Deus, A. F., Freire, P. P., Medeiros, A., Okoshi, K., et al. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00088.2014 · Cited by 38
Chromium ( d ‐Phenylalanine)3 Improves Obesity‐Induced Cardiac Contractile Defect in ob/ob Mice
Dong, F., Yang, X., Sreejayan, N., & Ren, J. T. (2007) · Obesity · doi:10.1038/oby.2007.322 · Cited by 38
Self-citation
Interaction between Age and Obesity on Cardiomyocyte Contractile Function: Role of Leptin and Stress Signaling
Ren, J. T., Dong, F., Cai, G., Zhao, P., Nunn, J. M., Wold, L. E., & Pei, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010085 · Cited by 37
Self-citation
Retracted
Obesity induces upregulation of genes involved in myocardial Ca2+ handling
Lima‐Leopoldo, A. P., Sugizaki, M. M., Leopoldo, A. S., Carvalho, R. F., Nogueira, C. R., do Nascimento, A. F., Martinez, P. F., Luvizotto, R. D. A. M., Padovani, C. R., & Cicogna, A. C. (2008) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2008000700011 · Cited by 39
Heart energy metabolism impairment in Western-diet induced obese mice
Neves, F. A., Cortez, E. A. C., Bernardo, A. F., de Mattos, A. B. M., Vieira, A. K. G., Malafaia, T. D. O., Thole, A. A., Rodrigues-Cunha, A. C. D. S., Garcia‐Souza, É. P., Sichieri, R., et al. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.08.014 · Cited by 40
Possible amelioration of atherogenic diet induced dyslipidemia, hypothyroidism and hyperglycemia by the peel extracts of Mangifera indica, Cucumis melo and Citrullus vulgaris fruits in rats
Parmar, H. S., & Kar, A. (2008) · BioFactors · doi:10.1002/biof.5520330102 · Cited by 36
Obesity reduces left ventricular strains, torsion, and synchrony in mouse models: a cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance study
Kramer, S. P., Powell, D. K., Haggerty, C. M., Friday, C. M., Mattingly, A. C., Cassis, L. A., Epstein, F. H., & Fornwalt, B. K. (2013) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/1532-429x-15-109 · Cited by 36
Cardiac fibrosis and vascular remodeling are attenuated by metformin in obese rats
Burlá, A. K., Lobato, N. S., Fortes, Z. B., Oigman, W., & Neves, M. F. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.09.012 · Cited by 34
Hydrogen sulfide alleviates cardiac contractile dysfunction in an Akt2-knockout murine model of insulin resistance: role of mitochondrial injury and apoptosis
Hu, N., Dong, M., & Ren, J. T. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2013 · Cited by 34
Self-citation
Diet-induced obesity suppresses sevoflurane preconditioning against myocardial ischemia–reperfusion injury: role of AMP-activated protein kinase pathway
Song, T., Lv, L.-Y., Xu, J., Tian, Z.-Y., Cui, W., Wang, Q., Qu, G., & Shi, X.-M. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.011165 · Cited by 34
Cardiac Dysfunction Induced by Obesity Is Not Related to β-Adrenergic System Impairment at the Receptor-Signalling Pathway
Ferron, A. J. T., Jacobsen, B. B., Sant’Ana, P. G., de Campos, D. H. S., de Tomasi, L. C., Luvizotto, R. D. A. M., Cicogna, A. C., Leopoldo, A. S., & Lima‐Leopoldo, A. P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138605 · Cited by 34
Identification of a QTL for Adipocyte Volume and of Shared Genetic Effects with Aspartate Aminotransferase
Bose, T., Voruganti, V. S., Tejero, M. E., Proffit, J. M., Cox, L. A., VandeBerg, J. L., Mahaney, M. C., Rogers, J., FREELAND-GRAVES, J. H., Cole, S. A., et al. (2010) · Biochemical Genetics · doi:10.1007/s10528-010-9337-0 · Cited by 32
Large Impact of Low Concentration Oxidized LDL on Angiogenic Potential of Human Endothelial Cells: A Microarray Study
Khaidakov, M., Mitra, S., Wang, X., Ding, Z., Bora, N. S., Lyzogubov, V. V., Romeo, F., Schichman, S. A., & Mehta, J. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047421 · Cited by 32
Alterações vasculares em ratos obesos por dieta rica em gordura: papel da Via L-arginina/NO Endotelial
Bruder-Nascimento, T. B., Baptista, R. D. F. F., Pereira, P. C., de Campos, D. H. S., Leopoldo, A. S., Lima‐Leopoldo, A. P., de Oliveira-Junior, S. A., Padovani, C. R., Cicogna, A. C., & Cordellini, S. (2011) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2011005000063 · Cited by 30
Foxo3a: An integrator of immune dysfunction during HIV infection
van Grevenynghe, J., Cubas, R. A., DaFonseca, S., Metcalf, T. U., Tremblay, C. L., Trautmann, L., Sékaly, R., Schatzle, J. D., & Haddad, E. K. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.05.008 · Cited by 30
Disfunção miocárdica e alterações no trânsito de cálcio intracelular em ratos obesos
Lima‐Leopoldo, A. P., Leopoldo, A. S., Sugizaki, M. M., Bruno, A., do Nascimento, A. F., Luvizotto, R. D. A. M., de Oliveira-Junior, S. A., Castardeli, É., Padovani, C. R., & Cicogna, A. C. (2011) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2011005000061 · Cited by 29
Effects of poly-γ-glutamic acid on serum and brain concentrations of glutamate and GABA in diet-induced obese rats
Lee, H., Chang, M., & Kim, S.-H. (2010) · Nutrition Research and Practice · doi:10.4162/nrp.2010.4.1.23 · Cited by 28
Cardiomyocyte apoptosis in animal models of obesity
Trivedi, P. S., & Barouch, L. A. (2008) · Current Hypertension Reports · doi:10.1007/s11906-008-0085-z · Cited by 27
Association between Cardiac Remodeling and Metabolic Alteration in an Experimental Model of Obesity Induced by Western Diet
Ferron, A. J. T., Francisqueti‐Ferron, F. V., Minatel, I. O., Silva, C. C. V. D. A., Bazan, S. G. Z., Kitawara, K. A. H., Garcia, J. L., Correa, C. R., Moreto, F., & Ferreira, A. L. A. (2018) · Nutrients · doi:10.3390/nu10111675 · Cited by 26
Mitochondrial aldehyde dehydrogenase rescues against diabetic cardiomyopathy through GSK3β-mediated preservation of mitochondrial integrity and Parkin-mediated mitophagy
Zhang, Y., Zou, R., Abudureyimu, M., Liu, Q., Ma, J., Xu, H., Yu, W., Yang, J. Z., Jia, J., Qian, S., et al. (2023) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjad056 · Cited by 25
Self-citation
Dietary Interaction of High Fat and Marginal Copper Deficiency on Cardiac Contractile Function
Relling, D. P., Esberg, L. B., Johnson, W. T., Murphy, E. J., Carlson, E. C., Lukaski, H. C., Saari, J. T., & Ren, J. T. (2007) · Obesity · doi:10.1038/oby.2007.146 · Cited by 25
Self-citation
Myocardial Ischemic‐reperfusion Injury in a Rat Model of Metabolic Syndrome
Mozaffari, M. S., & Schaffer, S. W. (2008) · Obesity · doi:10.1038/oby.2008.356 · Cited by 23
Eat and Death: Chronic Over-Eating
Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_3 · Cited by 22
Down-regulation of PPARα in the spinal cord contributes to augmented peripheral inflammation and inflammatory hyperalgesia in diet-induced obese rats
Wang, J., Zhang, Q., Zhao, L., Li, D., Fu, Z., & Liang, L. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.071 · Cited by 22
MagnoliaExtract (BL153) Protection of Heart from Lipid Accumulation Caused Cardiac Oxidative Damage, Inflammation, and Cell Death in High-Fat Diet Fed Mice
Sun, W., Zhang, Z., Chen, Q., Yin, X., Fu, Y., Zheng, Y., Cai, L., Kim, K.-S., Kim, K. H., Tan, Y., et al. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/205849 · Cited by 22
Sex-Dependent Expression of Caveolin 1 in Response to Sex Steroid Hormones Is Closely Associated with Development of Obesity in Rats
Mukherjee, R., Kim, S. W., Choi, M. S., & Yun, J. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090918 · Cited by 22
Saturated high-fat diet-induced obesity increases adenylate cyclase of myocardial β -adrenergic system and does not compromise cardiac function
Vileigas, D. F., de Deus, A. F., da Silva, D. C. T., de Tomasi, L. C., de Campos, D. H. S., Adorni, C. S., de Oliveira, S. M., Sant’Ana, P. G., Okoshi, K., Padovani, C. R., et al. (2016) · Physiological Reports · doi:10.14814/phy2.12914 · Cited by 21
Influence of Long-Term Obesity on Myocardial Gene Expression
Lima‐Leopoldo, A. P., Leopoldo, A. S., da Silva, D. C. T., do Nascimento, A. F., de Campos, D. H. S., Luvizotto, R. D. A. M., de Oliveira-Junior, S. A., Padovani, C. R., Nogueira, C. R., & Cicogna, A. C. (2013) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20130045 · Cited by 22
The role of dietary fatty acids in predicting myocardial structure in fat-fed rats
Jeckel, K. M., Miller, K. E., Chicco, A. J., Chapman, P. L., Mulligan, C. M., Falcone, P. H., Miller, M. L., Pagliassotti, M. J., & Frye, M. A. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-92 · Cited by 21
Protective Effect of Tomato-Oleoresin Supplementation on Oxidative Injury Recoveries Cardiac Function by Improving β-Adrenergic Response in a Diet-Obesity Induced Model
Ferron, A. J. T., Aldini, G., Francisqueti‐Ferron, F. V., Silva, C. C. V. D. A., Bazan, S. G. Z., Garcia, J. L., de Campos, D. H. S., Ghiraldeli, L., Kitawara, K. A. H., Altomare, A., et al. (2019) · Antioxidants · doi:10.3390/antiox8090368 · Cited by 19
Deficiency of bone morphogenetic protein-3b induces metabolic syndrome and increases adipogenesis
Martí-Pàmies, Í., Thoonen, R., Seale, P., Vite, A., Caplan, A., Tamez, J., Graves, L., Han, W., Buys, E. S., Bloch, D. B., et al. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00362.2019 · Cited by 19
Association Study to Evaluate FoxO1 and FoxO3 Gene in CHD in Han Chinese
Zhao, Y., Yu, Y., Tian, X., Yang, X., Li, X., Jiang, F., Chen, Y., & Shi, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086252 · Cited by 18
Association study of polymorphisms in FOXO3, AKT1 and IGF-2R genes with human longevity in a Han Chinese population
Li, N., Luo, H., Liu, X., Ma, S., He, L., Chen, R., Fang, H., & Zhang, D. (2015) · Oncotarget · doi:10.18632/oncotarget.6627 · Cited by 19
Early High-Fat Feeding Induces Alteration of Trace Element Content in Tissues of Juvenile Male Wistar Rats
Tinkov, A. A., Gatiatulina, E. R., Popova, E. V., Polyakova, V. S., Skalnaya, A. A., Agletdinov, E. F., Nikonorov, A. А., & Skalny, A. V. (2016) · Biological Trace Element Research · doi:10.1007/s12011-016-0777-1 · Cited by 19
Chronic high-fat diet-induced obesity decreased survival and increased hypertrophy of rats with experimental eccentric hypertrophy from chronic aortic regurgitation
Dhahri, W., Drolet, M., Roussel, É., Couët, J., & Arsenault, M. (2014) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-14-123 · Cited by 18
Obesity and Preclinical Changes of Cardiac Geometry and Function
Sung, J. K., & Kim, J. (2010) · Korean Circulation Journal · doi:10.4070/kcj.2010.40.2.55 · Cited by 18
Differential nutritional, endocrine, and cardiovascular effects in obesity-prone and obesity-resistant rats fed standard and hypercaloric diets.
de Oliveira-Junior, S. A., Dal‐Pai‐Silva, M., Martinez, P. F., de Campos, D. H. S., Lima‐Leopoldo, A. P., Leopoldo, A. S., do Nascimento, A. F., Okoshi, M. P., Okoshi, K., Padovani, C. R., et al. (2010) · PubMed · Cited by 18
Resistance training promotes reduction in Visceral Adiposity without improvements in Cardiomyocyte Contractility and Calcium handling in Obese Rats
Melo, A. B., Damiani, A. P. L., Coelho, P. M., de Assis, A. L. E. M., Nogueira, B. V., Guimarães‐Ferreira, L., Leite, R. D., Júnior, R. F. R., Lima‐Leopoldo, A. P., & Leopoldo, A. S. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.42612 · Cited by 15
Structural lesions and changing pattern of expression of genes encoding cardiac muscle proteins are associated with ventricular myocyte dysfunction in type 2 diabetic Goto-Kakizaki rats fed a high-fat diet
Howarth, F. C., Qureshi, M. A., Sobhy, Z. H. H., Parekh, K. A., Yammahi, S. R. R. K. D., Adrian, T. E., & Adeghate, E. A. (2011) · Experimental Physiology · doi:10.1113/expphysiol.2011.058446 · Cited by 17
Exercise-Induced Antisenescence and Autophagy Restoration Mitigate Metabolic Disorder–Induced Cardiac Disruption in Mice
Ko, J., Jang, Y. C., Quindry, J. C., Guttmann, R. P., Cosío-Lima, L., Powers, S. K., & Lee, Y. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003058 · Cited by 15
Adverse Effects of AMP-Activated Protein Kinase α2-Subunit Deletion and High-Fat Diet on Heart Function and Ischemic Tolerance in Aged Female Mice
Slámová, K., Papoušek, F., Janovská, P., Kopecký, J., & Kolář, F. (2016) · Physiological Research · doi:10.33549/physiolres.932979 · Cited by 15
Attenuated Cardiac oxidative stress, inflammation and apoptosis in Obese Mice with nonfatal infection of Escherichia coli
Guo, H., Zuo, Z., Wang, F., Gao, C., Chen, K., Fang, J. S., Cui, H., Ouyang, P., Geng, Y., Chen, Z., et al. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112760 · Cited by 14
Downregulation of Kir6.1/SUR2B channels in the obese rat aorta
Fan, L., Tian, H., Wang, J., Huo, J., Zhi, H., Ma, A., & Cao, Y. (2008) · Nutrition · doi:10.1016/j.nut.2008.09.005 · Cited by 14
Reducing Oxidative Stress and Enhancing Neurovascular Longevity During Diabetes Mellitus
Maiese, K., Chong, Z. Z., & Li, F. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195326697.003.0022 · Cited by 14
The Association Between Longevity-Associated FOXO3 Allele and Heart Disease in Septuagenarians and Octogenarians: The SONIC Study
Klinpudtan, N., Allsopp, R., Kabayama, M., Godai, K., Gondo, Y., Masui, Y., Akagi, Y., Srithumsuk, W., Sugimoto, K., Akasaka, H., et al. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab204 · Cited by 14
Estresse crônico melhora a função miocárdica sem alterar a atividade do canal-L para Ca+2 em ratos
Bruder-Nascimento, T. B., de Campos, D. H. S., Leopoldo, A. S., Lima‐Leopoldo, A. P., Okoshi, K., Cordellini, S., & Cicogna, A. C. (2012) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2012005000082 · Cited by 13
Tomato-Oleoresin Anti-Inflammatory Effect Recovers Obesity-Induced Cardiac Dysfunction by Modulating Myocardial Calcium Handling
Ferron, A. J. T., Francisqueti‐Ferron, F. V., Silva, C. C. V. D. A., Bazan, S. G. Z., de Campos, D. H. S., Garcia, J. L., Ghiraldeli, L., Minatel, I. O., Corrêa, C. R., Moreto, F., et al. (2020) · Cellular Physiology and Biochemistry · doi:10.33594/000000284 · Cited by 13
Interaction Between High‐Fat Diet and Alcohol Dehydrogenase on Ethanol‐Elicited Cardiac Depression in Murine Myocytes
Ren, J. T. (2007) · Obesity · doi:10.1038/oby.2007.350 · Cited by 13
Self-citation
Semaglutide Normalizes Increased Cardiomyocyte Calcium Transients in a Rat Model of High Fat Diet-Induced Obesity
Sequeira, V., Theisen, J., Ermer, K. J., Oertel, M., Xu, A., Weissman, D., Ecker, K., Dudek, J., Faßnacht, M., Nickel, A. G., et al. (2024) · ESC Heart Failure · doi:10.1002/ehf2.15152 · Cited by 12
Effects of aerobic exercise training and açai supplementation on cardiac structure and function in rats submitted to a high-fat diet
Lavorato, V. N., de Miranda, D. C., Isoldi, M. C., Drummond, F. R., Soares, L. L., Reis, E. C. C., Pelúzio, M. D. C. G., Pedrosa, M. L., Silva, M. E., & Natali, A. J. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110168 · Cited by 13
Exercise training prevents the attenuation of anesthetic pre‐conditioning‐mediated cardioprotection in diet‐induced obese rats
Li, L., MENG, F., Li, N.-Y., Zhang, L., Wang, J., Wang, H., Li, D., Zhang, X., Dong, P., & Chen, Y. (2014) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.12414 · Cited by 11
Cardiac function and intracellular Ca2+ handling proteins are not impaired by high-saturated-fat diet-induced obesity
de Deus, A. F., Vileigas, D. F., Silva, D. C. T., de Tomasi, L. C., de Campos, D. H. S., Okoshi, K., Padovani, C. R., & Cicogna, A. C. (2019) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20198085 · Cited by 11
Moderate exercise training does not prevent the reduction in myocardial L-type Ca2+ channels protein expression at obese rats
da Silva, V. L., Lima‐Leopoldo, A. P., Ferron, A. J. T., Cordeiro, J. P., Freire, P. P., de Campos, D. H. S., Padovani, C. R., Sugizaki, M. M., Cicogna, A. C., & Leopoldo, A. S. (2017) · Physiological Reports · doi:10.14814/phy2.13466 · Cited by 10
Hypercaloric diet models do not develop heart failure, but the excess sucrose promotes contractility dysfunction
Matias, A. M., Coelho, P. M., Marques, V. B., dos SANTOS, L., de Assis, A. L. E. M., Nogueira, B. V., Lima‐Leopoldo, A. P., & Leopoldo, A. S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228860 · Cited by 10
Strength Training Reduces Fat Accumulation and Improves Blood Lipid Profile Even in the Absence of Skeletal Muscle Hypertrophy in High-Fat Diet-Induced Obese Condition
Contreiro, C. D. E., Caldas, L. C., Nogueira, B. V., Leopoldo, A. S., Lima‐Leopoldo, A. P., & Guimarães‐Ferreira, L. (2020) · Journal of Obesity · doi:10.1155/2020/8010784 · Cited by 12
Obesity does not Lead to Imbalance Between Myocardial Phospholamban Phosphorylation and Dephosphorylation
Freire, P. P., Alves, C. A. B., de Deus, A. F., Leopoldo, A. P. L., Leopoldo, A. S., da Silva, D. C. T., de Tomasi, L. C., de Campos, D. H. S., & Cicogna, A. C. (2014) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20140083 · Cited by 9
Altered ATP-sensitive potassium channels may underscore obesity-triggered increase in blood pressure1
Fan, L., Tian, H., Ma, A., Zhi, H., Huo, J., & Cao, Y. (2008) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2008.00810.x · Cited by 9
Mechanical function of cardiac fibre bundles is partly protected by exercise in response to diet-induced obesity in rats
Boldt, K., Rios, J. L., Joumaa, V., & Herzog, W. (2020) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2020-0275 · Cited by 8

Authors: Relling, D. P., Esberg, L. B., Fang, C. X., Johnson, W. T., Murphy, E. J., Carlson, E. C., Saari, J. T., & Ren, J.
Affiliations: University of North Dakota (US)
University of Wyoming (US)
Agricultural Research Service (US)
Corresponding author: Ren, Jun
ORCID: Johnson, W Thomas
Murphy, Eric J
Ren, Jun
Venue: Journal of Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-03
Volume: 24
Issue: 3
Pages: 549-561
ISSN: 0263-6352 (ISSN-L)
DOI: 10.1097/01.hjh.0000203846.34314.94
OpenAlex: W1979714251
Cited by: 151
References: 56
Citations by year: 2024: 5 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 10 · 2019: 2 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 12 · 2013: 10 · 2012: 9
FWCI: 7.35
Type: journal article
Language: en
Open access: closed
Locations: Journal of Hypertension (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Agriculture
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: high-fat diet, youth obesity, cardiomyocyte dysfunction, FOXO3, mitochondrial aconitase, intracellular calcium homeostasis, SERCA2a, phospholamban, Kv1.2 potassium channel, insulin resistance, dyslipidemia, ceramide, triglycerides, mitochondrial damage, cardiac contractility
MeSH terms: Forkhead Box Protein O3, Phospholamban, Aconitate Hydratase, Calcium-Transporting ATPases, Animals, Calcium, Calcium-Binding Proteins, Ceramides, Dietary Fats, Male, Obesity, Sarcoplasmic Reticulum, Triglycerides, Tyrosine, Up-Regulation, Rats, Sprague-Dawley, Apoptosis, Nitric Oxide Synthase, Potassium Channels, Voltage-Gated, Myocytes, Cardiac, Sirtuins, STAT3 Transcription Factor, Rats, Forkhead Transcription Factors, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Sirtuin 1, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks