The DOI matches its Crossref record.
Effects of trazodone hydrochloride and imipramine on polysomnography in healthy subjects
Open accessAbstract
Polysomnography was performed on eight healthy men with trazodone hydrochloride, imipramine and placebo. Trazodone hydrochloride increased slow wave sleep significantly. Imipramine prolonged rapid eye movement (REM) latency and decreased the percentage of REM sleep significantly. Trazodone decreased stages 1 and 2 sleep, while imipramine increased it. These findings suggest that the antidepressive effect of trazodone might be different from that of imipramine with the suppression of REM sleep.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Yamadera et al. observed significant increases in slow wave sleep associated with trazodone administration in healthy subjects.
“Yamadera et al. [1998] also observed significant increases in slow wave sleep associated with trazodone administration in healthy subjects.”
From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Yamadera et al., 1998
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 29
- BoissieJR Portmann‐CristescoE SoubrieP FichelleJ. In: Ban TA and Silverstini B (eds).Pharmacological and Biochemical Features of Trazodone. Trazodone Modern Problems of Pharmacopsychiatry.Separatum Basel Vol. 9 1974; 18–28. · DOI
- 10.1016/S0031-6989(79)80088-0 · DOI
- 10.1007/BF00172629 · DOI · Paper page
- Sharf MB, 1990, Sleep laboratory evaluation of the effects and efficacy of trazodone in depressed insomniac patients, J.␣Psychiatry, 51, 13
- Ware JC, 1990, Increased deep sleep after trazodone use: A double‐blind placebo‐controlled study in healthy young adults, J.␣Clin. Psychiatry, 51, 18
- Okino H, 1994, Effects of trazodone on nocturnal sleep, Psychosom. Ther, 6, 61
- 10.1111/j.1365-2125.1983.tb04977.x · DOI · Paper page
- 10.1007/BF02245272 · DOI · Paper page
- 10.1192/bjp.120.559.663 · DOI
- Toyoda J, 1974, The effects of chlorpromazine and imipramine on the human nocturnal sleep electroencephalogram, Folia Psychiat. Neurol. Jpn, 18, 198
- Nakagawa H, 1987, Effects of imipramine on nocturnal sleep of patients with depression and normal subjects, J. Kanazawa Med. University, 12, 62
- 10.1097/00006842-194611000-00003 · DOI
- Green WJ, 1966, Sleep continuity changes in depression, J.␣Nerv. Ment. Dis, 143, 102
- 10.1001/archpsyc.1968.01740090056006 · DOI
- 10.1016/S0140-6736(72)92090-9 · DOI
- 10.1001/archpsyc.1979.01780010091010 · DOI
- 10.1001/archpsyc.1980.01780160017001 · DOI
- 10.1016/0014-2999(94)90690-4 · DOI
- Sheldon H, 1993, Pharmacokinetics of antidepressants: Why and how they are relevant to treatment, J. Clin. Psychiatry, 54, 14
- 10.1016/0006-3223(91)91290-8 · DOI · Paper page
- Idzikowski C, 1986, 5‐hydroxytryptamines‐2‐antagonist increases human slow wave sleep, Brain Res, 376, 85
- 10.1185/03007998009109467 · DOI
- 10.1007/BF00426203 · DOI
- 10.1016/0006-3223(94)00135-P · DOI
- 10.1176/ajp.152.2.274 · DOI
- Maeda T, 1986, Mechanism of paradoxical sleep, Shinkei Shimpo, 30, 1003
- Sakai K, 1981, Physiology of paradoxical sleep, Shinkei Shimpo, 25, 1050
- Hendrickse WA, 1994, The effects of fluoxetine on the polysomnogram of depressed out patients: a pilot study, Neuropharmacology, 10, 85
- 10.1097/00004850-199409000-00009 · DOI · Paper page
Cited by
Sorted by citations
Depression, sleep physiology, and antidepressant drugs
Winokur, A., Gary, K. A., Rodner, S., Rae-Red, C., Fernando, A. T., & Szuba, M. P. (2001) · Depression and Anxiety · doi:10.1002/da.1043 · Cited by 179
Sleep and Antidepressant Treatment
Wichniak, A., Wierzbicka, A., & Jernajczyk, W. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212803523608 · Cited by 142
Metadata
- Authors
- YAMADERA, H., NAKAMURA, S., SUZUKI, H., & ENDO, S.
- Affiliations
- Nippon Medical School (JP)
- Corresponding author
- YAMADERA, HIROSHI
- ORCID
- SUZUKI, HIDEAKI
- Venue
- Psychiatry and Clinical Neurosciences
- Publisher
- Wiley
- Published
- 1998-07
- Volume
- 52
- Issue
- 4
- Pages
- 439-443
- ISSN
- 1323-1316 (ISSN-L)
- 1440-1819
- OpenAlex
- W1601733754
- Cited by
- 48
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 1 · 2012: 3
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychiatry and Clinical Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- trazodone hydrochloride, imipramine, polysomnography, sleep stages, slow-wave sleep, REM sleep, REM latency, antidepressant effects, selective serotonin reuptake inhibitors, tricyclic antidepressants
- MeSH terms
- Adult, Antidepressive Agents, Tricyclic, Humans, Imipramine, Male, Sleep, Trazodone, Polysomnography, Antidepressive Agents, Second-Generation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
