Modulation of Hyperreactivity to 35% CO2 After One Week of Treatment With Paroxetine and Reboxetine: A Double-Blind, Randomized Study
Abstract
The effects of short treatments (7 days) with paroxetine and with reboxetine on the reactivity to inhalations of 35% carbon dioxide (CO2)/65% oxygen (O2) were compared in 28 patients with Panic Disorder who had positive responses to 35% CO2 inhalations. A double-blind, randomized design was applied. Each patient was given the 35% CO2 challenge on days 0 (before starting the treatment) and 7. Anxiety reactivity to CO2 decreased significantly with both drugs but the decrease was significantly stronger in the group treated with paroxetine. The rate of patients whose reactivity has reduced of at least 50% after 7 days was significantly higher in the group treated with paroxetine (10/14, 71.5%) than in the one treated with reboxetine (3/14, 21.5%). These results indicate that the modulation of the serotonergic system is more relevant for CO2 hyperreactivity than the modulation of the noradrenergic one.
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A previous study by the authors' group showed that reboxetine was significantly less effective than paroxetine in decreasing the frequency of panic attacks induced by inhalation of 35% carbon dioxide/65% oxygen gas mixture in patients with panic disorder.
“a previous study conducted by our group showed that reboxetine, a selective noradrenaline reuptake inhibitor, was significantly less effective than paroxetine (an SSRI) in decreasing the frequency of PAs induced by inhalation of 35% carbon dioxide (CO2)/65% oxygen (O2) gas mixture in patients with PD [36].”
From Management of Treatment-Resistant Panic Disorder (2017) · cites this paper as [36]
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- Authors
- Perna, G., Bertani, A., Caldirola, D., Di Pasquale, D., Migliarese, G., & Bellodi, L.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- Corresponding author
- Perna, Giampaolo
- Venue
- Journal of Clinical Psychopharmacology
- Published
- 2004-06
- Volume
- 24
- Issue
- 3
- Pages
- 277-282
- ISSN
- 0271-0749 (ISSN-L)
- OpenAlex
- W1992554765
- Cited by
- 37
- References
- 52
- Citations by year
- 2026: 2 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 2 · 2012: 4
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- panic disorder, paroxetine, reboxetine, serotonergic system, noradrenergic system
- MeSH terms
- Reboxetine, Adolescent, Adult, Analysis of Variance, Carbon Dioxide, Double-Blind Method, Female, Humans, Male, Morpholines, Chi-Square Distribution, Bronchial Hyperreactivity, Panic Disorder, Paroxetine, Statistics, Nonparametric
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