Genetic progression in the pancreatic ducts
Open accessAbstract
The genetic progression described by Yamano et al in this issue of The American Journal of Pathology helps establish a progression model for pancreatic ductal carcinoma. This progression model has a number of important implications for the classification of lesions in the pancreas and for the future early detection and chemoprevention of pancreatic carcinoma.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
GEMMs combining Kras mutation with inactivation of Cdkn2a and Tp53, or with inactivation of TGFβ-SMAD4 signaling, develop invasive and metastatic PDAC, validating these tumor suppressor pathways in PDAC progression.
“GEMMs with compound mutations that combine Kras mutation with the inactivation of tumor suppressor genes Cdkn2a and Tp53, or with the inactivation of the TGFβ-SMAD4 signaling pathway in the pancreas develop invasive and metastatic PDAC (74–76), thus validating the role of these tumor suppressor pathways in PDAC progression (4).”
From KRAS mutation in pancreatic cancer (2021) · cites this paper as [4]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Greenlee, R. T., Murray, T., Bolden, S., & Wingo, P. A. (2000) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.50.1.7 · Cited by 3,850 · see citing works
Reducing Mortality from Colorectal Cancer by Screening for Fecal Occult Blood
Mandel, J. S., Bond, J. H., Church, T. R., Snover, D. C., Bradley, G. M., Schuman, L. M., & Ederer, F. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305133281901 · Cited by 3,221 · see citing works
Randomised study of screening for colorectal cancer with faecal-occult-blood test
Kronborg, O., Fenger, C., Olsen, J., Jørgensen, O. D., & Søndergaard, O. (1996) · The Lancet · doi:10.1016/s0140-6736(96)03430-7 · Cited by 2,495 · see citing works
<i>DPC4</i> , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., et al. (1996) · Science · doi:10.1126/science.271.5247.350 · Cited by 2,337 · see citing works
Self-citationTreatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis
Giardiello, F. M., Hamilton, S. R., Krush, A. J., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305063281805 · Cited by 1,729 · see citing works
Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386761a0 · Cited by 1,240 · see citing works
Pancreaticoduodenectomy for Cancer of the Head of the Pancreas 201 Patients
Yeo, C. J., Cameron, J. L., Lillemoe, K. D., Sitzmann, J. V., Hruban, R. H., Goodman, S. N., Dooley, W. C., Coleman, J., & Pitt, H. A. (1995) · Annals of Surgery · doi:10.1097/00000658-199506000-00011 · Cited by 945 · see citing works
Self-citationProgression model for pancreatic cancer.
Hruban, R. H., Goggins, M., Parsons, J., & Kern, S. E. (2000) · PubMed · Cited by 872 · see citing works
Self-citationRecent Advances in Chemoprevention of Cancer
Hong, W. K., & Sporn, M. B. (1997) · Science · doi:10.1126/science.278.5340.1073 · Cited by 826 · see citing works
Tumor-suppressive pathways in pancreatic carcinoma.
Rozenblum, E., Schutte, M. E. M., Goggins, M., Hahn, S. A., Panzer, S., ZAHURAK, M. L., Goodman, S. N., Sohn, T. A., Hruban, R. H., Yeo, C. J., et al. (1997) · PubMed · Cited by 693 · see citing works
Self-citationCyclooxygenase-2 expression is up-regulated in human pancreatic cancer.
Tucker, O., Dannenberg, A. J., Yang, E. K., Zhang, F., Teng, L., Daly, J. M., Soslow, R. A., Masferrer, J. L., Woerner, B. M., Koki, A. T., et al. (1999) · PubMed · Cited by 690 · see citing works
Hruban, R. H., van Mansfeld, A. D. M., Offerhaus, G. J. A., van Weering, D. H. J., Allison, D. C., Goodman, S. N., Kensler, T. W., Bose, K., Cameron, J. L., & Bos, J. L. (1993) · PubMed Central · Cited by 650 · see citing works
Self-citationWilentz, R. E., Iacobuzio–Donahue, C. A., Argani, P., McCarthy, D. M., Parsons, J. L., Yeo, C. J., Kern, S. E., & Hruban, R. H. (2000) · PubMed · Cited by 591 · see citing works
Self-citationRedston, M. S., Caldas, C., Seymour, A. B., Hruban, R. H., da Costa, L., Yeo, C. J., & Kern, S. E. (1994) · PubMed · Cited by 451 · see citing works
Self-citationp16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.
Moskaluk, C. A., Hruban, R. H., & Kern, S. E. (1997) · PubMed · Cited by 429 · see citing works
Self-citationPellegata, N. S., Sessa, F., Renault, B., Bonato, M., Leone, B. E., Solcia, E., & Ranzani, G. N. (1994) · PubMed · Cited by 389 · see citing works
Caldas, C., Hahn, S. A., Hruban, R. H., Redston, M. S., Yeo, C. J., & Kern, S. E. (1994) · PubMed · Cited by 377 · see citing works
Self-citationYanagisawa, A., Ohtake, K., Ohashi, K., Hori, M., Kitagawa, T., Sugano, H., & Kato, Y. (1993) · PubMed · Cited by 354 · see citing works
Morphological lesions associated with human primary invasive nonendocrine pancreas cancer.
Cubilla, A. L., & FITZGERALD, P. J. (1976) · PubMed · Cited by 352 · see citing works
Wilentz, R. E., Geradts, J., Maynard, R. D., Offerhaus, G. J. A., Kang, M., Goggins, M., Yeo, C. J., Kern, S. E., & Hruban, R. H. (1998) · PubMed · Cited by 337 · see citing works
Self-citationProgression of Pancreatic Intraductal Neoplasias to Infiltrating Adenocarcinoma of the Pancreas
Brat, D. J., Lillemoe, K. D., Yeo, C. J., Warfield, P. B., & Hruban, R. H. (1998) · The American Journal of Surgical Pathology · doi:10.1097/00000478-199802000-00003 · Cited by 309 · see citing works
Self-citationImmunohistochemical Labeling for Dpc4 Mirrors Genetic Status in Pancreatic Adenocarcinomas
Wilentz, R. E., Su, G. H., Dai, J. L., Sparks, A. B., Argani, P., Sohn, T. A., Yeo, C. J., Kern, S. E., & Hruban, R. H. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64703-7 · Cited by 304 · see citing works
Self-citationGenetic, Immunohistochemical, and Clinical Features of Medullary Carcinoma of the Pancreas
Wilentz, R. E., Goggins, M., Redston, M. S., Marcus, V., Adsay, V. N., Riall, T. S., Kadkol, S. S., Yeo, C. J., Choti, M. A., ZAHURAK, M. L., et al. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65035-3 · Cited by 281 · see citing works
Self-citationOverexpression of p53 Protein in Adenocarcinoma of the Pancreas
DiGiuseppe, J. A., Hruban, R. H., Goodman, S. N., Polak, M., van den Berg, F. M., Allison, D. C., Cameron, J. L., & Offerhaus, G. J. A. (1994) · American Journal of Clinical Pathology · doi:10.1093/ajcp/101.6.684 · Cited by 217 · see citing works
Self-citationBRCA2 Is Inactivated Late in the Development of Pancreatic Intraepithelial Neoplasia
Goggins, M., Hruban, R. H., & Kern, S. E. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65047-x · Cited by 213 · see citing works
Self-citationDay, J. D., DiGiuseppe, J. A., Yeo, C. J., Lai-Goldman, M., Anderson, S. M., Goodman, S. N., Kern, S. E., & Hruban, R. H. (1996) · Human Pathology · doi:10.1016/s0046-8177(96)90364-0 · Cited by 211 · see citing works
Self-citationPancreatic Duct Hyperplasia and Cancer
Sommers, S. C., Murphy, S. A., & Warren, S. (1954) · Gastroenterology · doi:10.1016/s0016-5085(19)36105-0 · Cited by 181 · see citing works
The c ‐ erbB ‐ 2 proto‐oncogene in human pancreatic cancer
Hall, P. A., Hughes, C. M., Staddon, S., et al. (1990) · The Journal of Pathology · doi:10.1002/path.1711610305 · Cited by 171 · see citing works
Genetic Progression and Divergence in Pancreatic Carcinoma
Yamano, M., Fujii, H., Takagaki, T., Kadowaki, N., Watanabe, H., & Shirai, T. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65083-3 · Cited by 160 · see citing works
Kl�ppel, G., Bommer, G., R�ckert, K., & Seifert, G. (1980) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00430702 · Cited by 156 · see citing works
Kronborg, O., Fenger, C., Olsen, J. H., et al. (1989) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528909093096 · Cited by 147 · see citing works
Colonic mucosal proliferation is related to serum deoxycholic acid levels
Ochsenkühn, T., Bayerdörffer, E., Meining, A. G., Schinkel, M., Thiede, C., Nüssler, V., Sackmann, M. F., Hatz, R. A., Neubauer, A., & Paumgartner, G. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990415)85:8 · Cited by 138 · see citing works
THE RESULTS OF TREATMENT OF 4389 CASES OF PRECLINICAL CERVICAL SQUAMOUS CARCINOMA
Boyes, D. A., Worth, A. J., & Fidler, H. K. (1970) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1970.tb04397.x · Cited by 137 · see citing works
DiGiuseppe, J. A., Hruban, R. H., Offerhaus, G. J. A., et al. (1994) · PubMed · Cited by 137 · see citing works
Self-citationEndometriosis of the urinary bladder in a man with prostatic carcinoma
Pinkert, T. C., Catlow, C. E., & Straus, R. (1979) · Cancer · doi:10.1002/1097-0142(197904)43:4 · Cited by 110 · see citing works
Brockie, E. S., Anand, A., & Albores‐Saavedra, J. (1998) · Annals of Diagnostic Pathology · doi:10.1016/s1092-9134(98)80020-8 · Cited by 89 · see citing works
Furukawa, T., Chiba, R., Kobari, M., Matsuno, S., Nagura, H., & Takahashi, T. (1994) · PubMed · Cited by 82 · see citing works
Pathology of incipient pancreatic cancer
Hruban, R. H., Wilentz, R. E., Goggins, M., Offerhaus, G. J. A., Yeo, C. J., & Kern, S. E. (1999) · Annals of Oncology · doi:10.1093/annonc/10.suppl_4.s9 · Cited by 76 · see citing works
Self-citationSchultz, K. R., Ranade, S., Neglia, J. P., & Ravindranath, Y. (1993) · Cancer · doi:10.1002/1097-0142(19930701)72:1 · Cited by 50 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [9]9. Kozuka, S ∙ Sassa, R ∙ Taki, T ... Relation of pancreatic duct hyperplasia to carcinoma Cancer. 1979; 43:1418-1428 Crossref Scopus (309) PubMed Google Scholar
Cited by
Sorted by citations
Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609 · see citing works
Self-citationPreinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471 · see citing works
Self-citationGuerra, C., Schuhmacher, A. J., Cañamero, M., Grippo, P. J., Verdaguer, L., Pérez-Gallego, L., Dubus, P., Sandgren, E. P., & Barbacid, M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.012 · Cited by 1,224 · see citing works
Maitra, A., Adsay, N. V., Argani, P., Iacobuzio-Donahue, C., De Marzo, A., Cameron, J. L., Yeo, C. J., & Hruban, R. H. (2003) · Modern Pathology · doi:10.1097/01.mp.0000086072.56290.fb · Cited by 429 · see citing works
Self-citationZhang, W., Nandakumar, N., Shi, Y., Manzano, M., Smith, A., Graham, G., Gupta, S., Vietsch, E. E., Laughlin, S. Z., Wadhwa, M., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2005049 · Cited by 360 · see citing works
KRAS mutation in pancreatic cancer
Luo, J. (2021) · Seminars in Oncology · doi:10.1053/j.seminoncol.2021.02.003 · Cited by 360 · see citing works
Telomere Shortening Is Nearly Universal in Pancreatic Intraepithelial Neoplasia
van Heek, N. T., Meeker, A. K., Kern, S. E., Yeo, C. J., Lillemoe, K. D., Cameron, J. L., Offerhaus, G. J. A., Hicks, J. L., Wilentz, R. E., Goggins, M. G., et al. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64432-x · Cited by 363 · see citing works
Self-citationLöhr, M., Klöppel, G., Maisonneuve, P., Lowenfels, A. B., & Lüttges, J. (2005) · Neoplasia · doi:10.1593/neo.04445 · Cited by 343 · see citing works
“evolution of PanINs [38].”
Inflammation and the development of pancreatic cancer
Farrow, B., & Evers, B. M. (2002) · Surgical Oncology · doi:10.1016/s0960-7404(02)00015-4 · Cited by 338 · see citing works
Molecular pathogenesis of pancreatic cancer
Hansel, D. E., Kern, S. E., & Hruban, R. H. (2003) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.4.070802.110341 · Cited by 159 · see citing works
Self-citationHustinx, S. R., Leoni, L. M., Yeo, C. J., Brown, P. N., Goggins, M., Kern, S. E., Hruban, R. H., & Maitra, A. (2005) · Modern Pathology · doi:10.1038/modpathol.3800377 · Cited by 125 · see citing works
Self-citationEpithelial and stromal co-evolution and complicity in pancreatic cancer
Hingorani, S. R. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00530-w · Cited by 108 · see citing works
Qiu, W., Sahin, F., Iacobuzio-Donahue, C. A., Garcia-Carracedo, D., Wang, W. M., Kuo, C.-Y., Chen, D., Arking, D. E., Lowy, A. M., Hruban, R. H., et al. (2011) · Oncotarget · doi:10.18632/oncotarget.357 · Cited by 99 · see citing works
Self-citationPAM4-Reactive MUC1 Is a Biomarker for Early Pancreatic Adenocarcinoma
Gold, D. V., Karanjawala, Z., Modrak, D. E., Goldenberg, D. M., & Hruban, R. H. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1488 · Cited by 93 · see citing works
Self-citationNotch2-positive progenitors with the intrinsic ability to give rise to pancreatic ductal cells
Lee, K. M., Yasuda, H., Hollingsworth, M. A., & Ouellette, M. M. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700298 · Cited by 88 · see citing works
Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers
Rajbhandari, N., Lin, W.-C., Wehde, B. L., Triplett, A. A., & Wagner, K.-U. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.013 · Cited by 68 · see citing works
Matsuda, Y. (2019) · Pathology International · doi:10.1111/pin.12837 · Cited by 61 · see citing works
Human Pancreatic Duct Epithelial Cell Model for KRAS Transformation
(2008) · Methods in Enzymology · doi:10.1016/s0076-6879(07)00401-6 · Cited by 39 · see citing works
Plangger, A., Rath, B., Stickler, S., Hochmair, M., Lang, C., Weigl, L., Funovics, M., & Hamilton, G. (2022) · Discover Oncology · doi:10.1007/s12672-022-00550-w · Cited by 25 · see citing works
- Authors
- Hruban, R. H., Wilentz, R. E., & Kern, S. E.
- Affiliations
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Johns Hopkins Hospital (US)
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 156
- Issue
- 6
- Pages
- 1821-1825
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC1850064
- OpenAlex
- W1980741832
- Cited by
- 373
- References
- 39
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 9 · 2022: 7 · 2021: 7 · 2020: 2 · 2019: 9 · 2018: 10 · 2017: 14 · 2016: 11 · 2015: 14 · 2014: 14 · 2013: 15 · 2012: 13
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- American Journal Of Pathology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (CA62924)
- National Cancer Institute (P50CA062924, CA 62924)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Keywords
- pancreatic ductal carcinoma, progression model, pancreatic duct, early detection, chemoprevention
- MeSH terms
- Animals, Humans, Pancreatic Ducts, Pancreatic Neoplasms, Precancerous Conditions, Genes, ras, Gene Expression, Genes, Tumor Suppressor, Carcinoma, Ductal, Breast, Disease Progression, Genes, erbB-2, Loss of Heterozygosity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
