Cited by 936Pancreatic and Hepatic Oncology ResearchCancer Genomics and DiagnosticsPancreatitis Pathology and Treatment

Phenotype and Genotype of Pancreatic Cancer Cell Lines

Open access
Deer, Emily L., González-Hernández, Jessica, Coursen, Jill D., Shea, Jill E., Ngatia, Josephat, Scaife, Courtney L., Firpo, Matthew A., Mulvihill, Sean J.·2010·Pancreas

Abstract

The dismal prognosis of pancreatic adenocarcinoma is due in part to a lack of molecular information regarding disease development. Established cell lines remain a useful tool for investigating these molecular events. Here we present a review of available information on commonly used pancreatic adenocarcinoma cell lines as a resource to help investigators select the cell lines most appropriate for their particular research needs. Information on clinical history; in vitro and in vivo growth characteristics; phenotypic characteristics, such as adhesion, invasion, migration, and tumorigenesis; and genotypic status of commonly altered genes (KRAS, p53, p16, and SMAD4) was evaluated. Identification of both consensus and discrepant information in the literature suggests careful evaluation before selection of cell lines and attention be given to cell line authentication.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1097/mpa.0b013e3181c15963

Cites

125 of 125 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Discrepancies in mutational status of TP53 and CDKN2A/p16 among cell lines caution researchers about discrepancies between laboratory-specific and literature-reported mutational statuses.

    “Discrepancies in the mutational status of TP53 and CDKN2A/p16 among cell lines caution researchers about discrepancies between laboratory-specific and literature-reported mutational statuses [20].”
  • The MiaPaca2 cell line was initially generated from a primary PDAC lesion of a 65-year-old male with tumor involving pancreatic body, tail, and periaortic invasion.

    “The MiaPaca2 cell line was initially generated from a primary PDAC lesion of a 65-year-old male, where the tumor had involved the pancreatic body, tail, and demonstrated periaortic invasion24.”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

1 retracted

Flagged first, then by citations

Research works printed but not linked: 3

  1. [24]Givant-Horwitz V Davidson B Reich R Laminin-induced signaling in tumor cells: the role of the M(r) 67,000 laminin receptor Cancer Res 2004 64 3572 3579 15150114
  2. [45]Jimenez RE Hartwig W Antoniu BA Effect of matrix metalloproteinase inhibition on pancreatic cancer invasion and metastasis: an additive strategy for cancer control Ann Surg 2000 231 644 654 10767785 PMC1421051
  3. [65]Poligone B Baldwin AS Positive and negative regulation of NF-kappaB by COX-2: roles of different prostaglandins J Biol Chem 2001 276 38658 38664 11509575

Cited by

Sorted by citations

Authors
Deer, E. L., González-Hernández, J., Coursen, J. D., Shea, J. E., Ngatia, J., Scaife, C. L., Firpo, M. A., & Mulvihill, S. J.
Affiliations
University of Utah (US)
Venue
Pancreas
Published
2010-05
Volume
39
Issue
4
Pages
425-435
ISSN
0885-3177 (ISSN-L)
OpenAlex
W2168992025
Cited by
936
References
125
Citations by year
2026: 34 · 2025: 50 · 2024: 67 · 2023: 67 · 2022: 83 · 2021: 84 · 2020: 84 · 2019: 84 · 2018: 77 · 2017: 79 · 2016: 63 · 2015: 39 · 2014: 58 · 2013: 23 · 2012: 29
FWCI
2.34
Type
journal article
Language
en
Open access
Locations
  • Pancreas (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (T35 HL 07744, T35HL007744)
Topics
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
  • Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
Keywords
pancreatic ductal adenocarcinoma, pancreatic cancer cell lines, cell line selection, cell line authentication, cell adhesion, cell invasion, cell migration, tumorigenicity, KRAS mutation, p53, p16, SMAD4, molecular alterations
MeSH terms
Genotype, Humans, Pancreatic Neoplasms, Phenotype, Proto-Oncogene Proteins, Tumor Suppressor Protein p53, Proto-Oncogene Proteins p21(ras), ras Proteins, Cyclin-Dependent Kinase Inhibitor p16, Cell Line, Tumor, Smad4 Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review