The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Contribution of Depression to Cognitive Impairment and Dementia in Older Adults
Abstract
BACKGROUND: The objective of this review is to provide information for clinicians regarding current research and opinions on the association of depression to conditions of cognitive impairment and dementia. We also intend to integrate this current research and thinking into strategies for the assessment and treatment of depression in the context of cognitive impairment. REVIEW SUMMARY: Depression is highly prevalent in mild cognitive impairment and most dementias. It may be a risk factor for the subsequent development of dementia and in some conditions may be a prodromal symptom. It is important to detect and effectively treat depression because the comorbidity of depression and cognitive impairment is associated with greater cognitive and functional decline and higher rates of institutionalization. Depression often can be differentiated from Alzheimer disease and other dementias based on characteristics of clinical history and presentation. Screening of depression and cognitive impairment will help characterize the presence and severity of these conditions, but limitations in screening approaches may necessitate comprehensive assessment in complex cases where differential diagnosis is important to treatment planning. CONCLUSION: Although depression and cognitive impairment are important issues in the treatment of older adults, there are particular risks when they occur together. Appropriate assessment and screening can help guide the clinician to appropriate and timely interventions. Pharmacologic and nonpharmacologic treatment approaches are both efficacious in reducing depression in cognitive impairment and dementia.
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Cites
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Mild Cognitive Impairment: Clinical Characterization and Outcome
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“Experimental studies have found depressed individuals to be most prominently affected in the domains of executive function,(11,17) memory,(17,18) and processing speed,(19) results that are consistent with meta-analyses of the broader literature.(20,21) Increasing severity of depression and specific symptoms reflecting…”
ResultExecutive Dysfunction and Long-term Outcomes of Geriatric Depression
Alexopoulos, G. S., Meyers, B. S., Young, R. C., Kalayam, B., Kakuma, T., Gabrielle, M., Sirey, J. A., & Hull, J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.3.285 · Cited by 486
Cited by
Diffusion tensor imaging of cerebral white matter integrity in cognitive aging
Madden, D. J., Bennett, I. J., Burzynska, A., Potter, G. G., Chen, N.-K., & Song, A. W. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.08.003 · Cited by 472
Self-citationDodd, J. W., Getov, S. V., & Jones, P. W. (2010) · European Respiratory Journal · doi:10.1183/09031936.00125109 · Cited by 426
Naismith, S. L., Norrie, L. M., Mowszowski, L., & Hickie, I. B. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.009 · Cited by 270
Emotion and episodic memory in neuropsychiatric disorders
Dere, E., Pause, B. M., & Pietrowsky, R. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.03.017 · Cited by 165
Larouche, E., Hudon, C., & Goulet, S. (2019) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2018.11.008 · Cited by 41
Metadata
- Authors
- Potter, G. G., & Steffens, D. C.
- Venue
- The Neurologist
- Published
- 2007-05
- Volume
- 13
- Issue
- 3
- Pages
- 105-117
- ISSN
- 1074-7931 (ISSN-L)
- OpenAlex
- W2085013652
- Cited by
- 209
- References
- 22
- FWCI
- 8.01
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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