Biological correlates of abuse in women with premenstrual dysphoric disorder and healthy controls
Abstract
OBJECTIVE: To examine the biological correlates associated with histories of sexual or physical abuse in women meeting DSM criteria for premenstrual dysphoric disorder (PMDD) and in healthy, non-PMDD controls. METHODS: Twenty-eight women with prospectively confirmed PMDD were compared with 28 non-PMDD women for cardiovascular and neuroendocrine measures at rest and in response to mental stressors, and for beta-adrenergic receptor responsivity, during both the follicular and luteal phase of the menstrual cycle. Structured interview was used to assess psychiatric history and prior sexual and physical abuse experiences. All subjects were free of current psychiatric comorbidity and medication use. RESULTS: More PMDD women had prior sexual and physical abuse experiences than controls (20 vs. 10, respectively). Relative to nonabused PMDD women, PMDD women with prior abuse (sexual or physical) exhibited significantly lower resting norepinephrine (NE) levels and significantly greater beta1- and beta2-adrenoceptor responsivity and greater luteal phase NE reactivity to mental stress. For non-PMDD control women, abuse was associated with blunted cortisol, cardiac output, and heart rate reactivity to mental stress relative to nonabused controls. CONCLUSIONS: The results of this initial study suggest that a history of prior abuse is associated with alterations in physiological reactivity to subsequent mental stress in women, but that the biological correlates of abuse may be different for PMDD vs. non-PMDD women.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dysregulation of allostatic systems can manifest as either hypo- or hyper-responsiveness to stress later in life, with consequent impairment in endogenous pain regulation.
“However, dysregulation of allostatic systems can manifest as either hypo- or hyper- responsiveness to stress later in life,(14–16) with consequent impairment in endogenous pain regulation.(17–19)”
Dysregulation of allostatic systems can manifest as either hypo- or hyper-responsiveness to stress later in life, with consequent impairment in endogenous pain regulation.
“However, dysregulation of allostatic systems can manifest as either hypo- or hyper- responsiveness to stress later in life,(14–16) with consequent impairment in endogenous pain regulation.(17–19)”
Adult women with a history of abuse show blunted cortisol reactivity to challenge.
“This is consistent with research from our group demonstrating blunted cortisol reactivity to challenge in adult women with a history of abuse.(14)”
Cites
Kirschbaum, C., Pirke, K.-M., & Hellhammer, D. H. (2008) · Neuropsychobiology · doi:10.1159/000119004 · Cited by 6,093 · see citing works
Heim, C. (2000) · JAMA · doi:10.1001/jama.284.5.592 · Cited by 1,968 · see citing works
Resnick, H. S., Kilpatrick, D. G., Dansky, B. S., Saunders, B. E., & al, E. (1993) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.61.6.984 · Cited by 1,868 · see citing works
Resnick, H. S., Kilpatrick, D. G., Dansky, B. S., Saunders, B. E., & Best, C. L. (1993) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.61.6.984 · Cited by 1,868 · see citing works
The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders
Heim, C., Ehlert, U., & Hellhammer, D. H. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00035-9 · Cited by 1,688 · see citing works
Methodological Guidelines for Impedance Cardiography
Sherwood, A., Allen, M. T., Fahrenberg, J., Kelsey, R. M., Lovallo, W. R., & van Doornen, L. J. P. (1990) · Psychophysiology · doi:10.1111/j.1469-8986.1990.tb02171.x · Cited by 1,169 · see citing works
Self-citationDevelopment and evaluation of an impedance cardiac output system.
Kubicek, W. G., Karnegis, J. N., PATTERSON, R. P., Witsoe, D. A., & Mattson, R. H. (1966) · PubMed · Cited by 1,143 · see citing works
Hemodynamics of Blood Pressure Responses During Active and Passive Coping
Sherwood, A., Dolan, C. A., & Light, K. C. (1990) · Psychophysiology · doi:10.1111/j.1469-8986.1990.tb03189.x · Cited by 420 · see citing works
Self-citationEffect of previous trauma on acute plasma cortisol level following rape
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.11.1675 · Cited by 418 · see citing works
Abuse-Related Posttraumatic Stress Disorder: Evidence for Chronic Neuroendocrine Activation in Women
Lemieux, A. M., & Coe, C. L. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199503000-00002 · Cited by 411 · see citing works
Stein, M. B., Yehuda, R., Koverola, C., & Hanna, C. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00489-1 · Cited by 345 · see citing works
Sexual and Physical Abuse History in Gastroenterology Practice
Leserman, J., Drossman, D. A., Li, Z., Toomey, T. C., Nachman, G., & Glogau, L. (1996) · Psychosomatic Medicine · doi:10.1097/00006842-199601000-00002 · Cited by 341 · see citing works
Self-citationAllopregnanolone levels and reactivity to mental stress in premenstrual dysphoric disorder.
Girdler, S., Straneva, P. A., Light, K., Pedersen, C., & Morrow, A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01044-1 · Cited by 268 · see citing works
Self-citationKaufman, J., Birmaher, B., Perel, J., Dahl, R. E., Moreci, P., Nelson, B., Wells, W., & Ryan, N. D. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00470-2 · Cited by 263 · see citing works
A Standardized Isoproterenol Sensitivity Test
Cleaveland, C. R. (1972) · Archives of Internal Medicine · doi:10.1001/archinte.1972.03650010035007 · Cited by 227 · see citing works
Human β-Adrenoceptors: Relation of Myocardial and Lymphocyte β-Adrenoceptor Density
Brodde, O., Kretsch, R., Ikezono, K., et al. (1986) · Science · doi:10.1126/science.3006250 · Cited by 179 · see citing works
Orr, S. P., Lasko, N. B., Metzger, L. J., Berry, N. J., Ahern, C. E., & Pitman, R. K. (1998) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.66.6.906 · Cited by 173 · see citing works
Orr, S. P., Lasko, N. B., Metzger, L. J., et al. (1998) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.66.6.906 · Cited by 139 · see citing works
Physiologic reactivity to startling tones in women with posttraumatic stress disorder.
Metzger, L. J., Orr, S. P., Berry, N. J., Ahern, C. E., Lasko, N. B., & Pitman, R. K. (1999) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.108.2.347 · Cited by 127 · see citing works
Bancroft, J., Cook, A., Davidson, D., Bennie, J., & Goodwin, G. M. (1991) · Psychological Medicine · doi:10.1017/s0033291700020407 · Cited by 122 · see citing works
Prevalence of sexual abuse history in a sample of women seeking treatment for premenstrual syndrome
Golding, J. M., Taylor, D. L., Menard, L., & King, M. (2000) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.3109/01674820009075612 · Cited by 120 · see citing works
Physiologic reactivity to startling tones in women with posttraumatic stress disorder.
Metzger, L. J., Orr, S. P., Berry, N. J., et al. (1999) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.108.2.347 · Cited by 100 · see citing works
Menstrual cycle and premenstrual syndrome: Modifiers of cardiovascular reactivity in women.
Girdler, S. S., Pedersen, C. A., Stern, R. A., & Light, K. C. (1993) · Health Psychology · doi:10.1037/0278-6133.12.3.180 · Cited by 95 · see citing works
Self-citationHypothalamic-Pituitary-Adrenal Function in Patients with the Premenstrual Syndrome
Rabin, D. S., Schmidt, P. J., CAMPBELL, G., Gold, P. W., Jensvold, M. F., Rubinow, D. R., & Chrousos, G. P. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-5-1158 · Cited by 93 · see citing works
Wang, S., & Mason, J. W. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199903000-00001 · Cited by 68 · see citing works
Psychosocial factors in premenstrual dysphoria: Stressors, appraisal, and coping processes
Fontana, A. M., & Palfai, T. G. (1994) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(94)90053-1 · Cited by 67 · see citing works
Sexual Abuse and Premenstrual Syndrome
Paddison, P. L., Gise, L. H., Lebovits, A., Strain, J. J., Cirasole, D. M., & Levine, J. P. (1990) · Psychosomatics · doi:10.1016/s0033-3182(90)72162-7 · Cited by 64 · see citing works
Sherwood, A., & Hinderliter, A. L. (1993) · American Journal of Hypertension · doi:10.1093/ajh/6.7.630 · Cited by 62 · see citing works
Self-citationNoradrenaline in basic models of depression
Leonard, B. E. (1997) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(97)00415-x · Cited by 55 · see citing works
A psychoendocrine study of premenstrual tension syndrome
Haskett, R. F., Steiner, M. S., & Carroll, B. J. (1984) · Journal of Affective Disorders · doi:10.1016/0165-0327(84)90024-7 · Cited by 45 · see citing works
CSF and endocrine studies of premenstrual syndrome.
Bl, P., Rh, G., Jn, W., et al. (1991) · PubMed · Cited by 45 · see citing works
Redei, E., & Freeman, E. W. (1993) · European Journal of Endocrinology · doi:10.1530/acta.0.1280536 · Cited by 41 · see citing works
Fontana, A. M., & Badawy, S. Z. A. (1997) · Behavioral Medicine · doi:10.1080/08964289.1997.10543548 · Cited by 38 · see citing works
Rubinow, D. R., & Schmidt, P. J. (1992) · The Endocrinologist · doi:10.1097/00019616-199201000-00008 · Cited by 34 · see citing works
Sexual Assault History and Premenstrual Distress in Two General Population Samples
GOLDING, J. M., & Taylor, D. (1996) · Journal of Women s Health · doi:10.1089/jwh.1996.5.143 · Cited by 33 · see citing works
The Effect of Hypertension, Sodium, and Race on Isoproterenol Sensitivity
Dimsdale, J. E., Ziegler, M. G., & Graham, R. M. (1988) · Clinical and Experimental Hypertension · doi:10.1080/07300077.1988.11878781 · Cited by 32 · see citing works
Cortisol Response to Dexamethasone in Women with Premenstrual Syndrome
Roy‐Byrne, P., Rubinow, D. R., Gwirtsman, H. E., Hoban, C., & Grover, G. N. (2008) · Neuropsychobiology · doi:10.1159/000118298 · Cited by 29 · see citing works
Thyroid Axis Sustaining Hypothesis of Posttraumatic Stress Disorder
Prange, A. J. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199903000-00002 · Cited by 25 · see citing works
Gurguis, G. N. M., Yonkers, K. A., Blakeley, J. E., et al. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(98)00025-0 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Miller, G. E., Chen, E., & Zhou, E. S. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.1.25 · Cited by 2,467 · see citing works
The neurobiology of stress and development.
Gunnar, M., & Quevedo, K. (2007) · Annual Review of Psychology · doi:10.1146/annurev.psych.58.110405.085605 · Cited by 2,011 · see citing works
Miller, G. E., Chen, E., & Parker, K. J. (2011) · Psychological Bulletin · doi:10.1037/a0024768 · Cited by 1,785 · see citing works
Neurosteroids in the context of stress: implications for depressive disorders
Girdler, S. S., & Klatzkin, R. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.05.006 · Cited by 148 · see citing works
Self-citationGirdler, S. S., Leserman, J., Bunevicius, R., Klatzkin, R., Pedersen, C. A., & Light, K. C. (2007) · Health Psychology · doi:10.1037/0278-6133.26.2.201 · Cited by 73 · see citing works
Self-citationAndersen, E., Geiger, P., Schiller, C., Bluth, K., Watkins, L., Zhang, Y., Xia, K., Tauseef, H., Leserman, J., Girdler, S., et al. (2021) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000889 · Cited by 19 · see citing works
Self-citation
- Authors
- Girdler, S. S., Sherwood, A., Hinderliter, A. L., Leserman, J., Costello, N. L., Straneva, P. A., Pedersen, C. A., & Light, K. C.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- Psychosomatic Medicine
- Published
- 2003-09
- Volume
- 65
- Issue
- 5
- Pages
- 849-856
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2095116865
- Cited by
- 85
- References
- 39
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 8 · 2013: 6 · 2012: 6
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH051246, R01-MH51246)
- National Center for Research Resources (RR00046, M01RR000046)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- premenstrual dysphoric disorder, child sexual abuse, physical abuse, norepinephrine, cortisol, heart rate reactivity, cardiac output, menstrual cycle, luteal phase, women
- MeSH terms
- Adult, Cardiography, Impedance, Child, Child Abuse, Child Abuse, Sexual, Female, Follicular Phase, Hemodynamics, Humans, Hydrocortisone, Interview, Psychological, Luteal Phase, Norepinephrine, Premenstrual Syndrome, Prospective Studies, Receptors, Adrenergic, beta, Sex Offenses, Stress, Psychological, Violence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
