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Cited by 54Advanced MRI Techniques and ApplicationsLanthanide and Transition Metal ComplexesCharacterization and Applications of Magnetic Nanoparticles

Comparison of the iron oxide-based blood-pool contrast medium VSOP-C184 with gadopentetate dimeglumine for first-pass magnetic resonance angiography of the aorta and renal arteries in pigs

Schnorr, Jörg, Wagner, Susanne, Abramjuk, Claudia, Wojner, Ines, Schink, Tania, Kroencke, Thomas J., Schellenberger, Eyk, Hamm, Bernd +2 more·2004·Investigative Radiology
DOI 10.1097/01.rli.0000133944.30119.cc
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Abstract

RATIONALE AND OBJECTIVES: VSOP-C184 at a dose of 0.045 mmol Fe/kg has been shown to be an efficient blood pool contrast medium for equilibrium magnetic resonance angiography (MRA) that can be administered as a bolus. The present study was performed to determine whether VSOP-C184 is also suitable for first-pass MRA. MATERIALS AND METHODS: Fifteen MRA examinations at 1.5 T were performed in minipigs using a fast 3D fast low-angle shot (FLASH) sequence (repetition time = 4.5 ms, echo time = 1.7 ms, excitation angle = 25 degrees, matrix 256, body phased-array coil). The citrate-stabilized iron oxide preparation VSOP-C184 was investigated (total particle diameter: 7.0 +/- 0.15 nm; core size: 4 nm) and compared with gadopentetate dimeglumine (Gd-DTPA). The following doses were tested: VSOP-C184: 0.015, 0.025, and 0.035 mmol Fe/kg; Gd-DTPA: 0.1 and 0.2 mmol Gd/kg; n = 3 examinations/dose. Data were analyzed quantitatively (signal enhancement (ENH) and vessel edge definition (VED)) and qualitatively. RESULTS: First-pass MRA using the 3 doses of VSOP-C184 yielded the following ENH: aorta: 9.4 +/- 2.6; 12.31 +/- 1.2; 16.53 +/- 1.7; renal arteries: 7.6 +/- 2.2; 9.9 +/- 1.0; 13.2 +/- 0.5. The values for the 2 doses of Gd-DTPA were aorta: 12.9 +/- 1.0; 16.8 +/- 2.2; renal arteries: 11.2 +/- 1.23; 11.3 +/- 1.7. VED for the 3 doses of VSOP-C184 was aorta: 106.3 +/- 31.0; 135.3 +/- 58.8; 141.3 +/- 71.0; renal arteries: 102.2 +/- 24.3; 146.8 +/- 63.0; 126.9 +/- 37.6 and for the 2 doses of Gd-DTPA, aorta: 157.2 +/- 47.8; 164.2 +/- 36.8; renal arteries: 165.9 +/- 30.4; 170.3 +/- 38.2 respectively. The differences between VSOP-C184 and Gd-DTPA are clinically not relevant and statistically not significant (p > or = .05). Qualitative evaluation of image quality, contrast, and delineation of vessels showed the results obtained with VSOP-C184 at doses of 0.025 and 0.035 mmol Fe/kg to be similar to those of Gd-DTPA at 0.1 and 0.2 mmol Gd/kg. CONCLUSION: VSOP-C184 is suitable for first-pass MRA at doses of 0.025 and 0.035 mmol Fe/kg and thus, in addition to its blood pool characteristics, allows for selective visualization of the arteries without interfering venous signal.

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Authors
Schnorr, J., Wagner, S., Abramjuk, C., Wojner, I., Schink, T., Kroencke, T. J., Schellenberger, E., Hamm, B., Pilgrimm, H., & Taupitz, M.
Affiliations
Charité – Universitätsmedizin Berlin (DE)
Corresponding author
  • Schnorr, Jörg
  • Wagner, Susanne
  • Abramjuk, Claudia
  • Wojner, Ines
  • Schellenberger, Eyk
  • Hamm, Bernd
  • Taupitz, Matthias
ORCID
Venue
Investigative Radiology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-09
Volume
39
Issue
9
Pages
546-553
ISSN
0020-9996 (ISSN-L)
DOI
10.1097/01.rli.0000133944.30119.cc
OpenAlex
W2102134842
Cited by
54
References
36
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 2
FWCI
4.75
Type
journal article
Language
en
Open access
closed
Locations
  • Investigative Radiology (publishedVersion)
  • PubMed (publishedVersion)
  • OPUS (Augsburg University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
Keywords
Gd-DTPA, iron oxide contrast agents, aorta, renal artery, signal amplification, dose comparison, minipigs, FLASH sequence, gadolinium-based contrast agents, liver function
MeSH terms
Animals, Aorta, Abdominal, Contrast Media, Ferric Compounds, Renal Artery, Swine, Swine, Miniature, Magnetic Resonance Angiography, Gadolinium DTPA, Ferrosoferric Oxide

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