Pneumonia models and innate immunity to respiratory bacterial pathogens

Knapp, Sylvia; Schultz, Marcus J; Poll, Tom van der

doi:10.1097/01.shk.0000191385.41689.f3

Cited by 56Sepsis Diagnosis and TreatmentImmune Response and InflammationInflammation biomarkers and pathways

Pneumonia models and innate immunity to respiratory bacterial pathogens

Knapp, Sylvia, Schultz, Marcus J, Poll, Tom van der·2005·Shock

DOI 10.1097/01.shk.0000191385.41689.f3

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Abstract

Preclinical sepsis models have been used for decades to study the pathophysiologic processes during sepsis and shock. Although these studies revealed promising immunomodulating agents for the treatment of sepsis, clinical trials evaluating the efficacy of these new agents in patients with sepsis were disappointing. The main reason for this unsatisfactory experience might be that unlike the clinical situation, most of these preclinical models are devoid of a localized infectious source from which the infection disseminates. Studies on the effects of several immunomodulating strategies have demonstrated strikingly opposite results when sepsis models with a more natural route of infection, such as pneumonia, were used. In this review, we will give insights into pneumonia models and discuss results and differences in the innate immune responses during distinct pulmonary infection models.

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Resident alveolar macrophages are considered the most important first line of defense against respiratory pneumococcal infections.
“Among host innate immune players, resident alveolar macrophages (AMs) are considered to be the most important first line of defense against respiratory pneumococcal infections (13), through their high phagocytic capacity (14–16).”
From Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections (2013) · cites this paper as [13]

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Authors: Knapp, S., Schultz, M. J., & Poll, T. V. D.
Affiliations: University of Vienna (AT)
University of Amsterdam (NL)
Corresponding author: Knapp, Sylvia
ORCID: Knapp, Sylvia
Schultz, Marcus J
Poll, Tom van der
Venue: Shock
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-12
Volume: 24
Issue: Supplement 1
Pages: 12-18
ISSN: 1073-2322 (ISSN-L)
DOI: 10.1097/01.shk.0000191385.41689.f3
OpenAlex: W2044306937
Cited by: 56
References: 74
Citations by year: 2025: 2 · 2024: 1 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 4 · 2013: 3 · 2012: 5
FWCI: 0.85
Type: journal article
Language: en
Open access: closed
Locations: Shock (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords: innate immunity, bacterial respiratory pathogens, sepsis model, immunomodulating agents, pulmonary infection, sepsis
MeSH terms: Animals, Communicable Diseases, Disease Models, Animal, Humans, Immunity, Innate, Immunologic Factors, Pneumonia, Bacterial, Sepsis

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Pneumonia models and innate immunity to respiratory bacterial pathogens

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