Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection

Dockrell, David H; Marriott, Helen M; Prince, Lynne R; Ridger, Victoria C; Ince, Paul G; Hellewell, Paul G; Whyte, Moira K B

doi:10.4049/jimmunol.171.10.5380

Cited by 239Pneumonia and Respiratory InfectionsPhagocytosis and Immune RegulationImmune Response and Inflammation

Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection

Open access

Dockrell, David H, Marriott, Helen M, Prince, Lynne R, Ridger, Victoria C, Ince, Paul G, Hellewell, Paul G, Whyte, Moira K B·2003·The Journal of Immunology

DOI 10.4049/jimmunol.171.10.5380

Open this paper in CoChat — free account Open PDF

Abstract

The role of alveolar macrophages (AM) in host defense against pulmonary infection has been difficult to establish using in vivo models. This may reflect a reliance on models of fulminant infection. To establish a unique model of resolving infection, with which to address the function of AM, C57BL/6 mice received low-dose intratracheal administration of pneumococci. Administration of low doses of pneumococci produced a resolving model of pulmonary infection characterized by clearance of bacteria without features of pneumonia. AM depletion in this model significantly increased bacterial outgrowth in the lung. Interestingly, a significant increase in the number of apoptotic AM was noted with the low-dose infection as compared with mock infection. Caspase inhibition in this model decreased AM apoptosis and increased the number of bacteremic mice, indicating a novel role for caspase activation in pulmonary innate defense against pneumococci. These results suggest that AM play a key role in clearance of bacteria from the lung during subclinical infection and that induction of AM apoptosis contributes to the microbiologic host defense against pneumococci.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.4049/jimmunol.171.10.5380

Cites

68 of 68 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Resident alveolar macrophages have high phagocytic capacity.
“Among host innate immune players, resident alveolar macrophages (AMs) are considered to be the most important first line of defense against respiratory pneumococcal infections (13), through their high phagocytic capacity (14–16).”
From Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections (2013) · cites this paper as [15]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287 · see citing works
Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications
van Rooijen, N., & Sanders, A. (1994) · Journal of Immunological Methods · doi:10.1016/0022-1759(94)90012-4 · Cited by 1,763 · see citing works
Shigella flexneri induces apoptosis in infected macrophages
Zychlinsky, A., Prévost, M., & Sansonetti, P. (1992) · Nature · doi:10.1038/358167a0 · Cited by 1,259 · see citing works
Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production
Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A. B., Quintal, L. J., Sekut, L., Talanian, R. V., Paskind, M. P., et al. (1997) · Nature · doi:10.1038/386619a0 · Cited by 1,204 · see citing works
Molecular Cloning of the Interleukin-1β Converting Enzyme
Cerretti, D. P., Kozlosky, C. J., Mosley, B., Nelson, N. C., Ness, K. V., Greenstreet, T. A., March, C. J., Kronheim, S. R., Druck, T., Cannizzaro, L. A., et al. (1992) · Science · doi:10.1126/science.1373520 · Cited by 1,147 · see citing works
Phagocytosis of Microbes: Complexity in Action
Underhill, D. M., & Ozinsky, A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.103001.114744 · Cited by 1,124 · see citing works
The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1
Hersh, D., Monack, D. M., Smith, M. R., Ghori, N., Falkow, S., & Zychlinsky, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2396 · Cited by 788 · see citing works
Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte
Hotchkiss, R. S., Chang, K., Swanson, P. E., Tinsley, K. W., Hui, J. J., Klender, P. M., Xanthoudakis, S., Roy, S., Black, C. A., Grimm, E. L., et al. (2000) · Nature Immunology · doi:10.1038/82741 · Cited by 526 · see citing works
Granulocyte Apoptosis and Its Role in the Resolution and Control of Lung Inflammation
Haslett, C. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.supplement_1.4 · Cited by 517 · see citing works
Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis
Keane, J., Balcewicz-Sablinska, M. K., Remold, H. G., Chupp, G. L., Meek, B., Fenton, M. J., & Kornfeld, H. (1997) · Infection and Immunity · doi:10.1128/iai.65.1.298-304.1997 · Cited by 512 · see citing works
Prevention of lymphocyte cell death in sepsis improves survival in mice
Hotchkiss, R. S., Tinsley, K. W., Swanson, P. E., Chang, K. C., Cobb, J. P., Buchman, T. G., Korsmeyer, S. J., & Karl, I. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14541 · Cited by 454 · see citing works
Impairment of function in aging neutrophils is associated with apoptosis
Whyte, M. K. B., Meagher, L., MacDermot, J., & Haslett, C. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.11.5124 · Cited by 453 · see citing works
Self-citation
ATP-Induced Killing of Mycobacteria by Human Macrophages Is Mediated by Purinergic P2Z(P2X7) Receptors
Lammas, D. A., Stober, C. B., Harvey, C. J., Kendrick, N., Panchalingam, S., & Kumararatne, D. S. (1997) · Immunity · doi:10.1016/s1074-7613(00)80364-7 · Cited by 393 · see citing works
Pathogenesis of Pneumococcal Infection
TUOMANEN, E. I., AUSTRIAN, R. C., & Masure, H. R. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505113321907 · Cited by 381 · see citing works
Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-alpha.
Balcewicz-Sablinska, M. K., Keane, J., Kornfeld, H., & Remold, H. G. (1998) · PubMed · Cited by 375 · see citing works
Community‐Acquired Pneumonia in the Elderly
Marrie, T. J. (2000) · Clinical Infectious Diseases · doi:10.1086/318124 · Cited by 366 · see citing works
The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice
Brown, J., Hussell, T., Gilliland, S. M., Holden, D. W., Paton, J. C., Ehrenstein, M. R., Walport, M. J., & Botto, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012669199 · Cited by 366 · see citing works
Fas Ligand-Induced Apoptosis of Infected Human Macrophages Reduces the Viability of Intracellular Mycobacterium tuberculosis
Oddo, M., Renno, T., Attinger, A., Bakker, T. R., MacDonald, H. R., & Meylan, P. R. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.11.5448 · Cited by 346 · see citing works
Pneumococcal pneumolysin and H2O2 mediate brain cell apoptosis during meningitis
Braun, J., Sublett, J. E., Freyer, D., Mitchell, T. J., Cleveland, J. L., TUOMANEN, E. I., & Weber, J. R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci12035 · Cited by 314 · see citing works
Alveolar Macrophages Have a Protective Antiinflammatory Role during Murine Pneumococcal Pneumonia
Knapp, S., Leemans, J. C., Florquin, S., Branger, J., Maris, N. A., Pater, J. M., van Rooijen, N., & van der Poll, T. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200207-698oc · Cited by 302 · see citing works
Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival
Broug-Holub, E., Toews, G. B., van Iwaarden, J. F., Strieter, R. M., Kunkel, S. L., Paine, R., & Standiford, T. J. (1997) · Infection and Immunity · doi:10.1128/iai.65.4.1139-1146.1997 · Cited by 263 · see citing works
Neuroprotection by a caspase inhibitor in acute bacterial meningitis
Braun, J., Novak, R., Herzog, K., Bodner, S. M., Cleveland, J. L., & TUOMANEN, E. I. (1999) · Nature Medicine · doi:10.1038/6514 · Cited by 262 · see citing works
CD95/CD95 Ligand Interactions on Epithelial Cells in Host Defense to Pseudomonas aeruginosa
Grassmé, H., Kirschnek, S., Riethmueller, J., Riehle, A., von Kürthy, G., Lang, F. J. W., Weller, M., & Gulbins, E. (2000) · Science · doi:10.1126/science.290.5491.527 · Cited by 255 · see citing works
Role of Galectin-3 as an Adhesion Molecule for Neutrophil Extravasation During Streptococcal Pneumonia
Sato, S., Ouellet, N., Pelletier, I., Simard, M., Rancourt, A., & Bergeron, M. G. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.4.1813 · Cited by 253 · see citing works
Abrogation of bleomycin-induced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor
Wang, R., Ibarra-Sunga, O., Verlinski, L., Pick, R. L., & Uhal, B. D. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.1.l143 · Cited by 245 · see citing works
Flice-Inhibitory Protein Expression during Macrophage Differentiation Confers Resistance to FAS-Mediated Apoptosis
Perlman, H., Pagliari, L. J., Georganas, C., Mano, T., Walsh, K., & Pope, R. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.11.1679 · Cited by 222 · see citing works
Depletion of Alveolar Macrophages Exerts Protective Effects in Pulmonary Tuberculosis in Mice
Leemans, J. C., Juffermans, N. P., Florquin, S., van Rooijen, N., Vervoordeldonk, M. J., Verbon, A., van Deventer, S. J. H., & van der Poll, T. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.7.4604 · Cited by 216 · see citing works
Host Cellular Immune Response to Pneumococcal Lung Infection in Mice
Kadioglu, A., Gingles, N. A., Grattan, K., Kerr, A. R., Mitchell, T. J., & Andrew, P. W. (2000) · Infection and Immunity · doi:10.1128/iai.68.2.492-501.2000 · Cited by 205 · see citing works
The Role of Pneumolysin and Autolysin in the Pathology of Pneumonia and Septicemia in Mice Infected with a Type 2 Pneumococcus
Canvin, J. R., Marvin, A., Sivakumaran, M., Paton, J. C., Boulnois, G. J., Andrew, P. W., & Mitchell, T. J. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/172.1.119 · Cited by 203 · see citing works
Perspectives series: host/pathogen interactions. Apoptosis in bacterial pathogenesis.
Zychlinsky, A., & Sansonetti, P. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119557 · Cited by 201 · see citing works
Role of Alveolar Macrophages in Initiation and Regulation of Inflammation inPseudomonas aeruginosaPneumonia
Kooguchi, K., Hashimoto, S., Kobayashi, A., Kitamura, Y., Kudoh, I., Wiener-Kronish, J. P., & Sawa, T. (1998) · Infection and Immunity · doi:10.1128/iai.66.7.3164-3169.1998 · Cited by 199 · see citing works
Differential induction of apoptosis by virulent Mycobacterium tuberculosis in resistant and susceptible murine macrophages: role of nitric oxide and mycobacterial products
Rojas, M., Barrera, L. F., Puzo, G., & García, L. F. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.3.1352 · Cited by 179 · see citing works
Urokinase Receptor Is Necessary for Adequate Host Defense Against Pneumococcal Pneumonia
Rijneveld, A. W., Levi, M. M., Florquin, S., Speelman, P., Carmeliet, P., & van der Poll, T. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3507 · Cited by 173 · see citing works
An ICE‐like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells
Zhu, H., Fearnhead, H. O., & Cohen, G. M. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01116-v · Cited by 161 · see citing works
Characterization of murine lung interstitial macrophages in comparison with alveolar macrophages in vitro
Franke-Ullmann, G., Pförtner, C., Walter, P., Steinmüller, C., Lohmann-Matthes, M. L., & Kobzik, L. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.7.3097 · Cited by 160 · cited 2× · see citing works
“AM are the resident phagocytes of the lung and play a critical role in the innate defense against bacteria (7, 8, 11).”
Background
Community-acquired pneumonia
Brown, P. D., & Lerner, S. A. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02239-9 · Cited by 156 · see citing works
Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia.
Rubins, J. B., Charboneau, D., Paton, J. C., Mitchell, T. J., Andrew, P. W., & Janoff, E. N. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117631 · Cited by 145 · see citing works
Apoptosis of Epithelial Cells and Macrophages Due to Infection with the Obligate Intracellular Pathogen Chlamydia psittaci
Ojcius, D. M., Souque, P., Perfettini, J., & Dautry‐Varsat, A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.8.4220 · Cited by 141 · see citing works
Intracellular Trafficking and Killing ofStreptococcus pneumoniaeby Human Alveolar Macrophages Are Influenced by Opsonins
Gordon, S. B., Irving, G. R. B., Lawson, R. A., Lee, M. E., & Read, R. C. (2000) · Infection and Immunity · doi:10.1128/iai.68.4.2286-2293.2000 · Cited by 140 · see citing works
Evaluation of the role of mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFN-gamma and TNF-alpha in mouse macrophages.
Chan, E. D., Winston, B. W., Uh, S., Wynes, M. W., Rose, D. M., & Riches, D. W. H. (1999) · PubMed · Cited by 139 · see citing works
Monocytes recruited into the alveolar air space of mice show a monocytic phenotype but upregulate CD14
Maus, U. A., Herold, S., Muth, H., Maus, R., Ermert, L., Ermert, M., Weißmann, N., Rosseau, S., Seeger, W., Grimminger, F., et al. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.280.1.l58 · Cited by 138 · see citing works
The expression of Fas Ligand by macrophages and its upregulation by human immunodeficiency virus infection.
Dockrell, D. H., Badley, A. D., Villacian, J. S., Heppelmann, C. J. H., Algeciras, A., Ziesmer, S., Yagita∥, H., Lynch, D. H., Roche, P. C., Leibson, P. J., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1171 · Cited by 134 · see citing works
Self-citation
Immune‐Mediated Phagocytosis and Killing ofStreptococcus pneumoniaeAre Associated with Direct and Bystander Macrophage Apoptosis
Dockrell, D. H., Lee, M., Lynch, D. H., & Read, R. C. (2001) · The Journal of Infectious Diseases · doi:10.1086/323084 · Cited by 131 · see citing works
Self-citation
TNF-α Compensates for the Impaired Host Defense of IL-1 Type I Receptor-Deficient Mice During Pneumococcal Pneumonia
Rijneveld, A. W., Florquin, S., Branger, J., Speelman, P., van Deventer, S. J. H., & van der Poll, T. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.5240 · Cited by 126 · see citing works
Role of Genetic Resistance in Invasive Pneumococcal Infection: Identification and Study of Susceptibility and Resistance in Inbred Mouse Strains
Gingles, N. A., Alexander, J. E., Kadioglu, A., Andrew, P. W., Kerr, A. R., Mitchell, T. J., Hopes, E. A., Denny, P., Brown, S. D. M., Jones, H. B., et al. (2001) · Infection and Immunity · doi:10.1128/iai.69.1.426-434.2001 · Cited by 125 · see citing works
Evaluation of the Role of Mitogen-Activated Protein Kinases in the Expression of Inducible Nitric Oxide Synthase by IFN-γ and TNF-α in Mouse Macrophages
Chan, E. D., Winston, B. W., Uh, S., Wynes, M. W., Rose, D. M., & Riches, D. W. H. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.1.415 · Cited by 125 · see citing works
Pseudomonas aeruginosa –Induced Apoptosis Is Defective in Respiratory Epithelial Cells Expressing Mutant Cystic Fibrosis Transmembrane Conductance Regulator
Cannon, C. L., Kowalski, M. P., Stopak, K., & Pier, G. B. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.4898 · Cited by 122 · see citing works
Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia
Rubins, J. B., & Pomeroy, C. (1997) · Infection and Immunity · doi:10.1128/iai.65.7.2975-2977.1997 · Cited by 122 · see citing works
IL-18 Improves the Early Antimicrobial Host Response to Pneumococcal Pneumonia
Lauw, F. N., Branger, J., Florquin, S., Speelman, P., van Deventer, S. J. H., Akira, S., & van der Poll, T. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.1.372 · Cited by 119 · see citing works
Phagocytosis and Killing of Common Bacterial Pathogens of the Lung by Human Alveolar Macrophages
Jonsson, S., Musher, D. M., Chapman, A., Goree, A., & Lawrence, E. C. (1985) · The Journal of Infectious Diseases · doi:10.1093/infdis/152.1.4 · Cited by 115 · see citing works
Microbiological and Inflammatory Factors Associated with the Development of Pneumococcal Pneumonia
Dallaire, F., Ouellet, N., Bergeron, Y., Turmel, V., Gauthier, M., Simard, M., & Bergeron, M. G. (2001) · The Journal of Infectious Diseases · doi:10.1086/322021 · Cited by 114 · see citing works
Pathogenesis of Pneumococcal Pneumonia
Johnston, R. B. (1991) · Clinical Infectious Diseases · doi:10.1093/clinids/13.supplement_6.s509 · Cited by 112 · see citing works
Caspase-1-Deficient Mice Have Delayed Neutrophil Apoptosis and a Prolonged Inflammatory Response to Lipopolysaccharide-Induced Acute Lung Injury
Rowe, S. J., Allen, L., Ridger, V. C., Hellewell, P. G., & Whyte, M. K. B. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.11.6401 · Cited by 110 · see citing works
Self-citation
Differential Effects of CD18, CD29, and CD49 Integrin Subunit Inhibition on Neutrophil Migration in Pulmonary Inflammation
Ridger, V. C., Wagner, B. E., Wallace, W. A., & Hellewell, P. G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.5.3484 · Cited by 109 · see citing works
Self-citation
Role of Inflammatory Mediators in Resistance and Susceptibility to Pneumococcal Infection
Kerr, A. R., Irvine, J. J., Search, J. J., Gingles, N. A., Kadioglu, A., Andrew, P. W., McPheat, W. L., Booth, C. G., & Mitchell, T. J. (2002) · Infection and Immunity · doi:10.1128/iai.70.3.1547-1557.2002 · Cited by 105 · see citing works
Role of Pulmonary Alveolar Macrophages in Defense of the Lung againstPseudomonas aeruginosa
Cheung, D. O. Y., Halsey, K., & Speert, D. P. (2000) · Infection and Immunity · doi:10.1128/iai.68.8.4585-4592.2000 · Cited by 99 · see citing works
Induction of necrosis and apoptosis of neutrophil granulocytes byStreptococcus pneumoniae
Zysk, G., Bejo, L., Schneider-Wald, B. K., Nau, R., & Heinz, H.-P. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01336.x · Cited by 87 · see citing works
An overview of reflux-associated disorders in infants: apnea, laryngospasm, and aspiration
Orenstein, S. R. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00823-3 · Cited by 81 · see citing works
The Molecular Basis of Pneumococcal Infection: A Hypothesis
Cundell, D. R., Masure, H. R., & TUOMANEN, E. I. (1995) · Clinical Infectious Diseases · doi:10.1093/clind/21.supplement_3.s204 · Cited by 75 · see citing works
Pneumococcal Infections in Humans Are Associated with Increased Apoptosis and Trafficking of Type 1 Cytokine-Producing T Cells
Kemp, K., Brüünsgaard, H., Skinhøj, P., & Pedersen, B. K. (2002) · Infection and Immunity · doi:10.1128/iai.70.9.5019-5025.2002 · Cited by 72 · see citing works
Aspects on the Interaction of Streptococcus pneumoniae and Haemophilus influenzae With Human Respiratory Tract Mucosa
Håkansson, A., Carlstedt, I., Davies, J. R., Mossberg, A., Sabharwal, H., & Svanborg, C. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm/154.4_pt_2.s187 · Cited by 54 · see citing works
The Role of Opsonins in Recovery from Experimental Pneumococcal Pneumonia
GUCKIAN, J. C., Christensen, G. D., & Fine, D. P. (1980) · The Journal of Infectious Diseases · doi:10.1093/infdis/142.2.175 · Cited by 49 · see citing works
Lung Infections
Behnia, M. M., Robertson, K. A., & Martin, W. J. (2000) · CHEST Journal · doi:10.1378/chest.117.6.1771 · Cited by 37 · see citing works
MUCOSAL IMMUNOADJUVANT ACTIVITY OF LIPOSOMES: ROLE OF ALVEOLAR MACROPHAGES
de Haan, A., Groen, G., Prop, J., van Rooijen, N., & WILSHUT, J. (1996) · Immunology · doi:10.1046/j.1365-2567.1996.d01-787.x · Cited by 36 · see citing works
Modulation of Cytokines and Chemokines, Limited Pulmonary Vascular Bed Permeability, and Prevention of Septicemia and Death with Ceftriaxone and Interleukin‐10 in Pneumococcal Pneumonia
Wang, E., Simard, M., Ouellet, N., Bergeron, Y., Beauchamp, D., & Bergeron, M. G. (2000) · The Journal of Infectious Diseases · doi:10.1086/315811 · Cited by 31 · see citing works
PATHOLOGY OF THE EPIDEMIC STREPTOCOCCAL BRONCHOPNEUMONIA IN THE ARMY CAMPS
MacCallum, W. G. (1918) · JAMA · doi:10.1001/jama.1918.02600350008004 · Cited by 14 · see citing works
THE RELATION OF PROTEOLYTIC ENZYMES IN THE PNEUMONIC LUNG TO HYDROGEN ION CONCENTRATION. AN EXPLANATION OF RESOLUTION
Lord, F. T. (1919) · The Journal of Experimental Medicine · doi:10.1084/jem.30.4.379 · Cited by 13 · see citing works
Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2.
Yoshimura, A., Lien, E., Ingalls, R., Tuomanen, E., Dziarski, R., & Golenbock, D. (1999) · Journal of Immunology · doi:10.4049/jimmunol.163.1.1 · Cited by 2 · see citing works

Flagged first, then by citations

Sorted by citations

Pathogenesis, treatment, and prevention of pneumococcal pneumonia
van der Poll, T., & Opal, S. M. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61114-4 · Cited by 713 · see citing works
Inhibition of pulmonary antibacterial defense by interferon-γ during recovery from influenza infection
Sun, K., & Metzger, D. W. (2008) · Nature Medicine · doi:10.1038/nm1765 · Cited by 587 · see citing works
Diverse macrophage populations mediate acute lung inflammation and resolution
Aggarwal, N. R., King, L. S., & D’Alessio, F. R. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00341.2013 · Cited by 583 · see citing works
Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice
Shahangian, A., Chow, E. K., Tian, X., Kang, J. R., Ghaffari, A., Liu, S. Y., Belperio, J. A., Cheng, G., & Deng, J. C. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35412 · Cited by 479 · see citing works
Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections
Ghoneim, H. E., Thomas, P. G., & McCullers, J. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300014 · Cited by 394 · see citing works
The Scavenger Receptor MARCO Is Required for Lung Defense against Pneumococcal Pneumonia and Inhaled Particles
Arredouani, M. S., Yang, Z., Ning, Y., Qin, G., Soininen, R., Tryggvason, K., & Kobzik, L. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040731 · Cited by 361 · see citing works
Fas Determines Differential Fates of Resident and Recruited Macrophages during Resolution of Acute Lung Injury
Janssen, W. J., Barthel, L., Muldrow, A., Oberley‐Deegan, R. E., Kearns, M. T., Jakubzick, C., & Henson, P. M. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201011-1891oc · Cited by 339 · see citing works
Cell Death in the Lung: The Apoptosis–Necroptosis Axis
Sauler, M., Bazan, I. S., & Lee, P. J. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114320 · Cited by 325 · see citing works
Integrative Physiology of Pneumonia
Quinton, L. J., Walkey, A. J., & Mizgerd, J. P. (2018) · Physiological Reviews · doi:10.1152/physrev.00032.2017 · Cited by 308 · see citing works
Influenza and Bacterial Superinfection: Illuminating the Immunologic Mechanisms of Disease
Rynda‐Apple, A., Robinson, K. M., & Alcorn, J. F. (2015) · Infection and Immunity · doi:10.1128/iai.00298-15 · Cited by 283 · see citing works
Modulation of phagocyte apoptosis by bacterial pathogens
DeLeo, F. R. (2004) · APOPTOSIS · doi:10.1023/b:appt.0000031448.64969.fa · Cited by 264 · see citing works
Key mechanisms governing resolution of lung inflammation
Robb, C. T., Regan, K., Dorward, D. A., & Rossi, A. G. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0560-6 · Cited by 263 · see citing works
Pyocyanin Production by Pseudomonas aeruginosa Induces Neutrophil Apoptosis and Impairs Neutrophil-Mediated Host Defenses In Vivo
Allen, L., Dockrell, D. H., Pattery, T., Lee, D. G., Cornélis, P., Hellewell, P. G., & Whyte, M. K. B. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3643 · Cited by 255 · see citing works
Self-citation
Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lung
Small, C.-L., Shaler, C. R., McCormick, S., Jeyanathan, M., Damjanovic, D., Brown, E. G., Arck, P., Jordana, M., Kaushic, C., Ashkar, A. A., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902772 · Cited by 216 · see citing works
Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model
Jim, K. K., Engelen-Lee, J.-Y., van der Sar, A. M., Bitter, W., Brouwer, M. C., ENDE, A. V. D., Veening, J., van de Beek, D., & Vandenbroucke‐Grauls, C. M. J. E. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0655-y · Cited by 209 · see citing works
Immune Dysfunction and Bacterial Coinfections following Influenza
Metzger, D. W., & Sun, K. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301152 · Cited by 198 · see citing works
Alveolar Macrophages Transport Pathogens to Lung Draining Lymph Nodes
Kirby, A. C., Coles, M. C., & Kaye, P. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901089 · Cited by 183 · see citing works
The Apoptotic Response to Pneumolysin Is Toll-Like Receptor 4 Dependent and Protects against Pneumococcal Disease
Srivastava, A., Henneke, P., Visintin, A., Morse, S. C., Martin, V., Watkins, A. C., Paton, J. C., Wessels, M. R., Golenbock, D. T., & Malley, R. (2005) · Infection and Immunity · doi:10.1128/iai.73.10.6479-6487.2005 · Cited by 183 · see citing works
Streptococcus pneumoniae epidemiology, pathogenesis and control
Narciso, A. R., Dookie, R. S., Nannapaneni, P., Normark, S. J., & Henriques‐Normark, B. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01116-z · Cited by 152 · see citing works
Alveolar macrophages in pulmonary host defence – the unrecognized role of apoptosis as a mechanism of intracellular bacterial killing
Aberdein, J., Cole, J., Bewley, M. A., Marriott, H. M., & Dockrell, D. H. (2013) · Clinical & Experimental Immunology · doi:10.1111/cei.12170 · Cited by 142 · see citing works
Self-citation
Cigarette Smoke Exposure Impairs Pulmonary Bacterial Clearance and Alveolar Macrophage Complement-Mediated Phagocytosis of Streptococcus pneumoniae
Phipps, J. C., Aronoff, D. M., Curtis, J. L., Goel, D., O’Brien, E., & Mancuso, P. (2009) · Infection and Immunity · doi:10.1128/iai.00963-09 · Cited by 142 · see citing works
TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation
McGrath, E. E., Marriott, H. M., Lawrie, A., Francis, S., Sabroe, I., Renshaw, S. A., Dockrell, D. H., & Whyte, M. K. B. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0211062 · Cited by 138 · see citing works
Self-citation
Organ-Specific Mechanisms of Transendothelial Neutrophil Migration in the Lung, Liver, Kidney, and Aorta
Maas, S. L., Soehnlein, O., & Viola, J. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02739 · Cited by 137 · see citing works
Secondary Bacterial Infections in Influenza Virus Infection Pathogenesis
Smith, A. M., & McCullers, J. A. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_394 · Cited by 135 · see citing works
Pneumococcal Pneumonia
Dockrell, D. H., Whyte, M. K. B., & Mitchell, T. J. (2012) · CHEST Journal · doi:10.1378/chest.12-0210 · Cited by 125 · see citing works
Self-citation
Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages
Jubrail, J., Morris, P., Bewley, M. A., Stoneham, S. M., Johnston, S. A., Foster, S. J., Peden, A. A., Read, R. C., Marriott, H. M., & Dockrell, D. H. (2015) · Cellular Microbiology · doi:10.1111/cmi.12485 · Cited by 119 · see citing works
Self-citation
Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection
Marriott, H. M., Ali, F., Read, R. C., Mitchell, T. J., Whyte, M. K. B., & Dockrell, D. H. (2004) · The FASEB Journal · doi:10.1096/fj.03-1450fje · Cited by 119 · see citing works
Self-citation
Mathematical model of a three-stage innate immune response to a pneumococcal lung infection
Smith, A. M., McCullers, J. A., & Adler, F. R. (2011) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2011.01.052 · Cited by 118 · see citing works
Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections
Cohen, T. S., Hilliard, J. J., Jones-Nelson, O., Keller, A. E., O’Day, T. L., Tkaczyk, C., DiGiandomenico, A., Hamilton, M. M., Pelletier, M. R., Wang, Q., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad9922 · Cited by 118 · see citing works
Impairment of Apoptotic Cell Engulfment by Pyocyanin, a Toxic Metabolite of Pseudomonas aeruginosa
Bianchi, S. M., Prince, L. R., McPhillips, K. A., Allen, L., Marriott, H. M., Taylor, G. W., Hellewell, P. G., Sabroe, I., Dockrell, D. H., Henson, P. W., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200612-1804oc · Cited by 113 · see citing works
Self-citation
Macrophage LC3-associated phagocytosis is an immune defense against Streptococcus pneumoniae that diminishes with host aging
Inomata, M., Xu, S., Chandra, P., Meydani, S. N., Takemura, G., Philips, J. A., & Leong, J. M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2015368117 · Cited by 106 · see citing works
Importance of CXC Chemokine Receptor 2 in Alveolar Neutrophil and Exudate Macrophage Recruitment in Response to Pneumococcal Lung Infection
Herbold, W., Maus, R., Hahn, I., Ding, N., Srivastava, M., Christman, J. W., Mack, M., Reutershan, J., Briles, D. E., Paton, J. C., et al. (2010) · Infection and Immunity · doi:10.1128/iai.01169-09 · Cited by 103 · see citing works
The role of the macrophage in lung disease mediated by bacteria
Marriott, H. M., & Dockrell, D. H. (2007) · Experimental Lung Research · doi:10.1080/01902140701756562 · Cited by 102 · see citing works
Self-citation
Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages
Bewley, M. A., Preston, J. A., Mohasin, M., Marriott, H. M., Budd, R. C., Swales, J., Collini, P., Greaves, D. R., Craig, R. W., Brightling, C. E., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201608-1714oc · Cited by 102 · see citing works
Self-citation
Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance
Marriott, H. M., Bingle, C. D., Read, R. C., Braley, K. E., Kroemer, G., Hellewell, P. G., Craig, R. W., Whyte, M. K. B., & Dockrell, D. H. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200521766 · Cited by 100 · see citing works
Self-citation
Extracellular Adenosine Protects against Streptococcus pneumoniae Lung Infection by Regulating Pulmonary Neutrophil Recruitment
Ghanem, E. N. B., Clark, S. A., Roggensack, S. E., McIver, S. R., Alcaide, P., Haydon, P. G., & Leong, J. M. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005126 · Cited by 99 · see citing works
Interleukin-1β Regulates CXCL8 Release and Influences Disease Outcome in Response to Streptococcus pneumoniae, Defining Intercellular Cooperation between Pulmonary Epithelial Cells and Macrophages
Marriott, H. M., Gascoyne, K. A., Gowda, R., Geary, I., Nicklin, M. J. H., Iannelli, F., Pozzi, G., Mitchell, T. J., Whyte, M. K. B., Sabroe, I., et al. (2011) · Infection and Immunity · doi:10.1128/iai.05697-11 · Cited by 96 · see citing works
Self-citation
Decreased Alveolar Macrophage Apoptosis Is Associated with Increased Pulmonary Inflammation in a Murine Model of Pneumococcal Pneumonia
Marriott, H. M., Hellewell, P. G., Cross, S. S., Ince, P. G., Whyte, M. K. B., & Dockrell, D. H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.6480 · Cited by 95 · see citing works
Self-citation
TNF-related apoptosis-inducing ligand (TRAIL) exerts therapeutic efficacy for the treatment of pneumococcal pneumonia in mice
Steinwede, K., Henken, S., Bohling, J., Maus, R., Ueberberg, B., Brumshagen, C., Brincks, E. L., Griffith, T. S., Welte, T., & Maus, U. A. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20120983 · Cited by 91 · see citing works
CD11b Regulates Recruitment of Alveolar Macrophages but Not Pulmonary Dendritic Cells after Pneumococcal Challenge
Kirby, A. C., Raynes, J. G., & Kaye, P. M. (2005) · The Journal of Infectious Diseases · doi:10.1086/498874 · Cited by 86 · see citing works
Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses
Sadiku, P., Willson, J. A., Dickinson, R. S., Murphy, F. A., Harris, A. J., Lewis, A., Sammut, D., Mirchandani, A. S., Ryan, E. M., Watts, E., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90848 · Cited by 86 · see citing works
Self-citation
Effects of Influenza on Alveolar Macrophage Viability Are Dependent on Mouse Genetic Strain
Califano, D., Furuya, Y., & Metzger, D. W. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701406 · Cited by 84 · see citing works
Reactive Oxygen Species Regulate Neutrophil Recruitment and Survival in Pneumococcal Pneumonia
Marriott, H. M., Jackson, L. E., Wilkinson, T. S., Simpson, A. J., Mitchell, T. J., Buttle, D. J., Cross, S. S., Ince, P. G., Hellewell, P. G., Whyte, M. K. B., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200707-990oc · Cited by 82 · see citing works
Self-citation
Intracellular replication of Edwardsiella tarda in murine macrophage is dependent on the type III secretion system and induces an up-regulation of anti-apoptotic NF-κB target genes protecting the macrophage from staurosporine-induced apoptosis
Okuda, J., Arikawa, Y., Takeuchi, Y., Mahmoud, M. M., Suzaki, E., Kataoka, K., Suzuki, T., Okinaka, Y., & Nakai, T. (2006) · Microbial Pathogenesis · doi:10.1016/j.micpath.2006.08.002 · Cited by 80 · see citing works
Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism
Thompson, A. A. R., Dickinson, R. S., Murphy, F. A., Thomson, J. P., Marriott, H. M., Tavares, A., Willson, J. A., Williams, L., Lewis, A., Mirchandani, A. S., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aal2861 · Cited by 78 · see citing works
Self-citation
Interfering with immunity: detrimental role of type I IFNs during infection
Stifter, S. A., & Feng, C. G. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402794 · Cited by 78 · see citing works
Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression
Littmann, M., Albiger, B., Frentzen, A., Normark, S. J., Henriques‐Normark, B., & Plant, L. (2009) · EMBO Molecular Medicine · doi:10.1002/emmm.200900025 · Cited by 77 · see citing works
Pneumonia recovery reprograms the alveolar macrophage pool
Guillon, A., Arafa, E. I., Barker, K. A., Belkina, A. C., Martin, I. M. C., Shenoy, A. T., Wooten, A. K., Ana, C. L. D., Dai, A., Labadorf, A. T., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.133042 · Cited by 76 · see citing works
A Cardinal Role for Cathepsin D in Co-Ordinating the Host-Mediated Apoptosis of Macrophages and Killing of Pneumococci
Bewley, M. A., Marriott, H. M., Tulone, C., Francis, S., Mitchell, T. J., Read, R. C., Chain, B., Kroemer, G., Whyte, M. K. B., & Dockrell, D. H. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001262 · Cited by 74 · see citing works
Self-citation
Macrophage Turnover Kinetics in the Lungs of Mice Infected with S treptococcus pneumoniae
Taut, K., Winter, C., Briles, D. E., Paton, J. C., Christman, J. W., Maus, R., Baumann, R., Welte, T., & Maus, U. A. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0132oc · Cited by 74 · see citing works
Innate Immunity against Bacterial Infection following Hyperoxia Exposure Is Impaired in NRF2-Deficient Mice
Reddy, N. M., Vegiraju, S., Kalvakolanu, D. V., Yamamoto, M. P., Kensler, T. W., Hassoun, P. M., Kleeberger, S. R., & Reddy, S. P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901754 · Cited by 73 · see citing works
PM2.5 impairs macrophage functions to exacerbate pneumococcus-induced pulmonary pathogenesis
Chen, Y., Huang, M.-Z., Chen, C., Kuo, C.-Y., Yang, C., Chiang-Ni, C., Chen, Y. M., Hsieh, C.-M., Wu, H.-Y., Kuo, M., et al. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00362-2 · Cited by 69 · see citing works
The Role of Macrophages in the Innate Immune Response to Streptococcus pneumoniae and Staphylococcus aureus
Cole, J., Aberdein, J., Jubrail, J., & Dockrell, D. H. (2014) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2014.08.004 · Cited by 69 · see citing works
Self-citation
Influence of Neutropenia on the Course of Serotype 8 Pneumococcal Pneumonia in Mice
Marks, M. S., Burns, T., Abadi, M. A., Seyoum, B., Thornton, J. A., TUOMANEN, E. I., & Pirofski, L. (2007) · Infection and Immunity · doi:10.1128/iai.01579-06 · Cited by 69 · see citing works
Innate immune responses in pneumonia
Korkmaz, F. T., & Traber, K. E. (2023) · Pneumonia · doi:10.1186/s41479-023-00106-8 · Cited by 65 · see citing works
The role of pneumolysin in mediating lung damage in a lethal pneumococcal pneumonia murine model
Garcı́a-Suárez, M. D. M., Flórez, N., Astudillo, A., Vázquez, F., Villaverde, R., Fabrizio, K., Pirofski, L., & Méndez, F. J. (2007) · Respiratory Research · doi:10.1186/1465-9921-8-3 · Cited by 65 · see citing works
p53 integrates host defense and cell fate during bacterial pneumonia
Madenspacher, J. H., Azzam, K. M., Gowdy, K. M., Malcolm, K. C., Nick, J. A., Dixon, D., Aloor, J. J., Draper, D. W., Guardiola, J. J., Shatz, M., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121674 · Cited by 63 · see citing works
Neutrophils in community-acquired pneumonia: parallels in dysfunction at the extremes of age
Grudzinska, F. S., Brodlie, M., Scholefield, B. R., Jackson, T., Scott, A., THICKETT, D. R., & Sapey, E. (2019) · Thorax · doi:10.1136/thoraxjnl-2018-212826 · Cited by 63 · see citing works
The role of oral microbial colonization in ventilator-associated pneumonia
Brennan, M. T., Bahrani‐Mougeot, F. K., Fox, P. C., Kennedy, T. P., Hopkins, S., Boucher, R. C., & Lockhart, P. B. (2004) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2004.06.005 · Cited by 63 · see citing works
Airway Epithelial Cells Generate Pro-inflammatory Tenascin-C and Small Extracellular Vesicles in Response to TLR3 Stimuli and Rhinovirus Infection
Mills, J. T., Schwenzer, A., Marsh, E. K., Edwards, M. R., Sabroe, I., Midwood, K. S., & Parker, L. C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01987 · Cited by 62 · see citing works
Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation
Bewley, M. A., Naughton, M., Preston, J. A., Mitchell, A. M., Holmes, A., Marriott, H. M., Read, R. C., Mitchell, T. J., Whyte, M. K. B., & Dockrell, D. H. (2014) · mBio · doi:10.1128/mbio.01710-14 · Cited by 61 · see citing works
Self-citation
The Pla Protease of Yersinia pestis Degrades Fas Ligand to Manipulate Host Cell Death and Inflammation
Caulfield, A. J., Walker, M. E., Gielda, L. M., & Lathem, W. W. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.03.005 · Cited by 58 · see citing works
Modulation of the Inflammatory Response to Streptococcus pneumoniae in a Model of Acute Lung Tissue Infection
Xu, F., Droemann, D., Rupp, J., Shen, H., Wu, X., Goldmann, T., Hippenstiel, S., Zabel, P., & Dalhoff, K. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0328oc · Cited by 58 · see citing works
Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target
Yang, Z., Huang, Y.-C. T., Koziel, H., de Crom, R., Ruetten, H., Wohlfart, P., Thomsen, R. W., Kahlert, J. A., Sørensen, H. T., Józefowski, S., et al. (2014) · eLife · doi:10.7554/elife.03711 · Cited by 57 · see citing works
Alveolar Macrophage Apoptosis–associated Bacterial Killing Helps Prevent Murine Pneumonia
Preston, J. A., Bewley, M. A., Marriott, H. M., Houghton, A. M., Mohasin, M., Jubrail, J., Morris, L., Stephenson, Y. L., Cross, S. S., Greaves, D. R., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201804-0646oc · Cited by 57 · see citing works
Self-citation
Pneumonia models and innate immunity to respiratory bacterial pathogens
Knapp, S., Schultz, M. J., & Poll, T. V. D. (2005) · Shock · doi:10.1097/01.shk.0000191385.41689.f3 · Cited by 56 · see citing works
Second-Hand Cigarette Smoke Impairs Bacterial Phagocytosis in Macrophages by Modulating CFTR Dependent Lipid-Rafts
Ni, I., Ji, C. H., & Vij, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121200 · Cited by 55 · see citing works
Acute organ injury and long-term sequelae of severe pneumococcal infections
Kruckow, K. L., Zhao, K., Bowdish, D. M. E., & Orihuela, C. J. (2023) · Pneumonia · doi:10.1186/s41479-023-00110-y · Cited by 54 · see citing works
Pulmonary dendritic cells and alveolar macrophages are regulated by γδ T cells during the resolution of S. pneumoniae‐induced inflammation
Kirby, A. C., Newton, D., Carding, S. R., & Kaye, P. M. (2007) · The Journal of Pathology · doi:10.1002/path.2149 · Cited by 54 · see citing works
Viral and bacterial co-infection in severe pneumonia triggers innate immune responses and specifically enhances IP-10: a translational study.
Hoffmann, J., Machado, D., Terrier, O., Pouzol, S., Messaoudi, M., Basualdo, W., Espínola, E. E., Guillen, R. M., Rosa-Calatrava, M., Picot, V., et al. (2016) · Scientific Reports · doi:10.1038/srep38532 · Cited by 53 · see citing works
Contribution of anti-inflammatory/immune suppressive processes to the pathology of sepsis
Perl, M. (2006) · Frontiers in bioscience · doi:10.2741/1797 · Cited by 52 · see citing works
Streptococcus pneumoniae: The role of apoptosis in host defense and pathogenesis
Marriott, H. M., & Dockrell, D. H. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.06.001 · Cited by 51 · see citing works
Self-citation
Mechanistic links between acute respiratory tract infections and acute coronary syndromes
Bazaz, R., Marriott, H. M., Francis, S., & Dockrell, D. H. (2012) · Journal of Infection · doi:10.1016/j.jinf.2012.09.009 · Cited by 51 · see citing works
Self-citation
CD8+ T Cells Restrict Yersinia pseudotuberculosis Infection: Bypass of Anti-Phagocytosis by Targeting Antigen-Presenting Cells
Bergman, M. A., Loomis, W. P., Mecsas, J. C., Starnbach, M. N., & Isberg, R. R. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000573 · Cited by 51 · see citing works
Alcohol-induced mitochondrial DNA damage promotes injurious crosstalk between alveolar epithelial cells and alveolar macrophages
Sadikot, R. T., Bedi, B., Li, J., & Yeligar, S. M. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.08.006 · Cited by 50 · see citing works
Earliest Innate Immune Responses Require Macrophage RelA during Pneumococcal Pneumonia
Pittet, L. A., Quinton, L. J., Yamamoto, K., Robson, B. E., Ferrari, J. D., Algül, H., Schmid, R. M., & Mizgerd, J. P. (2011) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0210oc · Cited by 50 · see citing works
Cellular Regulation of the Inflammatory Response
Janssen, W. J., & Henson, P. M. (2011) · Toxicologic Pathology · doi:10.1177/0192623311428477 · Cited by 50 · see citing works
Nitric Oxide Is a Key Determinant of Group B Streptococcus–Induced Murine Macrophage Apoptosis
Ulett, G. C., & Adderson, E. E. (2005) · The Journal of Infectious Diseases · doi:10.1086/429693 · Cited by 49 · see citing works
The survival of fetal and bone marrow monocyte-derived alveolar macrophages is promoted by CD44 and its interaction with hyaluronan
Dong, Y., Poon, G. F. T., Arif, A. A., Lee‐Sayer, S. S. M., Dosanjh, M., & Johnson, P. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.83 · Cited by 48 · see citing works
Targeting the Networks that Underpin Contiguous Immunity in Asthma and Chronic Obstructive Pulmonary Disease
Sabroe, I., Parker, L. C., Dockrell, D. H., Davies, D. E., Dower, S., & Whyte, M. K. B. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200606-777pp · Cited by 48 · see citing works
Self-citation
E-Prostanoid 3 Receptor Deletion Improves Pulmonary Host Defense and Protects Mice from Death in Severe Streptococcus pneumoniae Infection
Aronoff, D. M., Lewis, C. A., Serezani, C. H., Eaton, K. A., Goel, D., Phipps, J. C., Peters-Golden, M. L., & Mancuso, P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900129 · Cited by 47 · see citing works
Suppression of Alveolar Macrophage Apoptosis Prolongs Survival of Rats and Mice with Pneumocystis Pneumonia
Lasbury, M. E., Durant, P. J., RAY, C. A., TSCHANG, D., Schwendener, R. A., & Lee, C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.6443 · Cited by 47 · see citing works
A group A Streptococcus ADP-ribosyltransferase toxin stimulates a protective interleukin 1β-dependent macrophage immune response.
Lin, A. E., Beasley, F. C., Keller, N., Hollands, A., Urbano, R., Troemel, E. R., Hoffman, H. M., & Nizet, V. (2015) · mBio · doi:10.1128/mbio.00133-15 · Cited by 46 · see citing works
Regulation of Apoptosis by Gram-Positive Bacteria: Mechanistic Diversity and Consequences for Immunity
Ulett, G. C., & Adderson, E. E. (2006) · Current Immunology Reviews · doi:10.2174/157339506776843033 · Cited by 46 · see citing works
Blunt chest trauma induces mediator-dependent monocyte migration to the lung
Seitz, D., Niesler, U., Palmer, A., Sulger, M., Braumüller, S. T., Perl, M., Gebhard, F. T., & Knöferl, M. W. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181e8ad10 · Cited by 44 · see citing works
Early Apoptosis of Macrophages Modulated by Injection of Yersinia pestis YopK Promotes Progression of Primary Pneumonic Plague
Peters, K. N., Dhariwala, M. O., Hanks, J. M. H., Brown, C. R., & Anderson, D. M. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003324 · Cited by 43 · see citing works
Surviving Deadly Lung Infections: Innate Host Tolerance Mechanisms in the Pulmonary System
Crane, M. J., Lee, K. M., FitzGerald, E. S., & Jamieson, A. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01421 · Cited by 42 · see citing works
The effect of HIV infection on the host response to bacterial sepsis
Huson, M. A. M., Grobusch, M. P., & van der Poll, T. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70917-x · Cited by 41 · see citing works
Proteomic Evaluation and Validation of Cathepsin D Regulated Proteins in Macrophages Exposed to Streptococcus pneumoniae
Bewley, M. A., Pham, T. K., Marriott, H. M., Noirel, J., Chu, H.-P., Ow, S. Y., Ryazanov, A. G., Read, R. C., Whyte, M. K. B., Chain, B., et al. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.008193 · Cited by 41 · see citing works
Self-citation
HIV gp120 in the Lungs of Antiretroviral Therapy–treated Individuals Impairs Alveolar Macrophage Responses to Pneumococci
Collini, P., Bewley, M. A., Mohasin, M., Marriott, H. M., Miller, R. F., Geretti, A. M., Beloukas, A. I., Papadimitropoulos, A., Read, R. C., Noursadeghi, M., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201708-1755oc · Cited by 41 · see citing works
Self-citation
Bactericidal activity of macrophages against Streptococcus uberis is different in mammary gland secretions of lactating and drying off cows
Denis, M., Parlane, N. A., Lacy-Hulbert, S. J., Summers, E. L., Buddle, B. M., & Wedlock, D. N. (2006) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2006.08.001 · Cited by 41 · see citing works
Direct and Indirect Anti-Inflammatory Effects of Tulathromycin in Bovine Macrophages: Inhibition of CXCL-8 Secretion, Induction of Apoptosis, and Promotion of Efferocytosis
Fischer, C. D., Beatty, J., Duquette, S. C., Morck, D. W., Lucas, M. J., & Buret, A. G. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01598-12 · Cited by 40 · see citing works
Critical Role of Zinc Transporter (ZIP8) in Myeloid Innate Immune Cell Function and the Host Response against Bacterial Pneumonia
Hall, S. C., Smith, D. R., Dyavar, S. R., Wyatt, T. A., Samuelson, D. R., Bailey, K. L., & Knoell, D. L. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001395 · Cited by 40 · see citing works
A mathematical model of intrahost pneumococcal pneumonia infection dynamics in murine strains
Mochan, E., Swigon, D., Ermentrout, B., Lukens, S., & Clermont, G. (2014) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2014.02.021 · Cited by 40 · see citing works
Glucocorticoid-Augmented Efferocytosis Inhibits Pulmonary Pneumococcal Clearance in Mice by Reducing Alveolar Macrophage Bactericidal Function
Stolberg, V. R., McCubbrey, A. L., Freeman, C. M., Brown, J. P., Crudgington, S., Taitano, S. H., Saxton, B. L., Mancuso, P., & Curtis, J. L. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402217 · Cited by 39 · see citing works
Interleukin 17A Promotes Pneumococcal Clearance by Recruiting Neutrophils and Inducing Apoptosis through a p38 Mitogen-Activated Protein Kinase-Dependent Mechanism in Acute Otitis Media
Wang, W., Zhou, A., Zhang, X., Xiang, Y., Huang, Y., Wang, L., Zhang, S., Liu, Y., Yin, Y., & He, Y. (2014) · Infection and Immunity · doi:10.1128/iai.00006-14 · Cited by 39 · see citing works
Defying death: Cellular survival strategies following plasmalemmal injury by bacterial toxins
Babiychuk, E. B., & Draeger, A. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.10.016 · Cited by 38 · see citing works
Role of IRE1α/XBP-1 in Cystic Fibrosis Airway Inflammation
Ribeiro, C. M. P., & Lubamba, B. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010118 · Cited by 38 · see citing works
Streptococcus pneumoniae pep27 mutant as a live vaccine for serotype-independent protection in mice
Kim, E., Choi, S., Kwon, M.-K., Tran, T. D., Park, S., Lee, K.-J., Bae, S., Briles, D. E., & Rhee, D. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.11.073 · Cited by 37 · see citing works
Importance of Bacterial Replication and Alveolar Macrophage-Independent Clearance Mechanisms during Early Lung Infection with Streptococcus pneumoniae
Camberlein, E., Cohen, J., José, R. J. P., Hyams, C. J., Callard, R. E., Chimalapati, S., Yuste, J., Edwards, L. A., Marshall, H., van Rooijen, N., et al. (2015) · Infection and Immunity · doi:10.1128/iai.02788-14 · Cited by 37 · see citing works

Alveolar Macrophages Have a Protective Antiinflammatory Role during Murine Pneumococcal Pneumonia
Knapp, S., Leemans, J. C., Florquin, S., Branger, J., Maris, N. A., Pater, J. M., van Rooijen, N., & van der Poll, T. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200207-698oc · Cited by 302 · see citing works
Decreased Alveolar Macrophage Apoptosis Is Associated with Increased Pulmonary Inflammation in a Murine Model of Pneumococcal Pneumonia
Marriott, H. M., Hellewell, P. G., Cross, S. S., Ince, P. G., Whyte, M. K. B., & Dockrell, D. H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.6480 · Cited by 95 · see citing works
Self-citation
Alveolar macrophages in pulmonary host defence – the unrecognized role of apoptosis as a mechanism of intracellular bacterial killing
Aberdein, J., Cole, J., Bewley, M. A., Marriott, H. M., & Dockrell, D. H. (2013) · Clinical & Experimental Immunology · doi:10.1111/cei.12170 · Cited by 142 · see citing works
Self-citation
Depletion of alveolar macrophages exacerbates respiratory mycoplasmosis in mycoplasma-resistant C57BL mice but not mycoplasma-susceptible C3H mice
Hickman‐Davis, J. M., Michalek, S. M., Gibbs-Erwin, J., & Lindsey, J. R. (1997) · Infection and Immunity · doi:10.1128/iai.65.6.2278-2282.1997 · Cited by 63 · see citing works
Role of Pulmonary Alveolar Macrophages in Defense of the Lung againstPseudomonas aeruginosa
Cheung, D. O. Y., Halsey, K., & Speert, D. P. (2000) · Infection and Immunity · doi:10.1128/iai.68.8.4585-4592.2000 · Cited by 99 · see citing works

Authors: Dockrell, D. H., Marriott, H. M., Prince, L. R., Ridger, V. C., Ince, P. G., Hellewell, P. G., & Whyte, M. K. B.
Affiliations: University of Sheffield (GB)
ORCID: Dockrell, David H
Marriott, Helen M
Prince, Lynne R
Ridger, Victoria C
Ince, Paul G
Hellewell, Paul G
Whyte, Moira K B
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2003-11
Volume: 171
Issue: 10
Pages: 5380-5388
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.171.10.5380
OpenAlex: W1781589933
Cited by: 239
References: 68
Citations by year: 2026: 5 · 2025: 6 · 2024: 4 · 2023: 11 · 2022: 9 · 2021: 11 · 2020: 15 · 2019: 13 · 2018: 9 · 2017: 12 · 2016: 12 · 2015: 18 · 2014: 18 · 2013: 12 · 2012: 10
FWCI: 5.55
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (submittedVersion)
Funders: Wellcome Trust
Topics: Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: alveolar macrophages, macrophage apoptosis, Streptococcus pneumoniae, asymptomatic infection, caspase activation, bacteremia, pulmonary innate immunity, host defense
MeSH terms: Amino Acid Chloromethyl Ketones, Animals, Cell Count, Disease Models, Animal, Dose-Response Relationship, Immunologic, Female, Immunity, Innate, Injections, Intraperitoneal, Intubation, Intratracheal, Mice, Inbred C57BL, Pneumonia, Pneumococcal, Streptococcus pneumoniae, Cysteine Proteinase Inhibitors, Up-Regulation, Bacteremia, Macrophages, Alveolar, Apoptosis, Mice, Caspase Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks