The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Influence of Preoperative Chemotherapy on the Risk of Major Hepatectomy for Colorectal Liver Metastases
Open accessAbstract
OBJECTIVE: : To assess the effects of preoperative systemic chemotherapy on remnant liver parenchyma, liver function, and morbidity after major liver resection for colorectal liver metastases. BACKGROUND: : Many patients operated upon for colorectal cancer liver metastases receive previous chemotherapy. Whether systemic chemotherapy alters liver parenchyma in such way that it increases the risks of liver resection remains unclear. PATIENTS AND METHODS: : Among 214 patients who received a liver resection for colorectal liver metastases between 1998 and 2002 in a single institution, 67 who underwent a major liver resection under total hepatic vascular exclusion form the basis of this report. Forty-five patients operated upon after systemic chemotherapy were compared with 22 who did not receive any chemotherapy in the 6 months prior to resection. Postoperative mortality, morbidity, liver function tests, and pathology of the resected liver in the two groups were compared. RESULTS: : There was no postoperative mortality. Values of liver function tests on days 1, 3, 5, and 10 were similar in both groups. Morbidity rate was higher in the chemotherapy group (38% versus 13.5%, P = 0.03). Postoperative morbidity was correlated with the number of cycles of chemotherapy administered before surgery but not to the type of chemotherapy. Preoperative chemotherapy was significantly associated with sinusoidal dilatation, atrophy of hepatocytes, and/or hepatocytic necrosis (49% versus 25%, P = 0.005). CONCLUSION: : Prolonged neoadjuvant systemic chemotherapy alters liver parenchyma and increases morbidity after major resection under total hepatic vascular exclusion, but it does not increase operative mortality. This should be taken into consideration before deciding a major liver resection in patients who have received preoperative chemotherapy.
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Cites
An Algorithm for the Grading of Activity in Chronic Hepatitis C
Bedossa, P., & Poynard, T. (1996) · Hepatology · doi:10.1002/hep.510240201 · Cited by 4,088
de Gramont, A., Figer, A., Seymour, M., Homerin, M., Hmissi, A., Cassidy, J., Boni, C., Cortes-Funes, H., Cervantes, A., Freyer, G., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.16.2938 · Cited by 3,815
Fong, Y., Fortner, J., Sun, R. L., Brennan, M. F., & Blumgart, L. H. (1999) · Annals of Surgery · doi:10.1097/00000658-199909000-00004 · Cited by 3,715
Douillard, J., Cunningham, D., Roth, A., Navarro, M., James, R., Karasek, P., Jandik, P., Iveson, T., Carmichael, J., Alakl, M., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02034-1 · Cited by 3,256
Self-citation(2012) · Hepatogastroenterology · doi:10.5754/hge12458 · Cited by 1,977
Resection of colorectal liver metastases
Scheele, J., Stang, R., Altendorf‐Hofmann, A., & Paul, M. (1995) · World Journal of Surgery · doi:10.1007/bf00316981 · Cited by 1,539
Resection of Nonresectable Liver Metastases from Colorectal Cancer After Neoadjuvant Chemotherapy
Bismuth, H., Adam, R., Lévi, F., Farabos, C., Waechter, F., Castaing, D., Majno, P., & Engerran, L. (1996) · Annals of Surgery · doi:10.1097/00000658-199610000-00009 · Cited by 963
de Gramont, A., Bosset, J. F., Milan, C., Rougier, P., Bouché, O., Etienne, P. L., Morvan, F., Louvet, C., Guillot, T., François, E., et al. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.2.808 · Cited by 908
Self-citationPortal Vein Embolization Before Right Hepatectomy: Prospective Clinical Trial
Farges, O., Belghiti, J., Kianmanesh, R., Marc Regimbeau, J., Santoro, R., Vilgrain, V., Denys, A., & Sauvanet, A. (2003) · Annals of Surgery · doi:10.1097/01.sla.0000048447.16651.7b · Cited by 676
Minagawa, M., Makuuchi, M., Torzilli, G., Takayama, T., Kawasaki, S., Kosuge, T., Yamamoto, J., & Imamura, H. (2000) · Annals of Surgery · doi:10.1097/00000658-200004000-00006 · Cited by 663
Cited by
Rahbari, N. N., Garden, O. J., Padbury, R., Brooke-Smith, M., Crawford, M., Adam, R., Koch, M., Makuuchi, M., Dematteo, R. P., Christophi, C., et al. (2011) · Surgery · doi:10.1016/j.surg.2010.10.001 · Cited by 2,319
Folprecht, G., Gruenberger, T., Bechstein, W. O., Raab, H.-R., Lordick, F., Hartmann, J. T., Lang, H., Frilling, A., Stoehlmacher, J., Weitz, J., et al. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70330-4 · Cited by 963
Treatment of Metastatic Colorectal Cancer: ASCO Guideline
Morris, V. K., Kennedy, E. B., Baxter, N. N., Benson, A. B., Cercek, A., Cho, M., Ciombor, K. K., Cremolini, C., Davis, A., Deming, D. A., et al. (2023) · Journal of Clinical Oncology · doi:10.1200/jco.22.01690 · Cited by 682
de Baere, T., Teriitehau, C., Deschamps, F., Catherine, L., Rao, P., Hakime, A., Auperin, A., Goere, D., Elias, D., & Hechelhammer, L. (2010) · Annals of Surgical Oncology · doi:10.1245/s10434-010-0979-2 · Cited by 139
Effects of systemic chemotherapy on the liver
Ramadori, G., & Cameron, S. (2010) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31651-5 · Cited by 132
Metadata
- Authors
- Karoui, M., Penna, C., Amin-Hashem, M., Mitry, E., Benoist, S., Franc, B., Rougier, P., & Nordlinger, B.
- Venue
- Annals of Surgery
- Published
- 2006-01
- Volume
- 243
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2078345568
- Cited by
- 721
- References
- 22
- FWCI
- 16.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Karoui, M., Penna, C., Amin-Hashem, M., Mitry, E., Benoist, S., Franc, B., Rougier, P., & Nordlinger, B. (2006). Influence of Preoperative Chemotherapy on the Risk of Major Hepatectomy for Colorectal Liver Metastases. Annals of Surgery. https://doi.org/10.1097/01.sla.0000193603.26265.c3
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