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Cited by 91Burn Injury Management and OutcomesClinical Nutrition and GastroenterologyHyperglycemia and glycemic control in critically ill and hospitalized patients

Early Enteral Nutrition Does Not Decrease Hypermetabolism Associated with Burn Injury

Peck, Michael D., Kessler, Mary, Cairns, Bruce A., Chang, Yih-Harn, Ivanova, Anastasia, Schooler, Wesley·2004·The Journal of Trauma: Injury, Infection, and Critical Care
DOI 10.1097/01.ta.0000145826.84657.38
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Abstract

Background A prospective, randomized study was performed to compare the effects of early versus late enteral feeding on postburn metabolism. Methods Burn patients were randomized to receive enteral feedings either within 24 hours (early) or 7 days (late) of injury. Basal energy expenditure (BEE) was calculated from Harris-Benedict equations and resting energy expenditure (REE) was obtained from indirect calorimetry. The average daily energy expenditure (DEE) was expressed as REE/BEE. Results Average age, burn size, infections, and length of stay were similar between groups. Mortality between groups was similar (early, 28%; late, 38%) and not significantly influenced by inhalation injury. When controlled for percentage of total body surface area burn, inhalation injury, and age, the early group had an increased rather than decreased DEE, with a mean DEE calorie 0.17 more than the late group (p = 0.07). Conclusion Early enteral feeding does not decrease the average energy expenditure associated with burn injury.

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Crossref · 10.1097/01.ta.0000145826.84657.38

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  • In comparing early enteral nutrition versus delayed enteral nutrition, results showed reduction of infectious complications in early enteral nutrition (RR 0.76, CI 0.59, 0.97, p<0.03).

    “In comparing early EN vs delayed EN (including six studies in ICU patients (51,52,53,54,55,56) and four studies including non-ICU patients (57,58,59,60)), and similar to an earlier metaanalysis (15), our results showed reduction of infectious complications in early EN (RR 0.76, CI 0.59, 0.97, p<0.03).”

    From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [51]

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Authors
Peck, M. D., Kessler, M., Cairns, B. A., Chang, Y.-H., Ivanova, A., & Schooler, W.
Affiliations
University of North Carolina at Chapel Hill (US)
ORCID
Venue
The Journal of Trauma: Injury, Infection, and Critical Care
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-12
Volume
57
Issue
6
Pages
1143-1149
ISSN
0022-5282 (ISSN-L)
DOI
10.1097/01.ta.0000145826.84657.38
OpenAlex
W1965276577
Cited by
91
References
27
Citations by year
2026: 4 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 2
FWCI
2.65
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Trauma: Injury, Infection, and Critical Care (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Center for Research Resources (RR00046, M01RR000046)
Topics
  • Health Sciences › Medicine › Epidemiology › Burn Injury Management and Outcomes
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
Keywords
early enteral nutrition, burns, hypermetabolism, energy expenditure, resting energy expenditure, basal energy expenditure, timing of enteral feeding, inhalation injury, mortality
MeSH terms
Adult, Burns, Energy Metabolism, Enteral Nutrition, Female, Humans, Male, Time Factors, Linear Models

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