Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients
Abstract
Primary cytomegalovirus (CMV) infection is a major cause of morbidity and mortality in recipients after solid organ transplantation (SOT). Widespread and prolonged use of antiviral drugs has changed the natural course of CMV disease by delaying its onset and causing drug resistance. CMV induces a strong cellular immune response, even in immunosuppressed patients, and has developed strategies to evade this immune surveillance. This review summarizes challenges in managing CMV infection in transplant recipients and highlights current insights in the cellular immune response against CMV.
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The incidence of clinical disease due to reactivations of CMV and EBV is very low in elderly individuals, in contrast to severely immunosuppressed transplant patients.
“Support for the functionality of these cells also comes from the observation that the incidence of clinical disease due to reactivations of CMV and EBV is very low in elderly individuals, in contrast to severely immunosuppressed transplant patients”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Rowshani et al., 2005
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Successful and Maladaptive T Cell Aging
Goronzy, J. J., & Weyand, C. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.010 · Cited by 362 · see citing works
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- Authors
- Rowshani, A. T., Bemelman, F. J., van Leeuwen, E. M. M., van Lier, R. A. W., & ten Berge, I. J. M.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Rowshani, Ajda T.
- Venue
- Transplantation
- Published
- 2005-02
- Volume
- 79
- Issue
- 4
- Pages
- 381-386
- ISSN
- 0041-1337 (ISSN-L)
- OpenAlex
- W2102048011
- Cited by
- 168
- References
- 74
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 2 · 2018: 4 · 2017: 7 · 2016: 11 · 2015: 3 · 2014: 10 · 2013: 5 · 2012: 7
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- cytomegalovirus infection, solid organ transplantation, immunosuppression, cell-mediated immunity, antiviral resistance, viral immune evasion, cytomegalovirus reactivation, transplant recipients
- MeSH terms
- Cytomegalovirus Infections, Cytomegalovirus, Humans, T-Lymphocytes, Vaccination, Viral Vaccines, Organ Transplantation
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