Cited by 96Renal Transplantation Outcomes and TreatmentsTransplantation: Methods and OutcomesChemokine receptors and signaling

High CXCL10 Expression in Rejected Kidneys and Predictive Role of Pretransplant Serum CXCL10 for Acute Rejection And Chronic Allograft Nephropathy

Lazzeri, Elena, Rotondi, Mario, Mazzinghi, Benedetta, Lasagni, Laura, Buonamano, Andrea, Rosati, Alberto, Pradella, Fabio, Fossombroni, Vittorio +6 more·2005·Transplantation

Abstract

BACKGROUND: Several experimental models have shown that CXCL10 is required for initiation and development of graft failure caused by both acute and chronic rejection. METHODS: CXCL10 expression and distribution was investigated in tissue specimens obtained from 22 patients suffering from acute rejection (AR) or chronic allograft nephropathy (CAN) by using in situ hybridization. Furthermore, pretransplantation sera of 316 cadaveric kidney-graft recipients were tested retrospectively for serum CXCL10 levels by a quantitative sandwich immunoassay. RESULTS: Bioptic specimens obtained from patients with CAN were characterized by wide CXCL10 expression not only at level of infiltrating inflammatory cells but also of vascular, tubular, and glomerular structures. In addition, assessment of pretransplant serum CXCL10 levels in 316 graft recipients and stratification of patients in three groups according to serum CXCL10 levels (<100 pg/mL, n=163; 100-150 pg/mL, n=69; >150 pg/mL, n=84) showed highly significant differences in 5-year survival rates for the two extreme groups (95.7% vs. 79.7%, P=0.0002). Accordingly, patients who developed severe, early AR (277.14+/-65.08 p=0.004) and those who developed CAN also showed increased pretransplant serum CXCL10 levels (193.2+/-36.9, P=0.03). Multivariate analysis demonstrated that among the analyzed variables, CXCL10 (relative risk [RR] 2.801) and delayed graft function (RR 3.728) had the highest predictive power of graft loss. CONCLUSIONS: These results suggest that pretransplant serum CXCL10 levels greater than 150 pg/mL confer an increased risk of early, severe, AR and subsequent CAN, finally resulting in renal-allograft failure. This finding might be used for the individualization of immunosuppressive therapies.

Integrity signals

Registry

Crossref · 10.1097/01.tp.0000160759.85080.2e

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Lazzeri, E., Rotondi, M., Mazzinghi, B., Lasagni, L., Buonamano, A., Rosati, A., Pradella, F., Fossombroni, V., La Villa, G., Gacci, M., Bertoni, E., Serio, M., Salvadori, M., & Romagnani, P.
Affiliations
  • Azienda Ospedaliero-Universitaria Careggi (IT)
  • University of Florence (IT)
Corresponding author
Romagnani, Paola
Venue
Transplantation
Published
2005-05
Volume
79
Issue
9
Pages
1215-1220
ISSN
0041-1337 (ISSN-L)
OpenAlex
W2016430264
Cited by
96
References
25
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 7 · 2018: 2 · 2017: 8 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 3
FWCI
2.87
Type
journal article
Language
en
Open access
closed
Locations
  • Transplantation (publishedVersion)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion)
Topics
  • Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
  • Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords
CXCL10, kidney transplantation, acute rejection, chronic allograft nephropathy, graft loss prediction, delayed graft function, renal allograft failure, inflammatory cell infiltration
MeSH terms
Biopsy, Cadaver, Graft Rejection, Humans, Kidney, Tissue Donors, Transplantation, Homologous, Biomarkers, Multivariate Analysis, Kidney Transplantation, Treatment Failure, Chemokines, CXC, Chemokine CXCL10

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review