Cited by 92Renal Transplantation Outcomes and TreatmentsTransplantation: Methods and OutcomesChemokine receptors and signaling

High Pretransplant Serum Levels of CXCL10/IP-10 Are Related to Increased Risk of Renal Allograft Failure

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Rotondi, Mario, Rosati, Alberto, Buonamano, Andrea, Lasagni, Laura, Lazzeri, Elena, Pradella, Fabio, Fossombroni, Vittorio, Cirami, Calogero +6 more·2004·American Journal of Transplantation

Abstract

In experimental models, the chemokine CXCL10/IP-10 is required for graft failure owing to both acute and chronic rejection. In the present study, pretransplantation sera from 316 cadaver kidney graft recipients were tested for serum CXCL10 and CCL22/MDC levels by an ELISA assay. Kidney graft recipients with normally functioning grafts showed significantly lower serum CXCL10 levels than patients who experienced graft failure, whereas no differences for serum CCL22 levels were observed. After the assignment of all patients to four groups according to serum CXCL10 levels, the death-censored survival rates of grafts were 97.5%, 93.6%, 89.7%, 78.7% (p = 0.0006) at 5 years, while no influence was observed on patient survival. Accordingly, patients with the highest CXCL10 levels showed an increased frequency and severity of rejection episodes. Serum C-reactive protein (CRP) level was also assayed in the same samples. Increase of serum CRP levels represented a predictive parameter for death, but not for graft failure. Multivariate analysis demonstrated that among the analyzed variables, CXCL10 had the highest predictive power of graft loss (RR 2.787). Thus, measurement of pretransplant serum CXCL10 levels might represent a clinically useful parameter to identify subjects who are at high risk of severe rejection and graft failure.

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Research works printed but not linked: 4

  1. Lazzeri E, Romagnani P. CXCR3-binding chemokines: multi- faceted therapeutic targets. Curr Drug Targets Immune Endocr Metabol Disord 2004, in press.
  2. Galli G, Chantry D, Annunziato F et al. Macrophage-derived chemokine production by activated human T cells in vitro and in vivo: preferential association with the production of type 2 cy- tokines. Eur J Immunol 2000; 30: 204-210.
  3. Campbell JD, Gangur V, Simons FE, HayGlass KT. Allergic humans are hyporesponsive to a CXCR3-ligand-mediated Th1 immunity- promoting loop. Faseb J 2004; 18: 329-331.
  4. Perez RV, Brown DJ, Katznelson SA et al. Pretransplant sys- temic inflammation and acute rejection after renal transplantation. Transplantation 2000; 69: 869-874.

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Authors
Rotondi, M., Rosati, A., Buonamano, A., Lasagni, L., Lazzeri, E., Pradella, F., Fossombroni, V., Cirami, C., Liotta, F., La Villa, G., Serio, M., Bertoni, E., Salvadori, M., & Romagnani, P.
Affiliations
  • University of Florence (IT)
  • Azienda Ospedaliero-Universitaria Careggi (IT)
Corresponding author
Romagnani, Paola
Venue
American Journal of Transplantation
Publisher
Elsevier BV
Published
2004-09
Volume
4
Issue
9
Pages
1466-1474
ISSN
1600-6135 (ISSN-L)
OpenAlex
W2046591654
Cited by
92
References
49
Citations by year
2025: 3 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 7 · 2012: 4
FWCI
4.65
Type
journal article
Language
en
Open access
Locations
  • American Journal of Transplantation (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion)
Funders
  • Ministero della Salute
  • Ministero dell’Istruzione, dell’Università e della Ricerca
  • Associazione Italiana per la Ricerca sul Cancro
  • Regione Toscana
Topics
  • Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
  • Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords
CXCL10, kidney transplantation, renal allograft failure, graft rejection, C-reactive protein, risk prediction
MeSH terms
Adult, Female, Graft Rejection, Graft Survival, Histocompatibility Testing, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Biomarkers, Kidney Transplantation, Treatment Failure, Chemokines, CXC, Chemokine CXCL10

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