High Pretransplant Serum Levels of CXCL10/IP-10 Are Related to Increased Risk of Renal Allograft Failure
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In experimental models, the chemokine CXCL10/IP-10 is required for graft failure owing to both acute and chronic rejection. In the present study, pretransplantation sera from 316 cadaver kidney graft recipients were tested for serum CXCL10 and CCL22/MDC levels by an ELISA assay. Kidney graft recipients with normally functioning grafts showed significantly lower serum CXCL10 levels than patients who experienced graft failure, whereas no differences for serum CCL22 levels were observed. After the assignment of all patients to four groups according to serum CXCL10 levels, the death-censored survival rates of grafts were 97.5%, 93.6%, 89.7%, 78.7% (p = 0.0006) at 5 years, while no influence was observed on patient survival. Accordingly, patients with the highest CXCL10 levels showed an increased frequency and severity of rejection episodes. Serum C-reactive protein (CRP) level was also assayed in the same samples. Increase of serum CRP levels represented a predictive parameter for death, but not for graft failure. Multivariate analysis demonstrated that among the analyzed variables, CXCL10 had the highest predictive power of graft loss (RR 2.787). Thus, measurement of pretransplant serum CXCL10 levels might represent a clinically useful parameter to identify subjects who are at high risk of severe rejection and graft failure.
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IP-10/CXCL10 was very significantly elevated during rejection.
“the pro-inflammatory chemokine IP-10/CXCL10, a molecule implicated in renal allograft loss, was very significantly elevated at this point”
From Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation (2019) · cites this paper as [17]
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- Authors
- Rotondi, M., Rosati, A., Buonamano, A., Lasagni, L., Lazzeri, E., Pradella, F., Fossombroni, V., Cirami, C., Liotta, F., La Villa, G., Serio, M., Bertoni, E., Salvadori, M., & Romagnani, P.
- Affiliations
- University of Florence (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Corresponding author
- Romagnani, Paola
- ORCID
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 4
- Issue
- 9
- Pages
- 1466-1474
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W2046591654
- Cited by
- 92
- References
- 49
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 7 · 2012: 4
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- American Journal of Transplantation (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Funders
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Associazione Italiana per la Ricerca sul Cancro
- Regione Toscana
- Topics
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Keywords
- CXCL10, kidney transplantation, renal allograft failure, graft rejection, C-reactive protein, risk prediction
- MeSH terms
- Adult, Female, Graft Rejection, Graft Survival, Histocompatibility Testing, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Biomarkers, Kidney Transplantation, Treatment Failure, Chemokines, CXC, Chemokine CXCL10
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