The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Host-Dependent Tumorigenesis of Embryonic Stem Cell Transplantation in Experimental Stroke
Abstract
The therapeutical potential of transplantation of undifferentiated and predifferentiated murine embryonic stem cells for the regeneration of the injured brain was investigated in two rodent stroke models. Undifferentiated embryonic stem cells xenotransplanted into the rat brain at the hemisphere opposite to the ischemic injury migrated along the corpus callosum towards the damaged tissue and differentiated into neurons in the border zone of the lesion. In the homologous mouse brain, the same murine embryonic stem cells did not migrate, but produced highly malignant teratocarcinomas at the site of implantation, independent of whether they were predifferentiated in vitro to neural progenitor cells. The authors demonstrated a hitherto unrecognized inverse outcome after xenotransplantation and homologous transplantation of embryonic stem cells, which raises concerns about safety provisions when the therapeutical potential of human embryonic stem cells is tested in preclinical animal models.
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Citations
Cites
Neuronal replacement from endogenous precursors in the adult brain after stroke
Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799
Cited by
Stem cell therapy for human neurodegenerative disorders–how to make it work
Lindvall, O., Kokaia, Z., & Martinez-Serrano, A. (2004) · Nature Medicine · doi:10.1038/nm1064 · Cited by 915
Pathophysiology and therapy of experimental stroke
Hossmann, K.-A. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9008-1 · Cited by 475
Self-citationThe Tumorigenicity of Human Embryonic Stem Cells
(2008) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)00005-5 · Cited by 451
Cell transplantation therapy for stroke
Bliss, T., Guzman, R., Daadi, M., & Steinberg, G. K. (2007) · Stroke · doi:10.1161/01.str.0000247888.25985.62 · Cited by 374
Neural stem/precursor cells for the treatment of ischemic stroke
Bacigaluppi, M., Pluchino, S., Martino, G., Kilic, E., & Hermann, D. M. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.06.012 · Cited by 111
Metadata
- Authors
- Erdö, F., Bührle, C., Blunk, J., Hoehn, M., Xia, Y., Fleischmann, B., Föcking, M., Küstermann, E., Kolossov, E., Hescheler, J., Hossmann, K.-A., & Trapp, T.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2003-07
- Volume
- 23
- Issue
- 7
- Pages
- 780-785
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2018708343
- Cited by
- 355
- References
- 1
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Erdö, F., Bührle, C., Blunk, J., Hoehn, M., Xia, Y., Fleischmann, B., Föcking, M., Küstermann, E., Kolossov, E., Hescheler, J., Hossmann, K.-A., & Trapp, T. (2003). Host-Dependent Tumorigenesis of Embryonic Stem Cell Transplantation in Experimental Stroke. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1097/01.wcb.0000071886.63724.fb
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
