Neural stem/precursor cells for the treatment of ischemic stroke
Abstract
In ischemic stroke, the third most frequent cause of mortality in industrialized countries, therapeutic options have until now been limited to the first hours after disease onset. Cell transplantation has emerged in various neurological disorders, including experimental stroke, as a successful recovery-promoting approach also in the post-acute stroke phase. However, before envisaging any translation into humans of such promising cell-based approaches we still need to clarify: (i) the ideal cell source for transplantation, (ii) the most appropriate route of cell administration, and, last but not least, (iii) the best approach to achieve an appropriate and functional integration of transplanted cells into the host tissue. Here we discuss, with special emphasis on neural stem/precursor cells, potential mechanisms that may be involved in the action of cell-based therapies in stroke.
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The survival rate of adult neural precursor cells in brain parenchyma is poor, and only a small percentage differentiate into neurons.
“The survival rate of adult neural precursor cells in the brain parenchyma is poor and only a small percentage of the cells differentiate into neurons.35,39–42”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [40]
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Bacigaluppi, M., Pluchino, S., Jametti, L. P., Kilic, E., Kilic, Ü., Salani, G., Brambilla, E., West, M. J., Comi, G., Martino, G., et al. (2009) · Brain · doi:10.1093/brain/awp174 · Cited by 350 · see citing works
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- Authors
- Bacigaluppi, M., Pluchino, S., Martino, G., Kilic, E., & Hermann, D. M.
- Affiliations
- University Hospital Zurich (CH)
- IRCCS Ospedale San Raffaele (IT)
- Corresponding author
- Hermann, Dirk M.
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 265
- Issue
- 1-2
- Pages
- 73-77
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W1975085253
- Cited by
- 111
- References
- 51
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 10 · 2015: 13 · 2014: 8 · 2013: 8 · 2012: 10
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- ischemic stroke, neural stem cells, neural progenitor cells, cell transplantation, cell therapy, cell sources, stroke recovery
- MeSH terms
- Animals, Cell Differentiation, Humans, Neurons, Stem Cells, Stroke, Stem Cell Transplantation, Cell Proliferation
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