The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Persistently Low Extracellular Glucose Correlates with Poor Outcome 6 Months after Human Traumatic Brain Injury despite a Lack of Increased Lactate: A Microdialysis Study
Open accessAbstract
Disturbed glucose brain metabolism after brain trauma is reflected by changes in extracellular glucose levels. The authors hypothesized that posttraumatic reductions in extracellular glucose levels are not due to ischemia and are associated with poor outcome. Intracerebral microdialysis, electroencephalography, and measurements of brain tissue oxygen levels and jugular venous oxygen saturation were performed in 30 patients with traumatic brain injury. Levels of glucose, lactate, pyruvate, glutamate, and urea were analyzed hourly. The 6-month Glasgow Outcome Scale extended (GOSe6) score was assessed for each patient. In regions of increased glucose utilization defined by positron emission tomography, the extracellular glucose concentration was less than 0.2 mmol/l. Extracellular glucose values were less than 0.2 mmol during postinjury days 0 to 7 in 19% to 30% of hourly samples on each day. Transient decreases in glucose levels occurred with electrographic seizures and nonischemic reductions in cerebral perfusion pressure and jugular venous oxygen saturation. Glutamate levels were elevated in the majority of low-glucose samples, but the lactate/pyruvate ratio did not indicate focal ischemia. Terminal herniation resulted in reductions in glucose with increases in the lactate/pyruvate ratio but not in lactate concentration alone. GOSe6 scores correlated with persistently low glucose levels, combined early low glucose levels and low lactate/glucose ratio, and with the overall lactate/glucose ratio. These results suggest that the level of extracellular glucose is typically reduced after traumatic brain injury and associated with poor outcome, but is not associated with ischemia.
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Metadata
- Authors
- Vespa, P. M., McArthur, D., O'Phelan, K., Glenn, T., Etchepare, M., Kelly, D., Bergsneider, M., Martin, N. A., & Hovda, D. A.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2003-07
- Volume
- 23
- Issue
- 7
- Pages
- 865-877
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2054553973
- Cited by
- 342
- References
- 48
- FWCI
- 7.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Persistently Low Extracellular Glucose Correlates with Poor Outcome 6 Months after Human Traumatic Brain Injury despite a Lack of Increased Lactate: A Microdialysis Study. https://app.cochat.ai/papers/10.1097/01.wcb.0000076701.45782.ef
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- Vespa, P. M., McArthur, D., O'Phelan, K., Glenn, T., Etchepare, M., Kelly, D., Bergsneider, M., Martin, N. A., & Hovda, D. A. (2003). Persistently Low Extracellular Glucose Correlates with Poor Outcome 6 Months after Human Traumatic Brain Injury despite a Lack of Increased Lactate: A Microdialysis Study. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1097/01.wcb.0000076701.45782.ef
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
