The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis
Open accessAbstract
OBJECTIVE: To determine whether nonconvulsive electrographic post-traumatic seizures result in increases in intracranial pressure and microdialysis lactate/pyruvate ratio. DESIGN: Prospective monitoring with retrospective data analysis. SETTING: Single center academic neurologic intensive care unit. PATIENTS: Twenty moderate to severe traumatic brain injury patients (Glasgow Coma Score 3-13). MEASUREMENTS AND MAIN RESULTS: Continuous electroencephalography and cerebral microdialysis were performed for 7 days after injury. Ten patients had seizures and were compared with a matched cohort of traumatic brain injury patients without seizures. The seizures were repetitive and constituted status epilepticus in seven of ten patients. Using a within-subject design, post-traumatic seizures resulted in episodic increases in intracranial pressure (22.4 +/- 7 vs. 12.8 +/- 4.3 mm Hg; p < .001) and an episodic increase in lactate/pyruvate ratio (49.4 +/- 16 vs. 23.8 +/- 7.6; p < .001) in the seizure group. Using a between-subjects comparison, the seizure group demonstrated a higher mean intracranial pressure (17.6 +/- 6.5 vs. 12.2 +/- 4.2 mm Hg; p < .001), a higher mean lactate/pyruvate ratio (38.6 +/- 18 vs. 27 +/- 9; p < .001) compared with nonseizure patients. The intracranial pressure and lactate/pyruvate ratio remained elevated beyond postinjury hour 100 in the seizure group but not the nonseizure group (p < .02). CONCLUSION: Post-traumatic seizures result in episodic as well as long-lasting increases in intracranial pressure and microdialysis lactate/pyruvate ratio. These data suggest that post-traumatic seizures represent a therapeutic target for patients with traumatic brain injury.
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Cites
Detection of electrographic seizures with continuous EEG monitoring in critically ill patients
Claassen, J., Mayer, S. A., Kowalski, R. G., Emerson, R. G., & Hirsch, L. J. (2004) · Neurology · doi:10.1212/01.wnl.0000125184.88797.62 · Cited by 1,190
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Self-citationVespa, P., Bergsneider, M., Hattori, N., Wu, H.-M., Huang, S.-C., Martin, N. A., Glenn, T. C., McArthur, D. L., & Hovda, D. A. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600073 · Cited by 638
Self-citationVespa, P. M., Nuwer, M. R., Nenov, V., Ronne-Engstrom, E., Hovda, D. A., Bergsneider, M., Kelly, D. F., Martin, N. A., & Becker, D. P. (1999) · Journal of Neurosurgery · doi:10.3171/jns.1999.91.5.0750 · Cited by 599
Self-citationAcute seizures after intracerebral hemorrhage: A factor in progressive midline shift and outcome
Vespa, P. M., O’Phelan, K., Shah, M., Mirabelli, J., Starkman, S., Kidwell, C., Saver, J., Nuwer, M. R., Frazee, J. G., McArthur, D. A., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000063316.47591.b4 · Cited by 561
Self-citationSeizures after head trauma: A population study
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Self-citationVespa, P. M., McArthur, D., O'Phelan, K., Glenn, T., Etchepare, M., Kelly, D., Bergsneider, M., Martin, N. A., & Hovda, D. A. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000076701.45782.ef · Cited by 342
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Cited by
Continuous electroencephalography in the medical intensive care unit*
Oddo, M., Carrera, E., Claassen, J., Mayer, S. A., & Hirsch, L. J. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181a00604 · Cited by 406
Nichol, G., Aufderheide, T. P., Eigel, B., Neumar, R. W., Lurie, K. G., Bufalino, V. J., Callaway, C. W., Menon, V., Bass, R. R., Abella, B. S., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181cdb7db · Cited by 323
Spreading depolarizations and late secondary insults after traumatic brain injury
Hartings, J. A., Strong, A. J., Fabricius, M., Manning, A., Bhatia, R., Dreier, J. P., Mazzeo, A. T., Tortella, F. C., & Bullock, M. R. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2009.0961 · Cited by 196
Vigil, F. A., Bozdemir, E., Bugay, V., Chun, S. H., Hobbs, M., Sanchez, I., Hastings, S. D., Veraza, R. J., Holstein, D. M., Sprague, S. M., et al. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19857818 · Cited by 51
Metadata
- Authors
- Vespa, P. M., Miller, C., McArthur, D., Eliseo, M., Etchepare, M., Hirt, D., Glenn, T. C., Martin, N., & Hovda, D.
- Venue
- Critical Care Medicine
- Published
- 2007-12
- Volume
- 35
- Issue
- 12
- Pages
- 2830-2836
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W1975508166
- Cited by
- 451
- References
- 17
- FWCI
- 10.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Vespa, P. M., Miller, C., McArthur, D., Eliseo, M., Etchepare, M., Hirt, D., Glenn, T. C., Martin, N., & Hovda, D. (2007). Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis. Critical Care Medicine. https://doi.org/10.1097/00003246-200712000-00023
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