Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease
Abstract
Recently, we confirmed the presence of enhanced neural reconstruction in Parkinson's disease and in an animal model of Parkinson's disease based on increased polysialic acid-like immunoreactivity. Changes in neurogenesis often appear parallel to changes in angiogenesis. Moreover, both these processes share similar modulating factors, like vascular endothelial growth factor (VEGF) and its receptors VEGFR-1 (Flt-1) and VEGFR-2 (Flk-1). Using immunohistochemistry, we identified in this study upregulation of VEGF in the substantia nigra but not in the striatum of patients with Parkinson's disease by enzyme-linked immunosorbent assay. Such overexpression may participate in vascular remodeling and neurogenesis in the substantia nigra of Parkinson's disease.
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Aberrant angiogenesis is frequently observed in Parkinson's disease patients in the substantia nigra pars compacta, locus coeruleus, and putamen.
“Aberrant angiogenesis is frequently observed in PD patients, as shown in the substantia nigra pars compacta, locus coeruleus, and putamen (144, 627).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [627]
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Vascular endothelial growth factor (VEGF) stimulates neurogenesis <i>in vitro</i> and <i>in vivo</i>
Jin, K., Zhu, Y., Sun, Y., Mao, X. O., Xie, L., & Greenberg, D. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182296499 · Cited by 1,507 · see citing works
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Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076 · see citing works
Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works
Microglia–blood vessel interactions: a double-edged sword in brain pathologies
Dudvarski Stankovic, N., Teodorczyk, M., Ploen, R., Zipp, F., & Schmidt, M. H. H. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1524-y · Cited by 301 · see citing works
Blood–brain barrier leakage is increased in parkinson’s disease
Al-Bachari, S., Naish, J. H., Parker, G. J. M., Emsley, H. C. A., & Parkes, L. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.593026 · Cited by 263 · see citing works
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- Authors
- Wada, K., Arai, H., Takanashi, M., Fukae, J., Oizumi, H., Yasuda, T., Mizuno, Y., & Mochizuki, H.
- Affiliations
- Ministry of Education, Culture, Sports, Science and Technology (JP)
- Corresponding author
- Mochizuki, Hideki
- Venue
- NeuroReport
- Published
- 2006-05-15
- Volume
- 17
- Issue
- 7
- Pages
- 705-709
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2163240536
- Cited by
- 109
- References
- 2
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 2 · 2018: 5 · 2017: 1 · 2016: 12 · 2015: 3 · 2014: 8 · 2013: 7 · 2012: 3
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- Parkinson's disease, vascular endothelial growth factor, VEGF receptors, VEGFR1, VEGFR2, substantia nigra, striatum, angiogenesis, neurogenesis, vascular remodeling, polysialic acid
- MeSH terms
- Aged, Aged, 80 and over, Brain, Diagnostic Imaging, Enzyme-Linked Immunosorbent Assay, Female, Glial Fibrillary Acidic Protein, Humans, Immunohistochemistry, Male, Middle Aged, Parkinson Disease, Case-Control Studies, Statistics, Nonparametric, Receptors, Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor A
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