Aging and sedentarism decrease vascularization and VEGF levels in the rat substantia nigra. Implications for Parkinson's disease
Open accessAbstract
It is not known if aging induces changes in nigral vascularization and nigral vascular endothelial growth factor (VEGF) levels similar to those previously reported for Parkinson's disease (PD). In this study nonexercised rats displayed age-dependent decreases in the density of nigral microvessels and VEGF mRNA expression, which were reversed by physical exercise. Such changes may enhance the vulnerability of dopaminergic neurons and the risk of developing PD, and may be reduced by exercise. Furthermore, the observed pattern is the opposite of that previously observed in PD, suggesting that the process underlying PD is not an accelerated age-dependent decline in the dopaminergic system.
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Exercise may modulate the function of the immune system through cells of the myeloid lineage including monocytes, macrophages and CNS resident microglia.
“Another recently identified role of exercise on the function of the immune system may be through the modulation of cells of the myeloid lineage including monocytes, macrophages and CNS resident microglia.105, 116, 117”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [105]
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Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease
Petzinger, G. M., Fisher, B. E., McEwen, S., Beeler, J. A., Walsh, J. P., & Jakowec, M. W. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70123-6 · Cited by 798 · see citing works
- Authors
- Villar-Cheda, B., Sousa-Ribeiro, D., Rodriguez-Pallares, J., Rodriguez-Perez, A. I., Guerra, M. J., & Labandeira-Garcia, J. L.
- Affiliations
- Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
- Universidade de Santiago de Compostela (ES)
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2008-10-29
- Volume
- 29
- Issue
- 2
- Pages
- 230-234
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2038773105
- Cited by
- 59
- References
- 15
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 7 · 2012: 3
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Economía y Competitividad
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- aging, sedentary behavior, Parkinson's disease, substantia nigra, vascularization, microvessel density, vascular endothelial growth factor, physical activity, dopaminergic neurons, neurovascular unit, age-related decline
- MeSH terms
- Aging, Animals, Disease Models, Animal, Gene Expression Regulation, Male, Parkinson Disease, Physical Conditioning, Animal, Substantia Nigra, Rats, Sprague-Dawley, Vascular Endothelial Growth Factor A, Rats
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