Conditioned pain modulation (the diffuse noxious inhibitory control-like effect): its relevance for acute and chronic pain states

Sex, gender, and pain: a review of recent clinical and experimental findings

Fillingim, R. B., King, C. D., Ribeiro-Dasilva, M. C., Rahim-Williams, B., & Riley, J. L. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2008.12.001 · Cited by 2,766

Prediction of chronic post-operative pain: Pre-operative DNIC testing identifies patients at risk

Yarnitsky, D., Crispel, Y., Eisenberg, E., Granovsky, Y., Ben-Nun, A., Sprecher, E., Best, L.-A., & Granot, M. (2008) · Pain · doi:10.1016/j.pain.2007.10.033 · Cited by 750

Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition

Julien, N., Goffaux, P., Arsenault, P., & Marchand, S. (2005) · Pain · doi:10.1016/j.pain.2004.12.032 · Cited by 634

Possible Deficiencies of Pain Modulation in Fibromyalgia

Lautenbacher, S., & Rollman, G. B. (1997) · Clinical Journal of Pain · doi:10.1097/00002508-199709000-00003 · Cited by 546

Recommendations on terminology and practice of psychophysical DNIC testing

Yarnitsky, D., Arendt‐Nielsen, L., Bouhassira, D., Edwards, R. R., Fillingim, R. B., Granot, M., Hansson, P. T., Lautenbacher, S., Marchand, S., & Wilder‐Smith, O. H. G. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2010.02.004 · Cited by 535

Characteristics and prediction of early pain after laparoscopic cholecystectomy

Bisgaard, T., Klarskov, B., Rosenberg, J., & Kehlet, H. (2001) · Pain · doi:10.1016/s0304-3959(00)00406-1 · Cited by 486

Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief

Kosek, E., & Ordeberg, G. (2000) · Pain · doi:10.1016/s0304-3959(00)00310-9 · Cited by 476

The methodology of experimentally induced diffuse noxious inhibitory control (DNIC)-like effect in humans

Pud, D., Granovsky, Y., & Yarnitsky, D. (2009) · Pain · doi:10.1016/j.pain.2009.02.015 · Cited by 465

Diffuse noxious inhibitory controls (DNIC) attenuate temporal summation of second pain in normal males but not in normal females or fibromyalgia patients

Staud, R. M., Robinson, M. E., Vierck, C. J., & Price, D. D. (2002) · Pain · doi:10.1016/s0304-3959(02)00325-1 · Cited by 383

Determinants of endogenous analgesia magnitude in a diffuse noxious inhibitory control (DNIC) paradigm: Do conditioning stimulus painfulness, gender and personality variables matter?

Granot, M., Weissman-Fogel, I., Crispel, Y., Pud, D., Granovsky, Y., Sprecher, E., & Yarnitsky, D. (2008) · Pain · doi:10.1016/j.pain.2007.06.029 · Cited by 371

Predicting pain after standard pain therapy for knee osteoarthritis – the first steps towards personalized mechanistic-based pain medicine in osteoarthritis

Petersen, K. K.-S. (2023) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2022-0082 · Cited by 22

Differences in chloride gradients allow for three distinct types of synaptic modulation by endocannabinoids

Wang, Y., & Burrell, B. D. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00235.2016 · Cited by 21

Physical Activity May Be Associated with Conditioned Pain Modulation in Women but Not Men among Healthy Individuals

Shiro, Y., Ikemoto, T., Terasawa, Y., Arai, Y.-C. P., Hayashi, K., Ushida, T., & Matsubara, T. (2017) · Pain Research and Management · doi:10.1155/2017/9059140 · Cited by 22

The Strengthening Exercises in Shoulder Impingement trial (The SExSI-trial) investigating the effectiveness of a simple add-on shoulder strengthening exercise programme in patients with long-lasting subacromial impingement syndrome: Study protocol for a pragmatic, assessor blinded, parallel-group, randomised, controlled trial

Clausen, M. B., Bandholm, T., Rathleff, M. S., Christensen, K. B., Zebis, M. K., Graven‐Nielsen, T., Hölmich, P., & Thorborg, K. (2018) · Trials · doi:10.1186/s13063-018-2509-7 · Cited by 24

Age and gender differences in mechanically induced intraoral temporal summation and conditioned pain modulation in healthy subjects

Khan, J., Korczeniewska, O. A., Benoliel, R., Kalladka, M., Eliav, E., & Nasri‐Heir, C. (2018) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2018.03.021 · Cited by 22

Effects of virtual reality on psychophysical measures of pain: superiority to imagination and nonimmersive conditions

Tesarz, J., Herpel, C., Meischner, M., Drusko, A., Friederich, H.-C., Flor, H., & Reichert, J. (2024) · Pain · doi:10.1097/j.pain.0000000000003083 · Cited by 21

Blood pressure-related pain modulation in fibromyalgia: Differentiating between static versus dynamic pain indicators

de la Coba, P., Bruehl, S., Duschek, S., & Reyes del Paso, G. A. (2018) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.10.006 · Cited by 21

Preoperative pain sensitivity and its correlation with postoperative acute and chronic pain: a systematic review and meta-analysis

Wu, F., Liu, J., Zheng, L., Chen, C., Basnet, D., Zhang, J., Shen, C., Feng, X., Sun, Y., Du, X., et al. (2024) · British Journal of Anaesthesia · doi:10.1016/j.bja.2024.05.010 · Cited by 24

Does Quantitative Sensory Testing Improve Prediction of Chronic Pain Trajectories? A Longitudinal Study of Youth With Functional Abdominal Pain Participating in a Randomized Controlled Trial of Cognitive Behavioral Treatment

Morris, M. C., Bruehl, S. P., Stone, A. L., Garber, J., Smith, C. A., Palermo, T. M., & Walker, L. S. (2021) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000956 · Cited by 21

Knee extensor force production and discomfort during neuromuscular electrical stimulation of quadriceps with and without gluteal muscle co-stimulation

Flodin, J., Mikkelsen, C., & Ackermann, P. W. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-04949-9 · Cited by 21

Can the painDETECT Questionnaire score and MRI help predict treatment outcome in rheumatoid arthritis: protocol for the Frederiksberg hospital's Rheumatoid Arthritis, pain assessment and Medical Evaluation (FRAME-cohort) study

Rifbjerg-Madsen, S., Christensen, A. W., Boesen, M., Christensen, R., Danneskiold‐Samsøe, B., Bliddal, H., Bartels, E. M., Locht, H., & Amris, K. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-006058 · Cited by 21

Fibromyalgia

Brummett, C. M., & Clauw, D. J. (2011) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e32834a1091 · Cited by 21

Psychophysical and Electrophysiological Evidence for Enhanced Pain Facilitation and Unaltered Pain Inhibition in Acute Low Back Pain Patients

Vuilleumier, P. H., Arguissain, F. G., Manresa, J. A. B., Neziri, A. Y., Nirkko, A. C., Andersen, O. K., Arendt‐Nielsen, L., & Curatolo, M. (2017) · Journal of Pain · doi:10.1016/j.jpain.2017.05.008 · Cited by 21

Fibromyalgia Syndrome: Novel Therapeutic Targets

Ablin, J. N., & Häuser, W. (2016) · Pain Management · doi:10.2217/pmt-2016-0007 · Cited by 21

Endogenous Opioid Antagonism in Physiological Experimental Pain Models: A Systematic Review

Werner, M. U., Pereira, M. P., Andersen, L. P. H., & Dahl, J. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125887 · Cited by 20

Analgesia induced by anodal tDCS and high-frequency tRNS over the motor cortex: Immediate and sustained effects on pain perception

Yao, J., Li, X., Zhang, W., Lin, X., Lyu, X., Lou, W., & Peng, W. (2021) · Brain stimulation · doi:10.1016/j.brs.2021.07.011 · Cited by 20

Descending pain modulatory efficiency in healthy subjects is related to structure and resting connectivity of brain regions

Huynh, V., Lütolf, R., Rosner, J., Luechinger, R., Curt, A., Kollias, S., Michels, L., & Hubli, M. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118742 · Cited by 18

Suffering from chronic tinnitus, chronic neck pain, or both: Does it impact the presence of signs and symptoms of central sensitization?

Meulemeester, K. D., Meeus, M., Pauw, R. D., Cagnie, B. J., Keppler, H., & Lenoir, D. (2023) · PLoS ONE · doi:10.1371/journal.pone.0290116 · Cited by 20

Referred pain and cutaneous responses from deep tissue electrical pain stimulation in the groin

Aasvang, E. K., Werner, M. U., & Kehlet, H. (2015) · British Journal of Anaesthesia · doi:10.1093/bja/aev170 · Cited by 20

Pharmacotherapy for Fibromyalgia

Smith, H. S., Bracken, D., & Smith, J. M. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00017 · Cited by 20

Psychopharmacology of chronic pain

Ciaramella, A. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64012-3.00019-8 · Cited by 20

Spinal manipulation and modulation of pain sensitivity in persistent low back pain: a secondary cluster analysis of a randomized trial

Nim, C. G., Weber, K. A., II, Kawchuk, G. N., & O’Neill, S. F. D. (2021) · Chiropractic & Manual Therapies · doi:10.1186/s12998-021-00367-4 · Cited by 19

The OPRM1 gene and interactions with the 5-HT1a gene regulate conditioned pain modulation in fibromyalgia patients and healthy controls

Tour, J., Sandström, A., Kadetoff, D., Schalling, M., & Kosek, E. (2022) · PLoS ONE · doi:10.1371/journal.pone.0277427 · Cited by 18

Does conditioned pain modulation predict the magnitude of placebo effects in patients with neuropathic pain?

Skyt, I., Moslemi, K., Baastrup, C., Grosen, K., Svensson, P. J., Jensen, T. S., & Vase, L. (2017) · European Journal of Pain · doi:10.1002/ejp.1164 · Cited by 19

Unilateral Lateral Epicondylalgia Shows a Pro-nociceptive Pain Profile

Bisset, L., Carty, M., & Smith, A. D. (2018) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000615 · Cited by 19

An Exploratory Study of Endogenous Pain Modulatory Function in Patients Following Mild Traumatic Brain Injury

Carey, C., Saxe, J. M., White, F. A., & Naugle, K. M. (2019) · Pain Medicine · doi:10.1093/pm/pnz058 · Cited by 19

Acute and Chronic Pain in Orofacial Trauma Patients

Khan, J., Zusman, T., Wang, Q., & Eliav, E. (2019) · Journal of Endodontics · doi:10.1016/j.joen.2019.05.010 · Cited by 20

The Effect of Pain Catastrophizing on Endogenous Inhibition of Pain and Spinal Nociception in Native Americans: Results From the Oklahoma Study of Native American Pain Risk

Toledo, T. A., Kuhn, B. L., Payne, M. F., Lannon, E. W., Palit, S., Sturycz, C. A., Hellman, N. M., Guereca, Y. M., Demuth, M. J., Huber, F. A., et al. (2020) · Annals of Behavioral Medicine · doi:10.1093/abm/kaaa004 · Cited by 19

Attenuation of the Diffuse Noxious Inhibitory Controls in Chronic Joint Inflammatory Pain Is Accompanied by Anxiodepressive-Like Behaviors and Impairment of the Descending Noradrenergic Modulation

Pereira-Silva, R., Costa‐Pereira, J. T., Alonso, R., Serrão, P., Martins, I., & Neto, F. L. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082973 · Cited by 18

Anti‐ and Pro‐Nociceptive mechanisms in neuropathic pain after human spinal cord injury

Lütolf, R., Schoenmacker, I. D., Rösner, J., Sirucek, L., Schweinhardt, P., Curt, A. E. P., & Hubli, M. (2022) · European Journal of Pain · doi:10.1002/ejp.2029 · Cited by 19

How to Distinguish Non-Inflammatory from Inflammatory Pain in RA?

Khot, S., Tackley, G., & Choy, E. (2024) · Current Rheumatology Reports · doi:10.1007/s11926-024-01159-4 · Cited by 22

Perspectives on next steps in classification of oro‐facial pain – Part 3: biomarkers of chronic oro‐facial pain – from research to clinic

Ceusters, W. M., Nasri‐Heir, C., Alnaas, D., Cairns, B. E., Michelotti, A., & Ohrbach, R. K. (2015) · Journal of Oral Rehabilitation · doi:10.1111/joor.12324 · Cited by 18

The Effect of Experimental Neck Pain on Pressure Pain Sensitivity and Axioscapular Motor Control

Christensen, S. W., Hirata, R. P., & Graven‐Nielsen, T. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.01.008 · Cited by 18

Do Diagnostic Blocks Have Beneficial Effects on Pain Processing?

Chua, N. H. L., Vissers, K. C. P., Arendt‐Nielsen, L., & Wilder‐Smith, O. H. G. (2011) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0b013e31821e5f7f · Cited by 18

Comparison of 2 Lumbar Manual Therapies on Temporal Summation of Pain in Healthy Volunteers

Penza, C. W., Horn, M. E., George, S. Z., & Bishop, M. D. (2017) · Journal of Pain · doi:10.1016/j.jpain.2017.07.007 · Cited by 18

Loss of Temporal Inhibition of Nociceptive Information Is Associated With Aging and Bodily Pain

Naugle, K. M., Cruz‐Almeida, Y., Fillingim, R. B., & Riley, J. L. (2017) · Journal of Pain · doi:10.1016/j.jpain.2017.08.003 · Cited by 18

Altered pain modulation to noxious heat thermal stimuli in burning mouth syndrome

Nishihara, C., Watanabe, K., Ozasa, K., Khan, J., Eliav, E., Imamura, Y., & Noma, N. (2020) · Oral Diseases · doi:10.1111/odi.13486 · Cited by 18

Conditioned Pain Modulation Decreases Over Time in Patients With Neuropathic Pain Following a Spinal Cord Injury

Gagné, M., Côté, I., Boulet, M., Jutzeler, C. R., Kramer, J. L. K., & Mercier, C. (2020) · Neurorehabilitation and neural repair · doi:10.1177/1545968320962497 · Cited by 18

Association between temporal summation and conditioned pain modulation in chronic low back pain: baseline results from 2 clinical trials

Kong, J., You, D. S., Law, C. S. W., Darnall, B. D., Gross, J. J., Manber, R., & Mackey, S. (2021) · PAIN Reports · doi:10.1097/pr9.0000000000000975 · Cited by 18

Age does not affect sex effect of conditioned pain modulation of pressure and thermal pain across 2 conditioning stimuli

Riley, J. L., Cruz‐Almeida, Y., Staud, R. M., & Fillingim, R. B. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000796 · Cited by 18

Descending Pain Modulation in Fibromyalgia: A Short Review of Mechanisms and Biomarkers

Carneiro, B. D., Torres, S., Costa‐Pereira, J. T., Pozza, D. H., & Tavares, I. (2025) · Diagnostics · doi:10.3390/diagnostics15212702 · Cited by 20

The Potential Clinical Utility of Pressure-Based vs. Heat-Based Paradigms to Measure Conditioned Pain Modulation in Healthy Individuals and Those With Chronic Pain

El‐Sayed, R., Fauchon, C., Kim, J. A., Firouzian, S., Osborne, N. R., Besik, A., Mills, E. P., Bhatia, A., & Davis, K. D. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.784362 · Cited by 17

Might pain be experienced in the brainstem rather than in the cerebral cortex?

Baron, M. S., & Devor, M. G. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113861 · Cited by 17

Mechanisms of chronic pain in inflammatory rheumatism: the role of descending modulation

Trouvin, A., Simunek, A., Coste, J., Medkour, T., Carvès, S., Bouhassira, D., & Perrot, S. (2022) · Pain · doi:10.1097/j.pain.0000000000002745 · Cited by 17

Comparison of Trigeminal and Spinal Modulation of Pain and Nociception

Rehberg, B., Baars, J. H., Kotsch, J., Koppe, P., & von Dincklage, F. (2012) · International Journal of Neuroscience · doi:10.3109/00207454.2011.649868 · Cited by 17

Descending nociceptive inhibition is modulated in a time-dependent manner in a double-hit model of chronic/tonic pain

Parent, A. J., Tétreault, P., Roux, M., Belleville, K., Longpré, J., Beaudet, N., Goffaux, P., & Sarret, P. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.065 · Cited by 18

Current methodological approaches in conditioned pain modulation assessment in pediatrics

Hwang, P., Ma, M.-L., Spiegelberg, N., & Ferland, C. E. (2017) · Journal of Pain Research · doi:10.2147/jpr.s150857 · Cited by 17

Effects of neuroplasticity in people with knee osteoarthritis

Iuamoto, L. R., Ito, F. L. K., Tomé, T. A., Hsing, W. T., Meyer, A., Imamura, M., & Battistella, L. R. (2022) · Medicine · doi:10.1097/md.0000000000028616 · Cited by 17

Multi-modal Quantitative Sensory Testing in Patients with Unilateral Chronic Neck Pain: An Exploratory Study

Chua, N. H. L., Timmerman, H., Vissers, K. C. P., & Oh, W.-S. (2012) · Journal of Musculoskeletal Pain · doi:10.3109/10582452.2012.733803 · Cited by 17

Ethnic Differences Identified by Pain Sensitivity Questionnaire Correlate With Clinical Pain Responses

Bell, B. A., Ruscheweyh, R., Kelley, B. J., Ness, T. J., Vetter, T. R., & Sellers, A. B. (2017) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0000000000000689 · Cited by 17

Biogastronomy: Factors that determine the biological response to meal ingestion

Pribić, T., & Azpiroz, F. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13309 · Cited by 17

Psychosocial and cardiometabolic predictors of chronic pain onset in Native Americans: serial mediation analyses of 2-year prospective data from the Oklahoma Study of Native American Pain Risk

Rhudy, J. L., Huber, F. A., Toledo, T. A., Kell, P. A., Street, E. N., & Shadlow, J. O. (2021) · Pain · doi:10.1097/j.pain.0000000000002458 · Cited by 17

Fibromyalgia is associated with hypersensitivity but not with abnormal pain modulation: evidence from QST trials and spinal fMRI

Staud, R. M., Godfrey, M. M., & Stroman, P. W. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1284103 · Cited by 17

Oral Delta-9-Tetrahydrocannabinol (THC) Increases Parasympathetic Activity and Supraspinal Conditioned Pain Modulation in Chronic Neuropathic Pain Male Patients: A Crossover, Double-Blind, Placebo-Controlled Trial

Weizman, L., Sharon, H., Dayan, L., Espaniol, J., Brill, S., Nahman‐Averbuch, H., Hendler, T., & Jacob, G. (2024) · CNS Drugs · doi:10.1007/s40263-024-01085-0 · Cited by 17

Sleep Deprivation Related Changes of Plasma Oxytocin in Males and Female Contraceptive Users Depend on Sex and Correlate Differentially With Anxiety and Pain Hypersensitivity

Schuh‐Hofer, S., Eichhorn, N., Grinevich, V., & Treede, R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00161 · Cited by 16

Enhanced pain modulation capacity among individuals with borderline personality disorder: A possible mechanism underlying their hypoalgesia

Defrin, R., Sagy, N. C., Biran, I., Goor‐Aryeh, I., Shai, R., & Ginzburg, K. (2019) · European Journal of Pain · doi:10.1002/ejp.1504 · Cited by 16

Spatial aspects of pain modulation are not disrupted in adolescents with migraine

Nahman‐Averbuch, H., Thomas, P. L., Schneider, V. J., Chamberlin, L. A., Peugh, J., Hershey, A. D., Powers, S. W., Coghill, R. C., & King, C. D. (2020) · Headache The Journal of Head and Face Pain · doi:10.1111/head.14017 · Cited by 16

A psychophysical study comparing massage to conditioned pain modulation: A single blind randomized controlled trial in healthy participants

Wilson, A. T., Riley, J. L., Bishop, M. D., Beneciuk, J. M., Godza, M., Cruz‐Almeida, Y., & Bialosky, J. E. (2021) · Journal of Bodywork and Movement Therapies · doi:10.1016/j.jbmt.2021.02.014 · Cited by 18

II. No need for translation when the same language is spoken

Sikandar, S., & Dickenson, A. H. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet210 · Cited by 16

An update on emerging drugs for fibromyalgia treatment

Atzeni, F., Gerardi, M. C., Masala, I. F., Alciati, A., Batticciotto, A., & Sarzi‐Puttini, P. (2017) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2017.1418323 · Cited by 17

Divergent effects of conditioned pain modulation on subjective pain and nociceptive-related brain activity

Albu, S., & Meagher, M. W. (2019) · Experimental Brain Research · doi:10.1007/s00221-019-05545-8 · Cited by 18

Safety and preliminary efficacy of transcutaneous auricular vagus nerve stimulation on chronic knee pain: A pilot trial

Aoyagi, K., Rivas, E., Shababi, R., Edwards, R. R., LaValley, M. P., Lechuga, J., Napadow, V., & Neogi, T. (2024) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2024.100545 · Cited by 15

Slowly repeated evoked pain (SREP) as a central sensitization marker in episodic migraine patients

de la Coba, P., Bruehl, S. P., & del Paso, G. A. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-84157-1 · Cited by 16

The interrater and test–retest reliability of 3 modalities of quantitative sensory testing in healthy adults and people with chronic low back pain or rheumatoid arthritis

Brady, S. M., Georgopoulos, V., Zanten, J. V., Duda, J. L., Metsios, G. S., Kitas, G. D., Fenton, S. A. M., Walsh, D. A., & McWilliams, D. F. (2023) · PAIN Reports · doi:10.1097/pr9.0000000000001102 · Cited by 15

Relationship Between Blood- and Cerebrospinal Fluid–Bound Neurotransmitter Concentrations and Conditioned Pain Modulation in Pain-Free and Chronic Pain Subjects

Parent, A. J., Beaudet, N., Daigle, K., Sabbagh, R., Sansoucy, Y., Marchand, S., Sarret, P., & Goffaux, P. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.01.007 · Cited by 15

Conditioned pain modulation is minimally influenced by cognitive evaluation or imagery of the conditioning stimulus

Kong, J., Bernaba, M., Johnson, K. A., & Mackey, S. (2014) · Journal of Pain Research · doi:10.2147/jpr.s65607 · Cited by 14

Medication overuse reinstates conditioned pain modulation in women with migraine

Guy, N., Voisin, D. L., Mulliez, A., Clavelou, P., & Dallel, R. (2017) · Cephalalgia · doi:10.1177/0333102417727545 · Cited by 15

Exercise‐induced hypoalgesia is present in people with Parkinson’s disease: Two observational cross‐sectional studies

Nguy, V., Barry, B. K., Moloney, N. A., Hassett, L. M., Canning, C. G., Lewis, S. J. G., & Allen, N. E. (2019) · European Journal of Pain · doi:10.1002/ejp.1400 · Cited by 15

Less Pain, Better Sleep? The Effect of a Multidisciplinary Back Pain App on Sleep Quality in Individuals Suffering from Back Pain – a Secondary Analysis of App User Data

Priebe, J. A., Utpadel-Fischler, D., & Toelle, T. R. (2020) · Journal of Pain Research · doi:10.2147/jpr.s232792 · Cited by 15

Do chronic low back pain subgroups derived from dynamic quantitative sensory testing exhibit differing multidimensional profiles?

Rabey, M. I., Kendell, M., Koren, S., Silva, I., Watts, L., Wong, C., Slater, H., Smith, A. J., & Beales, D. J. (2021) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2020-0126 · Cited by 15

An observational study of centrally facilitated pain in individuals with chronic low back pain

Georgopoulos, V., Akin-Akinyosoye, K., Smith, S. L., McWilliams, D. F., Hendrick, P. A., & Walsh, D. A. (2022) · PAIN Reports · doi:10.1097/pr9.0000000000001003 · Cited by 16

Differential pain modulation in patients with peripheral neuropathic pain and fibromyalgia

Gormsen, L. K., Bach, F. W., Rosenberg, R., & Jensen, T. S. (2012) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2012.01.002 · Cited by 15

Learned control over spinal nociception in patients with chronic back pain

Krafft, S., Göhmann, H. ‐., Sommer, J. B., Straube, A. M., & Ruscheweyh, R. (2017) · European Journal of Pain · doi:10.1002/ejp.1055 · Cited by 16

Left/Right Pain Asymmetry With Injectable Cosmetic Treatments for the Face

Fouché, J. J., van Loghem, J. A. J., Thuis, J., Heer, L. M. D., & van Oijen, M. G. H. (2017) · Aesthetic Surgery Journal · doi:10.1093/asj/sjw214 · Cited by 15

The descending modulation of pain

Bannister, K., Patel, R., & Hughes, S. (2025) · Pain · doi:10.1097/j.pain.0000000000003683 · Cited by 14

Moderate to severe acute pain disturbs motor cortex intracortical inhibition and facilitation in orthopedic trauma patients: A TMS study

Jodoin, M., Rouleau, D. M., Bellemare, A., Provost, C., Larson-Dupuis, C., Sandman, É., Laflamme, G. Y., Benoit, B., Leduc, S., Levesque, M., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0226452 · Cited by 14

Exploring the Relationship Between Endogenous Pain Modulation, Pain Intensity, and Depression in Patients Using Opioids for Chronic Low Back Pain

Lazaridou, A., Paschali, M., Zgierska, A. E., Garland, E. L., & Edwards, R. R. (2022) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000001063 · Cited by 14

Optimizing the early phase development of new analgesics by human pain biomarkers

Arendt-Nielsen, L., & Hoeck, H. C. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.147 · Cited by 14

Gainfully employing descending controls in acute and chronic pain management

White, K., Targett, M. P., & Harris, J. E. (2018) · The Veterinary Journal · doi:10.1016/j.tvjl.2018.05.005 · Cited by 14

An assessment of methodological quality of systematic reviews of acupuncture and related therapies for cancer-related pain

Anshasi, H. A., & Ahmad, M. M. (2018) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2018.06.013 · Cited by 14

Pain perception in chronic knee osteoarthritis with varying levels of pain inhibitory control: an exploratory study

Teixeira, P. E. P., Zehry, H. I., Chaudhari, S., Dipietro, L., & Fregni, F. (2020) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2020-0016 · Cited by 14

Behavioral and Regional Brain Responses to Inhalation of Capsaicin Modified by Painful Conditioning in Humans

Abubakar, A. B., Bautista, T. G., Dimmock, M., Mazzone, S. B., & Farrell, M. J. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.08.2105 · Cited by 14

Association Between Anxiety and Descending Pain Modulation of Thermal Stimuli in Patients with Burning Mouth Syndrome: A Cross-Sectional Study

Ozasa, K., Noma, N., Kobayashi, M., Takizawa, K., Young, A., Eliav, E., & Imamura, Y. (2022) · Journal of Oral & Facial Pain and Headache · doi:10.11607/ofph.3050 · Cited by 13

Objective evidence for chronic back pain relief by Medical Yoga therapy

Arya, S., Yadav, R. K., Venkataraman, S., Deepak, K. K., & Bhatia, R. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.1060685 · Cited by 14

Prognostic models for chronic postsurgical pain-Current developments, trends, and challenges

Segelcke, D., Rosenberger, D. C., & Pogatzki-Zahn, E. M. (2023) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000001299 · Cited by 13

Altered Endogenous Pain-Inhibitory Function in Older Adults With Chronic Pain Is Associated With Disruptions in Functional Connectivity During Resting State

Dorado, A., Terrasa, J. L., van der Meulen, M., Montoya, P., & González‐Roldán, A. M. (2024) · Journal of Pain · doi:10.1016/j.jpain.2024.104641 · Cited by 13

Men Report Greater Pain Relief Following Sustained Static Contractions Than Women When Matched for Baseline Pain

Bement, M. H., Drewek, B., & Hunter, S. K. (2014) · Journal of Motor Behavior · doi:10.1080/00222895.2013.872078 · Cited by 13

Working Memory Performance, Pain and Associated Clinical Variables in Women With Fibromyalgia

Gil‐Ugidos, A., Rodríguez, D., Pidal-Miranda, M., Samartin-Veiga, N., Fernández‐Prieto, M., & Carrillo‐de‐la‐Peña, M. T. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.747533 · Cited by 12

Effect of High-definition Transcranial Direct Current Stimulation on Conditioned Pain Modulation in Healthy Adults: A Crossover Randomized Controlled Trial

Wan, R., Wang, Y., Feng, B., Jiang, X., Xu, Y., Zhang, Z., Liu, Y., & Wang, Y. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.10.019 · Cited by 13

Monoaminergic mediation of hyperalgesic and analgesic descending control of nociception in mice

Nemoto, W., Kozak, D., Sotocinal, S. G., Tansley, S. N., Bannister, K., & Mogil, J. S. (2022) · Pain · doi:10.1097/j.pain.0000000000002806 · Cited by 13

Prolonged continuous theta burst stimulation increases motor corticospinal excitability and intracortical inhibition in patients with neuropathic pain: An exploratory, single-blinded, randomized controlled trial

Thakkar, B., Peterson, C. L., & Acevedo, E. O. (2023) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2023.102894 · Cited by 15

Acupuncture assisted local anesthesia for penile surgeries.

Hsu, G., Zaid, U. X., Hsieh, C., & Huang, S.-J. (2013) · PubMed Central · doi:10.3978/j.issn.2223-4683.2013.12.02 · Cited by 13

High prevalence of fibromyalgia symptoms among healthy full-term pregnant women

Saa’d, S., Many, A., Jacob, G., & Ablin, J. N. (2012) · Rheumatology International · doi:10.1007/s00296-012-2627-6 · Cited by 13

A Paradigm-Shift in Pain Medicine

Wilder‐Smith, O. H. G. (2013) · doi:10.13052/rp-9788793102545 · Cited by 13

Bilateral experimental neck pain reorganize axioscapular muscle coordination and pain sensitivity

Christensen, S. W., Hirata, R. P., & Graven‐Nielsen, T. (2016) · European Journal of Pain · doi:10.1002/ejp.972 · Cited by 13

Chronic Lateral Epicondylalgia Does Not Exhibit Mechanical Pain Modulation in Response to Noxious Conditioning Heat Stimulus

Lim, E. C. W., Sterling, M. M., & Vicenzino, B. (2017) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000475 · Cited by 13

Spinal Activation of Tropomyosin Receptor Kinase-B Recovers the Impaired Endogenous Analgesia in Neuropathic Pain Rats

Kato, D., Suto, T., Obata, H., & Saito, S. (2018) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000003592 · Cited by 13

Blood monoamines as potential biomarkers for conditioned pain modulation efficacy: An exploratory study in paediatrics

Ferland, C. E., Teles, A. R., Ingelmo, P. M., Saran, N., Marchand, S., & Ouellet, J. A. (2018) · European Journal of Pain · doi:10.1002/ejp.1307 · Cited by 13

Tracking Changes in Neuropathic Pain After Acute Spinal Cord Injury

Scheuren, P. S., Gagné, M., Jutzeler, C. R., Rösner, J., Mercier, C., & Kramer, J. L. K. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00090 · Cited by 13

Dysfunctional pain perception and modulation among torture survivors: The role of pain personification

Tsur, N., Defrin, R., Shahar, G., & Solomon, Z. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.031 · Cited by 13

Pain inhibits pain: Conditioned pain modulation (CPM)

Yi, T. A. N. G., Hu, L., DanDan, T. A. N. G., & Peng, W. (2015) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972015-00872 · Cited by 7

Effect of Pain Induction or Pain Reduction on Conditioned Pain Modulation in Adults: A Systematic Review

Goubert, D., Danneels, L. A., Cagnie, B. J., Oosterwijck, J. V., Kolba, K., Noyez, H., & Meeus, M. (2014) · Pain Practice · doi:10.1111/papr.12241 · Cited by 50

Assessment of conditioned pain modulation in healthy participants and patients with chronic pain: manifestations and implications for pain progression

Petersen, K. K., McPhee, M. E., Hoegh, M., & Graven‐Nielsen, T. (2019) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000419 · Cited by 47

Conditioned pain modulation—A comprehensive review

Ramaswamy, S., & Wodehouse, T. (2020) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2020.11.002 · Cited by 221

Conditioned Pain Modulation: A Predictor for Development and Treatment of Neuropathic Pain

Granovsky, Y. (2013) · Current Pain and Headache Reports · doi:10.1007/s11916-013-0361-8 · Cited by 75