The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Conditioned pain modulation (the diffuse noxious inhibitory control-like effect): its relevance for acute and chronic pain states
Abstract
PURPOSE OF REVIEW: There is a growing body of knowledge on pain modulation in various disease states. This article reviews the state of the art regarding the clinical relevance of pain inhibition as revealed by 'pain inhibits pain' test paradigms, trying to organize the clinically relevant data, and emphasizing the pathophysiology of pain. In line with recent experts' recommendations, the term conditioned pain modulation (CPM) will be used, replacing the previous terms 'diffuse noxious inhibitory control (DNIC)' or 'DNIC-like' effects. RECENT FINDINGS: Most of the work in this context was done on the idiopathic pain syndromes, such as irritable bowel syndrome, temporomandibular disorders, fibromyalgia, and tension type headache. The pattern of reduced CPM efficiency seems common to these syndromes and an assertion is made that low CPM efficiency, reflecting low pain inhibitory capacity, is a pathogenetic factor in the development of the idiopathic pain syndromes. Low CPM efficiency was shown to be predictive of acute and chronic postoperative pain, and, in some reports, to be associated with neuropathic pain levels. SUMMARY: Low CPM efficiency is associated with higher pain morbidity and vice versa. Further work is awaited on clarifying plasticity of CPM and its relevance to selection and efficacy of pain therapy.
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“negative affective responses to pain, and pain-related catastrophizing are as prominent in adolescent patients 400–402”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [400]
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Sex, gender, and pain: a review of recent clinical and experimental findings
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Prediction of chronic post-operative pain: Pre-operative DNIC testing identifies patients at risk
Yarnitsky, D., Crispel, Y., Eisenberg, E., Granovsky, Y., Ben-Nun, A., Sprecher, E., Best, L.-A., & Granot, M. (2008) · Pain · doi:10.1016/j.pain.2007.10.033 · Cited by 750
Self-citationWidespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition
Julien, N., Goffaux, P., Arsenault, P., & Marchand, S. (2005) · Pain · doi:10.1016/j.pain.2004.12.032 · Cited by 634
Possible Deficiencies of Pain Modulation in Fibromyalgia
Lautenbacher, S., & Rollman, G. B. (1997) · Clinical Journal of Pain · doi:10.1097/00002508-199709000-00003 · Cited by 546
Recommendations on terminology and practice of psychophysical DNIC testing
Yarnitsky, D., Arendt‐Nielsen, L., Bouhassira, D., Edwards, R. R., Fillingim, R. B., Granot, M., Hansson, P. T., Lautenbacher, S., Marchand, S., & Wilder‐Smith, O. H. G. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2010.02.004 · Cited by 535
Self-citationCharacteristics and prediction of early pain after laparoscopic cholecystectomy
Bisgaard, T., Klarskov, B., Rosenberg, J., & Kehlet, H. (2001) · Pain · doi:10.1016/s0304-3959(00)00406-1 · Cited by 486
Kosek, E., & Ordeberg, G. (2000) · Pain · doi:10.1016/s0304-3959(00)00310-9 · Cited by 476
Pud, D., Granovsky, Y., & Yarnitsky, D. (2009) · Pain · doi:10.1016/j.pain.2009.02.015 · Cited by 465
Self-citationStaud, R. M., Robinson, M. E., Vierck, C. J., & Price, D. D. (2002) · Pain · doi:10.1016/s0304-3959(02)00325-1 · Cited by 383
Granot, M., Weissman-Fogel, I., Crispel, Y., Pud, D., Granovsky, Y., Sprecher, E., & Yarnitsky, D. (2008) · Pain · doi:10.1016/j.pain.2007.06.029 · Cited by 371
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The association of sleep and pain: an update and a path forward
Finan, P. H., Goodin, B. R., & Smith, M. T. (2013) · The Journal of Pain · doi:10.1016/j.jpain.2013.08.007 · Cited by 1,620
Evaluating psychosocial contributions to chronic pain outcomes
Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719
Neurobiology of fibromyalgia and chronic widespread pain
Sluka, K. A., & Clauw, D. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.006 · Cited by 671
Chronic postsurgical pain in Europe: An observational study
Fletcher, D., Stamer, U. M., Pogatzki-Zahn, E., Zaslansky, R., Tanase, N. V., Perruchoud, C., Kranke, P., Komann, M., Lehman, T., & Meissner, W. (2015) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000000319 · Cited by 599
Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus
Backonja, M. “., Attal, N., Baron, R., Bouhassira, D., Drangholt, M., Dyck, P. J. B., Edwards, R. R., Freeman, R. L., Gracely, R. H., Haanpää, M., et al. (2013) · Pain · doi:10.1016/j.pain.2013.05.047 · Cited by 582
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Metadata
- Authors
- Yarnitsky, D.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- Corresponding author
- Yarnitsky, David
- ORCID
- Yarnitsky, David
- Venue
- Current Opinion in Anaesthesiology
- Published
- 2010-10
- Volume
- 23
- Issue
- 5
- Pages
- 611-615
- ISSN
- 0952-7907 (ISSN-L)
- OpenAlex
- W2004607543
- Cited by
- 745
- References
- 38
- Citations by year
- 2026: 39 · 2025: 42 · 2024: 43 · 2023: 38 · 2022: 55 · 2021: 62 · 2020: 55 · 2019: 57 · 2018: 58 · 2017: 61 · 2016: 51 · 2015: 38 · 2014: 54 · 2013: 54 · 2012: 22
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Anaesthesiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Keywords
- conditioned pain modulation, diffuse noxious inhibitory control, pain inhibition, fibromyalgia, irritable bowel syndrome, temporomandibular disorders, tension-type headache, postoperative pain, neuropathic pain, pain pathophysiology, pain management
- MeSH terms
- Acute Disease, Mental Disorders, Chronic Disease, Conditioning, Psychological, Humans, Terminology as Topic, Pain, Pain, Postoperative, Postoperative Pain, Peripheral Nervous System Diseases
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