Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition
Abstract
A deficit of endogenous pain inhibitory systems has been suggested to contribute to some chronic pain conditions, one of them being fibromyalgia. The aim of the investigation was to test whether endogenous pain inhibitory systems were activated by a spatial summation procedure in 30 fibromyalgia, 30 chronic low back pain, and 30 healthy volunteers who participated in a cross-over trial (two sessions). Each session consisted of visual analog scale ratings of pain during the immersion of different surfaces of the arm in circulating noxious cold (12 degrees C) water. The arm was arbitrarily divided into eight segments from the fingertips to the shoulder. One session was ascending (from the fingertips to the shoulder) and the other was descending (from the shoulder to the fingertips); they included eight consecutive 2-min immersions separated by 5-min resting periods. For healthy and low back pain subjects, pain was perceived differently during the ascending and descending sessions (P=0.0001). The descending session resulted in lower pain intensity and unpleasantness. This lowering of the perception curve seems to be due to a full recruitment of inhibitory systems at the beginning of the descending session as opposed to a gradual recruitment during the ascending session. For fibromyalgia subjects, no significant differences were found between the increasing and decreasing sessions (P>0.05). These data support a deficit of endogenous pain inhibitory systems in fibromyalgia but not in chronic low back pain. The treatments proposed to fibromyalgia patients should aim at stimulating the activity of those endogenous systems.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Central pain sensitization explains the occurrence and maintenance of spontaneous pain, as well as hypersensitivity to innocuous (allodynia) or low-intensity (hyperalgesia) stimulation in central pain sensitization syndromes.
“CPS explains the occurrence of spontaneous pain, and maintenance thereof, as well as hypersensitivity to innocuous (allodynia) or low-intensity (hyperalgesia) stimulation in the so-called central pain sensitization syndromes (CPSS) [2,8,9].”
From Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review (2021) · cites this paper as [8]
Cites
The american college of rheumatology 1990 criteria for the classification of fibromyalgia
Wolfe, F., Smythe, H. A., Yunus, M. B., Bennett, R. M., Bombardier, C., Goldenberg, D. L., Tugwell, P., Campbell, S. M., Abeles, M., Clark, P., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330203 · Cited by 9,563 · see citing works
Millan, M. J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00009-6 · Cited by 3,035 · see citing works
Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat
Bars, D. L., Dickenson, A. H., & Besson, J. (1979) · Pain · doi:10.1016/0304-3959(79)90049-6 · Cited by 1,370 · see citing works
Endogenous pain control mechanisms: Review and hypothesis
Basbaum, A. I., & Fields, H. L. (1978) · Annals of Neurology · doi:10.1002/ana.410040511 · Cited by 1,240 · see citing works
Brainstem Control of Spinal Pain-Transmission Neurons
Fields, H. L., & Basbaum, A. I. (1978) · Annual Review of Physiology · doi:10.1146/annurev.ph.40.030178.001245 · Cited by 834 · see citing works
Bars, D. L., Dickenson, A. H., & Besson, J. (1979) · Pain · doi:10.1016/0304-3959(79)90050-2 · Cited by 782 · see citing works
Staud, R., Vierck, C. J., Cannon, R. L., Mauderli, A. P., & Price, D. D. (2001) · Pain · doi:10.1016/s0304-3959(00)00432-2 · Cited by 774 · see citing works
Loeser, J. D. (2001) · Cited by 773 · see citing works
Elevated cerebrospinal fluid levels of substance p in patients with the fibromyalgia syndrome
Russell, I. J., Orr, M. D., Littman, B., Vipraio, G. A., Alboukrek, D., Michalek, J. E., Lopez, Y., & Mackillip, F. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780371106 · Cited by 679 · see citing works
Gebhart, G. F. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.008 · Cited by 585 · see citing works
Russell, I. J., Værøy, H., Javors, M. A., & Nyberg, F. (1992) · Arthritis & Rheumatism · doi:10.1002/art.1780350509 · Cited by 546 · see citing works
Possible Deficiencies of Pain Modulation in Fibromyalgia
Lautenbacher, S., & Rollman, G. B. (1997) · Clinical Journal of Pain · doi:10.1097/00002508-199709000-00003 · Cited by 546 · see citing works
Kosek, E., & Hansson, P. T. (1997) · Pain · doi:10.1016/s0304-3959(96)03295-2 · Cited by 539 · see citing works
Supraspinal contributions to hyperalgesia
Urban, M. O., & Gebhart, G. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7687 · Cited by 518 · see citing works
Vaerøy, H., Helle, R., Førre, Ø., Kåss, E., & Terenius, L. (1988) · Pain · doi:10.1016/0304-3959(88)90019-x · Cited by 421 · see citing works
Jc, W., Roby-Brami, A., & Bars, D. L. (1984) · Brain · doi:10.1093/brain/107.4.1095 · Cited by 387 · see citing works
Staud, R. M., Robinson, M. E., Vierck, C. J., & Price, D. D. (2002) · Pain · doi:10.1016/s0304-3959(02)00325-1 · Cited by 383 · see citing works
Is TENS purely a placebo effect? A controlled study on chronic low back pain
Marchand, S., Charest, J., Li, J., CHENARD, J.-R., Lavignolle, B., & Laurencelle, L. (1993) · Pain · doi:10.1016/0304-3959(93)90104-w · Cited by 250 · see citing works
Self-citationEncoding of nociceptive thermal stimuli by diffuse noxious inhibitory controls in humans
Willer, J. C., de Broucker, T., & Bars, D. L. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.62.5.1028 · Cited by 226 · see citing works
Giovengo, S. L., Russell, I. J., & Larson, A. A. (1999) · PubMed · Cited by 195 · see citing works
Staud, R. M., Price, D. D., Robinson, M. E., Mauderli, A. P., & Vierck, C. J. (2004) · Pain · doi:10.1016/j.pain.2004.05.009 · Cited by 139 · see citing works
The pathogenesis of chronic pain and fatigue syndromes, with special reference to fibromyalgia
Claliw, D. J. (1995) · Medical Hypotheses · doi:10.1016/0306-9877(95)90263-5 · Cited by 123 · see citing works
Spatial summation for pain perception: interaction of inhibitory and excitatory mechanisms
Marchand, S., & Arsenault, P. (2002) · Pain · doi:10.1016/s0304-3959(01)00399-2 · Cited by 101 · see citing works
Self-citationNeurobiological concepts of fibromyalgia - the possible role of descending spinal tracts
Mense, S. (2000) · Scandinavian Journal of Rheumatology · doi:10.1080/030097400446599 · Cited by 98 · see citing works
Odors modulate pain perceptionA gender-specific effect
Marchand, S., & Arsenault, P. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00703-5 · Cited by 93 · see citing works
Self-citationBouhassira, D., Gall, O., Chitour, D., & Bars, D. L. (1995) · Pain · doi:10.1016/0304-3959(94)00270-o · Cited by 84 · see citing works
Effects of Caffeine on Analgesia from Transcutaneous Electrical Nerve Stimulation
Marchand, S., Li, J., & Charest, J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508033330521 · Cited by 79 · see citing works
Self-citationStaud, R. M., Vierck, C. J., Robinson, M. E., & Price, D. D. (2004) · Pain · doi:10.1016/j.pain.2004.07.015 · Cited by 66 · see citing works
From aspirin to biologics: therapeutic implications for rheumatoid arthritis.
Yunus, M. B., Dailey, J. W., Aldag, J. C., Masi, A. T., & Jobe, P. C. (1992) · PubMed · Cited by 63 · see citing works
Flagged first, then by citations
1 of the 30 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage
Costigan, M., Scholz, J., & Woolf, C. J. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135531 · Cited by 2,025 · see citing works
Models and Mechanisms of Hyperalgesia and Allodynia
Sandkühler, J. (2009) · Physiological Reviews · doi:10.1152/physrev.00025.2008 · Cited by 1,148 · see citing works
Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment
Sarzi‐Puttini, P., Giorgi, V., Marotto, D., & Atzeni, F. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-00506-w · Cited by 837 · see citing works
Prediction of chronic post-operative pain: Pre-operative DNIC testing identifies patients at risk
Yarnitsky, D., Crispel, Y., Eisenberg, E., Granovsky, Y., Ben-Nun, A., Sprecher, E., Best, L.-A., & Granot, M. (2008) · Pain · doi:10.1016/j.pain.2007.10.033 · Cited by 750 · see citing works
Yarnitsky, D. (2010) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e32833c348b · Cited by 745 · see citing works
Assessment and manifestation of central sensitisation across different chronic pain conditions
Arendt‐Nielsen, L., Morlion, B., Perrot, S., Dahan, A., Dickenson, A., Kress, H. G., Wells, C., Bouhassira, D., & Drewes, A. M. (2018) · European Journal of Pain · doi:10.1002/ejp.1140 · Cited by 695 · see citing works
Neurobiology of fibromyalgia and chronic widespread pain
Sluka, K. A., & Clauw, D. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.006 · Cited by 671 · see citing works
Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update
Siracusa, R., Paola, R. D., Cuzzocrea, S., & Impellizzeri, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083891 · Cited by 710 · see citing works
Yunus, M. B. (2008) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2007.09.003 · Cited by 648 · see citing works
The influence of negative emotions on pain: Behavioral effects and neural mechanisms
Wiech, K., & Tracey, I. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.059 · Cited by 614 · see citing works
Deer, T. R., Mekhail, N. A., Provenzano, D. A., Pope, J. E., Krames, E. S., Leong, M. S., Levy, R. M., Abejón, D., Buchser, E., Burton, A., et al. (2014) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12208 · Cited by 606 · see citing works
Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy
Yarnitsky, D., Granot, M., Nahman‐Averbuch, H., Khamaisi, M., & Granovsky, Y. (2012) · Pain · doi:10.1016/j.pain.2012.02.021 · Cited by 561 · see citing works
Arendt‐Nielsen, L., & Yarnitsky, D. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.02.002 · Cited by 548 · see citing works
Assessment of mechanisms in localized and widespread musculoskeletal pain
Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.107 · Cited by 547 · see citing works
Fishman (2006) · doi:10.1097/01 · Cited by 547 · see citing works
Meeus, M., & Nijs, J. (2007) · Clinical Rheumatology · doi:10.1007/s10067-006-0433-9 · Cited by 541 · see citing works
The effects of sleep deprivation on pain inhibition and spontaneous pain in women
Smith, M. T., Edwards, R. R., McCann, U. D., & Haythornthwaite, J. A. (2007) · Sleep · doi:10.1093/sleep/30.4.494 · Cited by 539 · see citing works
Decreased Central μ-Opioid Receptor Availability in Fibromyalgia
Harris, R. E., Clauw, D. J., Scott, D., McLean, S. A., Gracely, R. H., & Zubieta, J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2849-07.2007 · Cited by 512 · see citing works
Nijs, J., Houdenhove, B. V., & Oostendorp, R. A. B. (2009) · Manual Therapy · doi:10.1016/j.math.2009.12.001 · Cited by 507 · see citing works
Häuser, W., Ablin, J., Fitzcharles, M.-A., Littlejohn, G., Luciano, J. V., Usui, C., & Walitt, B. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.22 · Cited by 505 · see citing works
A biopsychosocial formulation of pain communication.
Hadjistavropoulos, T., Craig, K. D., Duck, S., Cano, A., Goubert, L., Jackson, P. L., Mogil, J. S., Rainville, P., Sullivan, M. J. L., Williams, A. C. D. C., et al. (2011) · Psychological Bulletin · doi:10.1037/a0023876 · Cited by 466 · see citing works
Finan, P. H., Buenaver, L. F., Bounds, S. C., Hussain, S., Park, R. J., Haque, U. J., Campbell, C. M., Haythornthwaite, J. A., Edwards, R. R., & Smith, M. T. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34646 · Cited by 473 · see citing works
AAPT Diagnostic Criteria for Fibromyalgia
Arnold, L. M., Bennett, R. M., Crofford, L. J., Dean, L. E., Clauw, D. J., Goldenberg, D. L., Fitzcharles, M., Paiva, E. S., Staud, R. M., Sarzi‐Puttini, P., et al. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.10.008 · Cited by 437 · see citing works
The neurobiology of central sensitization
Harte, S. E., Harris, R. E., & Clauw, D. J. (2018) · Journal of Applied Biobehavioral Research · doi:10.1111/jabr.12137 · Cited by 404 · see citing works
Granot, M., Weissman-Fogel, I., Crispel, Y., Pud, D., Granovsky, Y., Sprecher, E., & Yarnitsky, D. (2008) · Pain · doi:10.1016/j.pain.2007.06.029 · Cited by 371 · see citing works
Lee, Y. C., Nassikas, N. J., & Clauw, D. J. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3306 · Cited by 377 · see citing works
Neurobiology of depression, fibromyalgia and neuropathic pain
Maletic, V. (2009) · Frontiers in bioscience · doi:10.2741/3598 · Cited by 369 · see citing works
Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain
Jensen, K. B., Kosek, E., Petzke, F., Carville, S., Fransson, P., Marcus, H., Williams, S. C. R., Choy, E., Giesecke, T., Mainguy, Y., et al. (2009) · Pain · doi:10.1016/j.pain.2009.03.018 · Cited by 358 · see citing works
Clauw, D. J. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.09.006 · Cited by 350 · see citing works
Role of endogenous pain modulation in chronic pain mechanisms and treatment
Yarnitsky, D. (2015) · Pain · doi:10.1097/01.j.pain.0000460343.46847.58 · Cited by 347 · see citing works
The role of sleep in pain and fibromyalgia
Choy, E. H. S. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.56 · Cited by 333 · see citing works
Tracy, L. M., Ioannou, L., Baker, K. S., Gibson, S. J., Georgiou‐Karistianis, N., & Giummarra, M. J. (2015) · Pain · doi:10.1097/j.pain.0000000000000360 · Cited by 318 · see citing works
Impairment of pain inhibition in chronic tension-type headache
Pielsticker, A., Haag, G., Zaudig, M., & Lautenbacher, S. (2005) · Pain · doi:10.1016/j.pain.2005.08.019 · Cited by 315 · see citing works
Central Sensitization and Altered Central Pain Processing in Chronic Low Back Pain
Roussel, N. A., Nijs, J., Meeus, M., Mylius, V., Fayt, C., & Oostendorp, R. A. B. (2013) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31826f9a71 · Cited by 289 · see citing works
van Wijk, G., & Veldhuijzen, D. S. (2010) · The Journal of Pain · doi:10.1016/j.jpain.2009.10.009 · Cited by 281 · see citing works
Stahl, S. M., Porreca, F., Taylor, C. P., Cheung, R. Y., Thorpe, A. J., & Clair, A. G. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.04.001 · Cited by 277 · see citing works
Fibromyalgia: A Critical and Comprehensive Review
Borchers, A. T., & Gershwin, M. E. (2015) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8509-4 · Cited by 279 · see citing works
Jensen, K., Loitoile, R., Kosek, E., Petzke, F., Carville, S., Fransson, P., Marcus, H., Williams, S. C. R., Choy, E., Mainguy, Y., et al. (2012) · Molecular Pain · doi:10.1186/1744-8069-8-32 · Cited by 263 · see citing works
Towards a neurophysiological signature for fibromyalgia
López‐Solà, M., Woo, C., Pujol, J., Deus, J., Harrison, B. J., Monfort, J., & Wager, T. D. (2016) · Pain · doi:10.1097/j.pain.0000000000000707 · Cited by 255 · see citing works
Understanding fibromyalgia: lessons from the broader pain research community.
Williams, D. A., & Clauw, D. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.001 · Cited by 250 · see citing works
Fibromyalgia: from pathophysiology to therapy
Schmidt‐Wilcke, T., & Clauw, D. J. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.98 · Cited by 231 · see citing works
Jensen, K. B., Srinivasan, P., Spaeth, R. B., Tan, Y. H. V., Kosek, E., Petzke, F. W., Carville, S. F., Fransson, P., Marcus, H. E., Williams, S., et al. (2013) · Arthritis & Rheumatism · doi:10.1002/art.38170 · Cited by 225 · see citing works
Pain imaging in health and disease — how far have we come?
Schweinhardt, P., & Bushnell, M. C. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43498 · Cited by 221 · see citing works
Conditioned pain modulation—A comprehensive review
Ramaswamy, S., & Wodehouse, T. (2020) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2020.11.002 · Cited by 221 · see citing works
Effects of catastrophizing on pain perception and pain modulation
Weissman-Fogel, I., Sprecher, E., & Pud, D. (2008) · Experimental Brain Research · doi:10.1007/s00221-007-1206-7 · Cited by 214 · see citing works
Van Oosterwijck, J., Meeus, M., Paul, L., De Schryver, M., Pascal, A., Lambrecht, L., & Nijs, J. (2013) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e31827c7a7d · Cited by 212 · see citing works
Meeus, M., Goubert, D., Backer, F. D., Struyf, F., Hermans, L., Coppieters, I., Wandele, I. D., Silva, H. D., & Calders, P. (2013) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2013.03.004 · Cited by 213 · see citing works
Mechanisms of Disease: pain in fibromyalgia syndrome
Staud, R. M., & Rodriguez, M. E. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0091 · Cited by 211 · see citing works
D’Agnelli, S., Arendt‐Nielsen, L., Gerra, M. C., Zatorri, K., Boggiani, L., Baciarello, M., & Bignami, E. G. (2018) · Molecular Pain · doi:10.1177/1744806918819944 · Cited by 209 · see citing works
Staud, R. M., Nagel, S., Robinson, M. E., & Price, D. D. (2009) · Pain · doi:10.1016/j.pain.2009.05.020 · Cited by 202 · see citing works
Rosenthal, P., & Borsook, D. (2015) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2014-306280 · Cited by 198 · see citing works
Review: Central pain mechanisms in the rheumatic diseases: Future directions
Phillips, K., & Clauw, D. J. (2012) · Arthritis & Rheumatism · doi:10.1002/art.37739 · Cited by 194 · see citing works
Staud, R. M., Craggs, J. G., Perlstein, W. M., Robinson, M. E., & Price, D. D. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2008.02.002 · Cited by 187 · see citing works
An experimental model to measure excitatory and inhibitory pain mechanisms in humans
Tousignant-Laflamme, Y., Pagé, S., Goffaux, P., & Marchand, S. (2008) · Brain Research · doi:10.1016/j.brainres.2008.06.120 · Cited by 182 · see citing works
Self-citationSprenger, C., Bingel, U., & Büchel, C. (2011) · Pain · doi:10.1016/j.pain.2010.11.018 · Cited by 183 · see citing works
Altered Central Sensitization and Pain Modulation in the CNS in Chronic Joint Pain
Arendt‐Nielsen, L., Skou, S. T., Nielsen, T. A., & Petersen, K. K. (2015) · Current Osteoporosis Reports · doi:10.1007/s11914-015-0276-x · Cited by 182 · see citing works
Corrêa, J. B., Costa, L. O. P., de Oliveira, N. T. B., Sluka, K. A., & Liebano, R. E. (2015) · Experimental Brain Research · doi:10.1007/s00221-015-4309-6 · Cited by 179 · see citing works
Wilder‐Smith, O. H. G., Schreyer, T., Scheffer, G. J., & Arendt‐Nielsen, L. (2010) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.3109/15360281003706069 · Cited by 177 · see citing works
Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome
Littlejohn, G. O. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.100 · Cited by 175 · see citing works
Petersen, K. K., Graven‐Nielsen, T., Simonsen, O. H., Laursen, M. B., & Arendt‐Nielsen, L. (2016) · Pain · doi:10.1097/j.pain.0000000000000531 · Cited by 170 · see citing works
Diagnosing and treating chronic musculoskeletal pain based on the underlying mechanism(s)
Clauw, D. J. (2015) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2015.04.024 · Cited by 169 · see citing works
Kindler, L. L., Bennett, R. M., & Jones, K. D. (2009) · Pain Management Nursing · doi:10.1016/j.pmn.2009.10.003 · Cited by 167 · see citing works
del Paso, G. A. R., Garrido, S., Pulgar, Á., & Duschek, S. (2010) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2010.09.012 · Cited by 167 · see citing works
Potvin, S., & Marchand, S. (2016) · Pain · doi:10.1097/j.pain.0000000000000573 · Cited by 164 · see citing works
Self-citationMeints, S. M., Mawla, I., Napadow, V., Kong, J., Gerber, J. A., Chan, S., Wasan, A. D., Kaptchuk, T. J., McDonnell, C., Carrière, J. S., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001461 · Cited by 166 · see citing works
The Physiology of Pain Mechanisms: From the Periphery to the Brain
Marchand, S. (2008) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2008.04.003 · Cited by 165 · see citing works
Self-citationNeurogenic inflammation in fibromyalgia
Littlejohn, G. O., & Guymer, E. K. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0672-2 · Cited by 167 · see citing works
Boyer, N., Dallel, R., Artola, A., & Monconduit, L. (2014) · Pain · doi:10.1016/j.pain.2014.03.001 · Cited by 161 · see citing works
Peripheral pain mechanisms in chronic widespread pain
Staud, R. M. (2011) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2010.01.010 · Cited by 160 · see citing works
Mechanisms of craniofacial pain
Chichorro, J. G., Porreca, F., & Sessle, B. J. (2017) · Cephalalgia · doi:10.1177/0333102417704187 · Cited by 159 · see citing works
Shahidi, B., Curran‐Everett, D., & Maluf, K. S. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.09.002 · Cited by 147 · see citing works
Hassett, A. L., & Gevirtz, R. (2009) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2009.05.003 · Cited by 144 · see citing works
Diffuse noxious inhibitory control is delayed in chronic fatigue syndrome: An experimental study
Meeus, M., Nijs, J., de Wauwer, N. V., Toeback, L., & Truijen, S. (2008) · Pain · doi:10.1016/j.pain.2008.05.018 · Cited by 142 · see citing works
Evidence for a key role of steroids in the modulation of pain
Mensah‐Nyagan, A. G., Meyer, L., Schaeffer, V., Kibaly, C., & Patte‐Mensah, C. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.004 · Cited by 137 · see citing works
Tampin, B., Slater, H., Hall, T. M., Lee, G., & Briffa, K. (2012) · Pain · doi:10.1016/j.pain.2012.08.007 · Cited by 133 · see citing works
Excitatory and inhibitory pain mechanisms during the menstrual cycle in healthy women
Tousignant‐Laflamme, Y., & Marchand, S. (2009) · Pain · doi:10.1016/j.pain.2009.06.018 · Cited by 132 · see citing works
Self-citationHuman evidence of a supra‐spinal modulating role of dopamine on pain perception
Potvin, S., Grignon, S., & Marchand, S. (2009) · Synapse · doi:10.1002/syn.20616 · Cited by 132 · see citing works
Self-citationFibromyalgia: A Disorder of the Brain?
Schweinhardt, P., Sauro, K. M., & Bushnell, M. C. (2007) · The Neuroscientist · doi:10.1177/1073858407312521 · Cited by 131 · see citing works
Biology and therapy of fibromyalgia. Evidence-based biomarkers for fibromyalgia syndrome
Dadabhoy, D., Crofford, L. J., Spaeth, M., Russell, I. J., & Clauw, D. J. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2443 · Cited by 130 · see citing works
Psychiatry and Pain Management: at the Intersection of Chronic Pain and Mental Health
Goesling, J., Lin, L. A., & Clauw, D. J. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0872-4 · Cited by 130 · see citing works
de Souza, J. B., Potvin, S., Goffaux, P., Charest, J., & Marchand, S. (2009) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e318183cfa4 · Cited by 129 · see citing works
Self-citationYelle, M. D., Oshiro, Y., Kraft, R., & Coghill, R. C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4648-08.2009 · Cited by 129 · see citing works
Clinical and Economic Characteristics of Patients With Fibromyalgia Syndrome
Lachaîne, J., Beauchemin, C., & Landry, P. (2010) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181cf599f · Cited by 127 · see citing works
Imai, Y., Petersen, K. K., Mørch, C. D., & Arendt Nielsen, L. (2016) · Somatosensory & Motor Research · doi:10.1080/08990220.2016.1229178 · Cited by 127 · see citing works
The common link between functional somatic syndromes may be central sensitisation
Bourke, J. H., Langford, R. M., & White, P. D. (2015) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2015.01.003 · Cited by 124 · see citing works
Gaumond, I., Arsenault, P., & Marchand, S. (2005) · Brain Research · doi:10.1016/j.brainres.2005.06.011 · Cited by 125 · see citing works
Self-citationCan we predict persistent postoperative pain by testing preoperative experimental pain?
Granot, M. (2009) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e32832a40e1 · Cited by 120 · see citing works
Resting state connectivity correlates with drug and placebo response in fibromyalgia patients
Schmidt-Wilcke, T., Ichesco, E., Hampson, J. P., Kairys, A., Peltier, S., Harte, S., Clauw, D. J., & Harris, R. E. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2014.09.007 · Cited by 122 · see citing works
del Paso, G. A. R., Garrido, S., Pulgar, Á., Martín‐Vázquez, M., & Duschek, S. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181da91f1 · Cited by 121 · see citing works
Lack of endogenous modulation and reduced decay of prolonged heat pain in older adults
Riley, J. L., King, C. D., Wong, F., Fillingim, R. B., & Mauderli, A. P. (2010) · Pain · doi:10.1016/j.pain.2010.04.020 · Cited by 122 · see citing works
Lv, Z., Shen, L., Zhu, B., Zhang, Z., Ma, C., Huang, G., Yin, J., Yu, L., Yu, S., Ming-qiao, D., et al. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-019-1899-6 · Cited by 122 · see citing works
Current and Emerging Pharmacotherapy for Fibromyalgia
Tzadok, R., & Ablin, J. N. (2020) · Pain Research and Management · doi:10.1155/2020/6541798 · Cited by 122 · see citing works
“In humans, such two descending pain inhibitory pathways exist: the noradrenaline/serotonin-mediated pathway and the opioidmediated one [62].”
BackgroundMeeus, M. (2017) · Pain Physician · doi:10.36076/ppj.2017.318 · Cited by 119 · see citing works
Neuronal-Glial Interactions Maintain Chronic Neuropathic Pain after Spinal Cord Injury
Gwak, Y. S., Hulsebosch, C. E., & Leem, J. W. (2017) · Neural Plasticity · doi:10.1155/2017/2480689 · Cited by 119 · see citing works
The balancing act: endogenous modulation of pain in functional gastrointestinal disorders
Wilder‐Smith, C. H. (2011) · Gut · doi:10.1136/gutjnl-2011-300253 · Cited by 118 · see citing works
Reduced brain habituation to somatosensory stimulation in patients with fibromyalgia
Montoya, P., Sitges, C., García‐Herrera, M., Rodríguez‐Cotes, A., Izquierdo, R., Truyols, M., & Collado, D. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21910 · Cited by 113 · see citing works
TMD and chronic pain: A current view
Furquim, B. D., Fiamengui, L. M. S. P., & Conti, P. C. R. (2015) · Dental Press Journal of Orthodontics · doi:10.1590/2176-9451.20.1.127-133.sar · Cited by 115 · see citing works
Pain inhibits pain; human brainstem mechanisms
Youssef, A. M., Macefield, V. G., & Henderson, L. A. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.08.060 · Cited by 113 · see citing works
Gerdle, B. U. C., Ghafouri, B., Ernberg, M. M., & Larsson, B. (2014) · Journal of Pain Research · doi:10.2147/jpr.s59144 · Cited by 111 · see citing works
Reidler, J. S., de Mendonça, M. E., Santana, M. B., Wang, X., Lenkinski, R. E., Motta, A. F., Marchand, S., Latif, L. A., & Fregni, F. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.01.005 · Cited by 113 · see citing works
Self-citation
- Authors
- Julien, N., Goffaux, P., Arsenault, P., & Marchand, S.
- Affiliations
- Université du Québec en Abitibi-Témiscamingue (CA)
- Université de Sherbrooke (CA)
- Corresponding author
- Marchand, Serge
- Venue
- Pain
- Published
- 2005-03
- Volume
- 114
- Issue
- 1
- Pages
- 295-302
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2059810347
- Cited by
- 634
- References
- 30
- Citations by year
- 2026: 7 · 2025: 23 · 2024: 15 · 2023: 19 · 2022: 22 · 2021: 31 · 2020: 32 · 2019: 20 · 2018: 35 · 2017: 26 · 2016: 32 · 2015: 44 · 2014: 36 · 2013: 49 · 2012: 40
- FWCI
- 16.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- fibromyalgia, widespread pain, endogenous pain inhibition, descending pain inhibition, spatial summation, cold pressor pain, chronic low back pain, descending pain modulation, pain unpleasantness
- MeSH terms
- Adult, Cold Temperature, Female, Fibromyalgia, Humans, Male, Middle Aged, Neural Inhibition, Pain, Pain Measurement, Regression Analysis, Cross-Over Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review