Neurobiology of fibromyalgia and chronic widespread pain

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Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity

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Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition

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Neural correlates of interindividual differences in the subjective experience of pain

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Neurophysiologic evidence for a central sensitization in patients with fibromyalgia

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Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy

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Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis

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Possible Deficiencies of Pain Modulation in Fibromyalgia

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Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects

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Decreased Central μ-Opioid Receptor Availability in Fibromyalgia

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Small fibre pathology in patients with fibromyalgia syndrome

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Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief

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Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1

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Chronic Pain and Fatigue Syndromes: Overlapping Clinical and Neuroendocrine Features and Potential Pathogenic Mechanisms

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Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients

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The dorsal posterior insula subserves a fundamental role in human pain

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Motor unit physiology: Some unresolved issues

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Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome

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The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort

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Enhanced temporal summation of second pain and its central modulation in fibromyalgia patients

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Aspects of fibromyalgia in the general population: sex, pain threshold, and fibromyalgia symptoms.

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The relation between tender points and fibromyalgia symptom variables: evidence that fibromyalgia is not a discrete disorder in the clinic

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Increased pain sensitivity in fibromyalgia: effects of stimulus type and mode of presentation

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Elevated insular glutamate in fibromyalgia is associated with experimental pain

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Default mode network connectivity encodes clinical pain: An arterial spin labeling study

Loggia, M. L., Kim, J., Gollub, R. L., Vangel, M. G., Kirsch, I., Kong, J., Wasan, A. D., & Napadow, V. (2012) · Pain · doi:10.1016/j.pain.2012.07.029 · Cited by 314 · see citing works

Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia

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Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: A longitudinal voxel‐based morphometric study

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Hyperexcitable C nociceptors in fibromyalgia

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Hyperexcitability in fibromyalgia.

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Brief Report: Decreased intrinsic brain connectivity is associated with reduced clinical pain in fibromyalgia

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Multi-method assessment of experimental and clinical pain in patients with fibromyalgia

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Patients with fibromyalgia display less functional connectivity in the brain’s pain inhibitory network

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Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia

Nagakura, Y., Oe, T., Aoki, T., & Matsuoka, N. (2009) · Pain · doi:10.1016/j.pain.2009.05.024 · Cited by 261 · see citing works

Diffuse Noxious Inhibitory Controls (DNIC) in Animals and in Man

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Systematic review with meta-analysis: cytokines in fibromyalgia syndrome

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Pregabalin Rectifies Aberrant Brain Chemistry, Connectivity, and Functional Response in Chronic Pain Patients

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Injection of nerve growth factor into human masseter muscle evokes long‐lasting mechanical allodynia and hyperalgesia

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Transcutaneous electrical nerve stimulation reduces pain, fatigue and hyperalgesia while restoring central inhibition in primary fibromyalgia

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ASIC3, an Acid-Sensing Ion Channel, is Expressed in Metaboreceptive Sensory Neurons

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Fibromyalgia: from pathophysiology to therapy

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The neuroscience and endocrinology of fibromyalgia

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Editorial review (thematic issue: An update on central sensitivity syndromes and the issues of nosology and psychobiology)

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Autonomic nervous system dysfunction may explain the multisystem features of fibromyalgia

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A Psychophysical Study of Auditory and Pressure Sensitivity in Patients With Fibromyalgia and Healthy Controls

Geisser, M. E., Glass, J. M., Rajcevska, L. D., Clauw, D. J., Williams, D. A., Kileny, P. R., & Gracely, R. H. (2008) · Journal of Pain · doi:10.1016/j.jpain.2007.12.006 · Cited by 217 · see citing works

Fibromyalgia Symptoms Are Reduced by Low-Dose Naltrexone: A Pilot Study

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Survey Criteria for Fibromyalgia Independently Predict Increased Postoperative Opioid Consumption after Lower-extremity Joint Arthroplasty

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Regular physical activity prevents development of chronic pain and activation of central neurons

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Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia

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Long-lasting delayed hyperalgesia after subchronic swim stress

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Stress Induces a Switch of Intracellular Signaling in Sensory Neurons in a Model of Generalized Pain

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Bradykinin and Nerve Growth Factor Play Pivotal Roles in Muscular Mechanical Hyperalgesia after Exercise (Delayed-Onset Muscle Soreness)

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Moderate Exercise Increases Expression for Sensory, Adrenergic, and Immune Genes in Chronic Fatigue Syndrome Patients But Not in Normal Subjects

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Evidence that central sensitisation is present in patients with shoulder impingement syndrome and influences the outcome after surgery

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Cerebrospinal fluid levels of opioid peptides in fibromyalgia and chronic low back pain

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NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin

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IL-8 and IL-6 primarily mediate the inflammatory response in fibromyalgia patients

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Reactivity to superficial and deep stimuli in patients with chronic musculoskeletal pain

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Abnormal endogenous pain modulation and somatic and visceral hypersensitivity in female patients with irritable bowel syndrome

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What do tender points measure? Influence of distress on 4 measures of tenderness.

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Role of brainstem serotonin in analgesia produced by low-intensity exercise on neuropathic pain after sciatic nerve injury in mice

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Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study

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Cytokine biomarkers and chronic pain: Association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness

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The effect of brief exercise cessation on pain, fatigue, and mood symptom development in healthy, fit individuals

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Increased pressure pain sensibility in fibromyalgia patients is located deep to the skin but not restricted to muscle tissue

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Fibromyalgia Survey Criteria Are Associated with Increased Postoperative Opioid Consumption in Women Undergoing Hysterectomy

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Reduced dermal nerve fiber diameter in skin biopsies of patients with fibromyalgia

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Effects of intrathecal antibodies to substance P, calcitonin gene-related peptide and galanin on repeated cold stress-induced hyperalgesia: comparison with carrageenan-induced hyperalgesia

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Sound stress-induced long-term enhancement of mechanical hyperalgesia in rats is maintained by sympathoadrenal catecholamines

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Lack of association between fibromyalgia syndrome and abnormalities in muscle energy metabolism

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Phosphorylation of CREB and Mechanical Hyperalgesia Is Reversed by Blockade of the cAMP Pathway in a Time-Dependent Manner after Repeated Intramuscular Acid Injections

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Reversal of acid‐induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2

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Effects of the N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan on Temporal Summation of Pain are Similar in Fibromyalgia Patients and Normal Control Subjects

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Resting state connectivity correlates with drug and placebo response in fibromyalgia patients

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