The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Central Sensitization and Small-fiber Neuropathy Are Associated in Patients With Fibromyalgia
Abstract
Objective: To study the prevalence of small-fiber neuropathy (SFN) in a large cohort of patients with fibromyalgia (FM) and to better characterize the subset of patients with both FM and SFN. Methods: This 1-year, retrospective, observational cohort study included 265 patients with FM. They all performed electrochemical skin conductance (ESC) using the Sudoscan device, 1 of the simplest and most reliable technique to assess the distal autonomic nerve fibers. They completed 4 self-assessment questionnaires: (1) the Central Sensitization Inventory (CSI), (2) the Neuropathic Pain Symptom Inventory (NPSI), and (3) the Hospital Anxiety and Depression Scale (HADS), the Fibromyalgia Impact Questionnaire (FIQ). Results: Fifty-three patients (20%) had reduced ESC values. These patients had higher CSI and HADS scores, and a larger intake of analgesic drugs compared with patients with no ESC abnormalities. Central sensitization, which was extreme in 69% of the patients (CSI score ≥60), was 1 of the main determinants of ESC abnormalities and was associated with a higher NPSI score, even though these 2 factors were not correlated. Conclusion: Over the past 10 years, studies have shown that a significant proportion of patients with FM have signs of small nerve fiber impairment. The possible involvement of SFN, in the occurrence and presentation of clinical symptoms in FM patients, remains however unclear. This is the first study that showed an association between central sensitization and both small nerve fiber impairment and neuropathic pain features in FM patients, rather than a direct association between SFN and neuropathic pain.
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Metadata
- Authors
- Dumolard, A., Lefaucheur, J.-P., Hodaj, E., Liateni, Z., Payen, J.-F., & Hodaj, H.
- Affiliations
- Centre Hospitalier Universitaire de Grenoble (FR)
- Université Paris-Est Créteil (FR)
- Pain Center, Department of Anaesthesia and Intensive Care
- Corresponding author
- Dumolard, Anne
- Liateni, Zaki
- Payen, Jean-François
- Hodaj, Hasan
- Venue
- The Clinical Journal of Pain
- Published
- 2022-11-16
- Volume
- 39
- Issue
- 1
- Pages
- 8-14
- ISSN
- 0749-8047 (ISSN-L)
- 1536-5409
- OpenAlex
- W4311898218
- Semantic Scholar
- f1ffd38dc2aec7df535c06dbdaf75cecd57527d8
- Cited by
- 26
- References
- 62
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 7 · 2023: 4
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Journal of Pain (publishedVersion)
- PubMed (publishedVersion)
- HAL (Le Centre pour la Communication Scientifique Directe) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- fibromyalgia, small fiber neuropathy, central sensitization, electrochemical skin conductance, autonomic nerve fibers, neuropathic pain, anxiety and depression, analgesic use, prevalence
- MeSH terms
- Fibromyalgia, Humans, Neuralgia, Surveys and Questionnaires, Retrospective Studies, Central Nervous System Sensitization
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