Cited by 659Anesthesia and Pain ManagementPain Management and TreatmentPediatric Pain Management Techniques

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Preoperative Anxiety and Catastrophizing: A Systematic Review and Meta-analysis of the Association With Chronic Postsurgical Pain

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Theunissen, Maurice, Peters, Madelon L., Bruce, Julie, Gramke, Hans-Fritz, Marcus, Marco A.·2012·The Clinical Journal of Pain

DOI 10.1097/ajp.0b013e31824549d6

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Abstract

OBJECTIVES: Anxiety and pain catastrophizing predict acute postoperative pain. However, it is not well established whether they also predict chronic postsurgical pain (CPSP). The aim of this systematic review and meta-analysis was to investigate whether high levels of preoperative anxiety or pain catastrophizing are associated with an increased risk of CPSP. METHODS: Electronic search databases included PubMed and PsychINFO. Additional literature was obtained by reference tracking and expert consultation. Studies from 1958 until October 2010, investigating the association between preoperative anxiety or pain catastrophizing and CPSP in adult surgery patients, were assessed. The primary outcome was the presence of pain at least 3 months postoperatively. RESULTS: Twenty-nine studies were included; 14 instruments were used to assess anxiety or pain catastrophizing. Sixteen studies (55%) reported a statistically significant association between anxiety or pain catastrophizing and CPSP. The proportion of studies reporting a statistically significant association was 67% for studies of musculoskeletal surgery and 36% for other types of surgery. There was no association with study quality, but larger studies were more likely to report a statistically significant relationship. The overall pooled odds ratio, on the basis of 15 studies, ranged from 1.55 (95% confidence interval, 1.10-2.20) to 2.10 (95% confidence interval, 1.49-2.95). Pain catastrophizing might be of higher predictive utility compared with general anxiety or more specific pain-related anxiety. DISCUSSION: There is evidence that anxiety and catastrophizing play a role in the development of CPSP. We recommend that anxiety measures should be incorporated in future studies investigating the prediction and transition from acute to chronic postoperative pain.

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Authors: Theunissen, M., Peters, M. L., Bruce, J., Gramke, H.-F., & Marcus, M. A.
Affiliations: Maastricht University Medical Centre (NL)
Maastricht University (NL)
University of Warwick (GB)
Corresponding author: Theunissen, Maurice
Gramke, Hans-Fritz
Marcus, Marco A.
ORCID: Theunissen, Maurice
Peters, Madelon L.
Bruce, Julie
Marcus, Marco A.
Venue: The Clinical Journal of Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-11
Volume: 28
Issue: 9
Pages: 819-841
ISSN: 0749-8047 (ISSN-L)
DOI: 10.1097/ajp.0b013e31824549d6
OpenAlex: W1974125795
Cited by: 659
References: 64
Citations by year: 2026: 45 · 2025: 31 · 2024: 34 · 2023: 91 · 2022: 50 · 2021: 53 · 2020: 39 · 2019: 111 · 2018: 49 · 2017: 37 · 2016: 33 · 2015: 30 · 2014: 35 · 2013: 20 · 2012: 1
FWCI: 5.31
Type: journal article
Language: en
Open access: green
cris.maastrichtuniversity.nl
Licence: other-oa
Locations: Clinical Journal of Pain (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
Keywords: preoperative anxiety, pain catastrophizing, chronic postoperative pain, postoperative pain, pain-related anxiety, musculoskeletal surgery, risk prediction, acute to chronic pain transition
MeSH terms: Anxiety, Female, Humans, Male, Pain Measurement, Postoperative Pain, Databases, Bibliographic, Catastrophization

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Preoperative Anxiety and Catastrophizing: A Systematic Review and Meta-analysis of the Association With Chronic Postsurgical Pain

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